David C Irwin

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. pmc Polymerized bovine hemoglobin decreases oxygen delivery during normoxia and acute hypoxia in the rat
    David C Irwin
    Cardiovascular Pulmonary Research Group, School of Medicine, University of Colorado Health Science Center, 4200 E 9Ave, Denver, CO 80262, USA
    Am J Physiol Heart Circ Physiol 295:H1090-H1099. 2008
  2. ncbi request reprint Pulmonary edema induced by cerebral hypoxic insult in a canine model
    David C Irwin
    Cardiovascular Pulmonary Research Group, University of Colorado Health Science Center, Denver, CO 80262, USA
    Aviat Space Environ Med 79:472-8. 2008
  3. pmc Mixed S-nitrosylated polymerized bovine hemoglobin species moderate hemodynamic effects in acutely hypoxic rats
    David Irwin
    University of Colorado Health Science Center, Cardiovascular Pulmonary Research Laboratory, School of Medicine, 4200 East 9th Avenue, Denver, CO 80262, USA
    Am J Respir Cell Mol Biol 42:200-9. 2010
  4. pmc Nrf2 activation: a potential strategy for the prevention of acute mountain sickness
    Christina Lisk
    Division of Cardiology, Cardiovascular Pulmonary Research Group, School of Medicine, Aurora, CO 80045, USA
    Free Radic Biol Med 63:264-73. 2013
  5. pmc Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration
    David C Irwin
    Cardiovascular Pulmonary Research Group, Division of Cardiology, School of Medicine, University of Colorado at Denver, Anschutz Medical Campus, Aurora, CO 80045, USA Electronic address
    Free Radic Biol Med 82:50-62. 2015
  6. pmc A potential role for reactive oxygen species and the HIF-1alpha-VEGF pathway in hypoxia-induced pulmonary vascular leak
    David C Irwin
    University of Colorado Health Science Center, School of Medicine, Denver, CO 80262, USA
    Free Radic Biol Med 47:55-61. 2009

Detail Information

Publications6

  1. pmc Polymerized bovine hemoglobin decreases oxygen delivery during normoxia and acute hypoxia in the rat
    David C Irwin
    Cardiovascular Pulmonary Research Group, School of Medicine, University of Colorado Health Science Center, 4200 E 9Ave, Denver, CO 80262, USA
    Am J Physiol Heart Circ Physiol 295:H1090-H1099. 2008
    ..We conclude that infusion of PBvHb is not likely to be useful in treating global hypoxia under these conditions...
  2. ncbi request reprint Pulmonary edema induced by cerebral hypoxic insult in a canine model
    David C Irwin
    Cardiovascular Pulmonary Research Group, University of Colorado Health Science Center, Denver, CO 80262, USA
    Aviat Space Environ Med 79:472-8. 2008
    ..We hypothesized that a cerebral insult induced with a venous hypoxic blood infusion to the brain would trigger neurogenic pulmonary edema in a canine model...
  3. pmc Mixed S-nitrosylated polymerized bovine hemoglobin species moderate hemodynamic effects in acutely hypoxic rats
    David Irwin
    University of Colorado Health Science Center, Cardiovascular Pulmonary Research Laboratory, School of Medicine, 4200 East 9th Avenue, Denver, CO 80262, USA
    Am J Respir Cell Mol Biol 42:200-9. 2010
    ..These data support the potential use of HBOC mixed with SNO-HBOC for the treatment of conditions in which acute hypoxia is present, such as tumor oxygenation, wound healing, hemorrhagic trauma, and sickle cell and hemolytic anemia...
  4. pmc Nrf2 activation: a potential strategy for the prevention of acute mountain sickness
    Christina Lisk
    Division of Cardiology, Cardiovascular Pulmonary Research Group, School of Medicine, Aurora, CO 80045, USA
    Free Radic Biol Med 63:264-73. 2013
    ..Nifedipine, in addition to its known vasodilatory activities in the lung and protection against high altitude pulmonary edema, may provide protection against brain vascular leak as well. ..
  5. pmc Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration
    David C Irwin
    Cardiovascular Pulmonary Research Group, Division of Cardiology, School of Medicine, University of Colorado at Denver, Anschutz Medical Campus, Aurora, CO 80045, USA Electronic address
    Free Radic Biol Med 82:50-62. 2015
    ..By preventing Hb-mediated pathology, Hp infusions: (1) demonstrate a critical role for Hb in vascular remodeling associated with hypoxia and (2) suggest a novel therapy for chronic hemolysis-associated PH. ..
  6. pmc A potential role for reactive oxygen species and the HIF-1alpha-VEGF pathway in hypoxia-induced pulmonary vascular leak
    David C Irwin
    University of Colorado Health Science Center, School of Medicine, Denver, CO 80262, USA
    Free Radic Biol Med 47:55-61. 2009
    ..Our data suggest that hypoxia-induced permeability is due, in part, to the ROS-HIF-1alpha-VEGF pathway...