Jula K Inrig

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Effect of hemoglobin target on progression of kidney disease: a secondary analysis of the CHOIR (Correction of Hemoglobin and Outcomes in Renal Insufficiency) trial
    Jula K Inrig
    Renal Division, University of Texas Southwestern, Dallas, TX 75390 8523, USA
    Am J Kidney Dis 60:390-401. 2012
  2. pmc Impact of higher hemoglobin targets on blood pressure and clinical outcomes: a secondary analysis of CHOIR
    Jula K Inrig
    Department of Medicine, Renal Division, Duke University Medical Center, Durham, NC, USA
    Nephrol Dial Transplant 27:3606-14. 2012
  3. pmc Decreased pulse pressure during hemodialysis is associated with improved 6-month outcomes
    Jula K Inrig
    Division of Nephrology, Department of Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8523, USA
    Kidney Int 76:1098-107. 2009
  4. pmc Intradialytic hypertension: a less-recognized cardiovascular complication of hemodialysis
    Jula K Inrig
    University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8523, USA
    Am J Kidney Dis 55:580-9. 2010
  5. pmc Association of blood pressure increases during hemodialysis with 2-year mortality in incident hemodialysis patients: a secondary analysis of the Dialysis Morbidity and Mortality Wave 2 Study
    Jula K Inrig
    Department of Medicine, UT Southwestern Medical Center, Dallas, TX 75390 8523, USA
    Am J Kidney Dis 54:881-90. 2009
  6. pmc Antihypertensive agents in hemodialysis patients: a current perspective
    Jula K Inrig
    University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 852, USA
    Semin Dial 23:290-7. 2010
  7. pmc Association between high-dose erythropoiesis-stimulating agents, inflammatory biomarkers, and soluble erythropoietin receptors
    Jula K Inrig
    Department of Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 8523, USA
    BMC Nephrol 12:67. 2011
  8. pmc Intradialytic hypertension and its association with endothelial cell dysfunction
    Jula K Inrig
    UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8523, USA
    Clin J Am Soc Nephrol 6:2016-24. 2011
  9. pmc Probing the mechanisms of intradialytic hypertension: a pilot study targeting endothelial cell dysfunction
    Jula K Inrig
    University of Texas Southwestern Medical Center, Dallas, Texas 75390 8523, USA
    Clin J Am Soc Nephrol 7:1300-9. 2012
  10. pmc A secondary analysis of the CHOIR trial shows that comorbid conditions differentially affect outcomes during anemia treatment
    Lynda A Szczech
    Renal Division, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Kidney Int 77:239-46. 2010

Detail Information

Publications27

  1. pmc Effect of hemoglobin target on progression of kidney disease: a secondary analysis of the CHOIR (Correction of Hemoglobin and Outcomes in Renal Insufficiency) trial
    Jula K Inrig
    Renal Division, University of Texas Southwestern, Dallas, TX 75390 8523, USA
    Am J Kidney Dis 60:390-401. 2012
    ..This study was undertaken to examine the impact of target hemoglobin level on progression of kidney disease in the CHOIR (Correction of Hemoglobin and Outcomes in Renal Insufficiency) trial...
  2. pmc Impact of higher hemoglobin targets on blood pressure and clinical outcomes: a secondary analysis of CHOIR
    Jula K Inrig
    Department of Medicine, Renal Division, Duke University Medical Center, Durham, NC, USA
    Nephrol Dial Transplant 27:3606-14. 2012
    ..Herein, we sought to determine whether changes in erythropoiesis-stimulating agent (ESA) dose and in hemoglobin were predictive of changes in blood pressure (BP) and whether these changes were associated with cardiovascular outcomes...
  3. pmc Decreased pulse pressure during hemodialysis is associated with improved 6-month outcomes
    Jula K Inrig
    Division of Nephrology, Department of Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8523, USA
    Kidney Int 76:1098-107. 2009
    ..Our study found that in prevalent dialysis subjects, a decrease in pulse pressure during dialysis was associated with improved outcomes. Further study is needed to identify how to control pulse pressure to improve outcomes...
  4. pmc Intradialytic hypertension: a less-recognized cardiovascular complication of hemodialysis
    Jula K Inrig
    University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8523, USA
    Am J Kidney Dis 55:580-9. 2010
    ..However, further work is necessary to elucidate the pathophysiologic mechanisms of intradialytic hypertension and its appropriate management and determine whether treatment of intradialytic hypertension can improve clinical outcomes...
  5. pmc Association of blood pressure increases during hemodialysis with 2-year mortality in incident hemodialysis patients: a secondary analysis of the Dialysis Morbidity and Mortality Wave 2 Study
    Jula K Inrig
    Department of Medicine, UT Southwestern Medical Center, Dallas, TX 75390 8523, USA
    Am J Kidney Dis 54:881-90. 2009
    ..However, the long-term consequences are uncertain. Thus, we sought to determine whether BP increases during HD were associated with greater 2-year mortality in incident HD patients...
  6. pmc Antihypertensive agents in hemodialysis patients: a current perspective
    Jula K Inrig
    University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 852, USA
    Semin Dial 23:290-7. 2010
    ..Newer antihypertensive agents, such as direct renin inhibitors, may provide alternative options to improve blood pressure but require testing for efficacy and safety in hemodialysis patients...
  7. pmc Association between high-dose erythropoiesis-stimulating agents, inflammatory biomarkers, and soluble erythropoietin receptors
    Jula K Inrig
    Department of Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 8523, USA
    BMC Nephrol 12:67. 2011
    ..We hypothesized that high-dose ESA requirement would be associated with elevated inflammatory biomarkers, decreased adipokines, and increased circulating, endogenous soluble erythropoietin receptors (sEpoR)...
  8. pmc Intradialytic hypertension and its association with endothelial cell dysfunction
    Jula K Inrig
    UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8523, USA
    Clin J Am Soc Nephrol 6:2016-24. 2011
    ..We hypothesized that intradialytic hypertension is associated in vivo with endothelial cell dysfunction, a novel predictor of adverse cardiovascular outcomes...
  9. pmc Probing the mechanisms of intradialytic hypertension: a pilot study targeting endothelial cell dysfunction
    Jula K Inrig
    University of Texas Southwestern Medical Center, Dallas, Texas 75390 8523, USA
    Clin J Am Soc Nephrol 7:1300-9. 2012
    ..This study hypothesized that carvedilol would improve endothelial cell function and reduce the occurrence of intradialytic hypertension...
  10. pmc A secondary analysis of the CHOIR trial shows that comorbid conditions differentially affect outcomes during anemia treatment
    Lynda A Szczech
    Renal Division, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Kidney Int 77:239-46. 2010
    ..These differential outcomes underscore the need for dedicated trials in these subpopulations...
  11. pmc Secondary analysis of the CHOIR trial epoetin-alpha dose and achieved hemoglobin outcomes
    Lynda A Szczech
    Department of Medicine, The Renal Division, Duke University Medical Center, Durham, North Carolina, USA
    Kidney Int 74:791-8. 2008
    ..Prospective studies are needed to confirm this relationship and determine safe dosing algorithms for patients unable to achieve target hemoglobin...
  12. pmc Relationship between interdialytic weight gain and blood pressure among prevalent hemodialysis patients
    Jula K Inrig
    Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA
    Am J Kidney Dis 50:108-18, 118.e1-4. 2007
    ..This study seeks to define the relationship between IDWG and BP in prevalent hemodialysis subjects...
  13. pmc Outcomes of Staphylococcus aureus infection in hemodialysis-dependent patients
    Yanhong Li
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA
    Clin J Am Soc Nephrol 4:428-34. 2009
    ..Staphylococcus aureus is a leading cause of infection in patients with ESRD. Clinical and economic outcomes associated with S. aureus bacteremia and other S. aureus infections in patients with ESRD were examined...
  14. ncbi request reprint Mortality, kidney disease and cardiac procedures following acute coronary syndrome
    Jula K Inrig
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    Nephrol Dial Transplant 23:934-40. 2008
    ..Cardiac interventions are underutilized in patients with chronic kidney disease (CKD) following acute coronary syndrome (ACS) partly due to nephrotoxicity concerns...
  15. pmc Intradialytic hypertension and the association with interdialytic ambulatory blood pressure
    Peter N Van Buren
    University of Texas Southwestern Medical Center Dallas, Dallas, TX 75390 8523, USA
    Clin J Am Soc Nephrol 6:1684-91. 2011
    ..We hypothesized that patients with intradialytic hypertension have higher interdialytic ambulatory systolic BP than those without intradialytic hypertension...
  16. ncbi request reprint Relationship between clinical outcomes and vascular access type among hemodialysis patients with Staphylococcus aureus bacteremia
    Jula K Inrig
    Department of Medicine, Division of Nephrology, Duke University Medical Center, Durham, NC 27705, USA
    Clin J Am Soc Nephrol 1:518-24. 2006
    ..Twelve-week mortality and costs that are associated with an episode of SAB are high in hemodialysis patients, regardless of vascular access type. Efforts should focus on the prevention of SAB in this high-risk group...
  17. ncbi request reprint Risk for cardiovascular outcomes among subjects with atherosclerotic cardiovascular disease and greater-than-normal estimated glomerular filtration rate
    Jula K Inrig
    Duke Clinical Research Institute, Duke University Medical Center, Box 3646, Durham, NC 27710, USA
    Clin J Am Soc Nephrol 2:1215-22. 2007
    ..This study sought to define the association of an elevated eGFR on the risk for death and cardiovascular outcomes among subjects with atherosclerotic cardiovascular disease...
  18. pmc Perioperative outcomes among patients with end-stage renal disease following coronary artery bypass surgery in the USA
    Dipen S Parikh
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Nephrol Dial Transplant 25:2275-83. 2010
    ..However, the impact of changes in ESRD patient volume and characteristics over time on operative outcomes is unclear...
  19. doi request reprint The prevalence of persistent intradialytic hypertension in a hemodialysis population with extended follow-up
    Peter N Van Buren
    Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8856, USA
    Int J Artif Organs 35:1031-8. 2012
    ..The proportion of patients in which intradialytic hypertension persists over time is unknown...
  20. pmc Interdialytic ambulatory blood pressure in patients with intradialytic hypertension
    Peter N Van Buren
    Division of Nephrology, Department of Internal Medicine, The University of Texas Southwestern Medical Center Dallas, Dallas, Texas, USA
    Curr Opin Nephrol Hypertens 21:15-23. 2012
    ....
  21. pmc Association of intradialytic blood pressure variability with increased all-cause and cardiovascular mortality in patients treated with long-term hemodialysis
    Jennifer E Flythe
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am J Kidney Dis 61:966-74. 2013
    ..Blood pressure is known to fluctuate widely during hemodialysis; however, little is known about the association between intradialytic blood pressure variability and outcomes...
  22. pmc Negative trials in nephrology: what can we learn?
    James E Novak
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Kidney Int 74:1121-7. 2008
    ..In this article, general principles of trial design will be discussed and the potential lessons learned from recent trials in nephrology will be critically reviewed...
  23. doi request reprint Veterans more likely to start hemodialysis with an arteriovenous fistula
    Dipen S Parikh
    Vascular Access Center of Durham, Durham, North Carolina 27707, USA
    Semin Dial 24:570-5. 2011
    ..Nonetheless, AVF rates remain suboptimal, indicating a need for ongoing vascular access evaluation and improvement...
  24. ncbi request reprint Anemia management in chronic kidney disease
    Barbara S Gillespie
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    Hemodial Int 11:15-20. 2007
    ..Here, we present a case that underscores the need to consider the study design when reviewing the data at a population level in order to determine what is most appropriate for our patient...
  25. pmc Hypertension and hemodialysis: pathophysiology and outcomes in adult and pediatric populations
    Peter N Van Buren
    Division of Nephrology, University of Texas Southwestern Medical Center at Dallas, Department of Internal Medicine, 5323 Harry Hines Blvd, Dallas, TX 75390 8523, USA
    Pediatr Nephrol 27:339-50. 2012
    ..Hypertension in adult and pediatric hemodialysis patients warrants aggressive management, although clinical trial evidence of a target BP that improves mortality does not currently exist...
  26. ncbi request reprint Mortality by dialysis modality among patients who have end-stage renal disease and are awaiting renal transplantation
    Jula K Inrig
    Department of Medicine, Division of Nephrology, Duke University Medical Center, Durham, NC 27705, USA
    Clin J Am Soc Nephrol 1:774-9. 2006
    ..Because the interpretation of observational data is highly affected by residual confounding and selection bias, further efforts should focus on the formation and testing of hypotheses to improve dialysis delivery...
  27. ncbi request reprint Use of vancomycin or first-generation cephalosporins for the treatment of hemodialysis-dependent patients with methicillin-susceptible Staphylococcus aureus bacteremia
    Martin E Stryjewski
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Clin Infect Dis 44:190-6. 2007
    ..Clinical outcomes resulting from such a therapeutic strategy have not been well defined...