Research Topics
Species | E Shelley HwangSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
The impact of surgery on ductal carcinoma in situ outcomes: the use of mastectomyE Shelley Hwang
Department of Surgery and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94115, USA
J Natl Cancer Inst Monogr 2010:197-9. 2010....
Risk factors for estrogen receptor-positive breast cancerE Shelley Hwang
Department of Surgery, University of California, San Francisco, Cancer Center, 94115, USA
Arch Surg 140:58-62. 2005..Some risk factors associated with breast cancer may be more predictive of estrogen receptor (ER)- positive than ER-negative tumors...- Patterns of chromosomal alterations in breast ductal carcinoma in situE Shelley Hwang
Department of Surgery, University of California San Francisco, San Francisco, California 94115, USA
Clin Cancer Res 10:5160-7. 2004..Genomic changes specific to pure DCIS versus invasive cancer, as well as alterations unique to individual DCIS subtypes, have not been fully defined... - Clonality of lobular carcinoma in situ and synchronous invasive lobular carcinomaE Shelley Hwang
Department of Surgery, University of California San Francisco, San Francisco, California 94115, USA
Cancer 100:2562-72. 2004..The possible genomic relation between synchronous LCIS and ILC was analyzed using the technique of array-based comparative genomic hybridization (CGH)... - Association between breast density and subsequent breast cancer following treatment for ductal carcinoma in situE Shelley Hwang
Department of Surgery, University of California, San Francisco Cancer Center, 1600 Divisadero Avenue, B606 San Francisco, CA 94115, USA
Cancer Epidemiol Biomarkers Prev 16:2587-93. 2007..All subjects had an American College of Radiology Breast Imaging Reporting and Data System (BI-RADS) breast density measure recorded prior to diagnosis... - Neoadjuvant hormonal therapy for ductal carcinoma in situ: trial design and preliminary resultsE Shelley Hwang
Department of Surgery, University of California San Francisco, San Francisco, California, USA
Ann Surg Oncol 11:37S-43S. 2004..We have initiated a clinical trial of neoadjuvant hormonal therapy for women with hormone receptor-positive DCIS. We discuss the clinical rationale and study design for this trial and present our preliminary results... - Ductal carcinoma in situ in BRCA mutation carriersE Shelley Hwang
University of California, San Francisco Cancer Risk Program and the Carol Franc Buck Breast Care Center, San Francisco CA, USA
J Clin Oncol 25:642-7. 2007.... - Magnetic resonance imaging in patients diagnosed with ductal carcinoma-in-situ: value in the diagnosis of residual disease, occult invasion, and multicentricityE Shelley Hwang
Department of Surgery, University of California San Francisco, San Francisco, California 94115, USA
Ann Surg Oncol 10:381-8. 2003..We studied the performance of MRI in patients with known DCIS for assessment of residual disease, occult invasion, and multicentricity to determine the clinical role of MRI in this setting... - Genomic alterations and phenotype of large compared to small high-grade ductal carcinoma in situE Shelley Hwang
Department of Surgery, University of California San Francisco, San Francisco, CA 94143 1710, USA
Hum Pathol 42:1467-75. 2011..Interestingly, larger tumors showed some molecular features associated with better prognosis. A more thorough evaluation of these differences could help identify the likelihood of recurrence or progression for in situ lesions... - The effects of acellular dermal matrix in expander-implant breast reconstruction after total skin-sparing mastectomy: results of a prospective practice improvement studyAnne Warren Peled
Department of Surgery, Division of Plastic and Reconstructive Surgery, University of California, San Francisco, USA
Plast Reconstr Surg 129:901e-908e. 2012..Neither outcome after total skin-sparing mastectomy and expander-implant reconstruction using acellular dermal matrix nor a strategy for optimal acellular dermal matrix selection criteria has been well described... 
Pathologic and biologic response to preoperative endocrine therapy in patients with ER-positive ductal carcinoma in situYunn Yi Chen
Department of Surgery, University of California San Francisco, San Francisco, USA
BMC Cancer 9:285. 2009....
Identification of a robust gene signature that predicts breast cancer outcome in independent data setsJames E Korkola
Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA
BMC Cancer 7:61. 2007..Breast cancer is a heterogeneous disease, presenting with a wide range of histologic, clinical, and genetic features. Microarray technology has shown promise in predicting outcome in these patients...- MRI measurements of breast tumor volume predict response to neoadjuvant chemotherapy and recurrence-free survivalSavannah C Partridge
Department of Radiology, University of California, San Francisco, San Francisco, CA 94143, USA
AJR Am J Roentgenol 184:1774-81. 2005.... - Internal mammary sentinel lymph node mapping for invasive breast cancer: implications for staging and treatmentCatherine Park
Department of Radiation Oncology, University of California, Mount Zion Medical Center, the UCSF Comprehensive Cancer Center, San Francisco, California, USA
Breast J 11:29-33. 2005..These factors may aid in the selection of patients who might benefit from further staging or treatment of the IMNs... - Increasing the time to expander-implant exchange after postmastectomy radiation therapy reduces expander-implant failureAnne Warren Peled
Division of Plastic Surgery, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
Plast Reconstr Surg 130:503-9. 2012..The sequence and timing of tissue expansion and implant exchange with regard to postmastectomy radiation therapy may impact complication rates... - The impact of preoperative magnetic resonance imaging on surgical treatment and outcomes for ductal carcinoma in situKaoru Itakura
Department of Surgery, University of California, San Francisco, USA
Clin Breast Cancer 11:33-8. 2011..We sought to determine whether preoperative MRI affects surgical treatment and outcomes in women with pure DCIS... - The effect of system-level access factors on receipt of reconstruction among Latina and white women with DCISCelia Patricia Kaplan
Division of General Internal Medicine, Department of Medicine, University of California, P O Box 0856, San Francisco, CA 94143 0856, USA
Breast Cancer Res Treat 129:909-17. 2011..Although ethnic/language differences in treatment selection were observed, multivariable analysis suggests that these differences could be explained by differential employment levels and geographic availability of plastic surgeons... - Role of postmastectomy radiation after neoadjuvant chemotherapy in stage II-III breast cancerBarbara L Fowble
Department of Radiation Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143 1708, USA
Int J Radiat Oncol Biol Phys 83:494-503. 2012..To identify a cohort of women treated with neoadjuvant chemotherapy and mastectomy for whom postmastectomy radiation therapy (PMRT) may be omitted according to the projected risk of local-regional failure (LRF)... - Protein acetylation and histone deacetylase expression associated with malignant breast cancer progressionJunko Suzuki
Department of Laboratory Medicine, University of California, San Francisco, CA, USA
Clin Cancer Res 15:3163-71. 2009..However, HDAC expression and protein acetylation have not been studied in the context of breast cancer progression... - Impact of chemotherapy on postoperative complications after mastectomy and immediate breast reconstructionAnne Warren Peled
Division of Breast Surgery, Department of Surgery, University of California San Francisco, 1600 Divisadero Street, San Francisco, CA 94115, USA
Arch Surg 145:880-5. 2010..To determine the impact of chemotherapy and the timing of chemotherapy on postoperative outcomes after mastectomy and immediate breast reconstruction... - Clinical application of array-based comparative genomic hybridization to define the relationship between multiple synchronous tumorsChrystal V Wa
Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA
Mod Pathol 18:591-7. 2005..We conclude that genetic analysis by array-based CGH can clearly elucidate the relationships between multiple tumors and may potentially serve as an important clinical tool... - Long-term reconstructive outcomes after expander-implant breast reconstruction with serious infectious or wound-healing complicationsAnne Warren Peled
Division of Plastic and Reconstructive Surgery, Department of Surgery, University of California, San Francisco, CA, USA
Ann Plast Surg 68:369-73. 2012..In extreme cases, these issues can lead to expander-implant loss. Little is known about the long-term reconstructive outcomes for patients who develop major complications threatening their expander-implant reconstructions... - Accuracy of selective sentinel lymphadenectomy after neoadjuvant chemotherapy: effect of clinical node status at presentationJulie E Lang
Department of Surgery, University of California San Francisco, San Francisco, CA 94114, USA
J Am Coll Surg 199:856-62. 2004.... - Total skin-sparing mastectomy: complications and local recurrence rates in 2 cohorts of patientsElisabeth R Garwood
Department of Surgery, Carol Franc Buck Breast Care Center, University of California at San Francisco, San Francisco, CA 94115, USA
Ann Surg 249:26-32. 2009..We sought to define the impact of surgical and reconstructive variables on complication rates and assess how changes in technique affect outcomes... - Is radiation indicated in patients with ductal carcinoma in situ and close or positive mastectomy margins?Linda W Chan
Department of Radiation Oncology, University of California, San Francisco, California 94143 1708, USA
Int J Radiat Oncol Biol Phys 80:25-30. 2011..The purpose of this study was to determine chest wall recurrence rates in women with DCIS and close (<5 mm) or positive mastectomy margins in order to evaluate the potential role of radiation therapy... - Type and duration of exogenous hormone use affects breast cancer histologyAnjali S Kumar
Department of Surgery, Kaiser Permanente Oakland Medical Center, Oakland, California, 94602, USA
Ann Surg Oncol 14:695-703. 2007..We conducted this investigation to assess whether the type of hormone used (none, estrogen, progesterone, or combined) and duration of use influences subsequent breast cancer histology... - Outcomes after total skin-sparing mastectomy and immediate reconstruction in 657 breastsAnne Warren Peled
Division of Plastic and Reconstructive Surgery, Department of Surgery, University of California, San Francisco, CA, USA
Ann Surg Oncol 19:3402-9. 2012..However, standard use of the procedure remains controversial as a result oft concerns regarding oncologic safety and risk of complications... - Evaluating the feasibility of extended partial mastectomy and immediate reduction mammoplasty reconstruction as an alternative to mastectomyEdward I Chang
Division of Plastic and Reconstructive Surgery, Department of Surgery, University of California, San Francisco, CA, USA
Ann Surg 255:1151-7. 2012..To assess the efficacy of using concurrent partial mastectomy and reduction mammoplasty for resection of a wide range of tumor sizes and compare oncologic outcomes and postoperative complications on the basis of tumor size... - Outcome of long term active surveillance for estrogen receptor-positive ductal carcinoma in situAnna F Meyerson
University of California, San Francisco, Department of Radiology, 1600 Divisadero Street, Ste C 250, San Francisco, CA 94115, USA
Breast 20:529-33. 2011..The purpose of this study was to assess outcomes in a cohort of 14 well-informed women who elected non-surgical active surveillance with endocrine treatment alone for estrogen receptor-positive DCIS... - Fluvastatin reduces proliferation and increases apoptosis in women with high grade breast cancerElisabeth R Garwood
Department of Surgery, University of California, San Francisco, CA, USA
Breast Cancer Res Treat 119:137-44. 2010..Effects were only evident in high grade tumors. These results support further evaluation of statins as chemoprevention for ER-negative high grade breast cancers... - Differentiation of lobular versus ductal breast carcinomas by expression microarray analysisJames E Korkola
Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143-0808, USA
Cancer Res 63:7167-75. 2003..In conclusion, specific changes in gene expression distinguish lobular from ductal breast carcinomas. These genes may be important in understanding the basis of phenotypic differences among breast cancers... - Leukocyte composition of human breast cancerBrian Ruffell
Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 109:2796-801. 2012.... - Array-based comparative genomic hybridization of ductal carcinoma in situ and synchronous invasive lobular cancerSarah J Nyante
Department of Surgery, University of California San Francisco, 94115, USA
Hum Pathol 35:759-63. 2004..The following case illustrates how array CGH may be used to better understand whether synchronous neoplasms share a common origin... - Applying the neoadjuvant paradigm to ductal carcinoma in situLaura Esserman
Department of Surgery, University of California San Francisco Medical Center, San Francisco, California 94115, USA
Ann Surg Oncol 11:28S-36S. 2004.... - Safety of immediate transverse rectus abdominis myocutaneous breast reconstruction for patients with locally advanced diseaseRobert D Foster
Division of Plastic and Reconstructive Surgery, Department of Surgery, University of California, San Francisco, CA 94143 0932, USA
Arch Surg 140:196-8; discussion 199-200. 2005..Immediate transverse rectus abdominis myocutaneous breast reconstruction combined with postoperative radiation therapy after mastectomy is safe and effective... - Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapyDavid G DeNardo
Department of Pathology, University of California, San Francisco, USA
Cancer Discov 1:54-67. 2011.... - Magnetic resonance imaging captures the biology of ductal carcinoma in situLaura J Esserman
Department of Surgery, University of California, San Francisco, USA
J Clin Oncol 24:4603-10. 2006..We investigated whether MRI features of DCIS reflect differences in biology and pathology... - Bacteriologic features of surgical site infections following breast surgeryRita A Mukhtar
Department of Surgery, Division of Infectious Diseases, University of California, San Francisco, San Francisco, CA, USA
Am J Surg 198:529-31. 2009..Breast SSIs were investigated to determine bacterial isolates, resistance patterns, and the appropriateness of cefazolin, the authors' institution's current regimen for perioperative antibiotic prophylaxis... - Selection of treatment among Latina and non-Latina white women with ductal carcinoma in situCelia P Kaplan
Division of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, California 94143 0856, USA
J Womens Health (Larchmt) 20:215-23. 2011.... - The impact of lobular histology on breast cancer treatmentE Shelley Hwang
University of California San Francisco, USA
Oncology (Williston Park) 25:362, 364-5. 2011..Until then, the mainstay of sound treatment decision-making remains a thorough clinical understanding of the disease and of the factors that can have an impact on outcome... - Failure to harvest sentinel lymph nodes identified by preoperative lymphoscintigraphy in breast cancer patientsChen-Teng Wu
Department of Surgery, University of California, San Francisco (UCSF) Medical Center at Mount Zion, 94143-1674, USA
Breast J 9:86-90. 2003..The possibility of failure to get the SLN should be explained to patients before surgery. Axillary lymph node dissection (ALND) should be done if selective SLN dissection is not successful... - Development of a novel method for measuring in vivo breast epithelial cell proliferation in humansLisa M Misell
KineMed, Inc, 5980 Horton St, Suite 470, Emeryville, CA 94608, USA
Breast Cancer Res Treat 89:257-64. 2005..In summary, this novel method of measuring BEC proliferation in vivo holds promise for assessing the effects of anti-proliferative chemopreventive and chemotherapeutic agents...
Research Grants
- Primary Hormonal Therapy for DCIS of the BreastEUN SIL HWANG; Fiscal Year: 2007..If patients could safely be spared from cancer progression while avoiding the morbidity of surgery and radiation for DCIS, the full benefit of early breast cancer detection could be realized. ..