George N Ioannou

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Iron in hepatitis C: villain or innocent bystander?
    George N Ioannou
    Health Services Research and Development, Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, USA
    Semin Gastrointest Dis 13:95-108. 2002
  2. ncbi request reprint Development and validation of a model predicting graft survival after liver transplantation
    George N Ioannou
    Division of Gastroenterology, Department of Medicine, Hepatitis C Resource Center, Health Services Research and Development, Seattle, WA, USA
    Liver Transpl 12:1594-606. 2006
  3. ncbi request reprint Similar effectiveness of boceprevir and telaprevir treatment regimens for hepatitis C virus infection on the basis of a nationwide study of veterans
    George N Ioannou
    Division of Gastroenterology, Veterans Affairs Puget Sound Health Care System, Seattle, Washington Health Services Research and Development, Veterans Affairs Puget Sound Health Care System, Seattle, Washington Division of Gastroenterology, University of Washington, Seattle, Washington Electronic address
    Clin Gastroenterol Hepatol 12:1371-80. 2014
  4. pmc Hepatic cholesterol crystals and crown-like structures distinguish NASH from simple steatosis
    George N Ioannou
    Research Enhancement Award Program and Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
    J Lipid Res 54:1326-34. 2013
  5. doi request reprint Effects of menopause and hormone replacement therapy on the associations of hyperuricemia with mortality
    George N Ioannou
    Division of Gastroenterology, Department of Medicine, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, WA, USA
    Atherosclerosis 226:220-7. 2013
  6. doi request reprint The prevalence of cirrhosis and hepatocellular carcinoma in patients with human immunodeficiency virus infection
    George N Ioannou
    Divisions of Gastroenterology, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, WA 98108, USA
    Hepatology 57:249-57. 2013
  7. doi request reprint Liver transplantation for hepatocellular carcinoma: impact of the MELD allocation system and predictors of survival
    George N Ioannou
    Division of Gastroenterology, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA
    Gastroenterology 134:1342-51. 2008
  8. ncbi request reprint Incidence and predictors of hepatocellular carcinoma in patients with cirrhosis
    George N Ioannou
    Division of Gastroenterology, Department of Medicine, Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, Washington 98108, USA
    Clin Gastroenterol Hepatol 5:938-45, 945.e1-4. 2007
  9. ncbi request reprint Association between dietary nutrient composition and the incidence of cirrhosis or liver cancer in the United States population
    George N Ioannou
    Division of Gastroenterology, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA fax
    Hepatology 50:175-84. 2009
  10. ncbi request reprint Cholelithiasis, cholecystectomy, and liver disease
    George N Ioannou
    Division of Gastroenterology, Department of Medicine, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    Am J Gastroenterol 105:1364-73. 2010

Detail Information

Publications48

  1. ncbi request reprint Iron in hepatitis C: villain or innocent bystander?
    George N Ioannou
    Health Services Research and Development, Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, USA
    Semin Gastrointest Dis 13:95-108. 2002
    ..Future studies should focus on the efficacy of combining iron depletion with pegylated interferon and ribavirin and on the effect of long-term iron depletion on histologic progression of chronic hepatitis C infection...
  2. ncbi request reprint Development and validation of a model predicting graft survival after liver transplantation
    George N Ioannou
    Division of Gastroenterology, Department of Medicine, Hepatitis C Resource Center, Health Services Research and Development, Seattle, WA, USA
    Liver Transpl 12:1594-606. 2006
    ..The models may be used to inform liver transplant candidates and their doctors what posttransplant survival would be expected when a given donor is offered and may be particularly helpful for marginal or high-risk donors...
  3. ncbi request reprint Similar effectiveness of boceprevir and telaprevir treatment regimens for hepatitis C virus infection on the basis of a nationwide study of veterans
    George N Ioannou
    Division of Gastroenterology, Veterans Affairs Puget Sound Health Care System, Seattle, Washington Health Services Research and Development, Veterans Affairs Puget Sound Health Care System, Seattle, Washington Division of Gastroenterology, University of Washington, Seattle, Washington Electronic address
    Clin Gastroenterol Hepatol 12:1371-80. 2014
    ....
  4. pmc Hepatic cholesterol crystals and crown-like structures distinguish NASH from simple steatosis
    George N Ioannou
    Research Enhancement Award Program and Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
    J Lipid Res 54:1326-34. 2013
    ....
  5. doi request reprint Effects of menopause and hormone replacement therapy on the associations of hyperuricemia with mortality
    George N Ioannou
    Division of Gastroenterology, Department of Medicine, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, WA, USA
    Atherosclerosis 226:220-7. 2013
    ..It remains unclear whether these associations differ by gender, menopausal status and hormone replacement therapy (HRT) and whether they persist after adjustment for known cardiovascular risk factors...
  6. doi request reprint The prevalence of cirrhosis and hepatocellular carcinoma in patients with human immunodeficiency virus infection
    George N Ioannou
    Divisions of Gastroenterology, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, WA 98108, USA
    Hepatology 57:249-57. 2013
    ..05; 95% CI, 1.03-1.08), and low CD4+ cell count (AOR, 2.36; 95% CI, 1.3-4.2). Among 5999 HIV/HCV-coinfected patients, 994 (18%) had ever received HCV antiviral treatment, of whom 165 (17%) achieved sustained virologic response...
  7. doi request reprint Liver transplantation for hepatocellular carcinoma: impact of the MELD allocation system and predictors of survival
    George N Ioannou
    Division of Gastroenterology, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA
    Gastroenterology 134:1342-51. 2008
    ..We aimed to determine the impact of this system on liver transplantation for HCC...
  8. ncbi request reprint Incidence and predictors of hepatocellular carcinoma in patients with cirrhosis
    George N Ioannou
    Division of Gastroenterology, Department of Medicine, Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, Washington 98108, USA
    Clin Gastroenterol Hepatol 5:938-45, 945.e1-4. 2007
    ..Independent predictors of hepatocellular carcinoma in patients with cirrhosis are not well established...
  9. ncbi request reprint Association between dietary nutrient composition and the incidence of cirrhosis or liver cancer in the United States population
    George N Ioannou
    Division of Gastroenterology, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA fax
    Hepatology 50:175-84. 2009
    ..007), whereas serum cholesterol level was not associated with risk of cirrhosis or liver cancer...
  10. ncbi request reprint Cholelithiasis, cholecystectomy, and liver disease
    George N Ioannou
    Division of Gastroenterology, Department of Medicine, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    Am J Gastroenterol 105:1364-73. 2010
    ..We sought to determine whether persons with cholelithiasis or a history of cholecystectomy were more likely to have elevated serum liver enzymes or to develop cirrhosis...
  11. ncbi request reprint Serum bilirubin and colorectal cancer risk: a population-based cohort study
    G N Ioannou
    Northwest Hepatitis C Resource Center, Veternas Affairs Puget Sound Health Care System, Gastroenterology, Seattle, WA 98108, USA
    Aliment Pharmacol Ther 23:1637-42. 2006
    ..Bilirubin has antioxidant properties and has been postulated to protect against the development of malignancies...
  12. ncbi request reprint Elevated serum alanine aminotransferase activity and calculated risk of coronary heart disease in the United States
    George N Ioannou
    Research Enhancement Award Program, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Hepatology 43:1145-51. 2006
    ..This association is more prominent in women...
  13. doi request reprint Hepatitis B virus in the United States: infection, exposure, and immunity rates in a nationally representative survey
    George N Ioannou
    Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, USA
    Ann Intern Med 154:319-28. 2011
    ..Up-to-date estimates of the prevalence of hepatitis B virus (HBV) infection, exposure, and immunity are necessary to assess the effectiveness of ongoing programs aimed at preventing HBV transmission...
  14. ncbi request reprint Is obesity a risk factor for cirrhosis-related death or hospitalization? A population-based cohort study
    George N Ioannou
    Veterans Affairs Medical Center, Health Services Research and Development, MS 152, Building 1, Room 422, 1660 South Columbian Way, Seattle, Washington 98108, USA
    Gastroenterology 125:1053-9. 2003
    ..Our aim was to determine whether increased body mass index (BMI) in the general population is associated with cirrhosis-related death or hospitalization...
  15. ncbi request reprint Contribution of metabolic factors to alanine aminotransferase activity in persons with other causes of liver disease
    George N Ioannou
    Gastroenterology, Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington USA
    Gastroenterology 128:627-35. 2005
    ....
  16. ncbi request reprint Iron deficiency and gastrointestinal malignancy: a population-based cohort study
    George N Ioannou
    Department of Medicine and Division of Gastroenterology, University of Washington Medical Center, Seattle, Washington 98108, USA
    Am J Med 113:276-80. 2002
    ..We investigated whether iron deficiency, with or without anemia, is associated with an increased likelihood of gastrointestinal malignancy...
  17. ncbi request reprint Is Helicobacter pylori seropositivity related to body mass index in the United States?
    G N Ioannou
    Primary and Specialty Medical Care Service, VA Puget Sound Health Care System, Seattle, WA, USA
    Aliment Pharmacol Ther 21:765-72. 2005
    ..Helicobacter pylori infection may decrease serum ghrelin and increase gastric leptin levels, which may, in turn, decrease body mass index...
  18. ncbi request reprint Is central obesity associated with cirrhosis-related death or hospitalization? A population-based, cohort study
    George N Ioannou
    Health Services Research and Development and Northwest Hepatitis C Resource Centers, Veterans Affairs Puget Sound System, Seattle, Washington, USA
    Clin Gastroenterol Hepatol 3:67-74. 2005
    ..We aimed to determine the interaction between body fat distribution (central versus peripheral) and increased body mass index (BMI) with regards to the risk of cirrhosis-related death or hospitalization...
  19. ncbi request reprint The effect of alcohol consumption on the prevalence of iron overload, iron deficiency, and iron deficiency anemia
    George N Ioannou
    Department of Medicine and Division of Gastroenterology, University of Washington Medical Center, and VA Medical Center, 1660 S Columbian Way, Seattle, WA 98108, USA
    Gastroenterology 126:1293-301. 2004
    ..Our aim was to investigate the relationship between alcohol consumption and iron overload, iron deficiency, or iron deficiency anemia in the U.S. population...
  20. ncbi request reprint Prevalence and trends of insulin resistance, impaired fasting glucose, and diabetes
    George N Ioannou
    Research Enhancement Award Program, Department of Medicine, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, WA 98108, USA
    J Diabetes Complications 21:363-70. 2007
    ..Our aim was to measure the prevalence and time trends of diabetes, impaired fasting glucose, and insulin resistance in the United States during the periods 1988-1994 and 1999-2002...
  21. ncbi request reprint Racial differences in the relationship between hepatitis C infection and iron stores
    George N Ioannou
    Department of Medicine and Division of Gastroenterology, University of Washington, Seattle, WA 98195, USA
    Hepatology 37:795-801. 2003
    ..This finding may partly explain the reduced response of HCV-positive African-Americans to antiviral treatment...
  22. ncbi request reprint Predictors of endoscopic and laboratory evaluation of iron deficiency anemia in hospitalized patients
    George N Ioannou
    Department of Medicine and Division of Gastroenterology, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
    South Med J 100:976-84. 2007
    ..Many hospitalized anemic patients do not undergo appropriate evaluation. We hypothesized that specific clinical variables were likely to be important in triggering evaluation for iron deficiency anemia...
  23. doi request reprint Is obesity associated with anemia of chronic disease? A population-based study
    Karlee J Ausk
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Obesity (Silver Spring) 16:2356-61. 2008
    ..However, overweight and obese persons were not more likely to be anemic compared with normal-weight persons...
  24. ncbi request reprint Relationship between transferrin-iron saturation, alcohol consumption, and the incidence of cirrhosis and liver cancer
    George N Ioannou
    Division of Gastroenterology, Department of Medicine, Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, Washington, USA
    Clin Gastroenterol Hepatol 5:624-9. 2007
    ..We examined the relation between baseline serum transferrin-iron saturation (TS) and the incidence of hospitalizations or deaths related to cirrhosis and liver cancer as well as the influence of alcohol consumption on this relationship...
  25. ncbi request reprint The prevalence and predictors of elevated serum aminotransferase activity in the United States in 1999-2002
    George N Ioannou
    Research Enhancement Award Program, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Am J Gastroenterol 101:76-82. 2006
    ..We aimed to describe the prevalence and associations of elevated serum aminotransferase activity in a recent, nationally representative U.S. survey...
  26. ncbi request reprint Association between serum uric acid level and chronic liver disease in the United States
    Anita Afzali
    Division of Gastroenterology, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Hepatology 52:578-89. 2010
    ..6-4.8 mg/dL, AHR = 1.3, 95% CI = 0.6-2.7). A higher serum UA level was associated with greater mean serum ALT and GGT levels and a greater probability of elevated serum ALT and GGT...
  27. pmc Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice
    Savitha Subramanian
    Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA, USA
    J Lipid Res 52:1626-35. 2011
    ..Dietary cholesterol appears to confer a second "hit" that results in a distinct hepatic phenotype characterized by increased inflammation and oxidative stress...
  28. ncbi request reprint Serum ferritin level predicts advanced hepatic fibrosis among U.S. patients with phenotypic hemochromatosis
    Elizabeth D Morrison
    University of Washington, Seattle, Washington 98195, USA
    Ann Intern Med 138:627-33. 2003
    ..DNA-based HFE gene testing can confirm hereditary hemochromatosis in most people of Northern European descent. However, liver biopsy is important to detect cirrhosis...
  29. ncbi request reprint Survival of liver transplant recipients with hemochromatosis in the United States
    Lei Yu
    Division of Gastroenterology, Department of Medicine Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    Gastroenterology 133:489-95. 2007
    ..We aimed to compare patients with hemochromatosis to those with other causes of liver disease with regard to post-transplantation survival...
  30. doi request reprint Non-alcoholic fatty liver disease as an independent manifestation of the metabolic syndrome: results of a US national survey in three ethnic groups
    Mark M Smits
    Division of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    J Gastroenterol Hepatol 28:664-70. 2013
    ..We formally tested this hypothesis using confirmatory factor analysis, which allows comparison of different models, with or without including NAFLD as a component of the MetS...
  31. doi request reprint Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis
    Christopher Savard
    Research Enhancement Award Program, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Hepatology 57:81-92. 2013
    ..Hepatic and metabolic effects induced by dietary fat and cholesterol together were more than twice as great as the sum of the separate effects of each dietary component alone, demonstrating significant positive interaction...
  32. doi request reprint Excellent posttransplant survival for patients with nonalcoholic steatohepatitis in the United States
    Anita Afzali
    Department of Medicine, Division of Gastroenterology, Veterans Affairs Puget Sound Health Care System and University of Washington, 1959 N E Pacific Street, Seattle, WA 98195, USA
    Liver Transpl 18:29-37. 2012
    ..In conclusion, NASH-related cirrhosis is increasing rapidly as an indication for liver transplantation in the United States and is associated with excellent posttransplant survival...
  33. ncbi request reprint Dietary cholesterol intake is associated with progression of liver disease in patients with chronic hepatitis C: analysis of the Hepatitis C Antiviral Long-term Treatment Against Cirrhosis trial
    Lei Yu
    Division of Gastroenterology, University of Washington, Seattle, Washington Electronic address
    Clin Gastroenterol Hepatol 11:1661-6.e1-3. 2013
    ..Little is known about whether dietary cholesterol affects disease progression in patients with chronic hepatitis C virus infection...
  34. pmc Insulin resistance predicts mortality in nondiabetic individuals in the U.S
    Karlee J Ausk
    Division of Gastroenterology, Department of Medicine, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle Washington, USA
    Diabetes Care 33:1179-85. 2010
    ..We aimed to determine whether insulin resistance, estimated by the homeostasis model assessment for insulin resistance (HOMA-IR), is associated with all-cause or disease-specific mortality among nondiabetic persons in the U.S...
  35. ncbi request reprint 25-Hydroxyvitamin D levels and albuminuria in the Third National Health and Nutrition Examination Survey (NHANES III)
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, WA 98117, USA
    Am J Kidney Dis 50:69-77. 2007
    ..Albuminuria is a risk factor for chronic kidney disease progression, end-stage renal disease, cardiovascular events, and mortality. Animal studies suggested that vitamin D insufficiency may contribute to the pathogenesis of albuminuria...
  36. doi request reprint Serum alpha-fetoprotein level independently predicts posttransplant survival in patients with hepatocellular carcinoma
    Kristin Berry
    Research and Development, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Liver Transpl 19:634-45. 2013
    ..We hope that these data, in combination with other factors, can be used to inform future studies and ongoing discussions aimed at improving the eligibility criteria for liver transplantation for patients with HCC...
  37. pmc Racial differences in the evaluation and treatment of hepatitis C among veterans: a retrospective cohort study
    Christine M Rousseau
    Northwest Health Services Research and Development Center of Excellence and the Northwest Hepatitis C Resource Center, VA Puget Sound Health Care System, Seattle, WA, USA
    Am J Public Health 98:846-52. 2008
    ..We examined the association between race and hepatitis C virus (HCV) evaluation and treatment of veterans in the Northwest Network of the Department of Veterans Affairs (VA)...
  38. doi request reprint Predictors of early treatment discontinuation among patients with genotype 1 hepatitis C and implications for viral eradication
    Lauren A Beste
    Health Services Research and Development Center of Excellence, VA Puget Sound Healthcare System, Seattle, Washington, USA
    Clin Gastroenterol Hepatol 8:972-8. 2010
    ..Risk factors for discontinuation before 48 weeks among patients with genotype 1 HCV vary over the course of therapy. We investigated the rates and risk factors for treatment discontinuation within 12 weeks, 12-24 weeks, and 24-48 weeks...
  39. pmc Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease
    Silvia Cermelli
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 6:e23937. 2011
    ..In both CHC and NAFLD patient groups, serum levels of miR-122 and miR-34a correlated with liver enzymes levels, fibrosis stage and inflammation activity. miR-122 levels also correlated with serum lipids in NAFLD patients...
  40. ncbi request reprint Prospective evaluation of a clinical guideline for the diagnosis and management of iron deficiency anemia
    George N Ioannou
    Division of Gastroenterology, University of Washington and Health Services Research and Development, Puget Sound Veterans Affairs Health Care System, Seattle, Washington, USA
    Am J Med 113:281-7. 2002
    ..We examined the effect of introducing an evidence-based clinical guideline on the diagnosis and evaluation of iron deficiency anemia...
  41. ncbi request reprint Predictors of colorectal cancer screening participation in the United States
    George N Ioannou
    Health Services Research, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Am J Gastroenterol 98:2082-91. 2003
    ..Our aim was to identify predictors of colorectal cancer screening in the United States and subgroups with particularly low rates of screening...
  42. doi request reprint Can computerized brain training games be used to identify early cognitive impairment in cirrhosis?
    Erica V Tartaglione
    1 Research and Development, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA 2 Joint first authors
    Am J Gastroenterol 109:316-23. 2014
    ..We evaluated whether commercially available, computerized "brain-training" games can be used to identify subtle cognitive impairments in patients with cirrhosis...
  43. pmc Anti-apoptotic phenotypes of cholestan-3β,5α,6β-triol-resistant human cholangiocytes: characteristics contributing to the genesis of cholangiocarcinoma
    Apinya Jusakul
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA Department of Veterans Affairs Medical Center, Seattle, WA, USA
    J Steroid Biochem Mol Biol 138:368-75. 2013
    ..Clonal expansion of such apoptosis-resistant cells may contribute to the genesis of cholangiocarcinoma. ..
  44. ncbi request reprint Association between gestational diabetes and pregnancy-induced hypertension
    Chris L Bryson
    VA Puget Sound Health Services Research and Development, Seattle, WA 98108 1597, USA
    Am J Epidemiol 158:1148-53. 2003
    ..2 for eclampsia and OR=3.1 for severe preeclampsia, p<0.05 for both) and among Black women (OR for eclampsia and preeclampsia together=3.9, p<0.05)...
  45. ncbi request reprint Iron, HFE mutations, and hepatocellular carcinoma: is hepatic iron a carcinogen?
    George N Ioannou
    Clin Gastroenterol Hepatol 1:246-8. 2003
  46. ncbi request reprint Percutaneous ablation for hepatocellular carcinoma
    George N Ioannou
    Hepatology 41:942; author reply 942-3. 2005
  47. ncbi request reprint The natural history of NAFLD: impressively unimpressive
    George N Ioannou
    Gastroenterology 129:1805. 2005