- Anatomy and neurophysiology of pruritusAkihiko Ikoma
Department of Dermatology and Surgery, University of California, San Francisco, San Francisco, CA, USA
Semin Cutan Med Surg 30:64-70. 2011..Itch sensitization must also be considered in discussions of itch. This review highlights anatomical and functional properties of itch pathways and their relation to understanding itch perception and pruritic diseases...
- Role of spinal neurotransmitter receptors in itch: new insights into therapies and drug developmentFerda Cevikbas
Department of Dermatology, University of California, San Francisco, CA 94143 0660, USA
CNS Neurosci Ther 17:742-9. 2011..Thus, the identification of itch-specific receptors and understanding itch-related circuits in the spinal cord may be innovative strategies for the development of novel antipruritic drugs...
- Mouse model of touch-evoked itch (alloknesis)Tasuku Akiyama
Department of Neurobiology, Physiology, and Behavior, University of California, Davis, Davis, California, USA
J Invest Dermatol 132:1886-91. 2012..In mice with experimental dry skin, there was a time-dependent increase in spontaneous and touch-evoked scratching. This animal model appears to be useful to investigate neural mechanisms of itch and alloknesis...
- Pruritus: management algorithms and experimental therapiesMartin Steinhoff
Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA
Semin Cutan Med Surg 30:127-37. 2011..Finally, we summarize current exciting developments of experimental strategies in itch research and in clinical development for itch therapy...