O Hyrien

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Mathematical and experimental approaches to identify and predict the effects of chemotherapy on neuroglial precursors
    Ollivier Hyrien
    Department of Biostatistics and Computational Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Cancer Res 70:10051-9. 2010
  2. pmc An age-dependent branching process model for the analysis of CFSE-labeling experiments
    Ollivier Hyrien
    Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Biol Direct 5:41. 2010
  3. pmc Saddlepoint approximations to the moments of multitype age-dependent branching processes, with applications
    O Hyrien
    Department of Biostatistics and Computational Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Biometrics 66:567-77. 2010
  4. pmc Stochastic modeling of oligodendrocyte generation in cell culture: model validation with time-lapse data
    Ollivier Hyrien
    Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Theor Biol Med Model 3:21. 2006
  5. ncbi request reprint A stochastic model to analyze clonal data on multi-type cell populations
    Ollivier Hyrien
    Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York 14641, USA
    Biometrics 61:199-207. 2005
  6. ncbi request reprint Estimating the life-span of oligodendrocytes from clonal data on their development in cell culture
    Ollivier Hyrien
    Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Math Biosci 193:255-74. 2005
  7. ncbi request reprint A comprehensive stochastic model of irradiated cell populations in culture
    Leonid Hanin
    Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Box 630, NY 14642, USA
    J Theor Biol 239:401-16. 2006
  8. ncbi request reprint Electrocardiographic method for identifying drug-induced repolarization abnormalities associated with a reduction of the rapidly activating delayed rectifier potassium current
    J P Couderc
    Rochester Univ, NY 14642, USA
    Conf Proc IEEE Eng Med Biol Soc 1:4010-5. 2006
  9. pmc Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: dose-response and time-course profiles measured by flow cytometry
    Stephen D Dertinger
    Litron Laboratories, Rochester, NY 14623, USA
    Mutat Res 634:119-25. 2007
  10. ncbi request reprint Improving the detection of subtle I(Kr)-inhibition: assessing electrocardiographic abnormalities of repolarization induced by moxifloxacin
    Jean Philippe Couderc
    Heart Research Follow Up Program, Cardiology Department, University of Rochester Medical Center, Rochester, New York, USA
    Drug Saf 31:249-60. 2008

Collaborators

Detail Information

Publications20

  1. pmc Mathematical and experimental approaches to identify and predict the effects of chemotherapy on neuroglial precursors
    Ollivier Hyrien
    Department of Biostatistics and Computational Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Cancer Res 70:10051-9. 2010
    ..These changes of precursor cell function in the chemotherapy-exposed brain may have profound clinic implications...
  2. pmc An age-dependent branching process model for the analysis of CFSE-labeling experiments
    Ollivier Hyrien
    Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Biol Direct 5:41. 2010
    ..Several mathematical models have been presented in the literature to describe cell kinetics during these experiments...
  3. pmc Saddlepoint approximations to the moments of multitype age-dependent branching processes, with applications
    O Hyrien
    Department of Biostatistics and Computational Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Biometrics 66:567-77. 2010
    ..New estimators are also constructed to analyze clonal data. The proposed methods are finally used to approximate the distribution of the generation, which has recently found several applications in cell biology...
  4. pmc Stochastic modeling of oligodendrocyte generation in cell culture: model validation with time-lapse data
    Ollivier Hyrien
    Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Theor Biol Med Model 3:21. 2006
    ..The second is to generate time-lapse data that may help biomathematicians to build stochastic models of cell proliferation and differentiation under other experimental scenarios...
  5. ncbi request reprint A stochastic model to analyze clonal data on multi-type cell populations
    Ollivier Hyrien
    Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York 14641, USA
    Biometrics 61:199-207. 2005
    ..This biological finding suggests that a molecular event determining the type of cell transformation is more likely to occur at the start rather than at the end of the mitotic cycle...
  6. ncbi request reprint Estimating the life-span of oligodendrocytes from clonal data on their development in cell culture
    Ollivier Hyrien
    Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Math Biosci 193:255-74. 2005
    ..The proposed method is illustrated with an analysis of the clonal development of O-2A progenitor cells isolated from the rat optic nerve and the corpus callosum...
  7. ncbi request reprint A comprehensive stochastic model of irradiated cell populations in culture
    Leonid Hanin
    Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Box 630, NY 14642, USA
    J Theor Biol 239:401-16. 2006
    ..The effects of dose rate on cell cycle duration and damage repair kinetics are studied. Continuous and acute exposures with the same total dose are compared in terms of their impact on cell survival...
  8. ncbi request reprint Electrocardiographic method for identifying drug-induced repolarization abnormalities associated with a reduction of the rapidly activating delayed rectifier potassium current
    J P Couderc
    Rochester Univ, NY 14642, USA
    Conf Proc IEEE Eng Med Biol Soc 1:4010-5. 2006
    ..We described in this paper the method and preliminary results, revealing the superiority of our technique that may play a role in the future of drug-safety assessment...
  9. pmc Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: dose-response and time-course profiles measured by flow cytometry
    Stephen D Dertinger
    Litron Laboratories, Rochester, NY 14623, USA
    Mutat Res 634:119-25. 2007
    ....
  10. ncbi request reprint Improving the detection of subtle I(Kr)-inhibition: assessing electrocardiographic abnormalities of repolarization induced by moxifloxacin
    Jean Philippe Couderc
    Heart Research Follow Up Program, Cardiology Department, University of Rochester Medical Center, Rochester, New York, USA
    Drug Saf 31:249-60. 2008
    ....
  11. doi request reprint Validating high-throughput micronucleus analysis of peripheral reticulocytes for radiation biodosimetry: benchmark against dicentric and CBMN assays in a mouse model
    Yuhchyau Chen
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Health Phys 98:218-27. 2010
    ..In mice, the dose range of detection is useful up to 1 Gy (C57Bl/6) and 2 Gy (C3H) but not reliable beyond these dose limits. The utilization of this automated analysis for human radiation biodosimetry is currently under investigation...
  12. pmc Modulation of single-cell IgG secretion frequency and rates in human memory B cells by CpG DNA, CD40L, IL-21, and cell division
    Alicia D Henn
    Division of Nephrology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 183:3177-87. 2009
    ..Finally, these data support a mixture model of IgG secretion in which IgG secreted over time is modulated by the frequency of IgG-SC and the distribution of their IgG secretion rates...
  13. pmc Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: effect of age
    Stephen D Dertinger
    Litron Laboratories, Rochester, NY, USA
    Mutat Res 675:77-80. 2009
    ....
  14. pmc Molecular accessibility in relation to cell surface topography and compression against a flat substrate
    Sandrine A Hocdé
    Department of Biomedical Engineering, University of Rochester, Rochester, New York, USA
    Biophys J 97:369-78. 2009
    ..Model predictions show good agreement with measurements of fluorescence intensity of different molecules labeled fluorescently on the surface of a human neutrophil compressed against a glass surface...
  15. pmc Gamma-radiation induces micronucleated reticulocytes in 3D bone marrow bioreactors in vitro
    Hongliang Sun
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY, United States
    Mutat Res 680:49-55. 2009
    ..5-2.0 Gy. The MN-RET response showed a downtrend beyond 2 Gy. Our data suggest that bone marrow culture in the 3D bioreactor may be a useful organ culture system for the investigation of radiation genotoxic effect in vitro...
  16. pmc A composite likelihood approach to the analysis of longitudinal clonal data on multitype cellular systems under an age-dependent branching process
    Rui Chen
    Department of Biostatistics and Computational Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biostatistics 12:173-91. 2011
    ..Our work demonstrates also that the proposed approach outperforms the existing ones...
  17. pmc Human follicular lymphoma CD39+-infiltrating T cells contribute to adenosine-mediated T cell hyporesponsiveness
    Shannon P Hilchey
    James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 183:6157-66. 2009
    ..In addition, these studies suggest that the A(2A/B) AR as well as CD39 are novel pharmacological targets for augmenting cancer immunotherapy...
  18. pmc Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies
    Stephen D Dertinger
    Litron Laboratories, Rochester, New York 14623, USA
    Toxicol Sci 115:401-11. 2010
    ....
  19. doi request reprint Tumor response kinetics after schedule-dependent paclitaxel chemoradiation treatment for inoperable non-small cell lung cancer: a model for low-dose chemotherapy radiosensitization
    Hong Zhang
    Departments of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA
    J Thorac Oncol 3:563-8. 2008
    ..Given our unique results, we analyzed the tumor response kinetics and conducted a statistical modeling of tumor response to characterize this regimen...
  20. ncbi request reprint Application of pharmacokinetic/pharmacodynamic and stochastic modelling to 6-mercaptopurine micronucleus induction in mouse bone marrow erythrocytes
    Virginie Klés
    AFSSA, Laboratoire d Etudes et de Recherches sur les Médicaments Vétérinaires et les Désinfectants, BP 90203, 35302 Fougeres Cedex, France
    J Appl Toxicol 23:59-70. 2003
    ..Moreover, the use of the stochastic model would help to schedule more accurately the bone marrow or blood harvesting times in the in vivo rodent micronucleus test...

Research Grants6

  1. Statistical Inference on Chemotherapy Effects from Flow Cytometry Data
    Ollivier Hyrien; Fiscal Year: 2009
    ....
  2. STOCHASTIC MODELING OF MULTI TYPE CELL SYSTEMS
    Ollivier Hyrien; Fiscal Year: 2010
    ..This approach will provide a detailed understanding of cell development in the normal spinal cord, and in the pathological condition of iron deficiency. ..
  3. Statistical Inference on Chemotherapy Effects from Flow Cytometry Data
    Ollivier Hyrien; Fiscal Year: 2010
    ....