Research Topics
Species | Nayyar IqbalSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Effects of a low-intensity intervention that prescribed a low-carbohydrate vs. a low-fat diet in obese, diabetic participantsNayyar Iqbal
Department of Medicine, Division of Endocrinology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Obesity (Silver Spring) 18:1733-8. 2010..5 kg, compared to 0.2 kg in the low-fat group (P = 0.147). Lipids, glycemic indexes, and dietary intake did not differ between groups at month 24 (or at months 6 or 12) (ClinicalTrials.gov number, NCT00108459)...
The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trialLinda Stern
Philadelphia Veterans Affairs Medical Center, University of Pennsylvania Medical Center, and Drexel University College of Medicine, Philadelphia, Pennsylvania 19104, USA
Ann Intern Med 140:778-85. 2004..Weight loss was similar between groups, but effects on atherogenic dyslipidemia and glycemic control were still more favorable with a low-carbohydrate diet after adjustment for differences in weight loss...
Relation of plasma fatty acid binding proteins 4 and 5 with the metabolic syndrome, inflammation and coronary calcium in patients with type-2 diabetes mellitusRoshanak Bagheri
Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Am J Cardiol 106:1118-23. 2010..These findings suggest that FABP4 and FABP5 may represent mediators of and biomarkers for metabolic and cardiovascular disease in type 2 diabetes mellitus...- A randomized study comparing the effects of a low-carbohydrate diet and a conventional diet on lipoprotein subfractions and C-reactive protein levels in patients with severe obesityPrakash Seshadri
Department of Internal Medicine, Division of Endocrinology, University of Pennsylvania Health System, Philadelphia 19104, USA
Am J Med 117:398-405. 2004..Both diets had similar effects on LDL and HDL subfractions... - Free fatty acids, insulin resistance, and corrected qt intervals in morbid obesity: effect of weight loss during 6 months with differing dietary interventionsPrakash Seshadri
Division of Endocrinology, Department of Medicine, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, USA
Endocr Pract 11:234-9. 2005..Improvements in insulin resistance seem to have a relatively weak mechanistic role, and a decrease in FFAs has no apparent role in the reduction of the QTc interval... - Usefulness of insulin resistance estimation and the metabolic syndrome in predicting coronary atherosclerosis in type 2 diabetes mellitusNehal N Mehta
Cardiovascular Institute, Philadelphia, Pennsylvania, USA
Am J Cardiol 107:406-11. 2011.... - Lipoprotein(a) is strongly associated with coronary artery calcification in type-2 diabetic womenAtif N Qasim
Department of Medicine, Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States
Int J Cardiol 150:17-21. 2011..The purpose of this study was to investigate whether type-2 diabetic subjects, relative to non-diabetics, might benefit more from Lp(a) measurement in the prediction of CHD risk, as measured by coronary artery calcium (CAC)... - Apolipoprotein B but not LDL cholesterol is associated with coronary artery calcification in type 2 diabetic whitesSeth S Martin
Cardiovascular Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Diabetes 58:1887-92. 2009..We investigated the hypothesis that apoB is a superior marker of CAC relative to LDL cholesterol... - Comparison of high-density lipoprotein cholesterol to apolipoprotein A-I and A-II to predict coronary calcium and the effect of insulin resistanceSeth S Martin
Cardiovascular Institute, University of Pennsylvania Medical Center, Philadelphia, USA
Am J Cardiol 107:393-8. 2011..In conclusion, HDL cholesterol outperformed apoA-I and apoA-II in CAC prediction, but its association with CAC was attenuated by measures of insulin resistance... - Four-year weight losses in the Look AHEAD study: factors associated with long-term successThomas A Wadden
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Obesity (Silver Spring) 19:1987-98. 2011..e., ≥ 5%) in overweight/obese participants with type 2 diabetes and maintain this loss in more than 45% of patients at 4 years... - Chromium picolinate does not improve key features of metabolic syndrome in obese nondiabetic adultsNayyar Iqbal
Division of General Internal Medicine, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA
Metab Syndr Relat Disord 7:143-50. 2009..The objective of this study was to determine the effects of chromium picolinate (CrPic) on glucose metabolism in patients with metabolic syndrome... - Association of lower plasma fetuin-a levels with peripheral arterial disease in type 2 diabetesLuis H Eraso
Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Diabetes Care 33:408-10. 2010..Fetuin-A is an inhibitor of vascular calcification and a mediator of insulin resistance. This study evaluated the association of plasma fetuin-A and peripheral arterial disease (PAD)... - Narrative review: effect of bariatric surgery on type 2 diabetes mellitusMarion L Vetter
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Ann Intern Med 150:94-103. 2009..This review discusses the various bariatric procedures and how they alter the enteroinsular axis. Familiarity with these effects can help physicians decide among the different surgical procedures and avoid postoperative hypoglycemia... - Effects of rosiglitazone on lipids, adipokines, and inflammatory markers in nondiabetic patients with low high-density lipoprotein cholesterol and metabolic syndromeFrederick F Samaha
Cardiovascular Division, Department of Medicine, Cardiovascular Institute, University of Pennsylvania Medical Center, Philadelphia, PA, USA
Arterioscler Thromb Vasc Biol 26:624-30. 2006..However, the full spectrum of potentially antiatherogenic mechanisms of PPAR-gamma agonists have not been fully tested in nondiabetic patients with metabolic syndrome... - Effects of metformin and leuprolide acetate on insulin resistance and testosterone levels in nondiabetic postmenopausal women: a randomized, placebo-controlled trialShrita M Patel
Division of Endocrinology, Diabetes, and Metabolism, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Fertil Steril 94:2161-6. 2010..To determine whether insulin sensitizers lower androgen levels and whether androgen suppression improves insulin resistance in nondiabetic postmenopausal women... - Coronary artery calcification at electron beam computed tomography is increased in asymptomatic type 2 diabetics independent of traditional risk factorsMegan L Wolfe
Department of Medicine, University of Pennsylvania, 421 Curie Boulevard, 815 BRB2/3, Philadelphia, PA 19104, USA
J Cardiovasc Risk 9:369-76. 2002.... - Gender differences in the association of C-reactive protein with coronary artery calcium in type-2 diabetesAtif N Qasim
The Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
Clin Endocrinol (Oxf) 74:44-50. 2011..Whether CRP has value as a CVD risk marker in type-2 diabetes (T2DM) is unclear. We examined whether CRP has gender differences in association with coronary artery calcium (CAC) in diabetic and nondiabetic samples without clinical CVD... - Selective PKC beta inhibition with ruboxistaurin and endothelial function in type-2 diabetes mellitusNehal N Mehta
Cardiovascular Institute, University of Pennsylvania Medical Center, 909 BRB 2 3, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
Cardiovasc Drugs Ther 23:17-24. 2009..Prior studies demonstrate beneficial effects of PKC beta inhibition on microvascular parameters, but, to date, no study has examined the effect on macrovascular atherosclerotic readouts... - Efficacy of cholesterol uptake inhibition added to statin therapy among subjects following a low-carbohydrate diet: a randomized controlled trialJulio A Chirinos
Department of Medicine, University of Pennsylvania and Philadelphia Veterans Affairs Medical Center, USA
Am Heart J 159:918.e1-6. 2010..However, the efficacy of cholesterol absorption inhibition added to statin therapy has not been studied in this common clinical setting... - One-year weight losses in the Look AHEAD study: factors associated with successThomas A Wadden
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Obesity (Silver Spring) 17:713-22. 2009..The lifestyle intervention was clinically effective in all subsets of an ethnically and demographically diverse population... - Low carbohydrate diets for weight loss: historical & environmental perspectivePrakash Seshadri
University of Pennsylvania School of Medicine, Division of Endocrinology, Philadelphia, PA 19104, USA
Indian J Med Res 123:739-47. 2006..Equally less known, is the applicability of a low carbohydrate diet to populations like India where many main dishes are carbohydrate-based... - The burden of type 2 diabetes: strategies to prevent or delay onsetNayyar Iqbal
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania, Philadelphia VA Medical Center, PA, USA
Vasc Health Risk Manag 3:511-20. 2007..Recent data suggest thiazolidinediones and blockade of the endocannabinoid system represent novel therapeutic approaches that may be used for the prevention of diabetes... - Value of electrocardiographic and ankle-brachial index abnormalities for prediction of coronary atherosclerosis in asymptomatic subjects with type 2 diabetes mellitusRoshanak Bagheri
Cardiovascular Institute, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, and Department of Medicine, Philadelphia Veterans Affairs Medical Center, Pennsylvania, USA
Am J Cardiol 99:951-5. 2007.... - Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetesMuredach P Reilly
Cardiovascular Division, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
J Clin Endocrinol Metab 89:3872-8. 2004..Whether leptin signaling promotes atherosclerosis directly or represents a therapeutic target for the prevention of atherosclerotic cardiovascular disease remains to be explored... - Clinical impact of capsule endoscopy on management of gastrointestinal disordersNuzhat A Ahmad
Gastroenterology Division, Department of Medicine, Hospital of University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Clin Gastroenterol Hepatol 6:433-7. 2008..The impact of capsule endoscopy (CE) findings on patient management is unknown. We assessed the impact of CE findings on patient management, and whether physicians use these to alter management plans... - Does lowering of blood glucose improve cardiovascular morbidity and mortality?Nayyar Iqbal
Section of Endocrinology, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA
Clin J Am Soc Nephrol 3:163-7. 2008 - Total parenteral nutrition in management of hyperlipidemic pancreatitis during pregnancyJennifer A Loh
Department of Medicine, Division of Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Endocr Pract 11:325-30. 2005.... - Outpatient weight management in African-Americans: the Healthy Eating and Lifestyle Program (HELP) studyShiriki K Kumanyika
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Prev Med 41:488-502. 2005..Effective clinical weight management approaches are needed to reach African-Americans... - Status of bone mineral density in patients selected for cardiac transplantationNayyar Iqbal
Division of Endocrinology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Section of Endocrinology, Department of Medicine, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
Endocr Pract 14:704-12. 2008..To determine the prevalence and correlates of low bone mineral density (BMD) in ambulatory outpatients with end-stage heart failure who were awaiting cardiac transplantation... - An inflammatory cascade leading to hyperresistinemia in humansMichael Lehrke
Division of Endocrinology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
PLoS Med 1:e45. 2004..CONCLUSIONS: Inflammation is a hyperresistinemic state in humans, and cytokine induction of resistin may contribute to insulin resistance in endotoxemia, obesity, and other inflammatory states... - Effect of a low-carbohydrate diet versus a low-fat, calorie-restricted diet on adipokine levels in obese, diabetic participantsMarion L Vetter
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
Diabetes Metab Syndr Obes 3:357-61. 2010..001 and P < 0.012, respectively). Modest weight loss, rather than macronutrient composition, likely accounted for the favorable changes observed in leptin and adiponectin over time... - Simvastatin vs therapeutic lifestyle changes and supplements: randomized primary prevention trialDavid J Becker
Division of Cardiology, Chestnut Hill Hospital, University of Pennsylvania Health System, Philadelphia, PA, USA
Mayo Clin Proc 83:758-64. 2008..To compare the lipid-lowering effects of an alternative regimen (lifestyle changes, red yeast rice, and fish oil) with a standard dose of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin)... - Tyrosine kinase inhibitors and the thyroid as both an unintended and an intended targetMarion L Vetter
Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19146, USA
Endocr Pract 14:618-24. 2008..To review the association of the tyrosine kinase inhibitor sunitinib with hypothyroidism as well as the mean time to onset, possible mechanisms, reversibility, and mean duration... - A low-carbohydrate as compared with a low-fat diet in severe obesityFrederick F Samaha
Philadelphia Veterans Affairs Medical Center, University of Pennsylvania Medical Center, Philadelphia, USA
N Engl J Med 348:2074-81. 2003..The effects of a carbohydrate-restricted diet on weight loss and risk factors for atherosclerosis have been incompletely assessed... - Diabetic muscle infarction of the forearm in a patient with long-standing type 1 diabetesSerena Cardillo
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Endocr Pract 12:188-92. 2006..The results of pathologic examination interpreted in the context of the patient's clinical history were consistent with the diagnosis...