W G Iacono

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi Eye movement dysfunction in schizophrenia: a heritable characteristic for enhancing phenotype definition
    M E Calkins
    Clinical Science and Psychopathology Research Traing Program, University of Minnesota, MN 55455 0344l, USA
    Am J Med Genet 97:72-6. 2000
  2. ncbi Minnesota Twin Family Study
    William G Iacono
    Minnesota Center for Twin and Family Research, Department of Psychology, University of Minnesota, Minneapolis 55455, USA
    Twin Res 5:482-7. 2002
  3. ncbi Substance use disorders, externalizing psychopathology, and P300 event-related potential amplitude
    William G Iacono
    Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA
    Int J Psychophysiol 48:147-78. 2003
  4. ncbi Association between P3 event-related brain potential amplitude and adolescent problem behavior
    William G Iacono
    Department of Psychology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Psychophysiology 43:465-9. 2006
  5. ncbi Minnesota Center for Twin and Family Research
    William G Iacono
    Minnesota Center for Twin and Family Research, University of Minnesota Twin Cities Campus, 75 East River Road, Minneapolis, MN 55455, USA
    Twin Res Hum Genet 9:978-84. 2006
  6. ncbi P3 event-related potential amplitude and the risk for disinhibitory disorders in adolescent boys
    William G Iacono
    Department of Psychology, University of Minnesota, 75 East River Rd, Minneapolis, MN 55455, USA
    Arch Gen Psychiatry 59:750-7. 2002
  7. ncbi Behavioral disinhibition and the development of early-onset addiction: common and specific influences
    William G Iacono
    Department of Psychology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Annu Rev Clin Psychol 4:325-48. 2008
  8. ncbi Father-child transmission of antisocial behavior: the moderating role of father's presence in the home
    Ryan W Blazei
    Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA
    J Am Acad Child Adolesc Psychiatry 47:406-15. 2008
  9. ncbi Alcohol and illicit drug dependence among parents: associations with offspring externalizing disorders
    N R Marmorstein
    Department of Psychology, Rutgers University, Camden, 311 North 5th Street, Camden, NJ 08102, USA
    Psychol Med 39:149-55. 2009
  10. ncbi Origins and consequences of age at first drink. II. Familial risk and heritability
    M McGue
    Department of Psychology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Alcohol Clin Exp Res 25:1166-73. 2001

Research Grants

  1. TWIN STUDY OF ADHD, CD, AND SUBSTANCE ABUSE
    William Iacono; Fiscal Year: 2004
  2. TWIN FAMILY STUDY OF VULNERABILITY TO SUBSTANCE ABUSE
    William Iacono; Fiscal Year: 2007
  3. Twin Study of ADHD, CD and Substance Abuse
    William Iacono; Fiscal Year: 2007
  4. Substance Abuse & Behavioral Disinhibition: Integrating Genes & Environment
    William Iacono; Fiscal Year: 2007
  5. Twin Study of ADHD, CD and Substance Abuse
    William Iacono; Fiscal Year: 2009
  6. TWIN FAMILY STUDY OF VULNERABILITY TO SUBSTANCE ABUSE
    William Iacono; Fiscal Year: 2002
  7. TWIN/FAMILY STUDY OF VULNERABILITY TO SUBSTANCE ABUSE
    William Iacono; Fiscal Year: 1993
  8. Twin Study of ADHD, CD and Substance Abuse
    William G Iacono; Fiscal Year: 2010

Detail Information

Publications105 found, 100 shown here

  1. ncbi Eye movement dysfunction in schizophrenia: a heritable characteristic for enhancing phenotype definition
    M E Calkins
    Clinical Science and Psychopathology Research Traing Program, University of Minnesota, MN 55455 0344l, USA
    Am J Med Genet 97:72-6. 2000
    ....
  2. ncbi Minnesota Twin Family Study
    William G Iacono
    Minnesota Center for Twin and Family Research, Department of Psychology, University of Minnesota, Minneapolis 55455, USA
    Twin Res 5:482-7. 2002
    ..This article provides an overview of study methods, highlights published findings, and describes procedures in place to foster collaboration with other investigators...
  3. ncbi Substance use disorders, externalizing psychopathology, and P300 event-related potential amplitude
    William G Iacono
    Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA
    Int J Psychophysiol 48:147-78. 2003
    ..These findings suggest that P3-AR indexes one aspect of the genetic diathesis for a spectrum of externalizing problem behavior...
  4. ncbi Association between P3 event-related brain potential amplitude and adolescent problem behavior
    William G Iacono
    Department of Psychology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Psychophysiology 43:465-9. 2006
    ..Our results suggest that reduced P3 may also be associated with early expression of behaviors that predict the development of these disorders...
  5. ncbi Minnesota Center for Twin and Family Research
    William G Iacono
    Minnesota Center for Twin and Family Research, University of Minnesota Twin Cities Campus, 75 East River Road, Minneapolis, MN 55455, USA
    Twin Res Hum Genet 9:978-84. 2006
    ..Measurement of EEG and autonomic nervous system reactivity is also part of the assessment battery for twin families. This article provides an overview of study design and includes a review of recent MCTFR findings...
  6. ncbi P3 event-related potential amplitude and the risk for disinhibitory disorders in adolescent boys
    William G Iacono
    Department of Psychology, University of Minnesota, 75 East River Rd, Minneapolis, MN 55455, USA
    Arch Gen Psychiatry 59:750-7. 2002
    ....
  7. ncbi Behavioral disinhibition and the development of early-onset addiction: common and specific influences
    William G Iacono
    Department of Psychology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Annu Rev Clin Psychol 4:325-48. 2008
    ..Specific environmental and genetic factors ultimately contribute to the differentiation among externalizing disorders...
  8. ncbi Father-child transmission of antisocial behavior: the moderating role of father's presence in the home
    Ryan W Blazei
    Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA
    J Am Acad Child Adolesc Psychiatry 47:406-15. 2008
    ..To demonstrate an environmental effect of being raised by an antisocial father and to test whether the transmission of antisocial behavior from father to child is moderated by the father's presence in the home...
  9. ncbi Alcohol and illicit drug dependence among parents: associations with offspring externalizing disorders
    N R Marmorstein
    Department of Psychology, Rutgers University, Camden, 311 North 5th Street, Camden, NJ 08102, USA
    Psychol Med 39:149-55. 2009
    ..This study examined how adolescent offspring risk for externalizing psychopathology varies with respect to parental alcoholism and illicit drug dependence...
  10. ncbi Origins and consequences of age at first drink. II. Familial risk and heritability
    M McGue
    Department of Psychology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Alcohol Clin Exp Res 25:1166-73. 2001
    ..We tested the common-inherited-vulnerability hypothesis by determining whether AFD is familial and heritable...
  11. ncbi Environmental contributions to the stability of antisocial behavior over time: are they shared or non-shared?
    S Alexandra Burt
    Department of Psychology, Michigan State University, East Lansing, MI, USA
    J Abnorm Child Psychol 38:327-37. 2010
    ..Such results provide an important constructive replication of prior research, strongly suggesting that shared environmental contributions to antisocial behavior are systematic in nature...
  12. ncbi Saccadic disinhibition in patients with acute and remitted schizophrenia and their first-degree biological relatives
    C E Curtis
    Department of Psychology, University of Minnesota, Minneapolis, MN 55455-0344, USA
    Am J Psychiatry 158:100-6. 2001
    ..CONCLUSIONS: These findings suggest that saccadic disinhibition is strongly associated with the genetic liability for schizophrenia...
  13. ncbi Genes mediate the association between P3 amplitude and externalizing disorders
    Brian M Hicks
    Department of Psychology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Psychophysiology 44:98-105. 2007
    ..22. Results replicated across the two age cohorts and demonstrate that reduced P3 amplitude is a marker of the biological vulnerability to externalizing disorders...
  14. ncbi Antisaccade performance in patients with schizophrenia and affective disorder
    J Katsanis
    Department of Psychology, University of Minnesota, USA
    J Abnorm Psychol 106:468-72. 1997
    ..The poor performance of the relatives could not be attributed to their having a psychiatric disorder. Comparison of the 3 patient groups indicated that antisaccade deficits were more pronounced in schizophrenia and bipolar disorder...
  15. ncbi Genetic and environmental influences on adolescent substance use and abuse
    M McGue
    Department of Psychology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Am J Med Genet 96:671-7. 2000
    ..The finding of significant environmental influences on all substance use measures underscores the importance of intervention on early adolescent substance use, a known predictor of adult substance abuse and dependence...
  16. ncbi Longitudinal follow-up of adolescents with late-onset antisocial behavior: a pathological yet overlooked group
    Naomi R Marmorstein
    Department of Psychology, Rutgers University, Camden, NJ 08102, USA
    J Am Acad Child Adolesc Psychiatry 44:1284-91. 2005
    ....
  17. ncbi Environmental contributions to adolescent delinquency: a fresh look at the shared environment
    S Alexandra Burt
    Department of Psychology, Michigan State University, 107D Psychology Building, East Lansing, MI 48824, USA
    J Abnorm Child Psychol 35:787-800. 2007
    ..Such findings provide an important extension of previous twin studies, as they suggest that passive genotype-environment correlations do not explain earlier findings of shared environmental influences on this association...
  18. ncbi Parental divorce and adolescent delinquency: ruling out the impact of common genes
    S Alexandra Burt
    Department of Psychology, Michigan State University, East Lansing, MI 48824, USA
    Dev Psychol 44:1668-77. 2008
    ..Results firmly supported the latter, suggesting that it is the experience of parental divorce, and not common genes, that drives the association between divorce and adolescent delinquency...
  19. ncbi Nonshared environmental mediation of the association between deviant peer affiliation and adolescent externalizing behaviors over time: results from a cross-lagged monozygotic twin differences design
    S Alexandra Burt
    Department of Psychology, Michigan State University, East Lansing, MI 48824, USA
    Dev Psychol 45:1752-60. 2009
    ..Implications are discussed...
  20. ncbi Lifetime tobacco, alcohol and other substance use in adolescent Minnesota twins: univariate and multivariate behavioral genetic analyses
    C Han
    Department of Psychology, University of Minnesota, Minneapolis 55455, USA
    Addiction 94:981-93. 1999
    ..We sought to estimate the contribution of genetic and environmental factors to adolescent tobacco, alcohol and other substance use...
  21. ncbi P300 amplitude in adolescent twins discordant and concordant for alcohol use disorders
    Scott R Carlson
    Department of Psychology, University of Minnesota, N218 Elliot Hall, 75 East River Road, Minneapolis, MN 55455, USA
    Biol Psychol 61:203-27. 2002
    ..The findings are consistent with P300 amplitude being a marker of vulnerability to alcohol use disorders...
  22. ncbi Sources of covariation among attention-deficit/hyperactivity disorder, oppositional defiant disorder, and conduct disorder: the importance of shared environment
    S A Burt
    Department of Psychology, University of Minnesota, Minneapolis 55455, USA
    J Abnorm Psychol 110:516-25. 2001
    ..The results revealed that although each disorder was influenced by genetic and environmental factors, a single shared environmental factor made the largest contribution to the covariation among ADHD, ODD, and CD...
  23. ncbi Searching for interactive effects in the etiology of early-onset substance use
    L N Legrand
    Department of Psychology, University of Minnesota, Minneapolis 55455, USA
    Behav Genet 29:433-44. 1999
    ..We were not able to support our second hypothesis; rather, temperament predicted substance use only through shared environmental factors...
  24. ncbi The death(s) of close friends and family moderate genetic influences on symptoms of major depressive disorder in adolescents
    S Gheyara
    Department of Psychology, Michigan State University, East Lansing, MI 48824, USA
    Psychol Med 41:721-9. 2011
    ..However, it is unclear whether these results persist when controlling for the possibility of confounding active gene-environment correlations (rGE)...
  25. ncbi Genetic and environmental influences on parent-son relationships: evidence for increasing genetic influence during adolescence
    I J Elkins
    University of Minnesota, Minneapolis 55455, USA
    Dev Psychol 33:351-63. 1997
    ..Scarr and K. McCartney (1983) that the importance of active gene-environment correlations increases during adolescence. Older adolescents may have more choice and impact on the nature of the relationships they have with their parents...
  26. ncbi The effects of childhood disruptive disorder comorbidity on P3 event-related brain potentials in preadolescents with ADHD
    Henry H Yoon
    University of Minnesota, Twin Cities, 75 East River Road, Minneapolis, MN 55455, United States
    Biol Psychol 79:329-36. 2008
    ....
  27. ncbi Psychiatric disorders among offspring of depressed mothers: associations with paternal psychopathology
    Naomi R Marmorstein
    Department of Psychology, Rutgers University, 311 N 5th St, Camden, NJ 08102, USA
    Am J Psychiatry 161:1588-94. 2004
    ....
  28. ncbi Modeling the impact of age and sex on a dimension of poly-substance use in adolescence: a longitudinal study from 11- to 17-years-old
    Jaime Derringer
    Department of Psychology, Washington University, St Louis, MO 63130, USA
    Drug Alcohol Depend 110:193-9. 2010
    ..This suggests that measurement and interpretation of adolescent substance use is enhanced by the consideration of a wide range of substances...
  29. ncbi Cohort effects on gender differences in alcohol dependence
    Laura C Holdcraft
    University of Minnesota, USA
    Addiction 97:1025-36. 2002
    ..CONCLUSIONS: Risk for alcohol dependence appears to be rising in younger generations, and particularly for younger women, making them an important target group for prevention and treatment programs...
  30. ncbi Longitudinal associations between depression and substance dependence from adolescence through early adulthood
    Naomi R Marmorstein
    Rutgers University, Camden, Department of Psychology, 311 North 5th Street, Camden, NJ 08102, USA
    Drug Alcohol Depend 107:154-60. 2010
    ..The goal of the present study was to examine longitudinal associations between depression and substance (alcohol and illicit drug) dependence during the period from adolescence through early adulthood...
  31. ncbi Electrodermal activation in first-episode psychotic patients and their first-degree relatives
    W G Iacono
    Department of Psychology, University of Minnesota, Minneapolis 55455, USA
    Psychiatry Res 88:25-39. 1999
    ..Electrodermal non-responding is not specific to schizophrenia and is not likely to be useful as an indicator of genetic risk...
  32. ncbi Origins and consequences of age at first drink. I. Associations with substance-use disorders, disinhibitory behavior and psychopathology, and P3 amplitude
    M McGue
    Department of Psychology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Alcohol Clin Exp Res 25:1156-65. 2001
    ..We investigated whether the association of age at first drink (AFD) with alcoholism was more consistent with the hypothesis that the former causes the latter or the hypothesis that both are manifestations of some common vulnerability...
  33. ncbi Evidence for a genetic etiology of early-onset delinquency
    J Taylor
    Department of Psychology, University of Minnesota, Twin Cities Campus, USA
    J Abnorm Psychol 109:634-43. 2000
    ..Family history data and a twin analysis provided evidence of greater genetic influence on early-onset than late-onset delinquency...
  34. ncbi Parental alcohol dependence and the transmission of adolescent behavioral disinhibition: a study of adoptive and non-adoptive families
    Serena M King
    Department of Psychology, Hamline University, St Paul, MN, USA
    Addiction 104:578-86. 2009
    ..To examine the genetic and environmental influences of parental alcoholism on offspring disinhibited behavior...
  35. ncbi Cross-generational effects on gender differences in psychoactive drug abuse and dependence
    Laura C Holdcraft
    Department of Psychology, University of Minnesota, 75 East River Road, Minneapolis, MN 55455 0344, USA
    Drug Alcohol Depend 74:147-58. 2004
    ..These differences may be decreasing in successive generations. Less is known about gender differences in course and symptomatology for other illicit drug use disorders, especially in community samples...
  36. ncbi Genetic and environmental influences on disordered eating: An adoption study
    Kelly L Klump
    Department of Psychology, Michigan State University, East Lansing, 48824 1116, USA
    J Abnorm Psychol 118:797-805. 2009
    ..Shared environmental factors did not contribute significantly to any disordered eating symptom. Our findings bolster those from twin studies and provide critical evidence of significant genetic effects on disordered eating symptoms...
  37. ncbi How are parent-child conflict and childhood externalizing symptoms related over time? Results from a genetically informative cross-lagged study
    S Alexandra Burt
    Department of Psychology, Michigan State University, Psychology Building, East Lansing, MI 48824, USA
    Dev Psychopathol 17:145-65. 2005
    ..These results suggest a "downward spiral" of interplay between parent-child conflict and EXT, and offer confirmation of a (partially) environmentally mediated effect of parenting on child behavior...
  38. ncbi Personality differences in children and adolescents with attention-deficit/hyperactivity disorder, conduct disorder, and controls
    Kelly C Cukrowicz
    Department of Psychology, Florida State University, Tallahassee, FL 32306, USA
    J Child Psychol Psychiatry 47:151-9. 2006
    ..Implications for treatment planning and theoretical development are discussed...
  39. ncbi A longitudinal investigation of the relationship between disordered eating attitudes and behaviors and parent-child conflict: a monozygotic twin differences design
    Alexia Spanos
    Department of Psychology, Michigan State University, East Lansing, MI 48824 1116, USA
    J Abnorm Psychol 119:293-9. 2010
    ..Findings suggest differences in parent-child conflict between genetically identical twins may be a consequence of, rather than a risk factor for, differences in disordered eating...
  40. ncbi Timing of menarche and the origins of conduct disorder
    S Alexandra Burt
    Department of Psychology, Michigan State University, East Lansing, MI 48824, USA
    Arch Gen Psychiatry 63:890-6. 2006
    ....
  41. ncbi Factorial invariance of the Dyadic Adjustment Scale across gender
    Susan C South
    Department of Psychology, University of Minnesota Twin Cities, USA
    Psychol Assess 21:622-8. 2009
    ....
  42. ncbi Puberty and the genetic diathesis of disordered eating attitudes and behaviors
    Kristen M Culbert
    Department of Psychology, Michigan State University, East Lansing, 48824 1116, USA
    J Abnorm Psychol 118:788-96. 2009
    ..Findings highlight the potentially important role of puberty in the genetic diathesis of disordered eating attitudes and behaviors and the need to use early indicators of pubertal status in studies of developmental effects...
  43. ncbi Using biological indices to classify schizophrenia and other psychotic patients
    S R Sponheim
    Department of Psychology, University of Minnesota, Minneapolis, MN, USA
    Schizophr Res 50:139-50. 2001
    ..Multivariate biologically defined clusters may offer an advantage over DSM-IV classification when examining nosology and etiology of psychotic disorders...
  44. ncbi Adolescent psychopathy features: 6-year temporal stability and the prediction of externalizing symptoms during the transition to adulthood
    Bryan R Loney
    Department of Psychology, Florida State University, Tallahassee, USA
    Aggress Behav 33:242-52. 2007
    ..These findings suggest that psychopathy features are relatively stable from adolescence to adulthood and provide possible insights into the development and maintenance of externalizing difficulties during the adult transition...
  45. ncbi Differential parent-child relationships and adolescent externalizing symptoms: cross-lagged analyses within a monozygotic twin differences design
    S Alexandra Burt
    Department of Psychology, Michigan State University, East Lansing, MI 48824, USA
    Dev Psychol 42:1289-98. 2006
    ..These results suggest that markedly different parent-child conflict has an environmentally mediated impact on child behavior through mid-adolescence, findings that yield insights into environmental influences on behavior...
  46. ncbi Trajectories of change in adolescent substance use and symptomatology: impact of paternal and maternal substance use disorders
    Brent Walden
    Department of Psychology, University of Minnesota, Twin Cities Campus, Minneapolis, MN 55455, USA
    Psychol Addict Behav 21:35-43. 2007
    ..There was evidence for an additive, rather than interactive, combined parental effect. Findings help clarify the impact of paternal and maternal SUD on the development of substance involvement during adolescence...
  47. ncbi Using the brain P300 response to identify novel phenotypes reflecting genetic vulnerability for adolescent substance misuse
    Henry H Yoon
    University of Minnesota, Twin Cities, 75 East River Road, Minneapolis, MN 55455, United States
    Addict Behav 31:1067-87. 2006
    ....
  48. ncbi Personality trait differences in boys and girls with clinical or sub-clinical diagnoses of conduct disorder versus antisocial personality disorder
    Jeanette Taylor
    Department of Psychology, Florida State University, Tallahassee, FL 32306 1270, USA
    J Adolesc 30:537-47. 2007
    ..The results suggest that individual differences in certain personality traits may contribute to differences in the type of antisocial behaviour disorder that emerges and thereby to the course of antisocial behaviour...
  49. ncbi Changes in genetic and environmental influences on disordered eating across adolescence: a longitudinal twin study
    Kelly L Klump
    Department of Psychology, Michigan State University, 107B Psychology Building, East Lansing, MI 48824 1116, USA
    Arch Gen Psychiatry 64:1409-15. 2007
    ..Previous research suggests substantial increases in genetic effects on disordered eating across adolescence. Unfortunately, these studies were cross-sectional and focused primarily on early (age 11 years) vs late (age 17 years) adolescence...
  50. ncbi Shared transmission of eating disorders and anxiety disorders
    Pamela K Keel
    Department of Psychology, University of Iowa, Iowa City, Iowa 55242, USA
    Int J Eat Disord 38:99-105. 2005
    ..Using twins from the population-based Minnesota Twin Family Study (MTFS), we examined comorbidity and shared transmission between eating pathology and these disorders...
  51. ncbi The different origins of stability and change in antisocial personality disorder symptoms
    S Alexandra Burt
    Department of Psychology, Michigan State University, East Lansing, MI 48824, USA
    Psychol Med 37:27-38. 2007
    ..To date, however, researchers have yet to resolve the origins of either stability or change in antisocial behavior from childhood/adolescence to adulthood...
  52. ncbi Personality and substance use disorders: II. Alcoholism versus drug use disorders
    M McGue
    Department of Psychology, University of Minnesota, Minneapolis 55455, USA
    J Consult Clin Psychol 67:394-404. 1999
    ..These findings suggest that the elevated levels of behavioral disinhibition observed with alcoholic individuals may be attributable to a subset of alcoholic individuals who also abuse drugs other than alcohol...
  53. ncbi A twin study of state and trait anxiety in childhood and adolescence
    L N Legrand
    Department of Psychology, University of Minnesota, Minneapolis 55455, USA
    J Child Psychol Psychiatry 40:953-8. 1999
    ..Heritability was estimated at 45%. Measures of state anxiety conformed more closely to Thapar and McGuffin's findings, with environmental factors accounting for the variance...
  54. ncbi Smooth pursuit and saccadic eye movement performance in a prefrontal leukotomy patient
    D C Gooding
    Department of Psychology, University of Wisconsin Madison 53706, USA
    J Psychiatry Neurosci 24:462-7. 1999
    ..Despite advanced age and a frontal leukotomy, this patient with schizophrenia displayed intact smooth pursuit, indicating that the frontal cortex is not necessary for normal smooth pursuit performance...
  55. ncbi Saccadic disinhibition in schizophrenia patients and their first-degree biological relatives. A parametric study of the effects of increasing inhibitory load
    C E Curtis
    Department of Psychology, University of Minnesota, N218 Elliott Hall, 75 East River Rd, Minneapolis, MN 55455-0344, USA
    Exp Brain Res 137:228-36. 2001
    ..Results also suggest that this genetic liability may be related to dysfunctional prefrontal cortical areas that provide top-down inhibitory control over reflexive saccade generation...
  56. ncbi Disordered eating and substance use in an epidemiological sample: II. Associations within families
    Kristin M von Ranson
    Dept of Psychology, University of Minnesota Twin Cities Campus, Minneapolis, MN, USA
    Psychol Addict Behav 17:193-201. 2003
    ..These results suggest that these problems are not cross-transmitted within families and suggest that the addiction model of eating disorders may be simplistic...
  57. ncbi Major depression and conduct disorder in youth: associations with parental psychopathology and parent-child conflict
    Naomi R Marmorstein
    Department of Psychology, Rutgers University, Camden, NJ, USA
    J Child Psychol Psychiatry 45:377-86. 2004
    ..This study examined conduct disorder (CD) and major depression (MDD) in adolescents in relationship to parent-child conflict and psychopathology in their parents...
  58. ncbi Major depression and conduct disorder in a twin sample: gender, functioning, and risk for future psychopathology
    Naomi R Marmorstein
    Rutgers University, Department of Psychology, Camden, NJ 08102, USA
    J Am Acad Child Adolesc Psychiatry 42:225-33. 2003
    ..This study described the functioning of adolescents with histories of these disorders and examined whether these patterns of association differed by gender...
  59. ncbi Drinks of the father: father's maximum number of drinks consumed predicts externalizing disorders, substance use, and substance use disorders in preadolescent and adolescent offspring
    Stephen M Malone
    University of Minnesota, Minneapolis 55455, USA
    Alcohol Clin Exp Res 26:1823-32. 2002
    ..This phenotype might supplement DSM diagnoses of alcohol dependence to reduce the number of false positives in genetic research...
  60. ncbi Risk for recurrence in depression
    Stephanie L Burcusa
    Department of Psychology, University of Minnesota, N218 Elliott Hall, 75 East River Road, Minneapolis, MN 55455, USA
    Clin Psychol Rev 27:959-85. 2007
    ....
  61. ncbi Sources of covariation among the child-externalizing disorders: informant effects and the shared environment
    S Alexandra Burt
    Department of Psychology, University of Minnesota, MN, USA
    Psychol Med 35:1133-44. 2005
    ....
  62. ncbi Beyond the DSM: defining endophenotypes for genetic studies of substance abuse
    Jon A Frederick
    Department of Psychology, University of Minnesota, 75 East River Road, Minneapolis, MN 55455, USA
    Curr Psychiatry Rep 8:144-50. 2006
    ....
  63. ncbi Rural environments reduce the genetic influence on adolescent substance use and rule-breaking behavior
    L N Legrand
    Department of Psychology, University of Minnesota, Twin Cities Campus, Minneapolis, MN 55455, USA
    Psychol Med 38:1341-50. 2008
    ..In this paper, we address whether rural environments moderate the genetic influence on adolescent substance use and rule-breaking behavior (i.e. externalizing psychopathology)...
  64. ncbi Parental smoking and adolescent problem behavior: an adoption study of general and specific effects
    Margaret Keyes
    Department of Psychology, University of Minnesota, 75 East River Rd, Minneapolis, MN 55455, USA
    Am J Psychiatry 165:1338-44. 2008
    ..The purpose of this study was to examine the genetic and environmental contributions to the risk represented by exposure to parental smoking and to assess the specificity of that risk...
  65. ncbi Genetic and environmental contributions to the diversity of substances used in adolescent twins: a longitudinal study of age and sex effects
    Jaime Derringer
    Department of Psychology, University of Minnesota, Minneapolis, MN, USA
    Addiction 103:1744-51. 2008
    ..To determine how genetic and environmental contributions affecting the number of psychoactive substances used varies with age and gender over the course of adolescence...
  66. ncbi Early onset problem behavior, young adult psychopathology, and contextual risk
    Margaret A Keyes
    Department of Psychology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Twin Res Hum Genet 10:45-53. 2007
    ..The results are discussed in the context of emerging research on the prognostic significance of early adolescent problem behavior for risk of adult psychopathology...
  67. ncbi Stability and change in religiousness during emerging adulthood
    Laura B Koenig
    Department of Psychology, University of Minnesota, USA
    Dev Psychol 44:532-43. 2008
    ..For the younger cohort, change was genetic in origin, while stability was environmental. In the older cohort, change was influenced by nonshared environment and stability by both genes and family environment...
  68. ncbi Shared-environmental contributions to high cognitive ability
    Robert M Kirkpatrick
    Department of Psychology, University of Minnesota, Minneapolis, MN, USA
    Behav Genet 39:406-16. 2009
    ..We discuss these results in terms of the need for cognitive-development research to combine genetically sensitive designs and modern statistical methods with broad, thorough environmental measurement...
  69. ncbi Prospective effects of attention-deficit/hyperactivity disorder, conduct disorder, and sex on adolescent substance use and abuse
    Irene J Elkins
    Department of Psychology, University of Minnesota, 75 E River Road, Minneapolis, MN 55455, USA
    Arch Gen Psychiatry 64:1145-52. 2007
    ..However, the ADHD-substance abuse relationship often disappears when co-occurring conduct disorder (CD) is considered...
  70. ncbi Stability, change, and heritability of borderline personality disorder traits from adolescence to adulthood: a longitudinal twin study
    Marina A Bornovalova
    Department of Psychology, University of Minnesota, 75 East River Road, Minneapolis, MN 55455, USA
    Dev Psychopathol 21:1335-53. 2009
    ....
  71. ncbi Environmental adversity and increasing genetic risk for externalizing disorders
    Brian M Hicks
    Department of Psychology, University of Minnesota, 75 E River Rd, Minneapolis, MN 55455, USA
    Arch Gen Psychiatry 66:640-8. 2009
    ..However, few attempts have been made to integrate findings and to articulate general mechanisms of gene-environment influence in the emergence of psychopathology...
  72. ncbi Gender differences and developmental change in externalizing disorders from late adolescence to early adulthood: A longitudinal twin study
    Brian M Hicks
    University of Minnesota, Department of Psychology, Minneapolis, MN 55455, USA
    J Abnorm Psychol 116:433-47. 2007
    ..Results illustrate the importance of gender and developmental context for symptom expression and the utility of structural models to integrate general trends and disorder-specific characteristics...
  73. ncbi Are there shared environmental influences on adolescent behavior? Evidence from a study of adoptive siblings
    Jacob P Buchanan
    Department of Psychology, University of Minnesota, 75 East River Rd, Minneapolis, MN, 55455, USA
    Behav Genet 39:532-40. 2009
    ..These findings support the use of adoptive sibling designs to directly estimate shared environmental effects and implicate the existence of systematic environmental influences on behavior that are potentially detectable...
  74. ncbi An adoption study of parental depression as an environmental liability for adolescent depression and childhood disruptive disorders
    ERIN C TULLY
    Department of Psychology, N218 Elliott Hall, University of Minnesota, 75 East River Rd, Minneapolis, MN 55455, USA
    Am J Psychiatry 165:1148-54. 2008
    ..The authors used an adoption study design to investigate environmental influences on risk for psychopathology in adolescents with depressed parents...
  75. ncbi Estimating facets of psychopathy from normal personality traits: a step toward community epidemiological investigations
    Stephen D Benning
    Department of Psychology, University of Minnesota, Minneapolis 55455, USA
    Assessment 12:3-18. 2005
    ..Additionally, PPI-I was selectively related to the interpersonal facet of Factor 1 of the Psychopathy Checklist-Revised (PCL-R), whereas PPI-II was related preferentially to Factor 2 of the PCL-R...
  76. ncbi Genetic and environmental influences on adolescents' perceptions of current family environment
    Ryan W Herndon
    Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA
    Behav Genet 35:373-80. 2005
    ..These findings support a genetic basis of perceptions of one's family environment and indicate that reports of control/structure may be more genetically influenced than previously believed based on retrospective reports...
  77. ncbi The effect of parental alcohol and drug disorders on adolescent personality
    Irene J Elkins
    Department of Psychiatry, University of Minnesota, Minneapolis, 55455, USA
    Am J Psychiatry 161:670-6. 2004
    ....
  78. ncbi Sensitivity and specificity of select biological indices in characterizing psychotic patients and their relatives
    Scott R Sponheim
    Veterans Affairs Medical Center, 116B One Veterans Drive, Minneapolis, MN 55417, USA
    Schizophr Res 63:27-38. 2003
    ..Although studies have detailed biological abnormalities in schizophrenia patients and their first-degree biological relatives, few studies have directly compared the utility of biological indices in these individuals...
  79. ncbi Etiologic connections among substance dependence, antisocial behavior, and personality: modeling the externalizing spectrum
    Robert F Krueger
    Department of Psychology, University of Minnesota, Minneapolis 55455 0344, USA
    J Abnorm Psychol 111:411-24. 2002
    ..These results reconcile evidence for general and specific causal factors within the externalizing spectrum and offer the externalizing factor as a novel target for future research...
  80. ncbi Perceptions of the parent-adolescent relationship: a longitudinal investigation
    Matt McGue
    Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Psychol 41:971-84. 2005
    ..Changes in the parent-child relationship are interpreted as reflecting genotype-environment correlation processes whereby adolescents increasingly influence their relationships with their parents...
  81. ncbi The association of early adolescent problem behavior and adult psychopathology: a multivariate behavioral genetic perspective
    Matt McGue
    Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA
    Behav Genet 36:591-602. 2006
    ..60) and accounted for primarily by genetic factors common to the two domains. Findings are discussed in the context of research on the prevention and developmental nature of substance use disorders and related psychopathology...
  82. ncbi The environments of adopted and non-adopted youth: evidence on range restriction from the Sibling Interaction and Behavior Study (SIBS)
    Matt McGue
    Department of Psychology, University of Minnesota, 75 East River Rd, Minneapolis, MN 55455, USA
    Behav Genet 37:449-62. 2007
    ..These data support the use of adoption studies to obtain direct estimates of the importance of shared environmental effects on psychological development...
  83. ncbi Event-related potentials and comorbidity in alcohol-dependent adult males
    S M Malone
    University of Minnesota, Minneapolis 55455, USA
    Psychophysiology 38:367-76. 2001
    ....
  84. ncbi The misclassification of blinks as saccades: implications for investigations of eye movement dysfunction in schizophrenia
    M E Calkins
    Department of Psychology, University of Minnesota, Minneapolis 55455-0344, USA
    Psychophysiology 38:761-7. 2001
    ....
  85. ncbi An investigation of female adolescent twins with both major depression and conduct disorder
    N R Marmorstein
    Department of Psychology, University of Minnesota, Minneapolis 55455, USA
    J Am Acad Child Adolesc Psychiatry 40:299-306. 2001
    ..The implications of these findings for research and treatment, including the high likelihood of substance and school adjustment problems in these youths, are discussed...
  86. ncbi A comparison of methods for the analysis of event-related potentials in deception detection
    J J Allen
    Department of Psychology, University of Arizona, Tucson 85721 0068, USA
    Psychophysiology 34:234-40. 1997
    ..One or the other method may be preferred depending upon incentive to deceive, the cost of incorrect decisions, and the availability of extra psychophysiological data...
  87. ncbi Genetic and environmental influences on anorexia nervosa syndromes in a population-based twin sample
    K L Klump
    Department of Psychology, Michigan State University, East Lansing, USA
    Psychol Med 31:737-40. 2001
    ..CONCLUSIONS: Findings support previous research indicating significant genetic and non-shared environmental influences on AN syndromes...
  88. ncbi Genetic amplification and the individualization of the parent-child relationship across adolescence
    S Ludeke
    University of Minnesota, Minneapolis, MN, USA
    Psychol Med 43:413-22. 2013
    ..Genetic factors have been shown to partially underlie some of these associations, but the changing role of genetic influence over time remains poorly understood...
  89. ncbi Use of antianxiety drugs as countermeasures in the detection of guilty knowledge
    W G Iacono
    Department of Psychology, University of Minnesota, Minneapolis 55455
    J Appl Psychol 77:60-4. 1992
    ..Innocent subjects who coincidentally obtained high scores on a recognition memory test covering details of the mock crime tended to obtain higher guilt scores on the GKT...
  90. ncbi Heritability of P300 amplitude development from adolescence to adulthood
    Scott R Carlson
    Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
    Psychophysiology 43:470-80. 2006
    ..Intercept may be a more useful aid in the search for genes associated with relevant psychopathology than single measures of P300. Over a broader age range growth indices may be useful "developmental" endophenotypes...
  91. ncbi Psychopathy, startle blink modulation, and electrodermal reactivity in twin men
    Stephen D Benning
    Department of Psychology, University of Minnesota Twin Cities, Minneapolis, Minnesota 55455, USA
    Psychophysiology 42:753-62. 2005
    ..Participants high in fearless dominance also exhibited deficient skin conductance magnitudes specifically to aversive pictures. Findings encourage further investigation of psychopathy and its etiology in community samples...
  92. ncbi Mendelian randomization: a novel test of the gateway hypothesis and models of gene-environment interplay
    Daniel E Irons
    Department of Psychology, University of Minnesota, 75 East River Road, Minneapolis, MN 55455, USA
    Dev Psychopathol 19:1181-95. 2007
    ....
  93. ncbi Etiological contributions to heavy drinking from late adolescence to young adulthood
    Serena M King
    Department of Psychology, University of Minnesota, Twin Cities, MN, USA
    J Abnorm Psychol 114:587-98. 2005
    ....
  94. ncbi Psychiatric disorder in the children of antisocial parents
    Ryan W Herndon
    Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA
    Psychol Med 35:1815-24. 2005
    ..Although parents with psychiatric disorders are likely to have children with psychiatric problems, the nature of disorder risk to offspring of antisocial parents has received limited attention...
  95. ncbi Development of substance dependence in two delinquency subgroups and nondelinquents from a male twin sample
    Jeanette Taylor
    Department of Psychology, Florida State University, Tallahassee 32306-1270, USA
    J Am Acad Child Adolesc Psychiatry 41:386-93. 2002
    ..Treatments for boys with early-onset delinquency should account for their increased risk for drug use problems in adolescence and the potential effects of those problems on the course of antisocial behavior...
  96. ncbi Disordered eating and substance use in an epidemiological sample: I. Associations within individuals
    Kristin M von Ranson
    Department of Psychology, University of Calgary, Calgary, Alberta, Canada
    Int J Eat Disord 31:389-403. 2002
    ..This study examined the strength of associations between disordered eating and eating disorders and substance use and substance use disorders (SU/SUDs) in an epidemiological sample...
  97. ncbi Genetic and environmental influences on antisocial behavior and alcohol dependence from adolescence to early adulthood
    Stephen M Malone
    Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Psychopathol 16:943-66. 2004
    ....
  98. ncbi Association between the low molecular weight cytosolic acid phosphatase gene ACP1*A and comorbid features of Tourette syndrome
    Nunzio Bottini
    The Burnham Institute, La Jolla, CA, USA
    Neurosci Lett 330:198-200. 2002
    ..0005), but this difference was restricted to cases with comorbid attention-deficit hyperactivity disorder (P<0.0001) and conduct disorder (P<0.0002), while having little relevance to TS itself...
  99. ncbi The Minnesota Eating Behavior Survey: a brief measure of disordered eating attitudes and behaviors
    Kristin M von Ranson
    Department of Psychology, University of Calgary, 2500 University Drive NW, Calgary, Alberta, Canada T2N 1N4
    Eat Behav 6:373-92. 2005
    ..This questionnaire has promise as a screening and assessment measure for eating disturbance in cross-sectional and longitudinal research involving individuals of a wide range of ages...
  100. ncbi Adolescent twins discordant for major depressive disorder: shared familial liability to externalizing and other internalizing disorders
    Stephanie L Burcusa
    University of Minnesota-Twin Cities, USA
    J Child Psychol Psychiatry 44:997-1005. 2003
    ..CONCLUSIONS: These results support a shared familial liability between MDD and other internalizing disorders and between MDD and externalizing disorders in adolescents...
  101. ncbi Symptom-based subfactors of DSM-defined conduct disorder: evidence for etiologic distinctions
    Jennifer L Tackett
    Department of Psychology, University of Minnesota, Twin Cities Campus, Minneapolis, MN 55455, USA
    J Abnorm Psychol 114:483-7. 2005
    ..The authors discuss implications of these findings for the assessment and treatment of CD...

Research Grants29

  1. TWIN STUDY OF ADHD, CD, AND SUBSTANCE ABUSE
    William Iacono; Fiscal Year: 2004
    ..Our intent is to continue to follow this cohort through early adulthood so that the applicability of these models for adult substance abuse can be assessed. ..
  2. TWIN FAMILY STUDY OF VULNERABILITY TO SUBSTANCE ABUSE
    William Iacono; Fiscal Year: 2007
    ..abstract_text> ..
  3. Twin Study of ADHD, CD and Substance Abuse
    William Iacono; Fiscal Year: 2007
    ....
  4. Substance Abuse & Behavioral Disinhibition: Integrating Genes & Environment
    William Iacono; Fiscal Year: 2007
    ..Also included will be hypothesis-generating exploratory analyses that take advantage of the richness of the phenotypic data available from our families and the rapid pace of development in molecular biology and statistical genetics. ..
  5. Twin Study of ADHD, CD and Substance Abuse
    William Iacono; Fiscal Year: 2009
    ..abstract_text> ..
  6. TWIN FAMILY STUDY OF VULNERABILITY TO SUBSTANCE ABUSE
    William Iacono; Fiscal Year: 2002
    ....
  7. TWIN/FAMILY STUDY OF VULNERABILITY TO SUBSTANCE ABUSE
    William Iacono; Fiscal Year: 1993
    ....
  8. Twin Study of ADHD, CD and Substance Abuse
    William G Iacono; Fiscal Year: 2010
    ..abstract_text> ..