Cheol Kyu Hwang

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc MicroRNAs in opioid pharmacology
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Neuroimmune Pharmacol 7:808-19. 2012
  2. pmc Up-regulation of the mu-opioid receptor gene is mediated through chromatin remodeling and transcriptional factors in differentiated neuronal cells
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota, 6 120 Jackson Hall, 321 Church St S E, Minneapolis, MN 55455, USA
    Mol Pharmacol 78:58-68. 2010
  3. ncbi request reprint Mouse mu opioid receptor distal promoter transcriptional regulation by SOX proteins
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis 55455, USA
    J Biol Chem 278:3742-50. 2003
  4. ncbi request reprint Transcriptional regulation of mouse mu opioid receptor gene by PU.1
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    J Biol Chem 279:19764-74. 2004
  5. pmc Evidence of endogenous mu opioid receptor regulation by epigenetic control of the promoters
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota, 6 120 Jackson Hall, 321 Church St S E, Minneapolis, MN 55455, USA
    Mol Cell Biol 27:4720-36. 2007
  6. ncbi request reprint Neuron-restrictive silencer factor (NRSF) functions as a repressor in neuronal cells to regulate the mu opioid receptor gene
    Chun Sung Kim
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Biol Chem 279:46464-73. 2004
  7. pmc Evidence of the neuron-restrictive silencer factor (NRSF) interaction with Sp3 and its synergic repression to the mu opioid receptor (MOR) gene
    Chun Sung Kim
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Nucleic Acids Res 34:6392-403. 2006
  8. doi request reprint Transcriptional regulation of mouse mu opioid receptor gene in neuronal cells by poly(ADP-ribose) polymerase-1
    Hack Sun Choi
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Cell Mol Med 12:2319-33. 2008
  9. doi request reprint Novel function of neuron-restrictive silencer factor (NRSF) for posttranscriptional regulation
    Chun Sung Kim
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Biochim Biophys Acta 1783:1835-46. 2008
  10. doi request reprint Epigenetic programming of mu-opioid receptor gene in mouse brain is regulated by MeCP2 and Brg1 chromatin remodelling factor
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, USA
    J Cell Mol Med 13:3591-615. 2009

Collaborators

Detail Information

Publications25

  1. pmc MicroRNAs in opioid pharmacology
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Neuroimmune Pharmacol 7:808-19. 2012
    ..This review will summarize our current knowledge of miRNA functions on opioids biology and briefly describe future research directions of miRNAs related to opioids...
  2. pmc Up-regulation of the mu-opioid receptor gene is mediated through chromatin remodeling and transcriptional factors in differentiated neuronal cells
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota, 6 120 Jackson Hall, 321 Church St S E, Minneapolis, MN 55455, USA
    Mol Pharmacol 78:58-68. 2010
    ..Subsequent recruitment of the activating transcription factor Sp1 to the remodeled promoter results in MOR up-regulation...
  3. ncbi request reprint Mouse mu opioid receptor distal promoter transcriptional regulation by SOX proteins
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis 55455, USA
    J Biol Chem 278:3742-50. 2003
    ..These data indicate that SOX proteins might contribute to the transcriptional activity of the mor gene and suggest that mu opioid receptor could mediate some of the developmental processes in which SOX proteins are included...
  4. ncbi request reprint Transcriptional regulation of mouse mu opioid receptor gene by PU.1
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    J Biol Chem 279:19764-74. 2004
    ..1-mediated repression of MOR promoter activity after trichostatin A treatment in neuroblastoma NMB cells. Our results suggest that PU.1 may be an important regulator of the MOR gene, particularly in brain and immune cells...
  5. pmc Evidence of endogenous mu opioid receptor regulation by epigenetic control of the promoters
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota, 6 120 Jackson Hall, 321 Church St S E, Minneapolis, MN 55455, USA
    Mol Cell Biol 27:4720-36. 2007
    ..Here, we propose that an epigenetic mechanism consisting of DNA methylation and chromatin modification underlies the cell stage-specific mechanism of MOR gene expression...
  6. ncbi request reprint Neuron-restrictive silencer factor (NRSF) functions as a repressor in neuronal cells to regulate the mu opioid receptor gene
    Chun Sung Kim
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Biol Chem 279:46464-73. 2004
    ..Our data suggested that NRSF can function as a repressor of MOR transcription in specific cells, via a mechanism dependent on the MOR NRSE...
  7. pmc Evidence of the neuron-restrictive silencer factor (NRSF) interaction with Sp3 and its synergic repression to the mu opioid receptor (MOR) gene
    Chun Sung Kim
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Nucleic Acids Res 34:6392-403. 2006
    ....
  8. doi request reprint Transcriptional regulation of mouse mu opioid receptor gene in neuronal cells by poly(ADP-ribose) polymerase-1
    Hack Sun Choi
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Cell Mol Med 12:2319-33. 2008
    ..Our data suggest that PARP-1 can function as a repressor of MOR transcription dependent on the MOR poly(C) sequence. We demonstrate for the first time a role of PARP-1 as a transcriptional repressor in MOR gene regulation...
  9. doi request reprint Novel function of neuron-restrictive silencer factor (NRSF) for posttranscriptional regulation
    Chun Sung Kim
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Biochim Biophys Acta 1783:1835-46. 2008
    ..We report here a novel function of NRSF that enhance the translation of the mu opioid receptor (MOR) gene through its RNA binding sequence, the neuron-restrictive silencer element (NRSE)...
  10. doi request reprint Epigenetic programming of mu-opioid receptor gene in mouse brain is regulated by MeCP2 and Brg1 chromatin remodelling factor
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, USA
    J Cell Mol Med 13:3591-615. 2009
    ..We conclude that MOR gene expression is epigenetically programmed in various brain regions and that MeCP2 assists the epigenetic program during DNA methylation and chromatin remodelling of the MOR promoter...
  11. ncbi request reprint uAUG-mediated translational initiations are responsible for human mu opioid receptor gene expression
    Kyu Young Song
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Cell Mol Med 14:1113-24. 2010
    ..This re-initiation resulted in negative expression of OPRM1 under normal conditions. These results indicate that re-initiation in MOR gene expression could play an important role in OPRM1 regulation...
  12. ncbi request reprint Transcriptional regulation of mouse mu opioid receptor gene: Sp3 isoforms (M1, M2) function as repressors in neuronal cells to regulate the mu opioid receptor gene
    Hack Sun Choi
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, 55455, USA
    Mol Pharmacol 67:1674-83. 2005
    ..These results suggest that the binding of the M1 and M2 isoforms of the Sp3 transcription factor to the Sp binding sequence may play a role in mouse MOR gene expression...
  13. ncbi request reprint Novel function of the poly(C)-binding protein alpha CP3 as a transcriptional repressor of the mu opioid receptor gene
    Hack Sun Choi
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    FASEB J 21:3963-73. 2007
    ..Our data suggest that alphaCP3 can function as a repressor of MOR transcription dependent on the MOR poly(C) sequence. We demonstrate for the first time a role of alphaCP3 as a transcriptional repressor in MOR gene regulation...
  14. pmc A proteomics approach for identification of single strand DNA-binding proteins involved in transcriptional regulation of mouse mu opioid receptor gene
    Hack Sun Choi
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Mol Cell Proteomics 7:1517-29. 2008
    ..We demonstrate novel roles as transcriptional regulators in Oprm1 regulation for hnRNP K and alphaCP binding to the single strand DNA element...
  15. pmc Inhibition of c-Jun NH2-terminal kinase stimulates mu opioid receptor expression via p38 MAPK-mediated nuclear NF-κB activation in neuronal and non-neuronal cells
    Yadav Wagley
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Biochim Biophys Acta 1833:1476-88. 2013
    ..All these results suggest a regulatory role of the p38 MAPK and NF-κB pathways in MOR gene expression and aid to our better understanding of the MOR gene regulation...
  16. pmc Poly(C)-binding proteins as transcriptional regulators of gene expression
    Hack Sun Choi
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Biochem Biophys Res Commun 380:431-6. 2009
    ..PCBPs can function as a signal-dependent and coordinated regulator of transcription in eukaryotic cells. We address the molecular mechanisms by which PCBPs binding to single- and double-stranded DNA mediates gene expression...
  17. doi request reprint Differential use of an in-frame translation initiation codon regulates human mu opioid receptor (OPRM1)
    Kyu Young Song
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Cell Mol Life Sci 66:2933-42. 2009
    ..The data suggest that MOP expression is controlled in part by initiation of the long form of MOP at the alternate site...
  18. pmc MicroRNA 339 down-regulates μ-opioid receptor at the post-transcriptional level in response to opioid treatment
    Qifang Wu
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    FASEB J 27:522-35. 2013
    ..Taken together, these results suggest that miR-339-3p may serve as a negative feedback modulator of MOR signals by regulating intracellular MOR biosynthesis...
  19. pmc Translational repression of mouse mu opioid receptor expression via leaky scanning
    Kyu Young Song
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nucleic Acids Res 35:1501-13. 2007
    ..These results support the hypothesis that uORFs in mouse MOR mRNA act as negative regulators through a ribosome leaky scanning mechanism. Such leaky scanning resulted in the suppression of mouse MOR under normal conditions...
  20. ncbi request reprint The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor
    Hack Sun Choi
    Department of Pharmacology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    Biochem Biophys Res Commun 343:1132-40. 2006
    ..In NMB cells expressing human MOR gene, transfection of SV1 or SV2 reduced binding activity of the endogenous MOR. These data support a potential role of SV1 and SV2 proteins as possible biological modulator of human mu-opioid receptor...
  21. pmc p38 mitogen-activated protein kinase and PI3-kinase are involved in up-regulation of mu opioid receptor transcription induced by cycloheximide
    Do Kyung Kim
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Neurochem 116:1077-87. 2011
    ..These observations suggest that CHX directly induces MOR gene transcription by recruiting the active transcription factor Sox18 to the MOR promoter through PI3- and/or p38 MAPK pathways...
  22. ncbi request reprint A major species of mouse mu-opioid receptor mRNA and its promoter-dependent functional polyadenylation signal
    Qifang Wu
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church St S E, Minneapolis, MN 55455, USA
    Mol Pharmacol 68:279-85. 2005
    ....
  23. doi request reprint Cholecystokinin-8 induces brain-derived neurotrophic factor expression in noradrenergic neuronal cells
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Neuropeptides 47:245-50. 2013
    ..These results suggest the first evidence that CCK-8S can protect noradrenergic neurons and enhance the expression of BDNF via ERK 1/2-Akt/PKB-PKA-dependent pathways...
  24. ncbi request reprint Isoliquiritigenin isolated from licorice Glycyrrhiza uralensis prevents 6-hydroxydopamine-induced apoptosis in dopaminergic neurons
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Biosci Biotechnol Biochem 76:536-43. 2012
    ..These results provide the first evidence that ISL can protect dopaminergic cells under oxidative stress conditions by regulating the apoptotic process...
  25. ncbi request reprint Developmental expression of the zinc finger transcription factor DRRF (dopamine receptor regulating factor)
    Ursula M D'Souza
    Genetic Pharmacology Unit, Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1406, USA
    Mech Dev 110:197-201. 2002
    ..This pattern of DRRF distribution during embryogenesis overlaps with that found in the adult brain, and with the expression profile of dopamine receptors both in the adult and during development...