Nayyar Iqbal

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi request reprint Effects of a low-intensity intervention that prescribed a low-carbohydrate vs. a low-fat diet in obese, diabetic participants
    Nayyar Iqbal
    Department of Medicine, Division of Endocrinology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 18:1733-8. 2010
  2. ncbi request reprint The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial
    Linda Stern
    Philadelphia Veterans Affairs Medical Center, University of Pennsylvania Medical Center, and Drexel University College of Medicine, Philadelphia, Pennsylvania 19104, USA
    Ann Intern Med 140:778-85. 2004
  3. pmc Relation of plasma fatty acid binding proteins 4 and 5 with the metabolic syndrome, inflammation and coronary calcium in patients with type-2 diabetes mellitus
    Roshanak Bagheri
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Cardiol 106:1118-23. 2010
  4. ncbi request reprint A randomized study comparing the effects of a low-carbohydrate diet and a conventional diet on lipoprotein subfractions and C-reactive protein levels in patients with severe obesity
    Prakash Seshadri
    Department of Internal Medicine, Division of Endocrinology, University of Pennsylvania Health System, Philadelphia 19104, USA
    Am J Med 117:398-405. 2004
  5. ncbi request reprint Free fatty acids, insulin resistance, and corrected qt intervals in morbid obesity: effect of weight loss during 6 months with differing dietary interventions
    Prakash Seshadri
    Division of Endocrinology, Department of Medicine, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, USA
    Endocr Pract 11:234-9. 2005
  6. pmc Usefulness of insulin resistance estimation and the metabolic syndrome in predicting coronary atherosclerosis in type 2 diabetes mellitus
    Nehal N Mehta
    Cardiovascular Institute, Philadelphia, Pennsylvania, USA
    Am J Cardiol 107:406-11. 2011
  7. pmc Lipoprotein(a) is strongly associated with coronary artery calcification in type-2 diabetic women
    Atif N Qasim
    Department of Medicine, Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States
    Int J Cardiol 150:17-21. 2011
  8. pmc Apolipoprotein B but not LDL cholesterol is associated with coronary artery calcification in type 2 diabetic whites
    Seth S Martin
    Cardiovascular Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes 58:1887-92. 2009
  9. pmc Comparison of high-density lipoprotein cholesterol to apolipoprotein A-I and A-II to predict coronary calcium and the effect of insulin resistance
    Seth S Martin
    Cardiovascular Institute, University of Pennsylvania Medical Center, Philadelphia, USA
    Am J Cardiol 107:393-8. 2011
  10. doi request reprint Measurement of waist circumference predicts coronary atherosclerosis beyond plasma adipokines
    Subhasish Bose
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 21:E118-23. 2013

Detail Information

Publications36

  1. doi request reprint Effects of a low-intensity intervention that prescribed a low-carbohydrate vs. a low-fat diet in obese, diabetic participants
    Nayyar Iqbal
    Department of Medicine, Division of Endocrinology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 18:1733-8. 2010
    ..5 kg, compared to 0.2 kg in the low-fat group (P = 0.147). Lipids, glycemic indexes, and dietary intake did not differ between groups at month 24 (or at months 6 or 12) (ClinicalTrials.gov number, NCT00108459)...
  2. ncbi request reprint The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial
    Linda Stern
    Philadelphia Veterans Affairs Medical Center, University of Pennsylvania Medical Center, and Drexel University College of Medicine, Philadelphia, Pennsylvania 19104, USA
    Ann Intern Med 140:778-85. 2004
    ..A previous paper reported the 6-month comparison of weight loss and metabolic changes in obese adults randomly assigned to either a low-carbohydrate diet or a conventional weight loss diet...
  3. pmc Relation of plasma fatty acid binding proteins 4 and 5 with the metabolic syndrome, inflammation and coronary calcium in patients with type-2 diabetes mellitus
    Roshanak Bagheri
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Cardiol 106:1118-23. 2010
    ..These findings suggest that FABP4 and FABP5 may represent mediators of and biomarkers for metabolic and cardiovascular disease in type 2 diabetes mellitus...
  4. ncbi request reprint A randomized study comparing the effects of a low-carbohydrate diet and a conventional diet on lipoprotein subfractions and C-reactive protein levels in patients with severe obesity
    Prakash Seshadri
    Department of Internal Medicine, Division of Endocrinology, University of Pennsylvania Health System, Philadelphia 19104, USA
    Am J Med 117:398-405. 2004
    ..To compare the effects of a low-carbohydrate diet and a conventional (fat- and calorie-restricted) diet on lipoprotein subfractions and inflammation in severely obese subjects...
  5. ncbi request reprint Free fatty acids, insulin resistance, and corrected qt intervals in morbid obesity: effect of weight loss during 6 months with differing dietary interventions
    Prakash Seshadri
    Division of Endocrinology, Department of Medicine, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, USA
    Endocr Pract 11:234-9. 2005
    ..To assess whether shortening of the corrected QT (QTc) interval is most closely associated with changes in weight, insulin resistance, or free fatty acids (FFAs) (or some combination of these factors)...
  6. pmc Usefulness of insulin resistance estimation and the metabolic syndrome in predicting coronary atherosclerosis in type 2 diabetes mellitus
    Nehal N Mehta
    Cardiovascular Institute, Philadelphia, Pennsylvania, USA
    Am J Cardiol 107:406-11. 2011
    ....
  7. pmc Lipoprotein(a) is strongly associated with coronary artery calcification in type-2 diabetic women
    Atif N Qasim
    Department of Medicine, Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States
    Int J Cardiol 150:17-21. 2011
    ..The purpose of this study was to investigate whether type-2 diabetic subjects, relative to non-diabetics, might benefit more from Lp(a) measurement in the prediction of CHD risk, as measured by coronary artery calcium (CAC)...
  8. pmc Apolipoprotein B but not LDL cholesterol is associated with coronary artery calcification in type 2 diabetic whites
    Seth S Martin
    Cardiovascular Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes 58:1887-92. 2009
    ..We investigated the hypothesis that apoB is a superior marker of CAC relative to LDL cholesterol...
  9. pmc Comparison of high-density lipoprotein cholesterol to apolipoprotein A-I and A-II to predict coronary calcium and the effect of insulin resistance
    Seth S Martin
    Cardiovascular Institute, University of Pennsylvania Medical Center, Philadelphia, USA
    Am J Cardiol 107:393-8. 2011
    ..In conclusion, HDL cholesterol outperformed apoA-I and apoA-II in CAC prediction, but its association with CAC was attenuated by measures of insulin resistance...
  10. doi request reprint Measurement of waist circumference predicts coronary atherosclerosis beyond plasma adipokines
    Subhasish Bose
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 21:E118-23. 2013
    ..The association of plasma adipokines beyond waist circumference (WC) with coronary artery calcification (CAC), a measure of subclinical atherosclerosis, is unknown...
  11. pmc Four-year weight losses in the Look AHEAD study: factors associated with long-term success
    Thomas A Wadden
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 19:1987-98. 2011
    ..e., ≥ 5%) in overweight/obese participants with type 2 diabetes and maintain this loss in more than 45% of patients at 4 years...
  12. pmc Association of lower plasma fetuin-a levels with peripheral arterial disease in type 2 diabetes
    Luis H Eraso
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes Care 33:408-10. 2010
    ..Fetuin-A is an inhibitor of vascular calcification and a mediator of insulin resistance. This study evaluated the association of plasma fetuin-A and peripheral arterial disease (PAD)...
  13. pmc Chromium picolinate does not improve key features of metabolic syndrome in obese nondiabetic adults
    Nayyar Iqbal
    Division of General Internal Medicine, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA
    Metab Syndr Relat Disord 7:143-50. 2009
    ..The objective of this study was to determine the effects of chromium picolinate (CrPic) on glucose metabolism in patients with metabolic syndrome...
  14. ncbi request reprint Narrative review: effect of bariatric surgery on type 2 diabetes mellitus
    Marion L Vetter
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Ann Intern Med 150:94-103. 2009
    ..This review discusses the various bariatric procedures and how they alter the enteroinsular axis. Familiarity with these effects can help physicians decide among the different surgical procedures and avoid postoperative hypoglycemia...
  15. ncbi request reprint Effects of rosiglitazone on lipids, adipokines, and inflammatory markers in nondiabetic patients with low high-density lipoprotein cholesterol and metabolic syndrome
    Frederick F Samaha
    Cardiovascular Division, Department of Medicine, Cardiovascular Institute, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Arterioscler Thromb Vasc Biol 26:624-30. 2006
    ..However, the full spectrum of potentially antiatherogenic mechanisms of PPAR-gamma agonists have not been fully tested in nondiabetic patients with metabolic syndrome...
  16. pmc Effects of metformin and leuprolide acetate on insulin resistance and testosterone levels in nondiabetic postmenopausal women: a randomized, placebo-controlled trial
    Shrita M Patel
    Division of Endocrinology, Diabetes, and Metabolism, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 94:2161-6. 2010
    ..To determine whether insulin sensitizers lower androgen levels and whether androgen suppression improves insulin resistance in nondiabetic postmenopausal women...
  17. ncbi request reprint Coronary artery calcification at electron beam computed tomography is increased in asymptomatic type 2 diabetics independent of traditional risk factors
    Megan L Wolfe
    Department of Medicine, University of Pennsylvania, 421 Curie Boulevard, 815 BRB2 3, Philadelphia, PA 19104, USA
    J Cardiovasc Risk 9:369-76. 2002
    ..We hypothesized that the presence and extent of CAC would be greater in asymptomatic type 2 diabetics than in non-diabetics independent of traditional risk factors...
  18. pmc Selective PKC beta inhibition with ruboxistaurin and endothelial function in type-2 diabetes mellitus
    Nehal N Mehta
    Cardiovascular Institute, University of Pennsylvania Medical Center, 909 BRB 2 3, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
    Cardiovasc Drugs Ther 23:17-24. 2009
    ..Prior studies demonstrate beneficial effects of PKC beta inhibition on microvascular parameters, but, to date, no study has examined the effect on macrovascular atherosclerotic readouts...
  19. pmc Gender differences in the association of C-reactive protein with coronary artery calcium in type-2 diabetes
    Atif N Qasim
    The Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
    Clin Endocrinol (Oxf) 74:44-50. 2011
    ..Whether CRP has value as a CVD risk marker in type-2 diabetes (T2DM) is unclear. We examined whether CRP has gender differences in association with coronary artery calcium (CAC) in diabetic and nondiabetic samples without clinical CVD...
  20. doi request reprint Efficacy of cholesterol uptake inhibition added to statin therapy among subjects following a low-carbohydrate diet: a randomized controlled trial
    Julio A Chirinos
    Department of Medicine, University of Pennsylvania and Philadelphia Veterans Affairs Medical Center, USA
    Am Heart J 159:918.e1-6. 2010
    ..However, the efficacy of cholesterol absorption inhibition added to statin therapy has not been studied in this common clinical setting...
  21. pmc One-year weight losses in the Look AHEAD study: factors associated with success
    Thomas A Wadden
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 17:713-22. 2009
    ..The lifestyle intervention was clinically effective in all subsets of an ethnically and demographically diverse population...
  22. ncbi request reprint Low carbohydrate diets for weight loss: historical & environmental perspective
    Prakash Seshadri
    University of Pennsylvania School of Medicine, Division of Endocrinology, Philadelphia, PA 19104, USA
    Indian J Med Res 123:739-47. 2006
    ..Equally less known, is the applicability of a low carbohydrate diet to populations like India where many main dishes are carbohydrate-based...
  23. ncbi request reprint Value of electrocardiographic and ankle-brachial index abnormalities for prediction of coronary atherosclerosis in asymptomatic subjects with type 2 diabetes mellitus
    Roshanak Bagheri
    Cardiovascular Institute, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, and Department of Medicine, Philadelphia Veterans Affairs Medical Center, Pennsylvania, USA
    Am J Cardiol 99:951-5. 2007
    ....
  24. pmc The burden of type 2 diabetes: strategies to prevent or delay onset
    Nayyar Iqbal
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania, Philadelphia VA Medical Center, PA, USA
    Vasc Health Risk Manag 3:511-20. 2007
    ..Recent data suggest thiazolidinediones and blockade of the endocannabinoid system represent novel therapeutic approaches that may be used for the prevention of diabetes...
  25. doi request reprint Clinical impact of capsule endoscopy on management of gastrointestinal disorders
    Nuzhat A Ahmad
    Gastroenterology Division, Department of Medicine, Hospital of University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Clin Gastroenterol Hepatol 6:433-7. 2008
    ..The impact of capsule endoscopy (CE) findings on patient management is unknown. We assessed the impact of CE findings on patient management, and whether physicians use these to alter management plans...
  26. ncbi request reprint Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes
    Muredach P Reilly
    Cardiovascular Division, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Clin Endocrinol Metab 89:3872-8. 2004
    ..Whether leptin signaling promotes atherosclerosis directly or represents a therapeutic target for the prevention of atherosclerotic cardiovascular disease remains to be explored...
  27. ncbi request reprint Does lowering of blood glucose improve cardiovascular morbidity and mortality?
    Nayyar Iqbal
    Section of Endocrinology, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA
    Clin J Am Soc Nephrol 3:163-7. 2008
  28. ncbi request reprint Total parenteral nutrition in management of hyperlipidemic pancreatitis during pregnancy
    Jennifer A Loh
    Department of Medicine, Division of Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Endocr Pract 11:325-30. 2005
    ..To describe a case of severe gestational hyperlipidemic pancreatitis successfully managed with minimal-lipid-containing parenteral nutrition (PN) followed by a minimal-fat diet, which resulted in delivery of a healthy full-term neonate...
  29. ncbi request reprint Status of bone mineral density in patients selected for cardiac transplantation
    Nayyar Iqbal
    Division of Endocrinology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Section of Endocrinology, Department of Medicine, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    Endocr Pract 14:704-12. 2008
    ..To determine the prevalence and correlates of low bone mineral density (BMD) in ambulatory outpatients with end-stage heart failure who were awaiting cardiac transplantation...
  30. ncbi request reprint Outpatient weight management in African-Americans: the Healthy Eating and Lifestyle Program (HELP) study
    Shiriki K Kumanyika
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Prev Med 41:488-502. 2005
    ..Effective clinical weight management approaches are needed to reach African-Americans...
  31. pmc An inflammatory cascade leading to hyperresistinemia in humans
    Michael Lehrke
    Division of Endocrinology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS Med 1:e45. 2004
    ..Adipocyte-derived resistin is a circulating protein implicated in insulin resistance in rodents, but the role of human resistin is uncertain because it is produced largely by macrophages...
  32. pmc Effect of a low-carbohydrate diet versus a low-fat, calorie-restricted diet on adipokine levels in obese, diabetic participants
    Marion L Vetter
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Diabetes Metab Syndr Obes 3:357-61. 2010
    ..001 and P < 0.012, respectively). Modest weight loss, rather than macronutrient composition, likely accounted for the favorable changes observed in leptin and adiponectin over time...
  33. ncbi request reprint Tyrosine kinase inhibitors and the thyroid as both an unintended and an intended target
    Marion L Vetter
    Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19146, USA
    Endocr Pract 14:618-24. 2008
    ..To review the association of the tyrosine kinase inhibitor sunitinib with hypothyroidism as well as the mean time to onset, possible mechanisms, reversibility, and mean duration...
  34. doi request reprint Simvastatin vs therapeutic lifestyle changes and supplements: randomized primary prevention trial
    David J Becker
    Division of Cardiology, Chestnut Hill Hospital, University of Pennsylvania Health System, Philadelphia, PA, USA
    Mayo Clin Proc 83:758-64. 2008
    ..To compare the lipid-lowering effects of an alternative regimen (lifestyle changes, red yeast rice, and fish oil) with a standard dose of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin)...
  35. ncbi request reprint A low-carbohydrate as compared with a low-fat diet in severe obesity
    Frederick F Samaha
    Philadelphia Veterans Affairs Medical Center, University of Pennsylvania Medical Center, Philadelphia, USA
    N Engl J Med 348:2074-81. 2003
    ..The effects of a carbohydrate-restricted diet on weight loss and risk factors for atherosclerosis have been incompletely assessed...
  36. ncbi request reprint Diabetic muscle infarction of the forearm in a patient with long-standing type 1 diabetes
    Serena Cardillo
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Endocr Pract 12:188-92. 2006
    ..To describe a case of diabetic muscle infarction affecting an upper extremity in a patient with long-term poorly controlled diabetes...