S Idell

Summary

Affiliation: University of Texas Health Center
Country: USA

Publications

  1. ncbi request reprint The pathogenesis of pleural space loculation and fibrosis
    Steven Idell
    The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    Curr Opin Pulm Med 14:310-5. 2008
  2. pmc Intrapleural adenoviral delivery of human plasminogen activator inhibitor-1 exacerbates tetracycline-induced pleural injury in rabbits
    Sophia Karandashova
    Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Am J Respir Cell Mol Biol 48:44-52. 2013
  3. ncbi request reprint Endothelium and disordered fibrin turnover in the injured lung: newly recognized pathways
    Steven Idell
    Department of Specialty Care Services, The University of Texas Health Center at Tyler, TX 75708, USA
    Crit Care Med 30:S274-80. 2002
  4. ncbi request reprint Intrapleural low-molecular-weight urokinase or tissue plasminogen activator versus single-chain urokinase in tetracycline-induced pleural loculation in rabbits
    Steven Idell
    Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    Exp Lung Res 33:419-40. 2007
  5. ncbi request reprint Adult respiratory distress syndrome: do selective anticoagulants help?
    Steven Idell
    The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    Am J Respir Med 1:383-91. 2002
  6. ncbi request reprint Intrapleural activation, processing, efficacy, and duration of protection of single-chain urokinase in evolving tetracycline-induced pleural injury in rabbits
    Steven Idell
    Lab C 6, Texas lung Injurty Institute, University of Texas Health Center at Tyler, 11937 US Hwy 271, Tyler, TX 75708, USA
    Am J Physiol Lung Cell Mol Physiol 292:L25-32. 2007
  7. ncbi request reprint Coagulation, fibrinolysis, and fibrin deposition in acute lung injury
    Steven Idell
    Department of Specialty Care Services, University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Crit Care Med 31:S213-20. 2003
  8. ncbi request reprint Single-chain urokinase alone or complexed to its receptor in tetracycline-induced pleuritis in rabbits
    Steven Idell
    Department of Specialty Care Services, The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    Am J Respir Crit Care Med 166:920-6. 2002
  9. doi request reprint Single-chain urokinase in empyema induced by Pasturella multocida
    Steven Idell
    The Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    Exp Lung Res 35:665-81. 2009
  10. ncbi request reprint Induction of plasminogen activator inhibitor-1 by urokinase in lung epithelial cells
    Sreerama Shetty
    Department of Specialty Care Services, University of Texas Health Center, Tyler, Texas 75708, USA
    J Biol Chem 278:18124-31. 2003

Research Grants

  1. Fibrinolytic Pathways in Lung Injury and Repair
    Steven Idell; Fiscal Year: 2008
  2. Fibrinolytic Pathways in Lung Injury and Repair
    Steven Idell; Fiscal Year: 2007
  3. CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASE
    Steven Idell; Fiscal Year: 2004
  4. CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASE
    Steven Idell; Fiscal Year: 2003
  5. CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASE
    Steven Idell; Fiscal Year: 2002
  6. CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASE
    Steven Idell; Fiscal Year: 2001
  7. CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASE
    Steven Idell; Fiscal Year: 2000
  8. CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASE
    Steven Idell; Fiscal Year: 2000
  9. CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASE
    Steven Idell; Fiscal Year: 1993
  10. CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASE
    Steven Idell; Fiscal Year: 1992

Collaborators

Detail Information

Publications49

  1. ncbi request reprint The pathogenesis of pleural space loculation and fibrosis
    Steven Idell
    The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    Curr Opin Pulm Med 14:310-5. 2008
    ..Investigation of mechanisms that underlie intrapleural loculation and fibrosis is therefore timely, as are studies on new strategies to medically address these problems with improved efficacy and safety...
  2. pmc Intrapleural adenoviral delivery of human plasminogen activator inhibitor-1 exacerbates tetracycline-induced pleural injury in rabbits
    Sophia Karandashova
    Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Am J Respir Cell Mol Biol 48:44-52. 2013
    ..Therefore, active PAI-1 in PFs affects the outcome of IPFT, and may be both a biomarker of pleural injury and a molecular target for its treatment...
  3. ncbi request reprint Endothelium and disordered fibrin turnover in the injured lung: newly recognized pathways
    Steven Idell
    Department of Specialty Care Services, The University of Texas Health Center at Tyler, TX 75708, USA
    Crit Care Med 30:S274-80. 2002
    ..Lastly, to review newly recognized posttranscriptional and urokinase-dependent pathways by which the fibrinolytic system is regulated in the lung...
  4. ncbi request reprint Intrapleural low-molecular-weight urokinase or tissue plasminogen activator versus single-chain urokinase in tetracycline-induced pleural loculation in rabbits
    Steven Idell
    Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    Exp Lung Res 33:419-40. 2007
    ..The authors conclude that scuPA reverses loculations as effectively as tPA at clinically applied intrapleural doses, whereas low-molecular-weight urokinase was ineffective...
  5. ncbi request reprint Adult respiratory distress syndrome: do selective anticoagulants help?
    Steven Idell
    The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    Am J Respir Med 1:383-91. 2002
    ..The ability of selective anticoagulants to effectively and safely alter clinical outcome in ARDS remains to be determined...
  6. ncbi request reprint Intrapleural activation, processing, efficacy, and duration of protection of single-chain urokinase in evolving tetracycline-induced pleural injury in rabbits
    Steven Idell
    Lab C 6, Texas lung Injurty Institute, University of Texas Health Center at Tyler, 11937 US Hwy 271, Tyler, TX 75708, USA
    Am J Physiol Lung Cell Mol Physiol 292:L25-32. 2007
    ..Single-chain urokinase induces sustained local fibrinolysis and reversibly prevents pleural loculation for up to 48 h after intrapleural administration after tetracycline-induced injury...
  7. ncbi request reprint Coagulation, fibrinolysis, and fibrin deposition in acute lung injury
    Steven Idell
    Department of Specialty Care Services, University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Crit Care Med 31:S213-20. 2003
    ..Another objective was to determine how novel anticoagulant or fibrinolytic strategies may be used to protect against acute inflammation or accelerated fibrosis in acute lung injury...
  8. ncbi request reprint Single-chain urokinase alone or complexed to its receptor in tetracycline-induced pleuritis in rabbits
    Steven Idell
    Department of Specialty Care Services, The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    Am J Respir Crit Care Med 166:920-6. 2002
    ..The data demonstrate that single-chain urokinase inhibits, whereas lysin-receptor complexes attenuate, adhesion formation in tetracycline-induced pleural injury in rabbits...
  9. doi request reprint Single-chain urokinase in empyema induced by Pasturella multocida
    Steven Idell
    The Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    Exp Lung Res 35:665-81. 2009
    ..These findings confirm that intrapleural scuPA generates fibrinolysis in empyema fluids but does not alter fibrotic repair at the pleural surface or the intensity of intrapleural inflammation in this empyema model...
  10. ncbi request reprint Induction of plasminogen activator inhibitor-1 by urokinase in lung epithelial cells
    Sreerama Shetty
    Department of Specialty Care Services, University of Texas Health Center, Tyler, Texas 75708, USA
    J Biol Chem 278:18124-31. 2003
    ..Induction of PAI-1 by exposure of lung epithelial cells to uPA is a newly recognized pathway by which PAI-1 could regulate local fibrinolysis and urokinase-dependent cellular responses in the setting of lung inflammation or neoplasia...
  11. ncbi request reprint Asbestos upregulates expression of the urokinase-type plasminogen activator receptor on mesothelial cells
    R C Perkins
    Department of Specialty Care, The University of Texas Health Center at Tyler, Tyler, Texas 75710, USA
    Am J Respir Cell Mol Biol 21:637-46. 1999
    ..We found that asbestos increases uPAR at the surface of rabbit and human mesothelial cells, suggesting that altered expression of this receptor could be involved in asbestos-induced remodeling of the pleural mesothelium...
  12. pmc Post-transcriptional regulation of urokinase-type plasminogen activator receptor expression in lipopolysaccharide-induced acute lung injury
    Yashodhar P Bhandary
    The Texas Lung Injury Institute, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Am J Respir Crit Care Med 179:288-98. 2009
    ..uPA induces its own expression in lung epithelial cells, which involves its interaction with cell surface uPAR. Regulation of uPAR expression is therefore crucial for uPA-mediated signaling in infectious acute lung injury (ALI)...
  13. ncbi request reprint Urokinase-type plasminogen activator induces tyrosine phosphorylation of a 78-kDa protein in H-157 cells
    G J Bhat
    Department of Specialty Care Services, The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    Am J Physiol 277:L301-9. 1999
    ..This novel signaling pathway represents a putative mechanism by which uPA could influence epithelial cell proliferation...
  14. pmc Thrombin-thrombomodulin inhibits prourokinase-mediated pleural mesothelial cell-dependent fibrinolysis
    A V Iakhiaev
    The Texas Lung Injury Institute, The University of Texas Health Center at Tyler 11937 US HWY 271 Tyler, TX 75708, USA
    Thromb Res 120:715-25. 2007
    ....
  15. pmc Plasminogen activator inhibitor-1 inhibits factor VIIa bound to tissue factor
    P Sen
    Center for Biomedical Research and The Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    J Thromb Haemost 9:531-9. 2011
    ..The present study was designed to investigate whether PAI-1 inhibits factor (F) VIIa complexed with tissue factor (TF), a well-known procoagulant risk factor...
  16. ncbi request reprint Regulation of tissue factor pathway inhibitor expression in smooth muscle cells
    U R Pendurthi
    Departments of Molecular Biology, Biochemistry and Medical Specialties, The University of Texas Health Center at Tyler, TX, USA
    Blood 94:579-86. 1999
    ..Our study also suggests that control of TFPI expression by serum or bFGF occurs via translational rather than transcriptional regulation...
  17. ncbi request reprint Regulation of urokinase receptor expression by protein tyrosine phosphatases
    Sreerama Shetty
    The Texas Lung Injury Institute, Department of Specialty Care Services, The University of Texas Health Center at Tyler, TX 75708, USA
    Am J Physiol Lung Cell Mol Physiol 292:L414-21. 2007
    ....
  18. pmc Regulation of urokinase receptor expression by p53: novel role in stabilization of uPAR mRNA
    Sreerama Shetty
    Texas Lung Injury Institute, Department of Specialty Care Services, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Mol Cell Biol 27:5607-18. 2007
    ....
  19. ncbi request reprint Thrombomodulin-mediated catabolism of protein C by pleural mesothelial and vascular endothelial cells
    Alexei V Iakhiaev
    The University of Texas Health Sciences Center at Tyler, Texas Lung Injury Institute, 11937 US Hwy 271, Tyler, TX 75708, USA
    Thromb Haemost 98:627-34. 2007
    ..This mechanism may be pathophysiologically relevant and can contribute to an acquired PC deficiency in conditions characterized by sustained thrombin generation...
  20. pmc Post-transcriptional regulation of plasminogen activator inhibitor type-1 expression in human pleural mesothelial cells
    Sreerama Shetty
    Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, 75708, USA
    Am J Respir Cell Mol Biol 43:358-67. 2010
    ..This newly recognized pathway could influence expression of PAI-1 by mesothelial or mesothelioma cells at the level of mRNA stability in the context of pleural inflammation or malignancy...
  21. ncbi request reprint Sulfation of nitrotyrosine: biochemistry and functional implications
    Ming Cheh Liu
    Department of Pharmacology, College of Pharmacy, The University of Toledo, Toledo, Ohio, USA
    IUBMB Life 59:622-7. 2007
    ..Functional implications of the sulfation of nitrotyrosine are discussed...
  22. pmc Regulation of plasminogen activator inhibitor-1 expression by tumor suppressor protein p53
    Sreerama Shetty
    Texas Lung Injury Institute, University of Texas Health Center, Tyler, Texas 75708, USA
    J Biol Chem 283:19570-80. 2008
    ..These observations demonstrate a novel role for p53 as an mRNA-binding protein that regulates increased PAI-1 expression and stabilization of PAI-1 mRNA in human lung epithelial and carcinoma cells...
  23. ncbi request reprint The fibrinolytic system and the regulation of lung epithelial cell proteolysis, signaling, and cellular viability
    Sreerama Shetty
    Lab C 6, Biomedical Research Bldg, The Univ of Texas Health Science Center at Tyler, 11937 U S Hwy 271, Tyler, TX 75708, USA
    Am J Physiol Lung Cell Mol Physiol 295:L967-75. 2008
    ....
  24. pmc Induction of tissue factor by urokinase in lung epithelial cells and in the lungs
    Sreerama Shetty
    Department of Specialty Care Services, The Texas Lung Injury Institute, University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708, USA
    Am J Respir Crit Care Med 181:1355-66. 2010
    ..Urokinase-type plasminogen activator (uPA) regulates extracellular proteolysis in lung injury and repair. Although alveolar expression of uPA increases, procoagulant activity predominates...
  25. pmc Regulation of intrapleural fibrinolysis by urokinase-alpha-macroglobulin complexes in tetracycline-induced pleural injury in rabbits
    Andrey A Komissarov
    Texas Lung Injury Institute of The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    Am J Physiol Lung Cell Mol Physiol 297:L568-77. 2009
    ..These complexes promote uPA-mediated plasminogen activation in scuPA-treated rabbits with TCN-induced pleural injury...
  26. pmc The urokinase receptor supports tumorigenesis of human malignant pleural mesothelioma cells
    Torry A Tucker
    The Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, 11937 US Hwy 271, Biomedical Research Building, Lab C 5, Tyler, TX 75708, USA
    Am J Respir Cell Mol Biol 42:685-96. 2010
    ....
  27. ncbi request reprint Regulation of urokinase receptor expression by phosphoglycerate kinase
    Sreerama Shetty
    Department of Specialty Care Services, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Am J Respir Cell Mol Biol 31:100-6. 2004
    ..Decline in 3H-thymidine incorporation and migration occurred in H157 cells transfected with PGK cDNA. These results demonstrate that PGK regulates uPAR expression at the post-transcriptional level...
  28. ncbi request reprint Asbestos induces tissue factor in Beas-2B cells via PI3 kinase-PKC-mediated signaling
    Alexei Iakhiaev
    Department of Specialty Care Services, University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    J Toxicol Environ Health A 67:1537-47. 2004
    ....
  29. ncbi request reprint Urokinase receptor mRNA stability involves tyrosine phosphorylation in lung epithelial cells
    Sreerama Shetty
    Associate Professor of Medicine, University of Texas Health Center at Tyler, Tyler, TX, 75708, USA
    Am J Respir Cell Mol Biol 30:69-75. 2004
    ....
  30. ncbi request reprint Pseudomonas aeruginosa outer membrane protein F is an adhesin in bacterial binding to lung epithelial cells in culture
    Ali O Azghani
    The University of Texas Health Center, Department of Specialty Care Services, Tyler, Texas, USA
    Microb Pathog 33:109-14. 2002
    ....
  31. ncbi request reprint Asbestos induces tissue factor in Beas-2B human lung bronchial epithelial cells in vitro
    Alexei Iakhiaev
    Biomedical Research, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Lung 182:251-64. 2004
    ..The mechanism involves alterations in steady-state TF mRNA that do not involve posttranscriptional regulation, implicating control of TF gene expression at the transcriptional level through Sp1 or other transcription factors...
  32. ncbi request reprint Regulation of urokinase receptor expression by phosphoglycerate kinase is independent of its catalytic activity
    Sreerama Shetty
    Department of Medicine, University of Texas Health Center, Tyler, TX 75708, USA
    Am J Physiol Lung Cell Mol Physiol 289:L591-8. 2005
    ..These results demonstrate that uPAR mRNA binding activity as well as PGK-mediated regulation of uPAR mRNA are independent of PGK enzymatic activity...
  33. ncbi request reprint Urokinase induces its own expression in Beas2B lung epithelial cells
    Sreerama Shetty
    Department of Medical Specialties, The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    Am J Physiol Lung Cell Mol Physiol 283:L319-28. 2002
    ....
  34. ncbi request reprint Activation and degradation of protein C by primary rabbit pleural mesothelial cells
    Alexei Iakhiaev
    Department of Medicine, The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    Lung 184:81-8. 2006
    ..Internalization and degradation of PC by RPMC and fibroblasts may regulate its intrapleural expression and influence remodeling of extravascular fibrin in the setting of evolving pleurodesis induced by TCN...
  35. pmc Plasmin enhances cell surface tissue factor activity in mesothelial and endothelial cells
    H Kothari
    Biomedical Research, The University of Texas Health Science Center, Tyler, TX 75708, USA
    J Thromb Haemost 7:121-31. 2009
    ..The mechanism(s) responsible for increased tissue factor (TF) expression in mesothelial cells in response to injury are at present unclear...
  36. ncbi request reprint Cigarette smoke toxicants as substrates and inhibitors for human cytosolic SULTs
    Shin Yasuda
    Biomedical Research Center, The University of Texas Health Center, 11937 US Highway 271, Tyler, TX 75708, USA
    Toxicol Appl Pharmacol 221:13-20. 2007
    ..By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds...
  37. pmc Expression and regulation of epithelial Na+ channels by nucleotides in pleural mesothelial cells
    Hong Guang Nie
    Department of Biochemistry, Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Am J Respir Cell Mol Biol 40:543-54. 2009
    ..Taken together, our data demonstrate that the ENaC channels are biochemically and functionally expressed in human pleural mesothelial cells, and can be up-regulated by cyclic AMP and cyclic GMP...
  38. pmc Generation and release of nitrotyrosine O-sulfate by HepG2 human hepatoma cells upon SIN-1 stimulation: identification of SULT1A3 as the enzyme responsible
    Shin Yasuda
    Biomedical Research Center and The Texas Lung Injury Institute, The University of Texas Health Center, 11937 U S Highway 271, Tyler, TX 75708, USA
    Biochem J 401:497-503. 2007
    ..The proportion of sulfated [3H]nitrotyrosine increased dramatically in the medium over time, implying that sulfation may play a significant role in the metabolism of free nitrotyrosine...
  39. ncbi request reprint Urokinase induces expression of its own receptor in Beas2B lung epithelial cells
    S Shetty
    Department of Medical Specialties, The University of Texas Health Center at Tyler, Biomedical Research Bldg, 11937 U S Highway 271, Tyler, TX 75708, USA
    J Biol Chem 276:24549-56. 2001
    ..Induction of uPAR by uPA represents a novel pathway by which epithelial cells can regulate uPAR-dependent cellular responses that may contribute to stromal remodeling in lung injury or neoplasia...
  40. ncbi request reprint Post-transcriptional regulation of urokinase mRNA. Identification of a novel urokinase mRNA-binding protein in human lung epithelial cells in vitro
    S Shetty
    Department of Specialty Care Services, The University of Texas Health Center, Tyler, Texas 75708, USA
    J Biol Chem 275:13771-9. 2000
    ..The mechanism involves an interaction between a 66-nucleotide sequence of the urokinase mRNA 3'-untranslated region with a newly recognized urokinase mRNA-binding protein to regulate urokinase mRNA stability...
  41. ncbi request reprint Pathogenesis of pleural fibrosis
    Steven E Mutsaers
    Centre for Asthma, Allergy and Respiratory Research, University of Western Australia, Australia
    Respirology 9:428-40. 2004
    ....
  42. ncbi request reprint Urokinase-type plasminogen activator potentiates lipopolysaccharide-induced neutrophil activation
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 170:5644-51. 2003
    ....
  43. ncbi request reprint Blockade of tissue factor: treatment for organ injury in established sepsis
    Martha Sue Carraway
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 167:1200-9. 2003
    ..These results show that blockade of coagulation attenuates acute lung and renal injury in established Gram-negative sepsis accompanied by antiinflammatory effects of therapy...
  44. ncbi request reprint Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and renal failure
    Karen E Welty-Wolf
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 290:L21-31. 2006
    ..Blockade of factor X binding to the tissue factor-factor VIIa complex attenuates lung and organ injuries in established E. coli sepsis by attenuating the neutrophilic response and inflammatory pathways...
  45. ncbi request reprint IL-2-mediated upregulation of uPA and uPAR in natural killer cells
    Gheath Al-Atrash
    Department of Molecular Biology and Immunology, Institute for Cancer Research, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Biochem Biophys Res Commun 292:184-9. 2002
    ..These data suggest that IL-2 upregulates both uPA and uPAR in NK cells through posttranscriptional as well as transcriptional mechanisms, partially explaining increases in NK cell invasiveness following IL-2 stimulation...
  46. ncbi request reprint The matrix unloaded: aerosolized heparin or urokinase for pulmonary fibrosis
    Steven Idell
    Am J Respir Crit Care Med 168:1268-9. 2003
  47. ncbi request reprint The kringle domain of urokinase-type plasminogen activator potentiates LPS-induced neutrophil activation through interaction with {alpha}V{beta}3 integrins
    Sang Hyun Kwak
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Leukoc Biol 78:937-45. 2005
    ..These results demonstrate that the KD of uPA, through interaction with alpha(V)beta(3) integrins, potentiates neutrophil activation...
  48. ncbi request reprint Expression profiling and disseminated intravascular coagulation: finding genes gone wild
    Steven Idell
    Am J Respir Crit Care Med 176:528-30. 2007
  49. ncbi request reprint Plasminogen activator inhibitor-1 potentiates LPS-induced neutrophil activation through a JNK-mediated pathway
    Sang Hyun Kwak
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Colorado, USA
    Thromb Haemost 95:829-35. 2006
    ..These results demonstrate that PAI-1 and uPA KD enhance LPS-induced neutrophil responses through their effects on JNK mediated pathways...

Research Grants16

  1. Fibrinolytic Pathways in Lung Injury and Repair
    Steven Idell; Fiscal Year: 2008
    ..This PPG will accelerate the acquisition of new, clinically relevant information that will hasten the development of better treatments for ALI and/or pleural injury. ..
  2. Fibrinolytic Pathways in Lung Injury and Repair
    Steven Idell; Fiscal Year: 2007
    ..This PPG will accelerate the acquisition of new, clinically relevant information that will hasten the development of better treatments for ALI and/or pleural injury. ..
  3. CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASE
    Steven Idell; Fiscal Year: 2004
    ..This work could identify better, clinically feasible therapeutic approaches to prevent pleural fibrosis. ..
  4. CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASE
    Steven Idell; Fiscal Year: 2003
    ..This work could identify better, clinically feasible therapeutic approaches to prevent pleural fibrosis. ..
  5. CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASE
    Steven Idell; Fiscal Year: 2002
    ..This work could identify better, clinically feasible therapeutic approaches to prevent pleural fibrosis. ..
  6. CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASE
    Steven Idell; Fiscal Year: 2001
    ..This work could identify better, clinically feasible therapeutic approaches to prevent pleural fibrosis. ..
  7. CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASE
    Steven Idell; Fiscal Year: 2000
    ..This work could identify better, clinically feasible therapeutic approaches to prevent pleural fibrosis. ..
  8. CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASE
    Steven Idell; Fiscal Year: 2000
    ..Our studies will define the role of these pathways in pleural organization and could provide novel clinical strategies to preempt or limit the process. ..
  9. CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASE
    Steven Idell; Fiscal Year: 1993
    ..These experiments will focus on the expression of mRNA for PAI-1 and the duration of the message under various conditions, such as cellular interaction with cytokines and the extracellular matrix...
  10. CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASE
    Steven Idell; Fiscal Year: 1992
    ..These experiments will focus on the expression of mRNA for PAI-1 and the duration of the message under various conditions, such as cellular interaction with cytokines and the extracellular matrix...
  11. CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASE
    Steven Idell; Fiscal Year: 1991
    ..These experiments will focus on the expression of mRNA for PAI-1 and the duration of the message under various conditions, such as cellular interaction with cytokines and the extracellular matrix...
  12. CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASE
    Steven Idell; Fiscal Year: 1999
    ..Our studies will define the role of these pathways in pleural organization and could provide novel clinical strategies to preempt or limit the process. ..
  13. Fibrinolytic Pathways in Lung Injury and Repair
    Steven Idell; Fiscal Year: 2008
    ..abstract_text> ..