M Luisa Iruela-Arispe

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors
    Sunyoung Lee
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles 90095, USA
    J Cell Biol 169:681-91. 2005
  2. ncbi request reprint Thrombospondin modules and angiogenesis
    M Luisa Iruela-Arispe
    Department of Molecular, Cell and Developmental Biology and Molecular Biology Institute, UCLA, Los Angeles, CA 90095 1570, USA
    Int J Biochem Cell Biol 36:1070-8. 2004
  3. ncbi request reprint Angiogenesis: novel and basic science insights and human therapy - keystone symposium
    Luisa Iruela-Arispe
    University of California Los Angeles, Department of Molecular, Cell and Developmental Biology, 555A MBI Building, Los Angeles, CA 90095, USA
    IDrugs 7:111-3. 2004
  4. doi request reprint Cellular and molecular mechanisms of vascular lumen formation
    M Luisa Iruela-Arispe
    Department of Molecular, Cell and Developmental Biology and Molecular Biology Institute, University of California, Los Angeles, 90095, USA
    Dev Cell 16:222-31. 2009
  5. ncbi request reprint ADAMTS1: a matrix metalloprotease with angioinhibitory properties
    M Luisa Iruela-Arispe
    Department of Molecular, UCLA, Los Angeles, California 90095, USA
    Ann N Y Acad Sci 995:183-90. 2003
  6. ncbi request reprint Inhibition of angiogenesis by thrombospondin-1 is mediated by 2 independent regions within the type 1 repeats
    M L Iruela-Arispe
    Department of Molecular, Cell, and Developmental Biology and the Molecular Biology Institute, UCLA, Los Angeles, Calif 90095, USA
    Circulation 100:1423-31. 1999
  7. pmc When it comes to blocking lymphatics, it is all a question of time
    M Luisa Iruela-Arispe
    Department of Molecular, Cell, and Developmental Biology, Molecular Biology Institute and Johnsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, California 90095, USA
    Am J Pathol 169:347-50. 2006
  8. pmc Regulation of thrombospondin1 by extracellular proteases
    M Luisa Iruela-Arispe
    Dept of Molecular, Cell and Developmental Biology, 615 Charles Young Drive South, BSRB 445F UCLA, Los Angeles, CA 90095, USA
    Curr Drug Targets 9:863-8. 2008
  9. ncbi request reprint Antiangiogenic domains shared by thrombospondins and metallospondins, a new family of angiogenic inhibitors
    M L Iruela-Arispe
    Department of Molecular, University of California, Los Angeles 90095, USA
    Ann N Y Acad Sci 886:58-66. 1999
  10. ncbi request reprint ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165
    Alfonso Luque
    Department of Molecular, University of California, Los Angeles, California 90095, USA
    J Biol Chem 278:23656-65. 2003

Research Grants

  1. Regulation of Vascular Function by Progesterone Receptor
    Luisa Iruela Arispe; Fiscal Year: 2007
  2. Notch Signaling in Vascular Development and Homeostasis
    Luisa Iruela Arispe; Fiscal Year: 2010
  3. THERAPEUTIC ANTIANGIOGENESIS
    Luisa Iruela Arispe; Fiscal Year: 2002
  4. VEGF Signaling and Tumor Microenvironment
    Luisa Iruela Arispe; Fiscal Year: 2007
  5. INHIBITION OF THE ANGIOGENIC RESPONSE
    Luisa Iruela Arispe; Fiscal Year: 2006
  6. SUPPRESSION OF VASCULAR GROWTH
    Luisa Iruela Arispe; Fiscal Year: 2007
  7. VEGF Signaling and Tumor Microenvironment
    Luisa Iruela Arispe; Fiscal Year: 2010
  8. VEGF Signaling and Tumor Microenvironment
    Luisa Iruela Arispe; Fiscal Year: 2009
  9. Notch Signaling in Vascular Development and Homeostasis
    Luisa Iruela Arispe; Fiscal Year: 2007
  10. SUPPRESSION OF VASCULAR GROWTH
    Luisa Iruela Arispe; Fiscal Year: 2003

Collaborators

Detail Information

Publications54

  1. pmc Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors
    Sunyoung Lee
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles 90095, USA
    J Cell Biol 169:681-91. 2005
    ..Our findings support the view that matrix-bound VEGF and nontethered VEGF provide different signaling outcomes. These findings reveal a novel aspect in the regulation of extracellular VEGF that holds significance for vascular patterning...
  2. ncbi request reprint Thrombospondin modules and angiogenesis
    M Luisa Iruela-Arispe
    Department of Molecular, Cell and Developmental Biology and Molecular Biology Institute, UCLA, Los Angeles, CA 90095 1570, USA
    Int J Biochem Cell Biol 36:1070-8. 2004
    ..We will also extend our comments to ADAMTS1, a member of a relatively novel group of matrix metalloproteinases with thrombospondin repeats and shown to affect endothelial cell function and angiogenesis...
  3. ncbi request reprint Angiogenesis: novel and basic science insights and human therapy - keystone symposium
    Luisa Iruela-Arispe
    University of California Los Angeles, Department of Molecular, Cell and Developmental Biology, 555A MBI Building, Los Angeles, CA 90095, USA
    IDrugs 7:111-3. 2004
  4. doi request reprint Cellular and molecular mechanisms of vascular lumen formation
    M Luisa Iruela-Arispe
    Department of Molecular, Cell and Developmental Biology and Molecular Biology Institute, University of California, Los Angeles, 90095, USA
    Dev Cell 16:222-31. 2009
    ..Here we review the recent literature on vascular lumen formation and compare it to lumen formation in other epithelial systems. We also discuss the regulation of lumen diameter after vascular morphogenesis has been completed...
  5. ncbi request reprint ADAMTS1: a matrix metalloprotease with angioinhibitory properties
    M Luisa Iruela-Arispe
    Department of Molecular, UCLA, Los Angeles, California 90095, USA
    Ann N Y Acad Sci 995:183-90. 2003
    ..The emerging theme is that both domains are likely required for the antiangiogenic/antitumor activities of ADAMTS1...
  6. ncbi request reprint Inhibition of angiogenesis by thrombospondin-1 is mediated by 2 independent regions within the type 1 repeats
    M L Iruela-Arispe
    Department of Molecular, Cell, and Developmental Biology and the Molecular Biology Institute, UCLA, Los Angeles, Calif 90095, USA
    Circulation 100:1423-31. 1999
    ..The antiangiogenic activity of TSP-1, as defined by cornea pocket assays, was previously mapped to the amino-terminal portion of the protein within the procollagen region and the type 1 repeats...
  7. pmc When it comes to blocking lymphatics, it is all a question of time
    M Luisa Iruela-Arispe
    Department of Molecular, Cell, and Developmental Biology, Molecular Biology Institute and Johnsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, California 90095, USA
    Am J Pathol 169:347-50. 2006
  8. pmc Regulation of thrombospondin1 by extracellular proteases
    M Luisa Iruela-Arispe
    Dept of Molecular, Cell and Developmental Biology, 615 Charles Young Drive South, BSRB 445F UCLA, Los Angeles, CA 90095, USA
    Curr Drug Targets 9:863-8. 2008
    ..We also discuss its biological relevance and potential therapeutic value of thrombospondin proteolysis with particular emphasis on angiogenesis...
  9. ncbi request reprint Antiangiogenic domains shared by thrombospondins and metallospondins, a new family of angiogenic inhibitors
    M L Iruela-Arispe
    Department of Molecular, University of California, Los Angeles 90095, USA
    Ann N Y Acad Sci 886:58-66. 1999
    ..We predict that these proteins are likely endogenous modulators of vascular growth with relevant therapeutic potential in cancer and other disease states...
  10. ncbi request reprint ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165
    Alfonso Luque
    Department of Molecular, University of California, Los Angeles, California 90095, USA
    J Biol Chem 278:23656-65. 2003
    ..ADAMTS1 and VEGF165 were also found in association in tumor extracts. These findings provide a mechanism for the anti-angiogenic activity of ADAMTS1 and describe a novel modulator of VEGF bioavailability...
  11. pmc An essential requirement for β1 integrin in the assembly of extracellular matrix proteins within the vascular wall
    Kirsten A Turlo
    Department of Molecular, Cellular, and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Dev Biol 365:23-35. 2012
    ..It further establishes a critical role of β1 integrin in the protection against aneurysms that is particularly confined to the ascending aorta and its branches...
  12. pmc Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells
    Tom T Chen
    Department of Molecular, Cellular, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Cell Biol 188:595-609. 2010
    ....
  13. pmc Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome
    Jennifer J Hofmann
    Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Development 139:4449-60. 2012
    ..This work shows that the endothelium is responsible for the wide spectrum of cardiac phenotypes displayed in Alagille Syndrome and it demonstrates a crucial role for Jag1 in valve morphogenesis...
  14. pmc Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism
    Ann C Zovein
    Department of Molecular, Cellular, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Dev Cell 18:39-51. 2010
    ..Combined, our findings demonstrate that beta1 integrin functions upstream of Par3 as part of a molecular cascade required for endothelial cell polarity and lumen formation...
  15. ncbi request reprint VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombination in the endothelium
    Arnaud Monvoisin
    Department of Molecular Cellular and Developmental Biology, UCLA, Los Angeles, California 90095, USA
    Dev Dyn 235:3413-22. 2006
    ..The VECad-Cre-ERT2 mouse is likely to be a valuable tool to study the function of genes involved in vascular development, homeostasis, and in complex processes involving neoangiogenesis, such as tumor growth...
  16. pmc Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome
    Jennifer J Hofmann
    Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA
    Development 137:4061-72. 2010
    ..These findings uncover the cellular basis for the defining feature of AGS, identify mesenchymal Jag1-dependent and -independent stages of duct development, and provide mechanistic information for the role of Jag1 in IHBD formation...
  17. pmc VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF
    Sean M Anderson
    Department of Chemical and Biomolecular Engineering, University of California, 420 Westwood Plaza, 5531 Boelter Hall, Los Angeles, CA 90095, USA
    Integr Biol (Camb) 3:887-96. 2011
    ..Here, mathematical models support the biological conclusions, further suggesting that VEGF internalization is significantly reduced when covalently bound, and indicating that VEGF is available for repeated phosphorylation events...
  18. ncbi request reprint Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1
    Nathan V Lee
    Department of Molecular, Cell, and Developmental Biology and Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Biol Chem 280:34796-804. 2005
    ..Together, these findings indicate that fibulin-1 is a new regulator of ADAMTS-1-mediated proteoglycan proteolysis and thus may play an important role in proteoglycan turnover in tissues where there is overlapping expression...
  19. pmc Autocrine VEGF signaling is required for vascular homeostasis
    Sunyoung Lee
    Department of Molecular, Cellular and Developmental Biology, Jonsson Comprehensive Cancer Center and Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA
    Cell 130:691-703. 2007
    ..These results reveal a cell-autonomous VEGF signaling pathway that holds significance for vascular homeostasis but is dispensable for the angiogenic cascade...
  20. ncbi request reprint ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors
    Juan Carlos Rodriguez-Manzaneque
    Department of Molecular, Cell and Developmental Biology, Molecular Biology Institute, University of California at Los Angeles, 611, Charles E Young Drive, Los Angeles, CA 90095, USA
    Biochem Biophys Res Commun 293:501-8. 2002
    ..Finally, we developed an activity assay using an artificial peptide substrate based on the interglobular domain cleavage site (E(373)-A) of rat aggrecan...
  21. pmc Fate tracing reveals the endothelial origin of hematopoietic stem cells
    Ann C Zovein
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Cell Stem Cell 3:625-36. 2008
    ..Moreover, AGM mesenchyme, as selectively traced via a myocardin Cre line, is incapable of hematopoiesis. Our genetic tracing strategy therefore reveals an endothelial origin of HSCs...
  22. pmc ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2
    Nathan V Lee
    Department of Molecular, Cell and Developmental Biology, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095, USA
    EMBO J 25:5270-83. 2006
    ..These findings have unraveled a mechanistic explanation for the angiostatic functions attributed to ADAMTS1 and demonstrated in vivo processing of TSP1 under situations of tissue repair...
  23. doi request reprint Vascular remodeling of the vitelline artery initiates extravascular emergence of hematopoietic clusters
    Ann C Zovein
    Department of Molecular, Cellular, and Developmental Biology, University of California at Los Angeles, Los Angeles, CA
    Blood 116:3435-44. 2010
    ..75 in the caudal half of the midgut mesentery, but by embryonic day 11.0 are sporadically found on the cranial side of the midgut, thus suggesting possible extravascular migration aided by midgut rotation...
  24. pmc CCN2/connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis
    Faith Hall-Glenn
    Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e30562. 2012
    ....
  25. doi request reprint Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation
    Lauren M Goddard
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell 156:549-62. 2014
    ..This program triggers concurrent suppression of several junctional proteins and leads to an effective, timely, and venous-specific regulation of vascular barrier function that is critical for embryo implantation. ..
  26. pmc When Cre-mediated recombination in mice does not result in protein loss
    Kirsten A Turlo
    Molecular Biology Institute, University of California, Los Angeles, California 90095, USA
    Genetics 186:959-67. 2010
    ..These findings highlight the potential for protein expression from the products of Cre-recombinase excised genes, particularly when deletion occurs in low turnover populations...
  27. pmc Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages
    Huanhuan He
    Department of Human Genetics, University of California, Los Angeles, CA, USA
    Blood 120:3152-62. 2012
    ..This work also highlights some of the molecules underlying the M2-like differentiation, a process that is relevant to the progression of both developmental and pathologic angiogenesis...
  28. pmc Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling
    Akanksha Chhabra
    Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Dev Cell 22:651-9. 2012
    ..These data provide genetic evidence of a signaling pathway that is required to restrict erythroid differentiation to specific anatomical niches during development...
  29. pmc Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy
    Saul J Priceman
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
    Blood 115:1461-71. 2010
    ....
  30. ncbi request reprint Generation of a mouse for conditional excision of progesterone receptor
    Minako K Hashimoto-Partyka
    Department of Molecular, Cell and Developmental Biology and Molecular Biology Institute, University of California, Los Angeles, 90095, USA
    Genesis 44:391-5. 2006
    ..Female mice homozygous for this null allele were sterile, as expected for PR knockout (PRKO) females. Conditional loss of PR will facilitate investigation of the spatial and temporal roles of PR in both normal development and disease...
  31. ncbi request reprint Expression of ADAMTS1 during murine development
    Shelley N M Thai
    Department of Molecular, Cell and Developmental Biology, Molecular Biology Institute, Room 559, UCLA, Los Angeles, CA 90095 1570, USA
    Mech Dev 115:181-5. 2002
    ..Expression was also detected in the tunica media of the aorta, pulmonary, and hepatic vessels...
  32. pmc Recent advances in vascular development
    Courtney K Domigan
    Department of Molecular, Cell and Developmental Biology and Molecular Biology Institute, University of California, Los Angeles, California, USA
    Curr Opin Hematol 19:176-83. 2012
    ..This review offers a concise summary of the most recent experimental advances in vascular development using the mouse as a model organism...
  33. pmc β1-integrin is essential for vasoregulation and smooth muscle survival in vivo
    Kirsten A Turlo
    From the Department of Molecular, Cellular, and Developmental Biology K A T, M L I A and Molecular Biology Institute J S, University of California, Los Angeles, CA Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO P B, A W J, R J K, S S S Interfaculty Institute of Biochemistry, University of Tuebingen, Tuebingen, Germany R F and Dalton Cardiovascular Research Center, Columbia, MO A W J, R J K, S S S
    Arterioscler Thromb Vasc Biol 33:2325-35. 2013
    ..Integrins contribute to vascular morphogenesis through regulation of adhesion and assembly of the extracellular matrix. However, the role of β1-integrin in the mature vascular wall is less clear...
  34. pmc Cellular and molecular regulation of vascular permeability
    Lauren M Goddard
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Thromb Haemost 109:407-15. 2013
    ....
  35. pmc Tubulogenesis
    M Luisa Iruela-Arispe
    Department of Molecular, Cell and Developmental Biology, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095, USA
    Development 140:2851-5. 2013
    ..An overview of the current understanding of the molecular processes and physical forces involved in tubulogenesis is presented in this review and the accompanying poster. ..
  36. pmc The phosphorylation of vascular endothelial growth factor receptor-2 (VEGFR-2) by engineered surfaces with electrostatically or covalently immobilized VEGF
    Sean M Anderson
    University of California, Los Angeles, Chemical and Biomolecular Engineering Department, Los Angeles, CA 90095, USA
    Biomaterials 30:4618-28. 2009
    ....
  37. pmc Progesterone receptor signaling in the microenvironment of endometrial cancer influences its response to hormonal therapy
    Deanna M Janzen
    Departments of Obstetrics and Gynecology, Molecular and Medical Pharmacology, and Molecular, Cell and Developmental Biology, David Geffen School of Medicine, Los Angeles, USA
    Cancer Res 73:4697-710. 2013
    ..On the basis of these results, stromal expression of PR may emerge as a reliable biomarker in predicting response to hormonal therapy...
  38. ncbi request reprint Modulation of protein delivery from modular polymer scaffolds
    Min Lee
    Department of Bioengineering, University of California, Los Angeles, CA 90095, USA
    Biomaterials 28:1862-70. 2007
    ..Strategies to deliver multiple growth factors and studies which investigate their release should consider these important variables...
  39. ncbi request reprint Notch signaling in blood vessels: who is talking to whom about what?
    Jennifer J Hofmann
    Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Circ Res 100:1556-68. 2007
    ..We also highlight questions and controversies regarding the contribution of this pathway to vascular development...
  40. pmc LUMENating blood vessels
    M Luisa Iruela-Arispe
    Department of Molecular, Cell, and Developmental Biology, UCLA, Los Angeles, CA 90095, USA
    Dev Cell 20:412-4. 2011
    ..In this issue of Developmental Cell, Xu et al. (2011) show that the small GTPase Rasip is a critical regulator of cytoskeleton dynamics and cell adhesion, which together drive the emergence of vascular lumens...
  41. ncbi request reprint Cellular responses of bioabsorbable polymeric material and Guglielmi detachable coil in experimental aneurysms
    Yuichi Murayama
    Division of Interventional Neuroradiology, Department of Radiological Sciences, Molecular Biology Institute, University of California at Los Angeles 90095, USA
    Stroke 33:1120-8. 2002
    ..We evaluated a new endovascular therapeutic, bioabsorbable polymeric material (BPM), which may promote cellular reaction in the aneurysms...
  42. ncbi request reprint Selective binding of lectins to embryonic chicken vasculature
    Shahla M Jilani
    Department of Molecular, Cell and Developmental Biology and Molecular Biology Institute, UCLA, Los Angeles, California 90095, USA
    J Histochem Cytochem 51:597-604. 2003
    ....
  43. pmc Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor
    Li V Yang
    Howard Hughes Medical Institute, University of California Los Angeles, 675 Charles E Young Drive South, Los Angeles, CA 90095 1662, USA
    Mol Cell Biol 27:1334-47. 2007
    ..These results suggest that GPR4 deficiency leads to partially penetrant vascular abnormalities during development and that this receptor functions in blood vessel pH sensing...
  44. pmc Signaling circuitry in vascular morphogenesis
    Carmen M Warren
    Department of Molecular, Cellular, and Developmental Biology, University of California Los Angeles, Los Angeles, California, USA
    Curr Opin Hematol 17:213-8. 2010
    ..In this mini-review, we have highlighted the recent breakthroughs in growth factor signaling that have made conceptual changes in our understanding of how blood vessels are formed...
  45. pmc My O'Myeloid, a tale of two lineages
    Ann C Zovein
    Department of Molecular, Cell and Developmental Biology and Molecular Biology Institute, University of California, Los Angeles, 90095, USA
    Proc Natl Acad Sci U S A 103:12959-60. 2006
  46. ncbi request reprint Myc-driven murine prostate cancer shares molecular features with human prostate tumors
    Katharine Ellwood-Yen
    Department of Medicine, and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cancer Cell 4:223-38. 2003
    ..This approach illustrates how genomic technologies can be applied to mouse cancer models to guide evaluation of human tumor databases...
  47. ncbi request reprint VE-Cadherin-Cre-recombinase transgenic mouse: a tool for lineage analysis and gene deletion in endothelial cells
    Jackelyn A Alva
    Department of Molecular, Cell and Developmental Biology and Molecular Biology Institute, UCLA, Los Angeles, California, USA
    Dev Dyn 235:759-67. 2006
    ..Furthermore, the constitutive nature of the VE-Cadherin promoter in the adult can be advantageous for analysis of gene deletion in pathological settings...
  48. doi request reprint Time to cut the cord: placental HSCs grow up
    Ann C Zovein
    Department of Molecular, Cellular, and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Cell Stem Cell 5:351-2. 2009
    ..2009) demonstrate the robust hematopoietic stem cell capacity of the human placenta. The study investigates components of the placental niche and paves the way for clinical applications of blood production...
  49. pmc Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation
    Wei Guo
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California 90095, USA
    Nature 453:529-33. 2008
    ..Our study indicates that multiple genetic or molecular alterations contribute cooperatively to LSC transformation...
  50. doi request reprint A ligand-independent VEGFR2 signaling pathway limits angiogenic responses in diabetes
    Carmen M Warren
    1Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Sci Signal 7:ra1. 2014
    ..These findings uncover a mode of ligand-independent VEGFR2 signaling that can progressively lead to continuously muted responses to exogenous VEGF and limit angiogenic events...
  51. pmc Selective suppression of endothelial cytokine production by progesterone receptor
    Lauren M Goddard
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Vascul Pharmacol 59:36-43. 2013
    ..They also suggest that progesterone-PR signaling in the endothelium directly impacts leukocyte trafficking in PR-expressing tissues. ..
  52. pmc Real-time maps of fluid flow fields in porous biomaterials
    Julia J Mack
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Biomaterials 34:1980-6. 2013
    ..It is anticipated that accurate flow maps within 3D matrices will be a critical step towards understanding cell behavior in response to controlled flow dynamics...
  53. ncbi request reprint Notch signaling in vascular morphogenesis
    Jackelyn A Alva
    Department of Molecular, Cell, and Developmental Biology and Molecular Biology Institute, UCLA, Los Angeles, California 90095, USA
    Curr Opin Hematol 11:278-83. 2004
    ..This review highlights recent developments in the role of the Notch signaling pathway during vascular morphogenesis, angiogenesis, and vessel homeostasis...
  54. doi request reprint Hybrid photopatterned enzymatic reaction (HyPER) for in situ cell manipulation
    Donald R Griffin
    Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, 420 Westwood Plaza, Los Angeles, CA 90095 USA
    Chembiochem 15:233-42. 2014
    ..This approach offers an innovative strategy to immobilize delicate bioactive signals, such as growth factors, without loss of activity and enables in situ cell manipulation of encapsulated cells. ..

Research Grants37

  1. Regulation of Vascular Function by Progesterone Receptor
    Luisa Iruela Arispe; Fiscal Year: 2007
    ..abstract_text> ..
  2. Notch Signaling in Vascular Development and Homeostasis
    Luisa Iruela Arispe; Fiscal Year: 2010
    ..Thus, this information is central to the generation of novel and more effective therapies that will enable manipulation of vascular function during pathological conditions. ..
  3. THERAPEUTIC ANTIANGIOGENESIS
    Luisa Iruela Arispe; Fiscal Year: 2002
    ..abstract_text> ..
  4. VEGF Signaling and Tumor Microenvironment
    Luisa Iruela Arispe; Fiscal Year: 2007
    ..These data will aid in further refinement of therapeutic strategies to inhibit angiogenesis in tumors. ..
  5. INHIBITION OF THE ANGIOGENIC RESPONSE
    Luisa Iruela Arispe; Fiscal Year: 2006
    ..abstract_text> ..
  6. SUPPRESSION OF VASCULAR GROWTH
    Luisa Iruela Arispe; Fiscal Year: 2007
    ..We anticipate that results from these experiments will shed light into the biology of tumor growth and angiogenesis. ..
  7. VEGF Signaling and Tumor Microenvironment
    Luisa Iruela Arispe; Fiscal Year: 2010
    ..These data will aid in further refinement of therapeutic strategies to inhibit angiogenesis in tumors. ..
  8. VEGF Signaling and Tumor Microenvironment
    Luisa Iruela Arispe; Fiscal Year: 2009
    ..These data will aid in further refinement of therapeutic strategies to inhibit angiogenesis in tumors. ..
  9. Notch Signaling in Vascular Development and Homeostasis
    Luisa Iruela Arispe; Fiscal Year: 2007
    ..Thus, this information is central to the generation of novel and more effective therapies that will enable manipulation of vascular function during pathological conditions. ..
  10. SUPPRESSION OF VASCULAR GROWTH
    Luisa Iruela Arispe; Fiscal Year: 2003
    ..We believe that identification and characterization of potent and novel inhibitors of angiogenesis is of significant biological and therapeutic relevance for pharmacological intervention to suppress vascular growth in tumors. ..
  11. Angiogenesis and Microcirculation Gordon Conference
    Luisa Iruela Arispe; Fiscal Year: 2005
    ..The conference will be held in Salve Regina University from August 10-15, 2003. ..
  12. Vascular Biology Training Grant
    Luisa Iruela Arispe; Fiscal Year: 2007
    ..End of Abstract) ..