Research Topics
| M IrwinSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Varicella zoster virus-specific immune responses to a herpes zoster vaccine in elderly recipients with major depression and the impact of antidepressant medicationsMichael R Irwin
Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience, University of California, Los Angeles, Los Angeles, CA 90095 7057, USA
Clin Infect Dis 56:1085-93. 2013....- Sleep disturbance, inflammation and depression risk in cancer survivorsMichael R Irwin
University of California, Los Angeles Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, CA 90095 7076, USA
Brain Behav Immun 30:S58-67. 2013.... - Mitigating cellular inflammation in older adults: a randomized controlled trial of Tai Chi ChihMichael R Irwin
Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, University of California, Los Angeles, CA 90095, USA
Am J Geriatr Psychiatry 20:764-72. 2012..To evaluate the effects of a behavioral intervention, Tai Chi Chih (TCC) on circulating markers of inflammation in older adults... - Sleep loss exacerbates fatigue, depression, and pain in rheumatoid arthritisMichael R Irwin
Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience and Department of Psychiatry and Biobehavioral Sciences, Los Angeles, California 90095 7076, USA
Sleep 35:537-43. 2012..This study evaluated the effect of sleep loss during part of the night on daytime mood symptoms and pain perceptions in patients with rheumatoid arthritis in comparison with control subjects... 
Comparative meta-analysis of behavioral interventions for insomnia and their efficacy in middle-aged adults and in older adults 55+ years of ageMichael R Irwin
Cousins Center for Psychoneuroimmunology, University of California, Los Angeles UCLA Neuropsychiatric Institute, Los Angeles, CA 90095 7057, USA
Health Psychol 25:3-14. 2006..A research agenda is recommended to examine the mechanisms of action of behavioral treatments on sleep with increased attention to the high prevalence of insomnia in older individuals...- Association between nocturnal vagal tone and sleep depth, sleep quality, and fatigue in alcohol dependenceMichael R Irwin
Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, Neuropsychiatric Institute, Los Angeles, CA 90095 7057, USA
Psychosom Med 68:159-66. 2006.... - Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammationMichael R Irwin
Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 7057, USA
Arch Intern Med 166:1756-62. 2006..The effects of sleep loss on the cellular and genomic mechanisms that contribute to inflammatory cytokine activity are not known... - Cocaine dependence and acute cocaine induce decreases of monocyte proinflammatory cytokine expression across the diurnal period: autonomic mechanismsMichael R Irwin
Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, CA 90095 7057, USA
J Pharmacol Exp Ther 320:507-15. 2007..Targeting sympathovagal balance might represent a novel strategy for partial amelioration of impairments of innate immunity in cocaine dependence... - Depressive disorders and immunity: 20 years of progress and discoveryMichael R Irwin
Cousins Center for Psychoneuroimmunology, University of California Los Angeles, Semel Institute for Neuroscience, 300 Medical Plaza, Suite 3 109, Los Angeles, CA, USA
Brain Behav Immun 21:374-83. 2007..Moreover, the work has served to instantiate brain-immune interactions as an essential component in psychiatric and medical co-morbidities and their impact on health and illness... - Augmenting immune responses to varicella zoster virus in older adults: a randomized, controlled trial of Tai ChiMichael R Irwin
Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, University of California at Los Angeles, Los Angeles, California, USA
J Am Geriatr Soc 55:511-7. 2007..To evaluate the effects of a behavioral intervention, Tai Chi, on resting and vaccine-stimulated levels of cell-mediated immunity (CMI) to varicella zoster virus (VZV) and on health functioning in older adults... - Human psychoneuroimmunology: 20 years of discoveryMichael R Irwin
Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, University of California, 300 Medical Plaza, Suite 3 109, Los Angeles, CA 90095 7057, USA
Brain Behav Immun 22:129-39. 2008.... - Sleep loss activates cellular inflammatory signalingMichael R Irwin
Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, CA 90095 7076, USA
Biol Psychiatry 64:538-40. 2008..This study was undertaken to test the effects of sleep loss on activation of nuclear factor (NF)-kappaB, a transcription factor that serves a critical role in the inflammatory signaling cascade... - Tumor necrosis factor antagonism normalizes rapid eye movement sleep in alcohol dependenceMichael R Irwin
Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience, University of California, Los Angeles, California 90095 7076, USA
Biol Psychiatry 66:191-5. 2009..This study was undertaken to test whether blockade of biologically active tumor necrosis factor-alpha (TNF-alpha) normalizes REM sleep in alcohol-dependent adults... - Sleep loss activates cellular markers of inflammation: sex differencesMichael R Irwin
University of California, Los Angeles Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90095 7076, USA
Brain Behav Immun 24:54-7. 2010..These results have implications for understanding the role of sleep disturbance in the differential risk profile for inflammatory disorders between the sexes... - Major depressive disorder and immunity to varicella-zoster virus in the elderlyMichael R Irwin
Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095 7057, USA
Brain Behav Immun 25:759-66. 2011.... - Reciprocal regulation of the neural and innate immune systemsMichael R Irwin
Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, 300 UCLA Medical Plaza, University of California, Los Angeles, California 90095 7076, USA
Nat Rev Immunol 11:625-32. 2011..CNS-mediated regulation of innate immune responses optimizes total organism fitness and provides new opportunities for therapeutic control of chronic infectious, inflammatory and neuropsychiatric diseases... - Sleep deprivation potentiates activation of cardiovascular and catecholamine responses in abstinent alcoholicsMichael R Irwin
Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, Neuropsychiatric Institute, Los Angeles 90095 7057, USA
Hypertension 45:252-7. 2005..It is possible that modest habitual sleep loss could contribute to triggering cardiac arrhythmias or other cardiovascular events in alcohol dependence... - Nocturnal proinflammatory cytokine-associated sleep disturbances in abstinent African American alcoholicsMichael Irwin
Cousins Center for Psychoneuroimmunology, Neuropsychiatric Institute, University of California, Los Angeles, CA, USA
Brain Behav Immun 18:349-60. 2004..These findings have implications for determining why sleep is disordered in alcoholics and may aid in the development of novel treatments to optimize sleep in this population... - Disordered sleep, nocturnal cytokines, and immunity: interactions between alcohol dependence and African-American ethnicityMichael R Irwin
Cousins Center for Psychoneuroimmunology, University of California, Los Angeles UCLA, Neuropsychiatric Institute, 300 Medical Plaza, Suite 3 109, University of California, Los Angeles, Los Angeles, CA 90095 7057, USA
Alcohol 32:53-61. 2004.... - Effects of a behavioral intervention, Tai Chi Chih, on varicella-zoster virus specific immunity and health functioning in older adultsMichael R Irwin
Cousins Center for Psychoneuroimmunonology, UCLA Neuropsychiatric Institute, University of California, Los Angeles 90095 7057, USA
Psychosom Med 65:824-30. 2003..This study examined whether a behavioral intervention, Tai Chi Chih (TCC), affects VZV specific immunity and health functioning in older adults who, on average, show impairments of health status and are at risk for shingles... - Improving sleep quality in older adults with moderate sleep complaints: A randomized controlled trial of Tai Chi ChihMichael R Irwin
University of California, Los Angeles, Cousins Center for Psychoneuroimmunology, Los Angeles, California, USA
Sleep 31:1001-8. 2008..To determine the efficacy of a novel behavioral intervention, Tai Chi Chih, to promote sleep quality in older adults with moderate sleep complaints... - Neuroimmunology of disordered sleep in depression and alcoholismM Irwin
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
Neuropsychopharmacology 25:S45-9. 2001..Moreover, in view of basic evidence of a reciprocal interaction between sleep and cytokines, further research is needed to understand whether alterations in cytokines contribute to disordered sleep... - Effects of sleep and sleep loss on immunity and cytokinesMichael Irwin
Cousins Center for Psychoneuroimmunology, UCLA Neuropsychiatric Institute and Department of Psychiatry and Biobehavioral Sciences, University of California, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7057, USA
Brain Behav Immun 16:503-12. 2002..Moreover, in view of basic evidence of a reciprocal interaction between sleep and cytokines, further research is needed to understand whether alterations in cytokines contribute to disordered sleep in patient populations... - Disordered sleep, nocturnal cytokines, and immunity in alcoholicsLaura Redwine
Department of Psychiatry, University of California, San Diego, La Jolla, USA
Psychosom Med 65:75-85. 2003..Moreover, the association between awake levels of the anti-inflammatory/T(H)2 cytokine IL-10 and subsequent amounts of delta sleep support the notion of a bidirectional interplay between cytokines and sleep in humans... - Cellular immunity to varicella-zoster virus in patients with major depressionM Irwin
VA Medical Center, University of California, San Diego, USA
J Infect Dis 178:S104-8. 1998..These data indicate that major depression is associated with a marked decline in VZV-specific cellular immunity... - Polysomnographic and spectral sleep EEG in primary alcoholics: an interaction between alcohol dependence and African-American ethnicityM Irwin
University of California, San Diego, and the San Diego VA Medical Center, 92161, USA
Alcohol Clin Exp Res 24:1376-84. 2000..Increasing evidence indicates that there are ethnic differences in sleep EEG and that African-Americans may be at elevated risk for disordered sleep... - Sleep deprivation as a probe of homeostatic sleep regulation in primary alcoholicsMichael Irwin
Cousins Center for Psychoneuroimmunology, Department of Psychiatry and Biobehavioral Sciences, University of California, 300 UCLA Medical Plaza, Los Angeles, CA 90095, USA
Biol Psychiatry 51:632-41. 2002..The differential effect of alcoholism on sleep stage physiology suggests a defect in the regulation or plasticity of slow wave sleep with implications for theories linking sleep depth to morbidity and outcome in alcoholics... - Nocturnal catecholamines and immune function in insomniacs, depressed patients, and control subjectsMichael Irwin
Cousins Center for Psychoneuroimmunonology, UCLA Neuropsychiatric Institute, University of California, Los Angeles, CA 90095 7057, USA
Brain Behav Immun 17:365-72. 2003..These data indicate that insomnia is associated with nocturnal sympathetic arousal and declines of natural immunity, and further support the role of sleep in the regulation of sympathetic nervous and immune system functioning... - Cellular adhesion molecule expression, nocturnal sleep, and partial night sleep deprivationLaura Redwine
Department of Medicine and Veterans Medical Research Foundation, University of California, San Diego, USA
Brain Behav Immun 18:333-40. 2004..These data indicate that acute sleep disruption is associated with alterations in cellular adhesion molecule expression, with implications for the regulation of immune cell trafficking... - Visual EEG differences in abstinent alcohol dependence and ethnicityEdwin M Valladares
Cousins Center for Psychoneuroimmunology, Neuropsychiatric Institute, University of California, Los Angeles, CA 90095-7057, USA
Sleep Med 7:79-80. 2006 - Central CRH suppresses specific antibody responses: effects of beta-adrenoceptor antagonism and adrenalectomyE M Friedman
Department of Psychiatry, University of California, San Diego, USA
Brain Behav Immun 15:65-77. 2001..Moreover, the adrenals may promote optimal primary antibody responses after exposure to physiological levels of antigen... - Melatonin modulation of lymphocyte proliferation and Th1/Th2 cytokine expressionE Kühlwein
Veterans Affairs San Diego Healthcare System, Department of Psychiatry, University of California, San Diego, La Jolla, CA 92161, USA
J Neuroimmunol 117:51-7. 2001..These data support the notion that physiologic doses of melatonin increase lymphocyte proliferation possibly due to decreases in production of the inhibitory cytokine IL-10... - Psychoneuroimmunology of depression: clinical implicationsMichael Irwin
Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, California 90095-7057, USA
Brain Behav Immun 16:1-16. 2002..Finally, the potential for biobehavioral interventions to impact psychological adaptation and the course of immune related disease is discussed... - Acute psychological stress: effects on chemotaxis and cellular adhesion molecule expressionLaura Redwine
Department of Psychiatry, University of California, San Diego, USA
Psychosom Med 65:598-603. 2003..In this study, we examine the effects of an acute psychological stress on chemotactic responses of PBMCs and on CAM expression in relation to measures of sympathetic activation... - Polysomnographic sleep dysregulation in cocaine dependenceEdwin M Valladares
Cousins Center for Psychoneuroimmunology, University of California Los Angeles, Semel Institute for Neuroscience and Human Behavior, Los Angeles, USA
ScientificWorldJournal 7:213-6. 2007..Few studies have used polysomnography to evaluate sleep in cocaine-dependent persons, yet these studies have the potential to advance treatments that will ultimately reduce morbidity in cocaine-dependent subjects... - Chronic stress and regulation of cellular markers of inflammation in rheumatoid arthritis: implications for fatigueMary C Davis
Department of Psychology, Arizona State University, P O Box 871104, Tempe, AZ 85287 1104, USA
Brain Behav Immun 22:24-32. 2008..The association between these markers of inflammation and fatigue was also tested... - Pain-related activation of leukocyte cellular adhesion molecules: preliminary findingsCharles A Griffis
School of Nursing, University of California at Los Angeles, Los Angeles, CA 90095 1702, USA
Neuroimmunomodulation 14:224-8. 2007..This study examined the effects of acute experimental pain on catecholamine and cortisol levels and leukocyte expression of cellular adhesion molecules... 
Stress activation of cellular markers of inflammation in rheumatoid arthritis: protective effects of tumor necrosis factor alpha antagonistsSarosh J Motivala
UCLA Semel Institute for Neuroscience and Human Behavior, Cousins Center for Psychoneuroimmunology, University of California, Los Angeles 90095 7076, USA
Arthritis Rheum 58:376-83. 2008..The purpose of this study was to determine whether RA patients show increased monocyte production of TNFalpha following acute psychological stress and whether such responses are abrogated in RA patients taking TNFalpha antagonists...- Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancerAndrew H Miller
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Winship Cancer Institute, 1365 C Clifton Rd, 5th Floor, Atlanta, GA 30322, USA
J Clin Oncol 26:971-82. 2008.... - Comparison of cognitive behavioral and mindfulness meditation interventions on adaptation to rheumatoid arthritis for patients with and without history of recurrent depressionAlex J Zautra
Department of Psychology, Arizona State University, Tempe, AZ 85287 1104, USA
J Consult Clin Psychol 76:408-21. 2008.... - Health consequences of Alzheimer's caregiving transitions: effects of placement and bereavementIgor Grant
Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0680, USA
Psychosom Med 64:477-86. 2002.... - Varicella-zoster virus-specific immune responses in elderly recipients of a herpes zoster vaccineM J Levin
University of Colorado Health Sciences Center, Denver, Colorado, USA
J Infect Dis 197:825-35. 2008..The trial included an immunology substudy to determine the relationship of VZV-specific immune responses to vaccination and clinical outcome... - Identification and treatment of symptoms associated with inflammation in medically ill patientsRobert Dantzer
Integrative Immunology and Behavior Program, 212 ERML, 1201 W Gregory Drive, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Psychoneuroendocrinology 33:18-29. 2008..This resulted in a number of recommendations that should improve the recognition and management of inflammation-associated symptoms in medically ill patients... - Sex differences in cardiac sympathovagal balance and vagal tone during nocturnal sleepEdwin M Valladares
Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience, 300 Medical Plaza, Suite 3 109, Los Angeles, CA 90095 7057, USA
Sleep Med 9:310-6. 2008..To analyze sex differences in nocturnal vagal tone and cardiac sympathovagal balance during sleep in healthy men and women... - Inflammatory markers and sleep disturbance in major depressionSarosh J Motivala
Cousins Center for Psychoneuroimmunology, UCLA Neuropsychiatric Institute, University of California, Los Angeles, CA, USA
Psychosom Med 67:187-94. 2005..This study was conducted to determine whether immune activation occurs in major depression, and to evaluate the associations between disordered sleep and markers of inflammation in patients with major depressive disorder... - Dissociation of inflammatory markers and natural killer cell activity in major depressive disorderJennifer L Pike
Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, Neuropsychiatric Institute, Los Angeles, CA 90095-7057, USA
Brain Behav Immun 20:169-74. 2006..The independent effect of depression on inflammatory markers and natural killer immune responses has implications for understanding individual differences in the adverse health effects of major depressive disorder... - Spurious tumor necrosis factor-alpha and interleukin-6 production by human monocytes from blood collected in endotoxin-contaminated vacutainer blood collection tubesNajib Aziz
Clin Chem 50:2215-6. 2004 - Abnormal nocturnal melatonin secretion and disordered sleep in abstinent alcoholicsEva Kühlwein
Cousins Center for Psychoneuroimmunonology, University of California, Los Angeles, Neuropsychiatric Institute, Los Angeles, California 90095 7057, USA
Biol Psychiatry 54:1437-43. 2003..Given the role of melatonin in the regulation of the sleep-wake cycle, this study examined the relationship between nocturnal expression of melatonin and sleep in alcoholics as compared with control subjects... - Inflammatory biomarkers for persistent fatigue in breast cancer survivorsAlicia Collado-Hidalgo
Cousins Center for Psychoneuroimmunology, University of California at Los Angeles Semel Institute for Neuroscience and Human Behavior, Los Angeles, California 90095-7076, USA
Clin Cancer Res 12:2759-66. 2006..83). CONCLUSION: These results extend links between fatigue and inflammatory markers to show a functional alteration in proinflammatory cytokine response to lipopolysaccharide and define a prognostic biomarker of behavioral fatigue... - Depression and immunity: inflammation and depressive symptoms in multiple sclerosisStefan M Gold
Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, 300 Medical Plaza, Suite 3109, Los Angeles, CA 90095, USA
Neurol Clin 24:507-19. 2006..For example, an inflammatory depression may require different therapeutic approaches than a reactive depression in MS. Future research should aim to characterize these subtypes better with the goal of optimizing treatment... - Impairments in health functioning and sleep quality in older adults with a history of depressionSarosh J Motivala
Department of Psychiatry and Biobehavioral Sciences, Cousins Center for Psychoneuroimmunology, University of California at Los Angeles, 90095, USA
J Am Geriatr Soc 54:1184-91. 2006..Moreover, in view of the association between sleep quality and health status, testing of interventions that target sleep quality might identify strategies to improve health functioning in older adults... - Leptin and cellular and innate immunity in abstinent alcoholics and controlsSarosh J Motivala
Cousin Center for Psychoneuroimmunology, University of California Los Angeles, Neuropsychiatric Institute, 90095 7076, USA
Alcohol Clin Exp Res 27:1819-24. 2003..Given evidence that concentrations of leptin are altered in alcoholics who also show immune abnormalities, this study examined the relationships between circulating levels of leptin and markers of cellular and innate immunity... - Inflammatory responses to psychological stress in fatigued breast cancer survivors: relationship to glucocorticoidsJulienne E Bower
Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, 300 UCLA Medical Plaza, Room 3306, Box 957076 Los Angeles, CA 90095 7076, USA
Brain Behav Immun 21:251-8. 2007..05). These data provide further evidence of enhanced inflammatory processes in fatigued breast cancer survivors and suggest that these processes may stem in part from decreased glucocorticoid response to stress... - Pro-inflammatory cytokines and depression in a familial cancer registryMary Frances O'Connor
Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90095 7076, USA
Psychooncology 16:499-501. 2007..The present data are important for characterizing persons at high risk for cancer who may later acquire knowledge of further increased risk through genetic testing... - Loss of slow-wave sleepSam M Eljammal
Cousins Center for Psychoneuroimmunmolog, University of California, Los Angeles, CA 90095-7057, USA
J Clin Sleep Med 2:213-4. 2006 - Sex differences in monocyte expression of IL-6: role of autonomic mechanismsMary Frances O'Connor
Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, 300 Medical Plaza, Los Angeles, CA 90095 7076, USA
Am J Physiol Regul Integr Comp Physiol 293:R145-51. 2007..Interventions that target autonomic mechanisms might constitute new strategies to constrain IL-6 production with impacts on inflammatory disease risk in women... - EEG and vagal tone degradation during nocturnal sleep in abstinent alcohol dependenceEdwin M Valladares
Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, UCLA David Geffen School of Medicine, University of California, Los Angeles, CA 90095-7057, USA
Sleep Med 8:284-5. 2007 - Cardiac-related hospitalization and/or death associated with immune dysregulation and symptoms of depression in heart failure patientsLaura S Redwine
Department of Medicine, University of California, San Diego, CA, USA
Psychosom Med 69:23-9. 2007..This study examined in CHF patients the relationship of depressive symptoms with cellular immune activity measured by Th1/Th2 ratios and cardiac rehospitalization and/or death... - Depression, C-reactive protein and two-year major adverse cardiac events in men after acute coronary syndromesNancy Frasure-Smith
Department of Psychiatry and School of Nursing, McGill University, Montreal, Canada
Biol Psychiatry 62:302-8. 2007.... - Tai Chi Chih acutely decreases sympathetic nervous system activity in older adultsSarosh J Motivala
Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience and Human Behavior, 300 Medical Plaza, Suite 3148, Los Angeles, California 90095 7057, USA
J Gerontol A Biol Sci Med Sci 61:1177-80. 2006..The purpose of this study was to examine whether the practice of Tai Chi Chih (TCC), a movement-based relaxation practice, would acutely promote decreases of sympathetic activity in elderly persons... - Single-factor scoring validation for the Health Assessment Questionnaire-Disability Index (HAQ-DI) in patients with systemic sclerosis and comparison with early rheumatoid arthritis patientsJason C Cole
Consulting Measurement Group, Huntington Beach, CA 91403, USA
Qual Life Res 15:1383-94. 2006..The goal of the current study was to examine the structural validity of the HAQ-DI in patients with systemic sclerosis (SSc, scleroderma) and to compare its performance with that in patients with RA... - Validation of a 3-factor scoring model for the Pittsburgh sleep quality index in older adultsJason C Cole
University of California, Cousins Center for Psychoneuroimmunology, Los Angeles, CA 90095-7076, USA
Sleep 29:112-6. 2006..CONCLUSIONS: These findings validate the factor structure of the PSQI and demonstrate that a 3-factor score should be used to assess disturbances in three separate factors of subjective sleep reports... - Complementary and alternative treatments for late-life depression, anxiety, and sleep disturbance: a review of randomized controlled trialsThomas W Meeks
Division of Geriatric Psychiatry, Department of Psychiatry, University of California, San Diego, USA
J Clin Psychiatry 68:1461-71. 2007..We reviewed randomized controlled trials of complementary and alternative medicine (CAM) treatments for depression, anxiety, and sleep disturbance in nondemented older adults... - Validation of single-factor structure and scoring protocol for the Health Assessment Questionnaire-Disability IndexJason C Cole
University of California, Los Angeles, CA, USA
Arthritis Rheum 53:536-42. 2005..In addition, the findings suggest some benefit from a secondary interpretation of the scores based on domains that measure motor skills... - Vaccination against Herpes Zoster and Postherpetic NeuralgiaMichael N Oxman
VA San Diego Healthcare System, San Diego, California, USA
J Infect Dis 197:S228-36. 2008..VZV vaccines can boost VZV-CMI. Therefore, we tested the hypothesis that VZV vaccination would protect older adults against HZ and PHN... - Depression and risk of cancer progression: an elusive linkMichael R Irwin
J Clin Oncol 25:2343-4. 2007
Research Grants
- Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune MechanismsMichael R Irwin; Fiscal Year: 2010..This project will constitute the first, randomized controlled clinical trial of the effects of TCC on sleep outcomes in breast cancer survivors, and will advance psychobiological models of insomnia treatment mechanisms. ..
- RESEARCH PERSPECTIVES IN PNI, TRAINEE TRAVELMichael Irwin; Fiscal Year: 2006..abstract_text> ..
- Sleep and Immune Mechanisms in Rheumatoid ArthritisMichael Irwin; Fiscal Year: 2007..Results from this study will guide the development of interventions that target disordered sleep with potential effects on disability in RA. ..
- Post-Graduate Training Program in Psychoneuroimmunology and Mental DisordersMichael Irwin; Fiscal Year: 2007....
- Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune MechanismsMichael Irwin; Fiscal Year: 2007..This project will constitute the first, randomized controlled clinical trial of the effects of TCC on sleep outcomes in breast cancer survivors, and will advance psychobiological models of insomnia treatment mechanisms. ..
- Sleep and Immune Mechanisms in Rheumatoid ArthritisMichael Irwin; Fiscal Year: 2009..Results from this study will guide the development of interventions that target disordered sleep with potential effects on disability in RA. ..
- Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune MechanismsMichael Irwin; Fiscal Year: 2009..This project will constitute the first, randomized controlled clinical trial of the effects of TCC on sleep outcomes in breast cancer survivors, and will advance psychobiological models of insomnia treatment mechanisms. ..
- Aging: Cytokine Mechanisms and Treatment of InsomniaMichael Irwin; Fiscal Year: 2009..This study will advance psychobiological models of disordered sleep and the potential benefits of two readily exportable behavioral interventions for promoting improvements in sleep outcomes in the elderly. ..
- Subjective Social Isolation and Sleep Disturbances: Inflammatory Mechanisms in AgMichael Irwin; Fiscal Year: 2009..This study will inform the development of potential treatments that target disordered sleep with possible prevention of disease outcomes in older adults who are socially isolated. ..
- Cocaine Dependence: EEG Sleep and CytokinesMichael Irwin; Fiscal Year: 2005..abstract_text> ..
- Alcoholism: Sleep and Cytokines in African AmericansMichael Irwin; Fiscal Year: 2005..g., cytokine antagonists) for sleep disturbance in alcoholism. ..
- BEHAVIORAL INTERVENTION FOR HERPES ZOSTER RISK IN AGINGMichael Irwin; Fiscal Year: 2003....
- DEPRESSION AND TRIAL OF VARICELLA VACCINE IN THE ELDERLYMichael Irwin; Fiscal Year: 2003....
- Subjective Social Isolation and Sleep Disturbances: Inflammatory Mechanisms in AgMichael R Irwin; Fiscal Year: 2010..This study will inform the development of potential treatments that target disordered sleep with possible prevention of disease outcomes in older adults who are socially isolated. ..