E Shelley Hwang

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi The impact of surgery on ductal carcinoma in situ outcomes: the use of mastectomy
    E Shelley Hwang
    Department of Surgery and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94115, USA
    J Natl Cancer Inst Monogr 2010:197-9. 2010
  2. ncbi Clonality of lobular carcinoma in situ and synchronous invasive lobular carcinoma
    E Shelley Hwang
    Department of Surgery, University of California San Francisco, San Francisco, California 94115, USA
    Cancer 100:2562-72. 2004
  3. ncbi Association between breast density and subsequent breast cancer following treatment for ductal carcinoma in situ
    E Shelley Hwang
    Department of Surgery, University of California, San Francisco Cancer Center, 1600 Divisadero Avenue, B606 San Francisco, CA 94115, USA
    Cancer Epidemiol Biomarkers Prev 16:2587-93. 2007
  4. ncbi Ductal carcinoma in situ in BRCA mutation carriers
    E Shelley Hwang
    University of California, San Francisco Cancer Risk Program and the Carol Franc Buck Breast Care Center, San Francisco CA, USA
    J Clin Oncol 25:642-7. 2007
  5. doi Genomic alterations and phenotype of large compared to small high-grade ductal carcinoma in situ
    E Shelley Hwang
    Department of Surgery, University of California San Francisco, San Francisco, CA 94143 1710, USA
    Hum Pathol 42:1467-75. 2011
  6. ncbi Risk factors for estrogen receptor-positive breast cancer
    E Shelley Hwang
    Department of Surgery, University of California, San Francisco, Cancer Center, 94115, USA
    Arch Surg 140:58-62. 2005
  7. ncbi Patterns of chromosomal alterations in breast ductal carcinoma in situ
    E Shelley Hwang
    Department of Surgery, University of California San Francisco, San Francisco, California 94115, USA
    Clin Cancer Res 10:5160-7. 2004
  8. ncbi Magnetic resonance imaging in patients diagnosed with ductal carcinoma-in-situ: value in the diagnosis of residual disease, occult invasion, and multicentricity
    E Shelley Hwang
    Department of Surgery, University of California San Francisco, San Francisco, California 94115, USA
    Ann Surg Oncol 10:381-8. 2003
  9. ncbi Neoadjuvant hormonal therapy for ductal carcinoma in situ: trial design and preliminary results
    E Shelley Hwang
    Department of Surgery, University of California San Francisco, San Francisco, California, USA
    Ann Surg Oncol 11:37S-43S. 2004
  10. doi Outcomes after total skin-sparing mastectomy and immediate reconstruction in 657 breasts
    Anne Warren Peled
    Division of Plastic and Reconstructive Surgery, Department of Surgery, University of California, San Francisco, CA, USA
    Ann Surg Oncol 19:3402-9. 2012

Research Grants

  1. Primary Hormonal Therapy for DCIS of the Breast
    EUN SIL HWANG; Fiscal Year: 2007

Detail Information

Publications52

  1. doi The impact of surgery on ductal carcinoma in situ outcomes: the use of mastectomy
    E Shelley Hwang
    Department of Surgery and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94115, USA
    J Natl Cancer Inst Monogr 2010:197-9. 2010
    ....
  2. ncbi Clonality of lobular carcinoma in situ and synchronous invasive lobular carcinoma
    E Shelley Hwang
    Department of Surgery, University of California San Francisco, San Francisco, California 94115, USA
    Cancer 100:2562-72. 2004
    ..The possible genomic relation between synchronous LCIS and ILC was analyzed using the technique of array-based comparative genomic hybridization (CGH)...
  3. ncbi Association between breast density and subsequent breast cancer following treatment for ductal carcinoma in situ
    E Shelley Hwang
    Department of Surgery, University of California, San Francisco Cancer Center, 1600 Divisadero Avenue, B606 San Francisco, CA 94115, USA
    Cancer Epidemiol Biomarkers Prev 16:2587-93. 2007
    ..All subjects had an American College of Radiology Breast Imaging Reporting and Data System (BI-RADS) breast density measure recorded prior to diagnosis...
  4. ncbi Ductal carcinoma in situ in BRCA mutation carriers
    E Shelley Hwang
    University of California, San Francisco Cancer Risk Program and the Carol Franc Buck Breast Care Center, San Francisco CA, USA
    J Clin Oncol 25:642-7. 2007
    ....
  5. doi Genomic alterations and phenotype of large compared to small high-grade ductal carcinoma in situ
    E Shelley Hwang
    Department of Surgery, University of California San Francisco, San Francisco, CA 94143 1710, USA
    Hum Pathol 42:1467-75. 2011
    ..Interestingly, larger tumors showed some molecular features associated with better prognosis. A more thorough evaluation of these differences could help identify the likelihood of recurrence or progression for in situ lesions...
  6. ncbi Risk factors for estrogen receptor-positive breast cancer
    E Shelley Hwang
    Department of Surgery, University of California, San Francisco, Cancer Center, 94115, USA
    Arch Surg 140:58-62. 2005
    ..Some risk factors associated with breast cancer may be more predictive of estrogen receptor (ER)- positive than ER-negative tumors...
  7. ncbi Patterns of chromosomal alterations in breast ductal carcinoma in situ
    E Shelley Hwang
    Department of Surgery, University of California San Francisco, San Francisco, California 94115, USA
    Clin Cancer Res 10:5160-7. 2004
    ..Genomic changes specific to pure DCIS versus invasive cancer, as well as alterations unique to individual DCIS subtypes, have not been fully defined...
  8. ncbi Magnetic resonance imaging in patients diagnosed with ductal carcinoma-in-situ: value in the diagnosis of residual disease, occult invasion, and multicentricity
    E Shelley Hwang
    Department of Surgery, University of California San Francisco, San Francisco, California 94115, USA
    Ann Surg Oncol 10:381-8. 2003
    ..We studied the performance of MRI in patients with known DCIS for assessment of residual disease, occult invasion, and multicentricity to determine the clinical role of MRI in this setting...
  9. ncbi Neoadjuvant hormonal therapy for ductal carcinoma in situ: trial design and preliminary results
    E Shelley Hwang
    Department of Surgery, University of California San Francisco, San Francisco, California, USA
    Ann Surg Oncol 11:37S-43S. 2004
    ..We have initiated a clinical trial of neoadjuvant hormonal therapy for women with hormone receptor-positive DCIS. We discuss the clinical rationale and study design for this trial and present our preliminary results...
  10. doi Outcomes after total skin-sparing mastectomy and immediate reconstruction in 657 breasts
    Anne Warren Peled
    Division of Plastic and Reconstructive Surgery, Department of Surgery, University of California, San Francisco, CA, USA
    Ann Surg Oncol 19:3402-9. 2012
    ..However, standard use of the procedure remains controversial as a result oft concerns regarding oncologic safety and risk of complications...
  11. doi The effects of acellular dermal matrix in expander-implant breast reconstruction after total skin-sparing mastectomy: results of a prospective practice improvement study
    Anne Warren Peled
    Department of Surgery, Division of Plastic and Reconstructive Surgery, University of California, San Francisco, USA
    Plast Reconstr Surg 129:901e-908e. 2012
    ..Neither outcome after total skin-sparing mastectomy and expander-implant reconstruction using acellular dermal matrix nor a strategy for optimal acellular dermal matrix selection criteria has been well described...
  12. pmc Pathologic and biologic response to preoperative endocrine therapy in patients with ER-positive ductal carcinoma in situ
    Yunn Yi Chen
    Department of Surgery, University of California San Francisco, San Francisco, USA
    BMC Cancer 9:285. 2009
    ....
  13. pmc Identification of a robust gene signature that predicts breast cancer outcome in independent data sets
    James E Korkola
    Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA
    BMC Cancer 7:61. 2007
    ..Breast cancer is a heterogeneous disease, presenting with a wide range of histologic, clinical, and genetic features. Microarray technology has shown promise in predicting outcome in these patients...
  14. doi FOXP3-positive regulatory T lymphocytes and epithelial FOXP3 expression in synchronous normal, ductal carcinoma in situ, and invasive cancer of the breast
    Aseem Lal
    Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Breast Cancer Res Treat 139:381-90. 2013
    ..013 for normal, p = 0.001 for IDC). These findings implicate both Treg infiltration and up-regulated epithelial FOXP3 expression in breast cancer progression...
  15. ncbi Internal mammary sentinel lymph node mapping for invasive breast cancer: implications for staging and treatment
    Catherine Park
    Department of Radiation Oncology, University of California, Mount Zion Medical Center, the UCSF Comprehensive Cancer Center, San Francisco, California, USA
    Breast J 11:29-33. 2005
    ..These factors may aid in the selection of patients who might benefit from further staging or treatment of the IMNs...
  16. ncbi MRI measurements of breast tumor volume predict response to neoadjuvant chemotherapy and recurrence-free survival
    Savannah C Partridge
    Department of Radiology, University of California, San Francisco, San Francisco, CA 94143, USA
    AJR Am J Roentgenol 184:1774-81. 2005
    ....
  17. ncbi Increasing the time to expander-implant exchange after postmastectomy radiation therapy reduces expander-implant failure
    Anne Warren Peled
    Division of Plastic Surgery, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Plast Reconstr Surg 130:503-9. 2012
    ..The sequence and timing of tissue expansion and implant exchange with regard to postmastectomy radiation therapy may impact complication rates...
  18. ncbi The impact of preoperative magnetic resonance imaging on surgical treatment and outcomes for ductal carcinoma in situ
    Kaoru Itakura
    Department of Surgery, University of California, San Francisco, USA
    Clin Breast Cancer 11:33-8. 2011
    ..We sought to determine whether preoperative MRI affects surgical treatment and outcomes in women with pure DCIS...
  19. pmc The effect of system-level access factors on receipt of reconstruction among Latina and white women with DCIS
    Celia Patricia Kaplan
    Division of General Internal Medicine, Department of Medicine, University of California, P O Box 0856, San Francisco, CA 94143 0856, USA
    Breast Cancer Res Treat 129:909-17. 2011
    ..Although ethnic/language differences in treatment selection were observed, multivariable analysis suggests that these differences could be explained by differential employment levels and geographic availability of plastic surgeons...
  20. doi Role of postmastectomy radiation after neoadjuvant chemotherapy in stage II-III breast cancer
    Barbara L Fowble
    Department of Radiation Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143 1708, USA
    Int J Radiat Oncol Biol Phys 83:494-503. 2012
    ..To identify a cohort of women treated with neoadjuvant chemotherapy and mastectomy for whom postmastectomy radiation therapy (PMRT) may be omitted according to the projected risk of local-regional failure (LRF)...
  21. doi Impact of chemotherapy on postoperative complications after mastectomy and immediate breast reconstruction
    Anne Warren Peled
    Division of Breast Surgery, Department of Surgery, University of California San Francisco, 1600 Divisadero Street, San Francisco, CA 94115, USA
    Arch Surg 145:880-5. 2010
    ..To determine the impact of chemotherapy and the timing of chemotherapy on postoperative outcomes after mastectomy and immediate breast reconstruction...
  22. pmc Protein acetylation and histone deacetylase expression associated with malignant breast cancer progression
    Junko Suzuki
    Department of Laboratory Medicine, University of California, San Francisco, CA, USA
    Clin Cancer Res 15:3163-71. 2009
    ..However, HDAC expression and protein acetylation have not been studied in the context of breast cancer progression...
  23. ncbi Clinical application of array-based comparative genomic hybridization to define the relationship between multiple synchronous tumors
    Chrystal V Wa
    Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA
    Mod Pathol 18:591-7. 2005
    ..We conclude that genetic analysis by array-based CGH can clearly elucidate the relationships between multiple tumors and may potentially serve as an important clinical tool...
  24. pmc Ductal carcinoma in situ (DCIS): posttreatment follow-up care among Latina and non-Latina White women
    Monica E Lopez
    Division of General Internal Medicine, Department of Medicine, University of California San Francisco, 1545 Divisadero Street, San Francisco, CA 94143 0320, USA
    J Cancer Surviv 7:219-26. 2013
    ..There is a lack of information about posttreatment care among patients with ductal carcinoma in situ (DCIS). This study compares posttreatment care by ethnicity-language and physician specialty among Latina and White women with DCIS...
  25. ncbi Differentiation of lobular versus ductal breast carcinomas by expression microarray analysis
    James E Korkola
    Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143 0808, USA
    Cancer Res 63:7167-75. 2003
    ..In conclusion, specific changes in gene expression distinguish lobular from ductal breast carcinomas. These genes may be important in understanding the basis of phenotypic differences among breast cancers...
  26. doi Long-term reconstructive outcomes after expander-implant breast reconstruction with serious infectious or wound-healing complications
    Anne Warren Peled
    Division of Plastic and Reconstructive Surgery, Department of Surgery, University of California, San Francisco, CA, USA
    Ann Plast Surg 68:369-73. 2012
    ..In extreme cases, these issues can lead to expander-implant loss. Little is known about the long-term reconstructive outcomes for patients who develop major complications threatening their expander-implant reconstructions...
  27. ncbi Accuracy of selective sentinel lymphadenectomy after neoadjuvant chemotherapy: effect of clinical node status at presentation
    Julie E Lang
    Department of Surgery, University of California San Francisco, San Francisco, CA 94114, USA
    J Am Coll Surg 199:856-62. 2004
    ..It is important to determine whether SSL can be used after neoadjuvant chemotherapy and whether clinical node status at presentation affects accuracy of SSL...
  28. doi Is radiation indicated in patients with ductal carcinoma in situ and close or positive mastectomy margins?
    Linda W Chan
    Department of Radiation Oncology, University of California, San Francisco, California 94143 1708, USA
    Int J Radiat Oncol Biol Phys 80:25-30. 2011
    ..The purpose of this study was to determine chest wall recurrence rates in women with DCIS and close (<5 mm) or positive mastectomy margins in order to evaluate the potential role of radiation therapy...
  29. ncbi Type and duration of exogenous hormone use affects breast cancer histology
    Anjali S Kumar
    Department of Surgery, Kaiser Permanente Oakland Medical Center, Oakland, California, 94602, USA
    Ann Surg Oncol 14:695-703. 2007
    ..We conducted this investigation to assess whether the type of hormone used (none, estrogen, progesterone, or combined) and duration of use influences subsequent breast cancer histology...
  30. doi Total skin-sparing mastectomy: complications and local recurrence rates in 2 cohorts of patients
    Elisabeth R Garwood
    Department of Surgery, Carol Franc Buck Breast Care Center, University of California at San Francisco, San Francisco, CA 94115, USA
    Ann Surg 249:26-32. 2009
    ..We sought to define the impact of surgical and reconstructive variables on complication rates and assess how changes in technique affect outcomes...
  31. doi Evaluating the feasibility of extended partial mastectomy and immediate reduction mammoplasty reconstruction as an alternative to mastectomy
    Edward I Chang
    Division of Plastic and Reconstructive Surgery, Department of Surgery, University of California, San Francisco, CA, USA
    Ann Surg 255:1151-7. 2012
    ..To assess the efficacy of using concurrent partial mastectomy and reduction mammoplasty for resection of a wide range of tumor sizes and compare oncologic outcomes and postoperative complications on the basis of tumor size...
  32. pmc Outcome of long term active surveillance for estrogen receptor-positive ductal carcinoma in situ
    Anna F Meyerson
    University of California, San Francisco, Department of Radiology, 1600 Divisadero Street, Ste C 250, San Francisco, CA 94115, USA
    Breast 20:529-33. 2011
    ..The purpose of this study was to assess outcomes in a cohort of 14 well-informed women who elected non-surgical active surveillance with endocrine treatment alone for estrogen receptor-positive DCIS...
  33. pmc Fluvastatin reduces proliferation and increases apoptosis in women with high grade breast cancer
    Elisabeth R Garwood
    Department of Surgery, University of California, San Francisco, CA, USA
    Breast Cancer Res Treat 119:137-44. 2010
    ..Effects were only evident in high grade tumors. These results support further evaluation of statins as chemoprevention for ER-negative high grade breast cancers...
  34. ncbi Ductal carcinoma in situ: knowledge of associated risks and prognosis among Latina and non-Latina white women
    Aparna R Parikh
    Division of Hematology and Oncology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Breast Cancer Res Treat 141:261-8. 2013
    ..In addition to the use of professional interpreters, efforts to create culturally and linguistically standardized information could improve knowledge and engagement in informed decision making for all DCIS patients...
  35. pmc Features of occult invasion in biopsy-proven DCIS at breast MRI
    Dorota Jakubowski Wisner
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California
    Breast J 19:650-8. 2013
    ..These results provide evidence that certain BI-RADS MRI criteria, as well as radiologist perception, correlate with occult invasion after an initial core biopsy of DCIS...
  36. pmc Leukocyte composition of human breast cancer
    Brian Ruffell
    Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 109:2796-801. 2012
    ....
  37. ncbi Applying the neoadjuvant paradigm to ductal carcinoma in situ
    Laura Esserman
    Department of Surgery, University of California San Francisco Medical Center, San Francisco, California 94115, USA
    Ann Surg Oncol 11:28S-36S. 2004
    ....
  38. ncbi Array-based comparative genomic hybridization of ductal carcinoma in situ and synchronous invasive lobular cancer
    Sarah J Nyante
    Department of Surgery, University of California San Francisco, 94115, USA
    Hum Pathol 35:759-63. 2004
    ..The following case illustrates how array CGH may be used to better understand whether synchronous neoplasms share a common origin...
  39. pmc Satisfaction with treatment decision-making and treatment regret among Latinas and non-Latina whites with DCIS
    Monica E Lopez
    Department of Medicine, University of California San Francisco, San Francisco, USA Medical Effectiveness Research Center for Diverse Populations, University of California San Francisco, San Francisco, USA Center for Aging in Diverse Communities, University of California San Francisco, San Francisco, USA
    Patient Educ Couns 94:83-9. 2014
    ..To examine differences in treatment decision-making participation, satisfaction, and regret among Latinas and non-Latina whites with DCIS...
  40. ncbi Safety of immediate transverse rectus abdominis myocutaneous breast reconstruction for patients with locally advanced disease
    Robert D Foster
    Division of Plastic and Reconstructive Surgery, Department of Surgery, University of California, San Francisco, CA 94143 0932, USA
    Arch Surg 140:196-8; discussion 199-200. 2005
    ..Immediate transverse rectus abdominis myocutaneous breast reconstruction combined with postoperative radiation therapy after mastectomy is safe and effective...
  41. doi Total skin-sparing mastectomy in BRCA mutation carriers
    Anne Warren Peled
    Division of Plastic and Reconstructive Surgery, Department of Surgery, University of California, San Francisco, San Francisco, CA, USA
    Ann Surg Oncol 21:37-41. 2014
    ..Oncologic outcomes after TSSM in BRCA mutation carriers have not been well-studied...
  42. pmc Survival after lumpectomy and mastectomy for early stage invasive breast cancer: the effect of age and hormone receptor status
    E Shelley Hwang
    Department of Surgery, Duke University Comprehensive Cancer Center, Durham, NC 27710, USA
    Cancer 119:1402-11. 2013
    ....
  43. pmc Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy
    David G DeNardo
    Department of Pathology, University of California, San Francisco, USA
    Cancer Discov 1:54-67. 2011
    ....
  44. ncbi Patient-reported outcomes and satisfaction after total skin-sparing mastectomy and immediate expander-implant reconstruction
    Anne Warren Peled
    From the Divisions of Plastic and Reconstructive Surgery, and Breast Surgery, Department of Surgery, University of California, San Francisco, San Francisco, CA and Division of Breast Surgery, Department of Surgery, Duke University Medical Center, Durham, NC
    Ann Plast Surg 72:S48-52. 2014
    ..Few studies looking at outcomes after TSSM and immediate reconstruction have focused on patient-reported outcomes and trends in satisfaction over time...
  45. pmc Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression
    Janna K Mouw
    Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco UCSF, San Francisco, California, USA
    Nat Med 20:360-7. 2014
    ..Our findings identify a mechanically regulated microRNA circuit that can promote malignancy and suggest potential prognostic roles for HOXA9 and miR-18a levels in stratifying patients with luminal breast cancers. ..
  46. pmc Magnetic resonance imaging captures the biology of ductal carcinoma in situ
    Laura J Esserman
    Department of Surgery, University of California, San Francisco, USA
    J Clin Oncol 24:4603-10. 2006
    ..We investigated whether MRI features of DCIS reflect differences in biology and pathology...
  47. doi Bacteriologic features of surgical site infections following breast surgery
    Rita A Mukhtar
    Department of Surgery, Division of Infectious Diseases, University of California, San Francisco, San Francisco, CA, USA
    Am J Surg 198:529-31. 2009
    ..Breast SSIs were investigated to determine bacterial isolates, resistance patterns, and the appropriateness of cefazolin, the authors' institution's current regimen for perioperative antibiotic prophylaxis...
  48. ncbi The impact of lobular histology on breast cancer treatment
    E Shelley Hwang
    University of California San Francisco, USA
    Oncology (Williston Park) 25:362, 364-5. 2011
    ..Until then, the mainstay of sound treatment decision-making remains a thorough clinical understanding of the disease and of the factors that can have an impact on outcome...
  49. doi Selection of treatment among Latina and non-Latina white women with ductal carcinoma in situ
    Celia P Kaplan
    Division of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, California 94143 0856, USA
    J Womens Health (Larchmt) 20:215-23. 2011
    ....
  50. ncbi Failure to harvest sentinel lymph nodes identified by preoperative lymphoscintigraphy in breast cancer patients
    Chen Teng Wu
    Department of Surgery, University of California, San Francisco UCSF Medical Center at Mount Zion, 94143 1674, USA
    Breast J 9:86-90. 2003
    ..The possibility of failure to get the SLN should be explained to patients before surgery. Axillary lymph node dissection (ALND) should be done if selective SLN dissection is not successful...
  51. ncbi Development of a novel method for measuring in vivo breast epithelial cell proliferation in humans
    Lisa M Misell
    KineMed, Inc, 5980 Horton St, Suite 470, Emeryville, CA 94608, USA
    Breast Cancer Res Treat 89:257-64. 2005
    ..In summary, this novel method of measuring BEC proliferation in vivo holds promise for assessing the effects of anti-proliferative chemopreventive and chemotherapeutic agents...

Research Grants2

  1. Primary Hormonal Therapy for DCIS of the Breast
    EUN SIL HWANG; Fiscal Year: 2007
    ..If patients could safely be spared from cancer progression while avoiding the morbidity of surgery and radiation for DCIS, the full benefit of early breast cancer detection could be realized. ..