Research Topics
Species | K A IczkowskiSummaryAffiliation: University of Florida Country: USA Publications
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Detail Information
Publications
Small lymphocytic lymphoma involving an enlarging complex renal cystKenneth A Iczkowski
Department of Pathology and Laboratory Medicine, Veterans Affairs Medical Center, Gainesville, FL 32608 1197, USA
Arch Pathol Lab Med 129:111-2. 2005..Partial nephrectomy revealed infiltration of the cyst wall by small lymphocytic lymphoma. To our knowledge, this is the first reported case of lymphoma arising in or colonizing a renal cyst...- Further evidence for increased macrophage migration inhibitory factor expression in prostate cancerKatherine L Meyer-Siegler
Research and Development Service 151, Bay Pines Veterans Administration Medical Center, Bay Pines, FL 33744, USA
BMC Cancer 5:73. 2005..Additional aims were to examine MIF expression, as well as the location of MIF's receptor, CD74, in human prostatic adenocarcinoma compared to matched benign prostate... - The dual 5-alpha-reductase inhibitor dutasteride induces atrophic changes and decreases relative cancer volume in human prostateKenneth A Iczkowski
Department of Pathology and Laboratory Medicine, Veterans Affairs Medical Center, Gainesville, Florida 32608 1197, USA
Urology 65:76-82. 2005..To perform the first evaluation of the effects of the 5-alpha-reductase inhibitor class of drugs on cancer histopathologic features at radical prostatectomy in a placebo-controlled multicenter trial... - Metafectene is superior to lipofectamine in the transfection of G(s) alpha prostate cancer cellsKenneth A Iczkowski
Pathology and Laboratory Medicine Service 113, VA Medical Center, 1601 S W Archer Road, Gainesville, FL 32608 1197
Mol Biotechnol 28:97-103. 2004..Thus, in vitro, metafectene transfection efficiency was sufficient to allow us to assess the functional significance of our RNAi construct, suggesting metafectene as an excellent candidate for RNAi-mediated anticancer gene therapy... - Postoperative bladder washing cytology after transurethral resection. Can it predict the recurrence of urothelial carcinoma?Kenneth A Iczkowski
Department of Pathology, Immunology and Laboratory Medicine 113, VA Medical Center, 1601 S W Archer Road, Gainesville, Florida 32608 1197, USA
Acta Cytol 48:380-4. 2004..To assess the ability of postoperative bladder washing cytology, performed immediately after transurethral resection of mostly stage Ta or T1 papillary urothelial carcinoma, to predict early recurrence... - Androgen ablation therapy for prostate carcinoma suppresses the immunoreactive telomerase subunit hTERTKenneth A Iczkowski
Department of Pathology and Laboratory Medicine, University of Florida, Gainesville, FL 32608, USA
Cancer 100:294-9. 2004..The effect of complete androgen ablation (CAA) on tumor hTERT expression was uncertain... - Adenoid cystic/basal cell carcinoma of the prostate: clinicopathologic findings in 19 casesKenneth A Iczkowski
Veterans Affairs Medical Center, and Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32608 1197, USA
Am J Surg Pathol 27:1523-9. 2003..3-11.8 years), two patients died of cancer (at 1.5 and 3 years after diagnosis), 3 remain alive with cancer, and 10 have no evidence of cancer. Thus, ACBCC of the prostate is a potentially aggressive neoplasm requiring ablative therapy... - Prostate cancer overexpresses CD44 variants 7-9 at the messenger RNA and protein levelKenneth A Iczkowski
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Pathology and Laboratory Medicine Service, Veterans Administration Medical Center, Gainesville, FL, USA
Anticancer Res 23:3129-40. 2003..In prostate cancer, prior data show down-regulated immunohistochemical expression of cell adhesion protein CD44 standard (CD44s) and most variants (CD44v)... - Paracrine calcitonin in prostate cancer is linked to CD44 variant expression and invasionKenneth A Iczkowski
Department of Pathology, Immunology, and Laboratory Medicine of The University of Florida, Gainesville, FL 32608 1197, USA
Anticancer Res 25:2075-83. 2005..Cell adhesion glycoprotein CD44 variant v7-v10 also faciliates invasion, but its modulation by the CT-Gsalpha system was unexplored... - Current prostate biopsy interpretation: criteria for cancer, atypical small acinar proliferation, high-grade prostatic intraepithelial neoplasia, and use of immunostainsKenneth A Iczkowski
Department of Pathology, The University of Florida, Veterans Administration Medical Center, Gainesville, FL, USA
Arch Pathol Lab Med 130:835-43. 2006..The past decade has brought major changes in prostate biopsy sampling, interpretation, and reporting... - Lobular carcinoma of the breast metastatic to the epidural space: a potential mimic of giant cell bone tumorKenneth A Iczkowski
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
Breast J 9:44-6. 2003..This is the first reported case in which metastatic breast carcinoma was accompanied by these giant cells but the giant cells were not present at the primary tumor site... - Telomerase reverse transcriptase subunit immunoreactivity: a marker for high-grade prostate carcinomaKenneth A Iczkowski
Department of Pathology, University of Florida, Gainesville, Florida, USA
Cancer 95:2487-93. 2002..One study used in situ hybridization in nine patients; however, to date, no immunohistochemical results have been published... - The predominant CD44 splice variant in prostate cancer binds fibronectin, and calcitonin stimulates its expressionKenneth A Iczkowski
Department of Pathology, The University of Florida, Veterans Administration Medical Center, Gainesville, FL, USA
Anticancer Res 26:2863-72. 2006..Prostate cancer (PC) consistently overexpresses variant the (v) isoform of the cell adhesion protein CD44, and loses expression of the standard (s) isoform... - Inflammatory pseudotumor and sarcoma of urinary bladder: differential diagnosis and outcome in thirty-eight spindle cell neoplasmsK A Iczkowski
Department of Pathology and Laboratory Medicine, University of Florida and Veterans Administration Medical Center, Gainesville, Florida 32608 1197, USA
Mod Pathol 14:1043-51. 2001..In conclusion, inflammatory pseudotumor, although overlapping with sarcoma in presentation, age range, and size, does not metastasize and remains histologically distinct from low-grade sarcoma... - New immunohistochemical markers in testicular tumorsKenneth A Iczkowski
Department of Pathology, Immunology, and Laboratory Medicine, The University of Florida, Gainesville, Florida, USA
Anal Quant Cytol Histol 28:181-7. 2006.... - Stable alterations of CD44 isoform expression in prostate cancer cells decrease invasion and growth and alter ligand binding and chemosensitivityKui Yang
Department of Pathology, University of Colorado Denver Health Science Center, Aurora, Colorado, USA
BMC Cancer 10:16. 2010..PCa loses expression of CD44 standard (CD44s) that is present in benign epithelium, and overexpresses the novel splice variant isoform, CD44v7-10... - MAP kinase pathways and calcitonin influence CD44 alternate isoform expression in prostate cancer cellsEric W Robbins
Department of Pathology, Anschutz Medical Campus, University of Colorado Denver, Aurora, Colorado, USA
BMC Cancer 8:260. 2008..Calcitonin has been found to increase proliferation and invasion in PC acting through the protein kinase A pathway... - Prostate cancer invasion is influenced more by expression of a CD44 isoform including variant 9 than by Muc18Archangel Levi Omara-Opyene
Department of Pathology, Immunology, and Laboratory Medicine, The University of Florida, Gainesville, FL, USA
Lab Invest 84:894-907. 2004..Its relative overexpression by G(s)alpha cells is a novel finding, suggesting a link between signal transduction and cell adhesion marker expression... - P504S immunostaining boosts diagnostic resolution of "suspicious" foci in prostatic needle biopsy specimensZhong Jiang
Department of Pathology, University of Massachusetts Medical School, Worcester, USA
Am J Clin Pathol 121:99-107. 2004..Thus, the consensus diagnosis rate improved from poor to good after supplementing 34 beta E12 immunostaining with P504S... - Prostate cancer diagnosed after initial biopsy with atypical small acinar proliferation suspicious for malignancy is similar to cancer found on initial biopsyKenneth A Iczkowski
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, Florida, USA
Urology 60:851-4. 2002..05). CONCLUSIONS: An ASAP diagnosis represents undersampled cancer in at least 40% of cases and places men at risk of prostate cancer with similar clinicopathologic findings as in other men with cancer... - Steam heat with an EDTA buffer and protease digestion optimizes immunohistochemical expression of basal cell-specific antikeratin 34betaE12 to discriminate cancer in prostatic epitheliumK A Iczkowski
Department of Pathology, Mayo Clinic Rochester, Minnesota 55905, USA
Mod Pathol 12:1-4. 1999..This helps to prevent misinterpretation of histologic mimics of cancer, such as atrophic acini and high-grade prostatic intraepithelial neoplasia, that result from false-negative staining... - Characterization of HKE2: an ancient antigen encoded in the major histocompatibility complexD A Ostrov
Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
Tissue Antigens 69:181-8. 2007..The localization of the HKE2 gene to the class II region, its cytoplasmic expression and putative protein-binding domain suggest that HKE2 may function in adaptive immunity and cancer... - Comamonas (Pseudomonas) testosteroni endocarditisGary R Cooper
Division of Cardiovascular Disease, Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
Cardiovasc Pathol 14:145-9. 2005..The patient had no evidence of reinfection after 32 months. The infection was almost certainly community acquired, as is usually true for this organism... - Utility of serial urinary cytology in the initial evaluation of the patient with microscopic hematuriaKogenta Nakamura
Division of Urology, The University of Florida, Jacksonville, Florida, USA
BMC Urol 9:12. 2009..We determine the utility of serial urinary cytologies in patients presenting with microscopic hematuria who were evaluated with upper and lower urinary tract studies to rule out a malignancy... - Persistent exposure to Mycoplasma induces malignant transformation of human prostate cellsKazunori Namiki
Department of Urology, The University of Florida, Gainesville, Florida, USA
PLoS ONE 4:e6872. 2009..genitalium or M. hyorhinis infection to lead to the malignant transformation of benign human epithelial cells and may serve as a model to further study the relationship between prostatitis and prostatic carcinogenesis... - Overexpression of NSAID-activated gene product in prostate cancerKenneth A Iczkowski
Department of Pathology, University of Florida, USA
Int J Surg Pathol 11:159-66. 2003..002). Decreased NAG-1 expression in higher grade cancer is consistent with its known antitumorigenic, proapoptotic activities... - Urothelial carcinoma recurrence in ileal orthotopic neobladder: urethrectomy and creation of ileal conduitChristopher D Moore
Department of Urology, University of Florida College of Medicine, Gainesville, Florida 32610, USA
Urology 69:184.e11-3. 2007..Intraluminal tumor cell seeding appears to be an important mechanism of metachronous transitional cell carcinoma recurrence in the urethra and ileal mucosa of a neobladder... - Adenoid cystic/basal cell carcinoma of the prostate strongly expresses HER-2/neuK A Iczkowski
Pathology and Laboratory Medicine Service, Veterans Administration Medical Center, Gainesville, Florida 32608 1197, USA
J Clin Pathol 59:1327-30. 2006..Benign acini expressed HER-2/neu only in the basal layer. The finding of strong, consistent HER-2/neu expression in ACBCC suggests that treatment with Herceptin (trastuzumab) may be effective in patients with this rare tumour... - Primary, localized vulvar B-cell lymphoma expressing CD44 variant 6 but not cadherins. A case reportK A Iczkowski
Department of Pathology, Reading Hospital, West Reading, Pennsylvania, USA
J Reprod Med 45:853-6. 2000..Primary extranodal lymphoma of the vulva is rare, with only 17 prior cases reported. Its immunohistochemical profile has not been characterized beyond B- or T-cell phenotype... - Exogenous mycoplasmal p37 protein alters gene expression, growth and morphology of prostate cancer cellsS Goodison
Department of Surgery, The University of Florida, Jacksonville, FL, USA
Cytogenet Genome Res 118:204-13. 2007..Taken together, these observations suggest that p37 potentiates the aggressiveness of prostate cancer and thus molecular events triggered by p37 maybe target for therapy... - CD44s expression is reduced in endometriotic lesions compared to eutopic endometrium in women with endometriosisW B Nothnick
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
Int J Gynecol Pathol 20:140-6. 2001..This cyclic pattern of CD44s expression was lost in corresponding endometriotic tissue. Reduced expression of CD44s in endometriotic tissue may provide insight into the pathophysiology of endometriosis... - Needle core length in sextant biopsy influences prostate cancer detection rateKenneth A Iczkowski
Department of Pathology and Laboratory Medicine, Veterans Affairs Medical Center, Gainesville, Florida 32608-1197, USA
Urology 59:698-703. 2002..6-fold and represents a quality assurance consideration. The effect of length on cancer or nonbenign detection was maximal at the prostatic apex where the cores were shortest... - Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumorsKenneth A Iczkowski
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32608, USA
Hum Pathol 39:275-81. 2008..For embryonal carcinoma, OCT3/4 was superior to PLAP and more specific than CD30. D2-40 is recommended to discriminate between seminoma and embryonal carcinoma... - Preoperative prediction of unifocal, unilateral, margin-negative, and small volume prostate cancerKenneth A Iczkowski
Department of Pathology, University of Colorado Health Science Center, Denver, Colorado 80045, USA
Urology 71:1166-71. 2008..Subtotal gland ablation by minimally invasive therapies such as cryotherapy demands preoperative prediction of unifocal, unilateral, margin-negative, and small volume (less than 0.5 mL) cancer... - Intraepithelial and stromal lymphocytes in the normal human prostateDavid G Bostwick
Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, Minnesota, USA
Prostate 55:187-93. 2003..The inverted CD4/CD8 ratio in the intraepithelial compartment suggests that cytotoxic/suppressor T cells are the first line of defense against luminal foreign agents reaching the prostate through retrograde flow... - Interobserver reproducibility in the diagnosis of invasive micropapillary carcinoma of the urinary tract among urologic pathologistsAnkur R Sangoi
Department of Pathology, Stanford University, Stanford, CA, USA
Am J Surg Pathol 34:1367-76. 2010..These findings suggest that more study of IMPC is needed to identify the individual pathologic features that might potentially correlate with an aggressive outcome and response to intravesical therapy... - Malignant mesothelioma of tunica vaginalis testis: a fatal case with liver metastasisKenneth A Iczkowski
Department of Pathology, Division of Urology, University of Florida College of Medicine and Veterans Affairs Medical Center, Gainesville, Florida, USA
J Urol 167:645-6. 2002 - Cyclophosphamide-induced cystitis increases bladder CXCR4 expression and CXCR4-macrophage migration inhibitory factor associationPedro L Vera
Bay Pines VA Healthcare System, Research and Development 151, Bay Pines, Florida, USA
PLoS ONE 3:e3898. 2008..We studied whether CXCR4-MIF associations occur in rat bladder and the effect of experimental cystitis... - High-grade prostatic intraepithelial neoplasia and atypical small acinar proliferation: predictive value for cancer in current practiceCory Schlesinger
Bostwick Laboratories, Richmond, VA, USA
Am J Surg Pathol 29:1201-7. 2005.... - Calcitonin increases invasiveness of prostate cancer cells: role for cyclic AMP-dependent protein kinase A in calcitonin actionVenkata S Sabbisetti
Pharmacology, University of Louisiana School of Pharmacy, College of Health Sciences, Monroe, 71209, USA
Int J Cancer 117:551-60. 2005..The action of CT may be mediated by protein kinase A signaling, which subsequently leads to increased cell invasion and secretion of gelatinases... - Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumorSeakwoo Lee
Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA
Cell Res 16:750-8. 2006..The present study indicates that MMP-26 and TIMP-4 may play an integral role during the conversion of HGPIN to invasive cancer and may also serve as markers for early prostate cancer diagnosis... - Inhibition of macrophage migration inhibitory factor or its receptor (CD74) attenuates growth and invasion of DU-145 prostate cancer cellsKatherine L Meyer-Siegler
Research and Development 151, The Bay Pines Veterans Affairs Healthcare System, 10000 Bay Pines Boulevard, Bay Pines, FL 33744, USA
J Immunol 177:8730-9. 2006..Thus, blocking MIF either at the ligand (MIF) or receptor (CD74) may provide new, targeted specific therapies for androgen-independent prostate cancer... - A working group classification of focal prostate atrophy lesionsAngelo M De Marzo
Johns Hopkins University School of Medicine, USA
Am J Surg Pathol 30:1281-91. 2006..In conclusion, these criteria for variants of focal prostate atrophy may facilitate studies to examine the relation between various patterns of prostate atrophy and prostate cancer...