Elizabeth Iorns

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. doi request reprint Whole genome in vivo RNAi screening identifies the leukemia inhibitory factor receptor as a novel breast tumor suppressor
    Elizabeth Iorns
    Department of Medicine, School of Medicine, University of Miami, 1501 NW 10th Ave BRB 701, Miami, FL 33136, USA
    Breast Cancer Res Treat 135:79-91. 2012
  2. doi request reprint Simultaneous analysis of tumor and stromal gene expression profiles from xenograft models
    Elizabeth Iorns
    Department of Medicine, University of Miami Miller School of Medicine, 1501 NW 10th Ave, BRB 701, Miami, FL 33136, USA
    Breast Cancer Res Treat 131:321-4. 2012
  3. doi request reprint CRK7 modifies the MAPK pathway and influences the response to endocrine therapy
    Elizabeth Iorns
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
    Carcinogenesis 30:1696-701. 2009
  4. pmc FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer
    Nicholas Turner
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Cancer Res 70:2085-94. 2010
  5. ncbi request reprint Dissecting resistance to endocrine therapy in breast cancer
    Christopher J Lord
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom
    Cell Cycle 7:1895-8. 2008
  6. doi request reprint Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer
    Elizabeth Iorns
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK
    Cancer Cell 13:91-104. 2008
  7. pmc A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor
    Nicholas C Turner
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
    EMBO J 27:1368-77. 2008
  8. doi request reprint The role of SATB1 in breast cancer pathogenesis
    Elizabeth Iorns
    Department of Medicine, University of Miami Miller School of Medicine, 1550 NW 10th Ave PAP 403, Miami, FL 33136, USA
    J Natl Cancer Inst 102:1284-96. 2010
  9. pmc Integrated functional, gene expression and genomic analysis for the identification of cancer targets
    Elizabeth Iorns
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom
    PLoS ONE 4:e5120. 2009
  10. doi request reprint Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization
    Elizabeth Iorns
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW36JB, UK
    Biochem J 417:361-70. 2009

Collaborators

Detail Information

Publications14

  1. doi request reprint Whole genome in vivo RNAi screening identifies the leukemia inhibitory factor receptor as a novel breast tumor suppressor
    Elizabeth Iorns
    Department of Medicine, School of Medicine, University of Miami, 1501 NW 10th Ave BRB 701, Miami, FL 33136, USA
    Breast Cancer Res Treat 135:79-91. 2012
    ..These results demonstrate the power of genome wide in vivo RNAi screens as a method for identifying novel genes regulating tumorigenesis...
  2. doi request reprint Simultaneous analysis of tumor and stromal gene expression profiles from xenograft models
    Elizabeth Iorns
    Department of Medicine, University of Miami Miller School of Medicine, 1501 NW 10th Ave, BRB 701, Miami, FL 33136, USA
    Breast Cancer Res Treat 131:321-4. 2012
    ..This methodology allows for simultaneous genome-wide analysis of gene expression profiles of both tumor cells and the associated stromal tissue...
  3. doi request reprint CRK7 modifies the MAPK pathway and influences the response to endocrine therapy
    Elizabeth Iorns
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
    Carcinogenesis 30:1696-701. 2009
    ..This study identifies a novel role for CRK7 in MAPK regulation and resistance to estrogen signaling inhibitors...
  4. pmc FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer
    Nicholas Turner
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Cancer Res 70:2085-94. 2010
    ..Our data suggest that amplification and overexpression of FGFR1 may be a major contributor to poor prognosis in luminal-type breast cancers, driving anchorage-independent proliferation and endocrine therapy resistance...
  5. ncbi request reprint Dissecting resistance to endocrine therapy in breast cancer
    Christopher J Lord
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom
    Cell Cycle 7:1895-8. 2008
    ..The results of a high-throughput RNA interference screen identifying novel determinants of tamoxifen resistance support this conjecture and demonstrate that such approaches can identify clinically relevant genes, such as CDK10...
  6. doi request reprint Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer
    Elizabeth Iorns
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK
    Cancer Cell 13:91-104. 2008
    ..The association of low levels of CDK10 with methylation of the CDK10 promoter suggests a mechanism by which CDK10 expression is reduced in tumors...
  7. pmc A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor
    Nicholas C Turner
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
    EMBO J 27:1368-77. 2008
    ..These results highlight the potential of synthetic lethal siRNA screens with chemical inhibitors to define new determinants of sensitivity and potential therapeutic targets...
  8. doi request reprint The role of SATB1 in breast cancer pathogenesis
    Elizabeth Iorns
    Department of Medicine, University of Miami Miller School of Medicine, 1550 NW 10th Ave PAP 403, Miami, FL 33136, USA
    J Natl Cancer Inst 102:1284-96. 2010
    ..SATB1 has been previously proposed as a key protein that controls the development and progression of breast cancer. We explored the potential of the SATB1 protein as a therapeutic target and prognostic marker for human breast cancer...
  9. pmc Integrated functional, gene expression and genomic analysis for the identification of cancer targets
    Elizabeth Iorns
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom
    PLoS ONE 4:e5120. 2009
    ..In conclusion, this strategy represents a novel and effective strategy for the identification of functionally important therapeutic targets in cancer...
  10. doi request reprint Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization
    Elizabeth Iorns
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW36JB, UK
    Biochem J 417:361-70. 2009
    ..Aside from identifying novel agents and targets for tamoxifen sensitization, this approach also provides evidence that performing chemical and genetic screens in parallel may be useful...
  11. pmc A new mouse model for the study of human breast cancer metastasis
    Elizabeth Iorns
    Department of Medicine and Division of Hematology and Oncology, University of Miami Miller School of Medicine, Miami, Florida, USA
    PLoS ONE 7:e47995. 2012
    ..By comparing multiple metastatic sites and independent cell lines, we have identified several gene expression changes that may be important for tumor growth at distant sites...
  12. doi request reprint PI3K independent activation of mTORC1 as a target in lapatinib-resistant ERBB2+ breast cancer cells
    Anna Maria Jegg
    Division of Hematology and Oncology, University of Miami Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA
    Breast Cancer Res Treat 136:683-92. 2012
    ..e., S6) may serve as a more robust biomarker to predict sensitivity to mTOR inhibitors in the context of lapatinib resistance than PI3K mutations, loss of PTEN and p-AKT levels...
  13. ncbi request reprint Utilizing RNA interference to enhance cancer drug discovery
    Elizabeth Iorns
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK
    Nat Rev Drug Discov 6:556-68. 2007
    ..Here, we discuss the existing applications of RNAi in cancer drug discovery and highlight areas in this process that may benefit from this technology in the future...
  14. pmc Rescue of tropomyosin deficiency in Drosophila and human cancer cells by synaptopodin reveals a role of tropomyosin α in RhoA stabilization
    Jenny S Wong
    Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    EMBO J 31:1028-40. 2012
    ..Our findings elucidate RhoA stabilization by structurally unrelated actin-binding proteins as a conserved mechanism for regulation of stress fibre dynamics and cell motility in a cell type-specific fashion...