L J Ignarro

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Nitric oxide as a unique signaling molecule in the vascular system: a historical overview
    L J Ignarro
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Center for the Health Sciences, Los Angeles, California 90095, USA
    J Physiol Pharmacol 53:503-14. 2002
  2. ncbi request reprint Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme
    P M Bauer
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095 1735, USA
    J Biol Chem 276:34458-64. 2001
  3. ncbi request reprint Gender differences of inducible nitric oxide production in SJL/J mice with experimental autoimmune encephalomyelitis
    M Ding
    Department of Neurology, School of Medicine, University of California, Los Angeles 90095, USA
    J Neuroimmunol 77:99-106. 1997
  4. ncbi request reprint Antisense knockdown of inducible nitric oxide synthase inhibits induction of experimental autoimmune encephalomyelitis in SJL/J mice
    M Ding
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 160:2560-4. 1998
  5. pmc Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation
    L J Ignarro
    Department of Molecular and Medical Pharmacology, Center for the Health Sciences, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 98:4202-8. 2001
  6. ncbi request reprint Increased nitric oxide concentrations in posterior hypothalamus and central sympathetic function on nitrate tolerance following subcutaneous nitroglycerin
    S X Ma
    Department of Obstetrics and Gynecology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    Nitric Oxide 3:153-61. 1999
  7. ncbi request reprint Lipopolysaccharide-induced expression of interferon-beta mediates the timing of inducible nitric-oxide synthase induction in RAW 264.7 macrophages
    A T Jacobs
    Department of Pharmacology, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 276:47950-7. 2001
  8. pmc Role of p42/p44 mitogen-activated-protein kinase and p21waf1/cip1 in the regulation of vascular smooth muscle cell proliferation by nitric oxide
    P M Bauer
    Department of Molecular and Medical Pharmacology, Center for the Health Sciences, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 98:12802-7. 2001
  9. ncbi request reprint Inducible nitric-oxide synthase and nitric oxide production in human fetal astrocytes and microglia. A kinetic analysis
    M Ding
    Department of, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Biol Chem 272:11327-35. 1997
  10. ncbi request reprint Certain S-substituted isothioureas not only inhibit NO synthase catalytic activity but also decrease translation and stability of inducible NO synthase protein
    L H Wei
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095 1735, USA
    Nitric Oxide 2:155-64. 1998

Collaborators

  • G Wu
  • J E Merrill
  • C Napoli
  • G Cirino
  • M Ding
  • P M Bauer
  • L H Wei
  • A Liguori
  • G M Buga
  • M Matteo
  • A T Jacobs
  • V S Kashyap
  • B Azizzadeh
  • S X Ma
  • M Rienzo
  • M L Balestrieri
  • F de Nigris
  • F P D'Armiento
  • L O Lerman
  • A Palagiano
  • W Palinski
  • S Williams-Ignarro
  • C Fiorito
  • M d'Amora
  • E Cicinelli
  • P Greco
  • Y S Cho
  • D Baldini
  • A Vitarelli
  • D Boffoli
  • W S Moore
  • S Horvath
  • K E Blackwell
  • J A Freischlag
  • J M Fukuto
  • R E Byrns
  • A E Pegg
  • T X Hoang
  • H T Yip
  • M B Wang
  • H A Gelabert
  • T D Reil
  • S M Morris
  • T C Calcaterra
  • R Byrns
  • X Y Li
  • N Arabolos

Detail Information

Publications17

  1. ncbi request reprint Nitric oxide as a unique signaling molecule in the vascular system: a historical overview
    L J Ignarro
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Center for the Health Sciences, Los Angeles, California 90095, USA
    J Physiol Pharmacol 53:503-14. 2002
    ....
  2. ncbi request reprint Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme
    P M Bauer
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095 1735, USA
    J Biol Chem 276:34458-64. 2001
    ..Finally S-nitrosylated ornithine decarboxylase was isolated from intact cells treated with nitric oxide, suggesting that nitric oxide may regulate ornithine decarboxylase activity by S-nitrosylation in vivo...
  3. ncbi request reprint Gender differences of inducible nitric oxide production in SJL/J mice with experimental autoimmune encephalomyelitis
    M Ding
    Department of Neurology, School of Medicine, University of California, Los Angeles 90095, USA
    J Neuroimmunol 77:99-106. 1997
    ..These data show an association between No production and EAE severity, suggesting a possible role of NO in the pathogenesis of EAE...
  4. ncbi request reprint Antisense knockdown of inducible nitric oxide synthase inhibits induction of experimental autoimmune encephalomyelitis in SJL/J mice
    M Ding
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 160:2560-4. 1998
    ..Thus, we have shown that the iNOS antisense ODN specifically blocked iNOS expression and ameliorated the induction of EAE...
  5. pmc Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation
    L J Ignarro
    Department of Molecular and Medical Pharmacology, Center for the Health Sciences, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 98:4202-8. 2001
    ..This study confirms the inhibitory role of the arginine-NO pathway in vascular smooth muscle proliferation and indicates that one mechanism of action of NO is cGMP-independent and attributed to its capacity to inhibit ODC...
  6. ncbi request reprint Increased nitric oxide concentrations in posterior hypothalamus and central sympathetic function on nitrate tolerance following subcutaneous nitroglycerin
    S X Ma
    Department of Obstetrics and Gynecology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    Nitric Oxide 3:153-61. 1999
    ..We conclude that NO formation is increased in the PH following systemically administered NTG and NO in the PH may facilitate central sympathetic functions which contribute to nitrate tolerance...
  7. ncbi request reprint Lipopolysaccharide-induced expression of interferon-beta mediates the timing of inducible nitric-oxide synthase induction in RAW 264.7 macrophages
    A T Jacobs
    Department of Pharmacology, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 276:47950-7. 2001
    ..Accordingly, we propose that the cytokine environment of macrophages may determine the rate and magnitude of nitric oxide production, thereby regulating the cytotoxic response to pathogen challenge...
  8. pmc Role of p42/p44 mitogen-activated-protein kinase and p21waf1/cip1 in the regulation of vascular smooth muscle cell proliferation by nitric oxide
    P M Bauer
    Department of Molecular and Medical Pharmacology, Center for the Health Sciences, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 98:12802-7. 2001
    ....
  9. ncbi request reprint Inducible nitric-oxide synthase and nitric oxide production in human fetal astrocytes and microglia. A kinetic analysis
    M Ding
    Department of, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Biol Chem 272:11327-35. 1997
    ..These findings suggest that a post-translational regulatory event might be involved in iNOS-mediated NO production in human glia...
  10. ncbi request reprint Certain S-substituted isothioureas not only inhibit NO synthase catalytic activity but also decrease translation and stability of inducible NO synthase protein
    L H Wei
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095 1735, USA
    Nitric Oxide 2:155-64. 1998
    ..These observations indicate that AEITU should not be used in cell culture experiments where the intent is solely to assess the consequences of inhibition of iNOS catalytic activity...
  11. ncbi request reprint Nitric oxide improves cisplatin cytotoxicity in head and neck squamous cell carcinoma
    B Azizzadeh
    Division of Head and Neck Surgery, Department of Molecular and Medical Pharmacology, University of California Los Angeles School of Medicine, Los Angeles, California 90095-1624, USA
    Laryngoscope 111:1896-900. 2001
    ..NO agonists should be considered in the future as a possible adjunct to cisplatin in the treatment of HNSCC. Further studies with animal models are necessary to further clarify this relationship...
  12. pmc Elevated arginase I expression in rat aortic smooth muscle cells increases cell proliferation
    L H Wei
    Department of Molecular and Medical Pharmacology, Center for the Health Sciences, School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 98:9260-4. 2001
    ..These observations suggest that arginase I plays a potentially important role in controlling RASMC proliferation...
  13. ncbi request reprint Acute arterial thrombosis causes endothelial dysfunction: a new paradigm for thrombolytic therapy
    V S Kashyap
    Vascular Surgery, Wilford Hall Medical Center, Lackland AFB, Tex, USA
    J Vasc Surg 34:323-9. 2001
    ..Supplementing standard thrombolytic therapy with the NO precursor, l-arginine, ameliorates the endothelial dysfunction seen after acute thrombosis by increasing local NO production...
  14. pmc Effects of nitric oxide-releasing aspirin versus aspirin on restenosis in hypercholesterolemic mice
    C Napoli
    Department of Medicine, Federico II University of Naples, 80131 Naples, Italy
    Proc Natl Acad Sci U S A 98:2860-4. 2001
    ....
  15. ncbi request reprint Sulfhydryl angiotensin-converting enzyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric oxide pathway in patients with essential hypertension
    C Napoli
    Department of Medicine, University of Naples, Naples, Italy
    Am Heart J 148:e5. 2004
    ....
  16. ncbi request reprint Influence of human menopausal gonadotrophin treatment on testicular blood flow and on seminal plasma nitric oxide levels in infertile males
    M Matteo
    Operative Unit of Obstetrics and Gynecology, Department of Surgical Sciences, University of Foggia, Foggia, and Institute of Obstetrics and Gynecology, University Hospital of Bari, Italy
    Int J Androl 29:441-5. 2006
    ..The results of this study confirmed the positive effect of exogenous hMG on testicular blood flow, but failed to demonstrate any effect of hMG treatment on NO levels in the seminal plasma in infertile males...
  17. ncbi request reprint Effect of gestational hypercholesterolaemia on omental vasoreactivity, placental enzyme activity and transplacental passage of normal and oxidised fatty acids
    A Liguori
    Regional Hospital of Pellegrini, Department of Medicine and Division of Cardiology CCU, ASLNA1, Naples 80100, Italy
    BJOG 114:1547-56. 2007
    ..The objective of this study was to elucidate the role of the placenta in mediating oxidative stress from mother to offspring...