C Ip

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. ncbi request reprint Activities of structurally-related lipophilic selenium compounds as cancer chemopreventive agents
    C Ip
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Anticancer Res 18:4019-25. 1998
  2. ncbi request reprint Cytostasis and cancer chemoprevention: investigating the action of triphenylselenonium chloride in in vivo models of mammary carcinogenesis
    C Ip
    Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14293, USA
    Anticancer Res 18:9-12. 1998
  3. ncbi request reprint Triphenylselenonium and diphenylselenide in cancer chemoprevention: comparative studies of anticarcinogenic efficacy, tissue selenium levels and excretion profile
    C Ip
    Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Anticancer Res 17:3195-9. 1997
  4. ncbi request reprint Review of the effects of trans fatty acids, oleic acid, n-3 polyunsaturated fatty acids, and conjugated linoleic acid on mammary carcinogenesis in animals
    C Ip
    Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Am J Clin Nutr 66:1523S-1529S. 1997
  5. ncbi request reprint Modulation of phase I and phase II xenobiotic-metabolizing enzymes by selenium-enriched garlic in rats
    C Ip
    Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Nutr Cancer 28:184-8. 1997
  6. ncbi request reprint Selenium modulation of cell proliferation and cell cycle biomarkers in normal and premalignant cells of the rat mammary gland
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Epidemiol Biomarkers Prev 9:49-54. 2000
  7. ncbi request reprint Chemoprevention of mammary cancer with Se-allylselenocysteine and other selenoamino acids in the rat
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Anticancer Res 19:2875-80. 1999
  8. ncbi request reprint Methylselenocysteine modulates proliferation and apoptosis biomarkers in premalignant lesions of the rat mammary gland
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Anticancer Res 21:863-7. 2001
  9. ncbi request reprint In vitro and in vivo studies of methylseleninic acid: evidence that a monomethylated selenium metabolite is critical for cancer chemoprevention
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 60:2882-6. 2000
  10. ncbi request reprint Chemical speciation influences comparative activity of selenium-enriched garlic and yeast in mammary cancer prevention
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Agric Food Chem 48:2062-70. 2000

Detail Information

Publications21

  1. ncbi request reprint Activities of structurally-related lipophilic selenium compounds as cancer chemopreventive agents
    C Ip
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Anticancer Res 18:4019-25. 1998
    ..Bioavailability was very low with diphenyl selenide, and undetectable with triphenylselenonium chloride. The chemical reactivities of these different selenium compounds are discussed in relation to the biological effects reported here...
  2. ncbi request reprint Cytostasis and cancer chemoprevention: investigating the action of triphenylselenonium chloride in in vivo models of mammary carcinogenesis
    C Ip
    Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14293, USA
    Anticancer Res 18:9-12. 1998
    ..These findings highlight the importance of understanding the range of activity of a given chemopreventive agent in order to maximize the probability of a successful outcome in the design of any future intervention trial...
  3. ncbi request reprint Triphenylselenonium and diphenylselenide in cancer chemoprevention: comparative studies of anticarcinogenic efficacy, tissue selenium levels and excretion profile
    C Ip
    Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Anticancer Res 17:3195-9. 1997
    ..Further studies are needed to clarify the basis for the differential effects of these phenyl selenide derivatives...
  4. ncbi request reprint Review of the effects of trans fatty acids, oleic acid, n-3 polyunsaturated fatty acids, and conjugated linoleic acid on mammary carcinogenesis in animals
    C Ip
    Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Am J Clin Nutr 66:1523S-1529S. 1997
    ..4) Conjugated linoleic acid is unique in the sense that concentrations < or = 1% are sufficient for producing significant cancer protection and that this effect seems to be independent of the other fatty acids...
  5. ncbi request reprint Modulation of phase I and phase II xenobiotic-metabolizing enzymes by selenium-enriched garlic in rats
    C Ip
    Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Nutr Cancer 28:184-8. 1997
    ..Our data seem to suggest that an increased detoxification of carcinogen via the phase II conjugating enzymes might represent a mechanism of tumor suppression by Se-garlic...
  6. ncbi request reprint Selenium modulation of cell proliferation and cell cycle biomarkers in normal and premalignant cells of the rat mammary gland
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Epidemiol Biomarkers Prev 9:49-54. 2000
    ....
  7. ncbi request reprint Chemoprevention of mammary cancer with Se-allylselenocysteine and other selenoamino acids in the rat
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Anticancer Res 19:2875-80. 1999
    ....
  8. ncbi request reprint Methylselenocysteine modulates proliferation and apoptosis biomarkers in premalignant lesions of the rat mammary gland
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Anticancer Res 21:863-7. 2001
    ..This is achieved by simultaneously modulating certain molecular pathways that are responsible for inhibiting cell proliferation and enhancing apoptosis...
  9. ncbi request reprint In vitro and in vivo studies of methylseleninic acid: evidence that a monomethylated selenium metabolite is critical for cancer chemoprevention
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 60:2882-6. 2000
    ..Methylseleninic acid could be an excellent tool, especially for molecular mechanism studies in cell culture, and some of these attributes are discussed...
  10. ncbi request reprint Chemical speciation influences comparative activity of selenium-enriched garlic and yeast in mammary cancer prevention
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Agric Food Chem 48:2062-70. 2000
    ....
  11. ncbi request reprint Chemoprevention with triphenylselenonium chloride in selenium-deficient rats
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Anticancer Res 20:4179-82. 2000
    ..Thus selenium chemoprevention efficacy can be separated experimentally from selenoprotein synthesis using this model system...
  12. ncbi request reprint Chemical form of selenium, critical metabolites, and cancer prevention
    C Ip
    Department of Breast Surgery, Roswell Park Cancer Institute, Buffalo, New York 14263
    Cancer Res 51:595-600. 1991
    ..However, the degree to which this occurs under chemoprevention conditions would argue against the involvement of selenoproteins in the anticarcinogenic action of these selenium compounds...
  13. ncbi request reprint Conjugated linoleic acid inhibits proliferation and induces apoptosis of normal rat mammary epithelial cells in primary culture
    M M Ip
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York, 14263, USA
    Exp Cell Res 250:22-34. 1999
    ..Moreover, the changes in mammary adipocyte PKC expression and lipid composition suggest that the adipose stroma may play an important in vivo role in mediating the ability of CLA to inhibit mammary carcinogenesis...
  14. ncbi request reprint Efficacy of trimethylselenonium versus selenite in cancer chemoprevention and its modulation by arsenite
    C Ip
    Department of Breast Surgery, Roswell Park Memorial Institute, Buffalo, NY 14263
    Carcinogenesis 9:1481-4. 1988
    ..The metabolism of selenium and its perturbation by arsenite are discussed in relation to the above findings...
  15. ncbi request reprint New approaches to cancer chemoprevention with difluoromethylornithine and selenite
    C Ip
    Department of Breast Surgery, Roswell Park Memorial Institute, Buffalo, NY 14263
    J Natl Cancer Inst 81:839-43. 1989
    ..The mechanism(s) that accounts for the heightened efficacy of combined DFMO and selenite chemoprevention will be discussed...
  16. ncbi request reprint Differential effect of dietary methionine on the biopotency of selenomethionine and selenite in cancer chemoprevention
    C Ip
    Department of Breast Surgery, Roswell Park Memorial Institute, Buffalo, NY 14263
    J Natl Cancer Inst 80:258-62. 1988
    ..These experiments suggest that adequate methionine intake is required for the utilization of selenomethionine for nutritional and anticarcinogenic purposes...
  17. ncbi request reprint Activity of methylated forms of selenium in cancer prevention
    C Ip
    Department of Breast Surgery, Roswell Park Memorial Institute, Buffalo, New York 14263
    Cancer Res 50:1206-11. 1990
    ..The substantial prophylactic efficacy of methylated selenides and the enhancement by arsenite suggest that partially methylated forms of selenium may be directly involved in the anticarcinogenic action of selenium...
  18. ncbi request reprint Control of rat mammary epithelium proliferation by conjugated linoleic acid
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Nutr Cancer 39:233-8. 2001
    ..These observations suggest that the responsiveness of mammary epithelial cells to CLA intervention may be dependent on their proliferative status...
  19. ncbi request reprint Characterization of the biological activity of gamma-glutamyl-Se-methylselenocysteine: a novel, naturally occurring anticancer agent from garlic
    Y Dong
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 61:2923-8. 2001
    ..On the basis of the collective biology, biochemistry, and molecular biology data, we conclude that GGMSC is an effective anticancer agent with a mechanism of action very similar to that of MSC...
  20. ncbi request reprint Mammary cancer chemoprevention by inorganic and organic selenium: single agent treatment or in combination with vitamin E and their effects on in vitro immune functions
    C Ip
    Department of Breast Surgery, Roswell Park Memorial Institute, Buffalo, NY 14263
    Carcinogenesis 8:1763-6. 1987
    ..The metabolism of inorganic versus organic selenium was discussed in relation to their role in the control of neoplastic growth as well as to their selective modulation by vitamin E...
  21. ncbi request reprint Induction of apoptosis by conjugated linoleic acid in cultured mammary tumor cells and premalignant lesions of the rat mammary gland
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Epidemiol Biomarkers Prev 9:689-96. 2000
    ....