Research Topics
| D H IngbarSummaryAffiliation: University of Minnesota Country: USA Publications
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Detail Information
Publications
Mechanisms of repair and remodeling following acute lung injuryD H Ingbar
Department of Medicine, University of Minnesota School of Medicine, Minneapolis, USA
Clin Chest Med 21:589-616. 2000..Intervention trials need to examine the long-term physiologic and functional outcomes...- Interactions of keratinocyte growth factor with a nitrating species after marrow transplantation in miceI Y Haddad
Division of Pulmonary and Critical Care Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
Am J Physiol 277:L391-400. 1999..However, the presence of a nitrating agent impairs KGF-derived responses... - High levels of peroxynitrite are generated in the lungs of irradiated mice given cyclophosphamide and allogeneic T cells. A potential mechanism of injury after marrow transplantationI Y Haddad
Departments of Pediatrics and Pulmonary Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
Am J Respir Cell Mol Biol 20:1125-35. 1999..NO, and that the addition of Cy favors peroxynitrite formation. Peroxynitrite generation clarifies the dependence of Cy-induced lung injury and lethality on the presence of allogeneic T cells... 
The critical early proinflammatory events associated with idiopathic pneumonia syndrome in irradiated murine allogeneic recipients are due to donor T cell infusion and potentiated by cyclophosphamideA Panoskaltsis-Mortari
Department of Pediatrics, BMT Division, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Clin Invest 100:1015-27. 1997..This demonstration of early injury after BMT indicates the need for very early therapeutic intervention before lung damage becomes profound and irreversible...- KGF pretreatment decreases B7 and granzyme B expression and hastens repair in lungs of mice after allogeneic BMTA Panoskaltsis-Mortari
Department of Pediatrics, Division of Hematology Oncology and Bone Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, USA
Am J Physiol Lung Cell Mol Physiol 278:L988-99. 2000.... - Oxidant effects on epithelial Na,K-ATPase gene expression and promoter functionC H Wendt
Department of Medicine, University of Minnesota School of Medicine, Minneapolis, USA
Environ Health Perspect 106:1213-7. 1998..Thus, hyperoxia induces Na,K-ATPase beta-1 promoter transcription, likely acting through a novel mechanism... - Cl-channel activation is necessary for stimulation of Na transport in adult alveolar epithelial cellsS M O'Grady
Departments of Physiology and Animal Science, University of Minnesota, St Paul 55108, Minnesota 55455, USA
Am J Physiol Lung Cell Mol Physiol 278:L239-44. 2000..Finally, we describe some preliminary in vivo data that suggest a role for Cl-channel activation in the process of amiloride-sensitive alveolar fluid absorption... - Up-regulation of Na,K-ATPase beta 1 transcription by hyperoxia is mediated by SP1/SP3 bindingC H Wendt
University of Minnesota, Department of Medicine, Minneapolis, Minnesota 55455, USA
J Biol Chem 275:41396-404. 2000..Other GC sites within the proximal promoter also demonstrated up-regulation of transcription by hyperoxia, however, the site at -55 had higher affinity for SP proteins... - Cell fusion to study nuclear-cytoplasmic interactions in endothelial cell apoptosisV A Polunovsky
Department of Medicine, Pulmonary and Critical Care Division, University of Minnesota Medical School, Minneapolis, USA
Am J Pathol 149:115-28. 1996.... - The effects of hyperoxic injury and antioxidant vitamins on death and proliferation of human small airway epithelial cellsH Jyonouchi
Departments of Pediatrics and Internal Medicine, University of Minnesota, Minneapolis, Minnesota, USA
Am J Respir Cell Mol Biol 19:426-36. 1998..Although A549 cells underwent cell death mainly by necrosis, they also were influenced by cell density and hyperoxia. Cell density also determined specific antioxidant vitamin protection in SAE cells... - Alveolar epithelial cells regulate the induction of endothelial cell apoptosisC H Wendt
Department of Medicine, University of Minnesota School of Medicine, Minneapolis 55410
Am J Physiol 267:C893-900. 1994..Our results suggest that alveolar epithelial cells regulate the response of mesenchymal cells to factors that induce apoptosis during injury and repair... - Human surfactant protein a suppresses T cell-dependent inflammation and attenuates the manifestations of idiopathic pneumonia syndrome in miceS Yang
Department of Pediatrics, Division of Pulmonary and Critical Care, University of Minnesota, Minneapolis, Minnesota 55455, USA
Am J Respir Cell Mol Biol 24:527-36. 2001..We conclude that SP-A downregulates T cell-dependent alveolar inflammation by multiple pathways leading to decreased IPS injury...