Alexei V Iakhiaev

Summary

Affiliation: University of Texas Health Center
Country: USA

Publications

  1. ncbi Asbestos induces tissue factor in Beas-2B cells via PI3 kinase-PKC-mediated signaling
    Alexei Iakhiaev
    Department of Specialty Care Services, University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    J Toxicol Environ Health A 67:1537-47. 2004
  2. ncbi Asbestos induces tissue factor in Beas-2B human lung bronchial epithelial cells in vitro
    Alexei Iakhiaev
    Biomedical Research, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Lung 182:251-64. 2004
  3. ncbi Activation and degradation of protein C by primary rabbit pleural mesothelial cells
    Alexei Iakhiaev
    Department of Medicine, The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    Lung 184:81-8. 2006
  4. ncbi Thrombin-thrombomodulin inhibits prourokinase-mediated pleural mesothelial cell-dependent fibrinolysis
    A V Iakhiaev
    The Texas Lung Injury Institute, The University of Texas Health Center at Tyler 11937 US HWY 271 Tyler, TX 75708, USA
    Thromb Res 120:715-25. 2007
  5. ncbi Thrombomodulin-mediated catabolism of protein C by pleural mesothelial and vascular endothelial cells
    Alexei V Iakhiaev
    The University of Texas Health Sciences Center at Tyler, Texas Lung Injury Institute, 11937 US Hwy 271, Tyler, TX 75708, USA
    Thromb Haemost 98:627-34. 2007
  6. ncbi Possible mechanisms contributing to oxidative inactivation of activated protein C: molecular dynamics study
    Armen Nalian
    Texas College, 2404 N Grand Avenue, Tyler, TX 75702, USA
    Thromb Haemost 100:18-25. 2008
  7. ncbi Acute cholesterol depletion impairs functional expression of tissue factor in fibroblasts: modulation of tissue factor activity by membrane cholesterol
    Samir K Mandal
    Biomedical Research Division, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Blood 105:153-60. 2005

Collaborators

Detail Information

Publications7

  1. ncbi Asbestos induces tissue factor in Beas-2B cells via PI3 kinase-PKC-mediated signaling
    Alexei Iakhiaev
    Department of Specialty Care Services, University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    J Toxicol Environ Health A 67:1537-47. 2004
    ....
  2. ncbi Asbestos induces tissue factor in Beas-2B human lung bronchial epithelial cells in vitro
    Alexei Iakhiaev
    Biomedical Research, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Lung 182:251-64. 2004
    ..The mechanism involves alterations in steady-state TF mRNA that do not involve posttranscriptional regulation, implicating control of TF gene expression at the transcriptional level through Sp1 or other transcription factors...
  3. ncbi Activation and degradation of protein C by primary rabbit pleural mesothelial cells
    Alexei Iakhiaev
    Department of Medicine, The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    Lung 184:81-8. 2006
    ..Internalization and degradation of PC by RPMC and fibroblasts may regulate its intrapleural expression and influence remodeling of extravascular fibrin in the setting of evolving pleurodesis induced by TCN...
  4. ncbi Thrombin-thrombomodulin inhibits prourokinase-mediated pleural mesothelial cell-dependent fibrinolysis
    A V Iakhiaev
    The Texas Lung Injury Institute, The University of Texas Health Center at Tyler 11937 US HWY 271 Tyler, TX 75708, USA
    Thromb Res 120:715-25. 2007
    ....
  5. ncbi Thrombomodulin-mediated catabolism of protein C by pleural mesothelial and vascular endothelial cells
    Alexei V Iakhiaev
    The University of Texas Health Sciences Center at Tyler, Texas Lung Injury Institute, 11937 US Hwy 271, Tyler, TX 75708, USA
    Thromb Haemost 98:627-34. 2007
    ..This mechanism may be pathophysiologically relevant and can contribute to an acquired PC deficiency in conditions characterized by sustained thrombin generation...
  6. ncbi Possible mechanisms contributing to oxidative inactivation of activated protein C: molecular dynamics study
    Armen Nalian
    Texas College, 2404 N Grand Avenue, Tyler, TX 75702, USA
    Thromb Haemost 100:18-25. 2008
    ..These are novel findings, which describe potentially pathophysiologically relevant changes in the functional stability of APC exposed to the oxidative stress...
  7. ncbi Acute cholesterol depletion impairs functional expression of tissue factor in fibroblasts: modulation of tissue factor activity by membrane cholesterol
    Samir K Mandal
    Biomedical Research Division, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Blood 105:153-60. 2005
    ..Overall, the data presented herein suggest that membrane cholesterol functions as a positive regulator of TF function by maintaining TF receptors, probably in noncaveolar lipid rafts, in a high-affinity state for VIIa binding...