M Irwin

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Depression and insomnia in cancer: prevalence, risk factors, and effects on cancer outcomes
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Department of Psychiatry and Biobehavioral Sciences, David Gefffen School of Medicine, University of California, Los Angeles, 300 UCLA Medical Plaza, Room 3130, Los Angeles, CA, 90095 7076, USA
    Curr Psychiatry Rep 15:404. 2013
  2. pmc Varicella zoster virus-specific immune responses to a herpes zoster vaccine in elderly recipients with major depression and the impact of antidepressant medications
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience, University of California, Los Angeles, Los Angeles, CA 90095 7057, USA
    Clin Infect Dis 56:1085-93. 2013
  3. pmc Sleep disturbance, inflammation and depression risk in cancer survivors
    Michael R Irwin
    University of California, Los Angeles Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, CA 90095 7076, USA
    Brain Behav Immun 30:S58-67. 2013
  4. pmc Mitigating cellular inflammation in older adults: a randomized controlled trial of Tai Chi Chih
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, University of California, Los Angeles, CA 90095, USA
    Am J Geriatr Psychiatry 20:764-72. 2012
  5. pmc Sleep loss exacerbates fatigue, depression, and pain in rheumatoid arthritis
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience and Department of Psychiatry and Biobehavioral Sciences, Los Angeles, California 90095 7076, USA
    Sleep 35:537-43. 2012
  6. ncbi request reprint Comparative meta-analysis of behavioral interventions for insomnia and their efficacy in middle-aged adults and in older adults 55+ years of age
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, University of California, Los Angeles UCLA Neuropsychiatric Institute, Los Angeles, CA 90095 7057, USA
    Health Psychol 25:3-14. 2006
  7. ncbi request reprint Association between nocturnal vagal tone and sleep depth, sleep quality, and fatigue in alcohol dependence
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, Neuropsychiatric Institute, Los Angeles, CA 90095 7057, USA
    Psychosom Med 68:159-66. 2006
  8. ncbi request reprint Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 7057, USA
    Arch Intern Med 166:1756-62. 2006
  9. ncbi request reprint Cocaine dependence and acute cocaine induce decreases of monocyte proinflammatory cytokine expression across the diurnal period: autonomic mechanisms
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, CA 90095 7057, USA
    J Pharmacol Exp Ther 320:507-15. 2007
  10. ncbi request reprint Depressive disorders and immunity: 20 years of progress and discovery
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, University of California Los Angeles, Semel Institute for Neuroscience, 300 Medical Plaza, Suite 3 109, Los Angeles, CA, USA
    Brain Behav Immun 21:374-83. 2007

Detail Information

Publications67

  1. pmc Depression and insomnia in cancer: prevalence, risk factors, and effects on cancer outcomes
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Department of Psychiatry and Biobehavioral Sciences, David Gefffen School of Medicine, University of California, Los Angeles, 300 UCLA Medical Plaza, Room 3130, Los Angeles, CA, 90095 7076, USA
    Curr Psychiatry Rep 15:404. 2013
    ..The clinical significance of depression and insomnia for cancer patients is further stressed by epidemiological observations that link depression and insomnia to cancer morbidity and mortality risk. ..
  2. pmc Varicella zoster virus-specific immune responses to a herpes zoster vaccine in elderly recipients with major depression and the impact of antidepressant medications
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience, University of California, Los Angeles, Los Angeles, CA 90095 7057, USA
    Clin Infect Dis 56:1085-93. 2013
    ....
  3. pmc Sleep disturbance, inflammation and depression risk in cancer survivors
    Michael R Irwin
    University of California, Los Angeles Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, CA 90095 7076, USA
    Brain Behav Immun 30:S58-67. 2013
    ....
  4. pmc Mitigating cellular inflammation in older adults: a randomized controlled trial of Tai Chi Chih
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, University of California, Los Angeles, CA 90095, USA
    Am J Geriatr Psychiatry 20:764-72. 2012
    ..To evaluate the effects of a behavioral intervention, Tai Chi Chih (TCC) on circulating markers of inflammation in older adults...
  5. pmc Sleep loss exacerbates fatigue, depression, and pain in rheumatoid arthritis
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience and Department of Psychiatry and Biobehavioral Sciences, Los Angeles, California 90095 7076, USA
    Sleep 35:537-43. 2012
    ..This study evaluated the effect of sleep loss during part of the night on daytime mood symptoms and pain perceptions in patients with rheumatoid arthritis in comparison with control subjects...
  6. ncbi request reprint Comparative meta-analysis of behavioral interventions for insomnia and their efficacy in middle-aged adults and in older adults 55+ years of age
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, University of California, Los Angeles UCLA Neuropsychiatric Institute, Los Angeles, CA 90095 7057, USA
    Health Psychol 25:3-14. 2006
    ..A research agenda is recommended to examine the mechanisms of action of behavioral treatments on sleep with increased attention to the high prevalence of insomnia in older individuals...
  7. ncbi request reprint Association between nocturnal vagal tone and sleep depth, sleep quality, and fatigue in alcohol dependence
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, Neuropsychiatric Institute, Los Angeles, CA 90095 7057, USA
    Psychosom Med 68:159-66. 2006
    ....
  8. ncbi request reprint Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 7057, USA
    Arch Intern Med 166:1756-62. 2006
    ..The effects of sleep loss on the cellular and genomic mechanisms that contribute to inflammatory cytokine activity are not known...
  9. ncbi request reprint Cocaine dependence and acute cocaine induce decreases of monocyte proinflammatory cytokine expression across the diurnal period: autonomic mechanisms
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, CA 90095 7057, USA
    J Pharmacol Exp Ther 320:507-15. 2007
    ..Targeting sympathovagal balance might represent a novel strategy for partial amelioration of impairments of innate immunity in cocaine dependence...
  10. ncbi request reprint Depressive disorders and immunity: 20 years of progress and discovery
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, University of California Los Angeles, Semel Institute for Neuroscience, 300 Medical Plaza, Suite 3 109, Los Angeles, CA, USA
    Brain Behav Immun 21:374-83. 2007
    ..Moreover, the work has served to instantiate brain-immune interactions as an essential component in psychiatric and medical co-morbidities and their impact on health and illness...
  11. ncbi request reprint Augmenting immune responses to varicella zoster virus in older adults: a randomized, controlled trial of Tai Chi
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, University of California at Los Angeles, Los Angeles, California, USA
    J Am Geriatr Soc 55:511-7. 2007
    ..To evaluate the effects of a behavioral intervention, Tai Chi, on resting and vaccine-stimulated levels of cell-mediated immunity (CMI) to varicella zoster virus (VZV) and on health functioning in older adults...
  12. ncbi request reprint Human psychoneuroimmunology: 20 years of discovery
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, University of California, 300 Medical Plaza, Suite 3 109, Los Angeles, CA 90095 7057, USA
    Brain Behav Immun 22:129-39. 2008
    ....
  13. pmc Sleep loss activates cellular inflammatory signaling
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, CA 90095 7076, USA
    Biol Psychiatry 64:538-40. 2008
    ..This study was undertaken to test the effects of sleep loss on activation of nuclear factor (NF)-kappaB, a transcription factor that serves a critical role in the inflammatory signaling cascade...
  14. pmc Improving sleep quality in older adults with moderate sleep complaints: A randomized controlled trial of Tai Chi Chih
    Michael R Irwin
    University of California, Los Angeles, Cousins Center for Psychoneuroimmunology, Los Angeles, California, USA
    Sleep 31:1001-8. 2008
    ..To determine the efficacy of a novel behavioral intervention, Tai Chi Chih, to promote sleep quality in older adults with moderate sleep complaints...
  15. pmc Sleep loss activates cellular markers of inflammation: sex differences
    Michael R Irwin
    University of California, Los Angeles Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90095 7076, USA
    Brain Behav Immun 24:54-7. 2010
    ..These results have implications for understanding the role of sleep disturbance in the differential risk profile for inflammatory disorders between the sexes...
  16. pmc Major depressive disorder and immunity to varicella-zoster virus in the elderly
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095 7057, USA
    Brain Behav Immun 25:759-66. 2011
    ....
  17. pmc Reciprocal regulation of the neural and innate immune systems
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, 300 UCLA Medical Plaza, University of California, Los Angeles, California 90095 7076, USA
    Nat Rev Immunol 11:625-32. 2011
    ..CNS-mediated regulation of innate immune responses optimizes total organism fitness and provides new opportunities for therapeutic control of chronic infectious, inflammatory and neuropsychiatric diseases...
  18. ncbi request reprint Sleep deprivation potentiates activation of cardiovascular and catecholamine responses in abstinent alcoholics
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, Neuropsychiatric Institute, Los Angeles 90095 7057, USA
    Hypertension 45:252-7. 2005
    ..It is possible that modest habitual sleep loss could contribute to triggering cardiac arrhythmias or other cardiovascular events in alcohol dependence...
  19. pmc Tumor necrosis factor antagonism normalizes rapid eye movement sleep in alcohol dependence
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience, University of California, Los Angeles, California 90095 7076, USA
    Biol Psychiatry 66:191-5. 2009
    ..This study was undertaken to test whether blockade of biologically active tumor necrosis factor-alpha (TNF-alpha) normalizes REM sleep in alcohol-dependent adults...
  20. ncbi request reprint Nocturnal proinflammatory cytokine-associated sleep disturbances in abstinent African American alcoholics
    Michael Irwin
    Cousins Center for Psychoneuroimmunology, Neuropsychiatric Institute, University of California, Los Angeles, CA, USA
    Brain Behav Immun 18:349-60. 2004
    ..These findings have implications for determining why sleep is disordered in alcoholics and may aid in the development of novel treatments to optimize sleep in this population...
  21. ncbi request reprint Effects of sleep and sleep loss on immunity and cytokines
    Michael Irwin
    Cousins Center for Psychoneuroimmunology, UCLA Neuropsychiatric Institute and Department of Psychiatry and Biobehavioral Sciences, University of California, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7057, USA
    Brain Behav Immun 16:503-12. 2002
    ..Moreover, in view of basic evidence of a reciprocal interaction between sleep and cytokines, further research is needed to understand whether alterations in cytokines contribute to disordered sleep in patient populations...
  22. ncbi request reprint Neuroimmunology of disordered sleep in depression and alcoholism
    M Irwin
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
    Neuropsychopharmacology 25:S45-9. 2001
    ..Moreover, in view of basic evidence of a reciprocal interaction between sleep and cytokines, further research is needed to understand whether alterations in cytokines contribute to disordered sleep...
  23. ncbi request reprint Disordered sleep, nocturnal cytokines, and immunity: interactions between alcohol dependence and African-American ethnicity
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, University of California, Los Angeles UCLA, Neuropsychiatric Institute, 300 Medical Plaza, Suite 3 109, University of California, Los Angeles, Los Angeles, CA 90095 7057, USA
    Alcohol 32:53-61. 2004
    ....
  24. ncbi request reprint Effects of a behavioral intervention, Tai Chi Chih, on varicella-zoster virus specific immunity and health functioning in older adults
    Michael R Irwin
    Cousins Center for Psychoneuroimmunonology, UCLA Neuropsychiatric Institute, University of California, Los Angeles 90095 7057, USA
    Psychosom Med 65:824-30. 2003
    ..This study examined whether a behavioral intervention, Tai Chi Chih (TCC), affects VZV specific immunity and health functioning in older adults who, on average, show impairments of health status and are at risk for shingles...
  25. ncbi request reprint Disordered sleep, nocturnal cytokines, and immunity in alcoholics
    Laura Redwine
    Department of Psychiatry, University of California, San Diego, La Jolla, USA
    Psychosom Med 65:75-85. 2003
    ..This study examined the relationships between sleep, nocturnal expression of immunoregulatory cytokines, and natural killer (NK) cell activity in alcoholic patients as compared with control subjects...
  26. ncbi request reprint Polysomnographic and spectral sleep EEG in primary alcoholics: an interaction between alcohol dependence and African-American ethnicity
    M Irwin
    University of California, San Diego, and the San Diego VA Medical Center, 92161, USA
    Alcohol Clin Exp Res 24:1376-84. 2000
    ..Increasing evidence indicates that there are ethnic differences in sleep EEG and that African-Americans may be at elevated risk for disordered sleep...
  27. ncbi request reprint Cellular immunity to varicella-zoster virus in patients with major depression
    M Irwin
    VA Medical Center, University of California, San Diego, USA
    J Infect Dis 178:S104-8. 1998
    ..These data indicate that major depression is associated with a marked decline in VZV-specific cellular immunity...
  28. ncbi request reprint Sleep deprivation as a probe of homeostatic sleep regulation in primary alcoholics
    Michael Irwin
    Cousins Center for Psychoneuroimmunology, Department of Psychiatry and Biobehavioral Sciences, University of California, 300 UCLA Medical Plaza, Los Angeles, CA 90095, USA
    Biol Psychiatry 51:632-41. 2002
    ..Using partial sleep deprivation, this study examined the extent to which abnormal sleep is reversible in alcoholic subjects...
  29. ncbi request reprint Nocturnal catecholamines and immune function in insomniacs, depressed patients, and control subjects
    Michael Irwin
    Cousins Center for Psychoneuroimmunonology, UCLA Neuropsychiatric Institute, University of California, Los Angeles, CA 90095 7057, USA
    Brain Behav Immun 17:365-72. 2003
    ..These data indicate that insomnia is associated with nocturnal sympathetic arousal and declines of natural immunity, and further support the role of sleep in the regulation of sympathetic nervous and immune system functioning...
  30. ncbi request reprint Cellular adhesion molecule expression, nocturnal sleep, and partial night sleep deprivation
    Laura Redwine
    Department of Medicine and Veterans Medical Research Foundation, University of California, San Diego, USA
    Brain Behav Immun 18:333-40. 2004
    ..These data indicate that acute sleep disruption is associated with alterations in cellular adhesion molecule expression, with implications for the regulation of immune cell trafficking...
  31. ncbi request reprint Visual EEG differences in abstinent alcohol dependence and ethnicity
    Edwin M Valladares
    Cousins Center for Psychoneuroimmunology, Neuropsychiatric Institute, University of California, Los Angeles, CA 90095 7057, USA
    Sleep Med 7:79-80. 2006
  32. ncbi request reprint Central CRH suppresses specific antibody responses: effects of beta-adrenoceptor antagonism and adrenalectomy
    E M Friedman
    Department of Psychiatry, University of California, San Diego, USA
    Brain Behav Immun 15:65-77. 2001
    ..Moreover, the adrenals may promote optimal primary antibody responses after exposure to physiological levels of antigen...
  33. ncbi request reprint Melatonin modulation of lymphocyte proliferation and Th1/Th2 cytokine expression
    E Kühlwein
    Veterans Affairs San Diego Healthcare System, Department of Psychiatry, University of California, San Diego, La Jolla, CA 92161, USA
    J Neuroimmunol 117:51-7. 2001
    ..These data support the notion that physiologic doses of melatonin increase lymphocyte proliferation possibly due to decreases in production of the inhibitory cytokine IL-10...
  34. ncbi request reprint Acute psychological stress: effects on chemotaxis and cellular adhesion molecule expression
    Laura Redwine
    Department of Psychiatry, University of California, San Diego, USA
    Psychosom Med 65:598-603. 2003
    ..In this study, we examine the effects of an acute psychological stress on chemotactic responses of PBMCs and on CAM expression in relation to measures of sympathetic activation...
  35. ncbi request reprint Psychoneuroimmunology of depression: clinical implications
    Michael Irwin
    Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, California 90095 7057, USA
    Brain Behav Immun 16:1-16. 2002
    ..Finally, the potential for biobehavioral interventions to impact psychological adaptation and the course of immune related disease is discussed...
  36. ncbi request reprint Polysomnographic sleep dysregulation in cocaine dependence
    Edwin M Valladares
    Cousins Center for Psychoneuroimmunology, University of California Los Angeles, Semel Institute for Neuroscience and Human Behavior, Los Angeles, USA
    ScientificWorldJournal 7:213-6. 2007
    ..Few studies have used polysomnography to evaluate sleep in cocaine-dependent persons, yet these studies have the potential to advance treatments that will ultimately reduce morbidity in cocaine-dependent subjects...
  37. pmc Identification and treatment of symptoms associated with inflammation in medically ill patients
    Robert Dantzer
    Integrative Immunology and Behavior Program, 212 ERML, 1201 W Gregory Drive, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Psychoneuroendocrinology 33:18-29. 2008
    ..This resulted in a number of recommendations that should improve the recognition and management of inflammation-associated symptoms in medically ill patients...
  38. ncbi request reprint Health consequences of Alzheimer's caregiving transitions: effects of placement and bereavement
    Igor Grant
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0680, USA
    Psychosom Med 64:477-86. 2002
    ....
  39. doi request reprint Stress activation of cellular markers of inflammation in rheumatoid arthritis: protective effects of tumor necrosis factor alpha antagonists
    Sarosh J Motivala
    UCLA Semel Institute for Neuroscience and Human Behavior, Cousins Center for Psychoneuroimmunology, University of California, Los Angeles 90095 7076, USA
    Arthritis Rheum 58:376-83. 2008
    ..The purpose of this study was to determine whether RA patients show increased monocyte production of TNFalpha following acute psychological stress and whether such responses are abrogated in RA patients taking TNFalpha antagonists...
  40. pmc Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer
    Andrew H Miller
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Winship Cancer Institute, 1365 C Clifton Rd, 5th Floor, Atlanta, GA 30322, USA
    J Clin Oncol 26:971-82. 2008
    ....
  41. doi request reprint Varicella-zoster virus-specific immune responses in elderly recipients of a herpes zoster vaccine
    M J Levin
    University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Infect Dis 197:825-35. 2008
    ..The trial included an immunology substudy to determine the relationship of VZV-specific immune responses to vaccination and clinical outcome...
  42. doi request reprint Comparison of cognitive behavioral and mindfulness meditation interventions on adaptation to rheumatoid arthritis for patients with and without history of recurrent depression
    Alex J Zautra
    Department of Psychology, Arizona State University, Tempe, AZ 85287 1104, USA
    J Consult Clin Psychol 76:408-21. 2008
    ....
  43. ncbi request reprint Pain-related activation of leukocyte cellular adhesion molecules: preliminary findings
    Charles A Griffis
    School of Nursing, University of California at Los Angeles, Los Angeles, CA 90095 1702, USA
    Neuroimmunomodulation 14:224-8. 2007
    ..This study examined the effects of acute experimental pain on catecholamine and cortisol levels and leukocyte expression of cellular adhesion molecules...
  44. pmc Chronic stress and regulation of cellular markers of inflammation in rheumatoid arthritis: implications for fatigue
    Mary C Davis
    Department of Psychology, Arizona State University, P O Box 871104, Tempe, AZ 85287 1104, USA
    Brain Behav Immun 22:24-32. 2008
    ..The association between these markers of inflammation and fatigue was also tested...
  45. ncbi request reprint Sex differences in cardiac sympathovagal balance and vagal tone during nocturnal sleep
    Edwin M Valladares
    Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience, 300 Medical Plaza, Suite 3 109, Los Angeles, CA 90095 7057, USA
    Sleep Med 9:310-6. 2008
    ..To analyze sex differences in nocturnal vagal tone and cardiac sympathovagal balance during sleep in healthy men and women...
  46. ncbi request reprint Abnormal nocturnal melatonin secretion and disordered sleep in abstinent alcoholics
    Eva Kühlwein
    Cousins Center for Psychoneuroimmunonology, University of California, Los Angeles, Neuropsychiatric Institute, Los Angeles, California 90095 7057, USA
    Biol Psychiatry 54:1437-43. 2003
    ..Given the role of melatonin in the regulation of the sleep-wake cycle, this study examined the relationship between nocturnal expression of melatonin and sleep in alcoholics as compared with control subjects...
  47. ncbi request reprint Inflammatory biomarkers for persistent fatigue in breast cancer survivors
    Alicia Collado-Hidalgo
    Cousins Center for Psychoneuroimmunology, University of California at Los Angeles Semel Institute for Neuroscience and Human Behavior, Los Angeles, California 90095 7076, USA
    Clin Cancer Res 12:2759-66. 2006
    ..This study seeks to define immunologic and inflammatory variables associated with persistent post-treatment fatigue in breast cancer survivors...
  48. ncbi request reprint Depression and immunity: inflammation and depressive symptoms in multiple sclerosis
    Stefan M Gold
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, 300 Medical Plaza, Suite 3109, Los Angeles, CA 90095, USA
    Neurol Clin 24:507-19. 2006
    ..For example, an inflammatory depression may require different therapeutic approaches than a reactive depression in MS. Future research should aim to characterize these subtypes better with the goal of optimizing treatment...
  49. ncbi request reprint Impairments in health functioning and sleep quality in older adults with a history of depression
    Sarosh J Motivala
    Department of Psychiatry and Biobehavioral Sciences, Cousins Center for Psychoneuroimmunology, University of California at Los Angeles, 90095, USA
    J Am Geriatr Soc 54:1184-91. 2006
    ....
  50. ncbi request reprint Dissociation of inflammatory markers and natural killer cell activity in major depressive disorder
    Jennifer L Pike
    Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, Neuropsychiatric Institute, Los Angeles, CA 90095 7057, USA
    Brain Behav Immun 20:169-74. 2006
    ..The independent effect of depression on inflammatory markers and natural killer immune responses has implications for understanding individual differences in the adverse health effects of major depressive disorder...
  51. ncbi request reprint Inflammatory responses to psychological stress in fatigued breast cancer survivors: relationship to glucocorticoids
    Julienne E Bower
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, 300 UCLA Medical Plaza, Room 3306, Box 957076 Los Angeles, CA 90095 7076, USA
    Brain Behav Immun 21:251-8. 2007
    ..05). These data provide further evidence of enhanced inflammatory processes in fatigued breast cancer survivors and suggest that these processes may stem in part from decreased glucocorticoid response to stress...
  52. ncbi request reprint Leptin and cellular and innate immunity in abstinent alcoholics and controls
    Sarosh J Motivala
    Cousin Center for Psychoneuroimmunology, University of California Los Angeles, Neuropsychiatric Institute, 90095 7076, USA
    Alcohol Clin Exp Res 27:1819-24. 2003
    ..Given evidence that concentrations of leptin are altered in alcoholics who also show immune abnormalities, this study examined the relationships between circulating levels of leptin and markers of cellular and innate immunity...
  53. ncbi request reprint Pro-inflammatory cytokines and depression in a familial cancer registry
    Mary Frances O'Connor
    Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90095 7076, USA
    Psychooncology 16:499-501. 2007
    ..The present data are important for characterizing persons at high risk for cancer who may later acquire knowledge of further increased risk through genetic testing...
  54. ncbi request reprint Tai Chi Chih acutely decreases sympathetic nervous system activity in older adults
    Sarosh J Motivala
    Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience and Human Behavior, 300 Medical Plaza, Suite 3148, Los Angeles, California 90095 7057, USA
    J Gerontol A Biol Sci Med Sci 61:1177-80. 2006
    ..The purpose of this study was to examine whether the practice of Tai Chi Chih (TCC), a movement-based relaxation practice, would acutely promote decreases of sympathetic activity in elderly persons...
  55. ncbi request reprint Depression, C-reactive protein and two-year major adverse cardiac events in men after acute coronary syndromes
    Nancy Frasure-Smith
    Department of Psychiatry and School of Nursing, McGill University, Montreal, Canada
    Biol Psychiatry 62:302-8. 2007
    ....
  56. ncbi request reprint Cardiac-related hospitalization and/or death associated with immune dysregulation and symptoms of depression in heart failure patients
    Laura S Redwine
    Department of Medicine, University of California, San Diego, CA, USA
    Psychosom Med 69:23-9. 2007
    ..This study examined in CHF patients the relationship of depressive symptoms with cellular immune activity measured by Th1/Th2 ratios and cardiac rehospitalization and/or death...
  57. ncbi request reprint EEG and vagal tone degradation during nocturnal sleep in abstinent alcohol dependence
    Edwin M Valladares
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, UCLA David Geffen School of Medicine, University of California, Los Angeles, CA 90095 7057, USA
    Sleep Med 8:284-5. 2007
  58. ncbi request reprint Sex differences in monocyte expression of IL-6: role of autonomic mechanisms
    Mary Frances O'Connor
    Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, 300 Medical Plaza, Los Angeles, CA 90095 7076, USA
    Am J Physiol Regul Integr Comp Physiol 293:R145-51. 2007
    ..Interventions that target autonomic mechanisms might constitute new strategies to constrain IL-6 production with impacts on inflammatory disease risk in women...
  59. ncbi request reprint Inflammatory markers and sleep disturbance in major depression
    Sarosh J Motivala
    Cousins Center for Psychoneuroimmunology, UCLA Neuropsychiatric Institute, University of California, Los Angeles, CA, USA
    Psychosom Med 67:187-94. 2005
    ..This study was conducted to determine whether immune activation occurs in major depression, and to evaluate the associations between disordered sleep and markers of inflammation in patients with major depressive disorder...
  60. ncbi request reprint Loss of slow-wave sleep
    Sam M Eljammal
    Cousins Center for Psychoneuroimmunmolog, University of California, Los Angeles, CA 90095 7057, USA
    J Clin Sleep Med 2:213-4. 2006
  61. ncbi request reprint Spurious tumor necrosis factor-alpha and interleukin-6 production by human monocytes from blood collected in endotoxin-contaminated vacutainer blood collection tubes
    Najib Aziz
    Clin Chem 50:2215-6. 2004
  62. ncbi request reprint Validation of single-factor structure and scoring protocol for the Health Assessment Questionnaire-Disability Index
    Jason C Cole
    University of California, Los Angeles, CA, USA
    Arthritis Rheum 53:536-42. 2005
    ..However, HAQ-DI scoring has not been validated. The purpose of this study was to examine the structural validity of the HAQ-DI and evaluate the latent factors underlying HAQ-DI scoring...
  63. ncbi request reprint Validation of a 3-factor scoring model for the Pittsburgh sleep quality index in older adults
    Jason C Cole
    University of California, Cousins Center for Psychoneuroimmunology, Los Angeles, CA 90095 7076, USA
    Sleep 29:112-6. 2006
    ..Yet, validation of the PSQI single-factor scoring has not been carried out...
  64. ncbi request reprint Single-factor scoring validation for the Health Assessment Questionnaire-Disability Index (HAQ-DI) in patients with systemic sclerosis and comparison with early rheumatoid arthritis patients
    Jason C Cole
    Consulting Measurement Group, Huntington Beach, CA 91403, USA
    Qual Life Res 15:1383-94. 2006
    ..The goal of the current study was to examine the structural validity of the HAQ-DI in patients with systemic sclerosis (SSc, scleroderma) and to compare its performance with that in patients with RA...
  65. ncbi request reprint Depression and risk of cancer progression: an elusive link
    Michael R Irwin
    J Clin Oncol 25:2343-4. 2007
  66. ncbi request reprint Complementary and alternative treatments for late-life depression, anxiety, and sleep disturbance: a review of randomized controlled trials
    Thomas W Meeks
    Division of Geriatric Psychiatry, Department of Psychiatry, University of California, San Diego, USA
    J Clin Psychiatry 68:1461-71. 2007
    ..We reviewed randomized controlled trials of complementary and alternative medicine (CAM) treatments for depression, anxiety, and sleep disturbance in nondemented older adults...
  67. doi request reprint Vaccination against Herpes Zoster and Postherpetic Neuralgia
    Michael N Oxman
    VA San Diego Healthcare System, San Diego, California, USA
    J Infect Dis 197:S228-36. 2008
    ..VZV vaccines can boost VZV-CMI. Therefore, we tested the hypothesis that VZV vaccination would protect older adults against HZ and PHN...

Research Grants39

  1. Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune Mechanisms
    Michael R Irwin; Fiscal Year: 2010
    ..This project will constitute the first, randomized controlled clinical trial of the effects of TCC on sleep outcomes in breast cancer survivors, and will advance psychobiological models of insomnia treatment mechanisms. ..
  2. RESEARCH PERSPECTIVES IN PNI, TRAINEE TRAVEL
    Michael Irwin; Fiscal Year: 2006
    ..abstract_text> ..
  3. Sleep and Immune Mechanisms in Rheumatoid Arthritis
    Michael Irwin; Fiscal Year: 2007
    ..Results from this study will guide the development of interventions that target disordered sleep with potential effects on disability in RA. ..
  4. Post-Graduate Training Program in Psychoneuroimmunology and Mental Disorders
    Michael Irwin; Fiscal Year: 2007
    ....
  5. Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune Mechanisms
    Michael Irwin; Fiscal Year: 2007
    ..This project will constitute the first, randomized controlled clinical trial of the effects of TCC on sleep outcomes in breast cancer survivors, and will advance psychobiological models of insomnia treatment mechanisms. ..
  6. Sleep and Immune Mechanisms in Rheumatoid Arthritis
    Michael Irwin; Fiscal Year: 2009
    ..Results from this study will guide the development of interventions that target disordered sleep with potential effects on disability in RA. ..
  7. Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune Mechanisms
    Michael Irwin; Fiscal Year: 2009
    ..This project will constitute the first, randomized controlled clinical trial of the effects of TCC on sleep outcomes in breast cancer survivors, and will advance psychobiological models of insomnia treatment mechanisms. ..
  8. Aging: Cytokine Mechanisms and Treatment of Insomnia
    Michael Irwin; Fiscal Year: 2009
    ..This study will advance psychobiological models of disordered sleep and the potential benefits of two readily exportable behavioral interventions for promoting improvements in sleep outcomes in the elderly. ..
  9. Subjective Social Isolation and Sleep Disturbances: Inflammatory Mechanisms in Ag
    Michael Irwin; Fiscal Year: 2009
    ..This study will inform the development of potential treatments that target disordered sleep with possible prevention of disease outcomes in older adults who are socially isolated. ..
  10. Cocaine Dependence: EEG Sleep and Cytokines
    Michael Irwin; Fiscal Year: 2005
    ..abstract_text> ..
  11. Alcoholism: Sleep and Cytokines in African Americans
    Michael Irwin; Fiscal Year: 2005
    ..g., cytokine antagonists) for sleep disturbance in alcoholism. ..
  12. BEHAVIORAL INTERVENTION FOR HERPES ZOSTER RISK IN AGING
    Michael Irwin; Fiscal Year: 2003
    ....
  13. DEPRESSION AND TRIAL OF VARICELLA VACCINE IN THE ELDERLY
    Michael Irwin; Fiscal Year: 2003
    ....
  14. Subjective Social Isolation and Sleep Disturbances: Inflammatory Mechanisms in Ag
    Michael R Irwin; Fiscal Year: 2010
    ..This study will inform the development of potential treatments that target disordered sleep with possible prevention of disease outcomes in older adults who are socially isolated. ..