Y Ip

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi Cell movements during gastrulation: snail dependent and independent pathways
    Y Tony Ip
    Program in Molecular Medicine and Department of Cell Biology University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Opin Genet Dev 12:423-9. 2002
  2. ncbi Toll and Toll-9 in Drosophila innate immune response
    Raul Bettencourt
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Endotoxin Res 10:261-8. 2004
  3. ncbi Hemolymph-dependent and -independent responses in Drosophila immune tissue
    Raul Bettencourt
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Cell Biochem 92:849-63. 2004
  4. ncbi Helicase89B is a Mot1p/BTAF1 homologue that mediates an antimicrobial response in Drosophila
    Yoshimasa Yagi
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, Massachusetts 01605, USA
    EMBO Rep 6:1088-94. 2005
  5. ncbi The repressor function of snail is required for Drosophila gastrulation and is not replaceable by Escargot or Worniu
    Kirugaval Hemavathy
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Dev Biol 269:411-20. 2004
  6. ncbi Worniu, a Snail family zinc-finger protein, is required for brain development in Drosophila
    Shovon I Ashraf
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Dev Dyn 231:379-86. 2004
  7. ncbi Msk is required for nuclear import of TGF-{beta}/BMP-activated Smads
    Lan Xu
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 178:981-94. 2007
  8. ncbi Heterodimers of NF-kappaB transcription factors DIF and Relish regulate antimicrobial peptide genes in Drosophila
    Takahiro Tanji
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 107:14715-20. 2010
  9. ncbi Multimerization and interaction of Toll and Spätzle in Drosophila
    Xiaodi Hu
    Program in Molecular Medicin, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 101:9369-74. 2004
  10. ncbi Identification of phosphatases for Smad in the BMP/DPP pathway
    Hong B Chen
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 20:648-53. 2006

Research Grants

  1. MOLECULAR MECHANISMS OF DROSOPHILA IMMUNE RESPONSES
    Y Ip; Fiscal Year: 2003
  2. MOLECULAR GENETICS OF DROSOPHILA GASTRULATION
    Y Ip; Fiscal Year: 2004
  3. Molecular mechanisms of Drosophilia immune response
    Y Ip; Fiscal Year: 2007
  4. Host-microbe interaction in Drosophila gut
    Y Ip; Fiscal Year: 2007
  5. MOLECULAR MECHANISMS OF DROSOPHILA IMMUNE RESPONSE
    Y Ip; Fiscal Year: 1999
  6. Genetic analysis of damage-induced intestinal stem cell division in Drosophila
    Y Tony Ip; Fiscal Year: 2010

Collaborators

  • Jin Jiang
  • Lan Xu
  • THOMAS H GRIDLEY
  • Alexander N R Weber
  • Ross L Cagan
  • Takahiro Tanji
  • Yoshimasa Yagi
  • Raul Bettencourt
  • Xiaodi Hu
  • Atish Ganguly
  • Shovon I Ashraf
  • Alla Amcheslavsky
  • Madhurima Chatterjee
  • Hong B Chen
  • Caroline R Craig
  • Kirugaval Hemavathy
  • James Y Ooi
  • Eun Young Yun
  • Jiali Shen
  • H Asha
  • Sili Zhou
  • Jill L Fink
  • Charles Dearolf
  • Stephen J Small
  • John Roote

Detail Information

Publications19

  1. ncbi Cell movements during gastrulation: snail dependent and independent pathways
    Y Tony Ip
    Program in Molecular Medicine and Department of Cell Biology University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Opin Genet Dev 12:423-9. 2002
    ..Together with other regulatory molecules including Wnt and BMP, the Snail pathways specify cell fate and reorganize cellular machineries to coordinate morphological changes and cell movements during gastrulation...
  2. ncbi Toll and Toll-9 in Drosophila innate immune response
    Raul Bettencourt
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Endotoxin Res 10:261-8. 2004
    ..Thus, the innate immune response in Drosophila is regulated by complex mechanisms, which involve Toll and other Toll-related proteins...
  3. ncbi Hemolymph-dependent and -independent responses in Drosophila immune tissue
    Raul Bettencourt
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Cell Biochem 92:849-63. 2004
    ..We further show that Dorsal mutant larvae have much lower phenoloxidase activity, consistent with a more important role of Dorsal in innate immunity than previously shown...
  4. ncbi Helicase89B is a Mot1p/BTAF1 homologue that mediates an antimicrobial response in Drosophila
    Yoshimasa Yagi
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, Massachusetts 01605, USA
    EMBO Rep 6:1088-94. 2005
    ..Thus, Helicase89B positively regulates gene expression during innate immune response and may act as a link between NF-kappaB-related transcription factors and the basal transcription machinery...
  5. ncbi The repressor function of snail is required for Drosophila gastrulation and is not replaceable by Escargot or Worniu
    Kirugaval Hemavathy
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Dev Biol 269:411-20. 2004
    ..Together, the results show that the repressor function of Snail is essential for gastrulation. The repression of target genes by Snail may permit other factors in the ventral cells to positively promote mesoderm invagination...
  6. ncbi Worniu, a Snail family zinc-finger protein, is required for brain development in Drosophila
    Shovon I Ashraf
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Dev Dyn 231:379-86. 2004
    ..The results suggest that the loss of Worniu function within the neuroblasts ultimately causes the larval brainstem to fail to go through shortening during development...
  7. ncbi Msk is required for nuclear import of TGF-{beta}/BMP-activated Smads
    Lan Xu
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 178:981-94. 2007
    ..We have thus identified new evolutionarily conserved proteins that are important in the signal transduction of TGF-beta and BMP into the nucleus...
  8. ncbi Heterodimers of NF-kappaB transcription factors DIF and Relish regulate antimicrobial peptide genes in Drosophila
    Takahiro Tanji
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 107:14715-20. 2010
    ..The DIF and Relish complex is detectable in whole animal extracts, suggesting that this heterodimer may function in vivo to increase the spectrum and level of antimicrobial peptide production in response to different infections...
  9. ncbi Multimerization and interaction of Toll and Spätzle in Drosophila
    Xiaodi Hu
    Program in Molecular Medicin, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 101:9369-74. 2004
    ..Together, our results suggest that multimerization may be a regulated, essential step for Toll-receptor activation...
  10. ncbi Identification of phosphatases for Smad in the BMP/DPP pathway
    Hong B Chen
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 20:648-53. 2006
    ..We show that the mammalian PDPs are important in dephosphorylation of BMP-activated Smad1 but not TGF-beta-activated Smad2 or Smad3. Thus, PDPs specifically inactivate Smads in the BMP/DPP pathway...
  11. ncbi Drosophila WntD is a target and an inhibitor of the Dorsal/Twist/Snail network in the gastrulating embryo
    Atish Ganguly
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Development 132:3419-29. 2005
    ..Thus, these results together demonstrate that WntD is regulated by the Dorsal/Twist/Snail network, and is an inhibitor of Dorsal nuclear localization and function...
  12. ncbi Regulators of the Toll and Imd pathways in the Drosophila innate immune response
    Takahiro Tanji
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Trends Immunol 26:193-8. 2005
    ..In this Review, we will discuss the recent genetic, genomic and RNA interference analyses that have unveiled additional intricacy in the Toll and Imd pathways...
  13. ncbi Learning the codes of fly immunity
    Raul Bettencourt
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Mol Cell 13:1-2. 2004
    ..In this issue of Molecular Cell, Senger and colleagues demonstrate that a large number of immunity genes in Drosophila fat bodies can be regulated by a simple code, REL-GATA...
  14. ncbi The Drosophila Toll-9 activates a constitutive antimicrobial defense
    James Y Ooi
    Program in Molecular Medicine and Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    EMBO Rep 3:82-7. 2002
    ....
  15. ncbi Tissue damage-induced intestinal stem cell division in Drosophila
    Alla Amcheslavsky
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell Stem Cell 4:49-61. 2009
    ..By using this newly established system of intestinal stem cell proliferation and tissue regeneration, we find that the insulin receptor signaling pathway is required for intestinal stem cell division...
  16. ncbi Pathogenic stimulation of intestinal stem cell response in Drosophila
    Madhurima Chatterjee
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Cell Physiol 220:664-71. 2009
    ..This system should allow molecular and genetic analyses of stem cell-mediated tissue repair...
  17. ncbi Toll and IMD pathways synergistically activate an innate immune response in Drosophila melanogaster
    Takahiro Tanji
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell Biol 27:4578-88. 2007
    ..These results illustrate how specific ligand binding by separate upstream pattern recognition receptors can be translated into a broad-spectrum host response, a hallmark of innate immunity...
  18. ncbi Drosophila innate immunity goes viral
    Y Tony Ip
    Nat Immunol 6:863-4. 2005
  19. ncbi A Drosophila p38 orthologue is required for environmental stress responses
    Caroline R Craig
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8103, Saint Louis, Missouri 63110, USA
    EMBO Rep 5:1058-63. 2004
    ..These phenotypes only partially overlap those caused by mutations in D-MEKK1 and dTAK1, suggesting that the D-p38a gene is required to mediate some, but not all, of the functions ascribed to p38 signalling...

Research Grants20

  1. MOLECULAR MECHANISMS OF DROSOPHILA IMMUNE RESPONSES
    Y Ip; Fiscal Year: 2003
    ....
  2. MOLECULAR GENETICS OF DROSOPHILA GASTRULATION
    Y Ip; Fiscal Year: 2004
    ..abstract_text> ..
  3. Molecular mechanisms of Drosophilia immune response
    Y Ip; Fiscal Year: 2007
    ..The successful achievement of the proposed research will provide important insights into the conserved immune processes and the design of agonists and antagonists to modulate the response to pathogens in humans. ..
  4. Host-microbe interaction in Drosophila gut
    Y Ip; Fiscal Year: 2007
    ..Data obtained from this R21 exploratory study will be used for future R01 grant submission and will provide novel diagnostic and therapeutic strategies to protect the public against pathogens and inflammatory diseases in the intestine. ..
  5. MOLECULAR MECHANISMS OF DROSOPHILA IMMUNE RESPONSE
    Y Ip; Fiscal Year: 1999
    ....
  6. Genetic analysis of damage-induced intestinal stem cell division in Drosophila
    Y Tony Ip; Fiscal Year: 2010
    ..The information obtained may yield novel strategies for treatment of inflammatory diseases and cancer. ..