Isa Hussaini

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi Phorbol 12-myristate 13-acetate induces protein kinase ceta-specific proliferative response in astrocytic tumor cells
    I M Hussaini
    Departments of Pathology Neuropathology, Biomedical Engineering, and Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 275:22348-54. 2000
  2. ncbi Dithiolane analogs of lignans inhibit interferon-gamma and lipopolysaccharide-induced nitric oxide production in macrophages
    I M Hussaini
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Acta Pharmacol Sin 21:897-904. 2000
  3. ncbi Matrix metalloproteinase-9 is differentially expressed in nonfunctioning invasive and noninvasive pituitary adenomas and increases invasion in human pituitary adenoma cell line
    Isa M Hussaini
    Department of Pathology, 415 Lane Rd, Box 800904, University of Virginia, Charlottesville, VA 22908, USA
    Am J Pathol 170:356-65. 2007
  4. ncbi Urokinase directly activates matrix metalloproteinases-9: a potential role in glioblastoma invasion
    Yunge Zhao
    Department of Pathology, University of Virginia, 415 Lane Road, MR5 Rm3332, Charlottesville, VA 22908, USA
    Biochem Biophys Res Commun 369:1215-20. 2008
  5. ncbi An extensive invasive intracranial human glioblastoma xenograft model: role of high level matrix metalloproteinase 9
    Yunge Zhao
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Am J Pathol 176:3032-49. 2010
  6. ncbi Immunohistochemistry of COUP-TFI: an adjuvant diagnostic tool for the identification of corticotroph microadenomas
    Zachary M Bush
    Division of Endocrinology and Metabolism, University of Virginia Health System, P O Box 801408, Charlottesville, VA, 22908 1408, USA
    Pituitary 13:1-7. 2010
  7. ncbi ADAM-10-mediated N-cadherin cleavage is protein kinase C-alpha dependent and promotes glioblastoma cell migration
    Zachary A Kohutek
    Departments of Pathology and Molecular Physiology and Biological Physics, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Neurosci 29:4605-15. 2009
  8. ncbi H-Ras increases urokinase expression and cell invasion in genetically modified human astrocytes through Ras/Raf/MEK signaling pathway
    Yunge Zhao
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    Glia 56:917-24. 2008
  9. ncbi Protein kinase C-alpha-mediated regulation of low-density lipoprotein receptor related protein and urokinase increases astrocytoma invasion
    Samson Amos
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Cancer Res 67:10241-51. 2007
  10. ncbi Epidermal growth factor receptor-mediated regulation of urokinase plasminogen activator expression and glioblastoma invasion via C-SRC/MAPK/AP-1 signaling pathways
    Samson Amos
    Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Neuropathol Exp Neurol 69:582-92. 2010

Research Grants

  1. REGULATION OF GBM INVASIVE GROWTH BY PROTEIN KINASE C-ETA
    Isa Hussaini; Fiscal Year: 2009
  2. Role of LRP in Astrocytoma Migration
    Isa Hussaini; Fiscal Year: 2007
  3. Role of PKCeta in Regulating Astrocytoma Invasive Growth
    Isa Hussaini; Fiscal Year: 2006
  4. REGULATION OF GBM INVASIVE GROWTH BY PROTEIN KINASE C-ETA
    Isa M Hussaini; Fiscal Year: 2010

Collaborators

Detail Information

Publications19

  1. ncbi Phorbol 12-myristate 13-acetate induces protein kinase ceta-specific proliferative response in astrocytic tumor cells
    I M Hussaini
    Departments of Pathology Neuropathology, Biomedical Engineering, and Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 275:22348-54. 2000
    ....
  2. ncbi Dithiolane analogs of lignans inhibit interferon-gamma and lipopolysaccharide-induced nitric oxide production in macrophages
    I M Hussaini
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Acta Pharmacol Sin 21:897-904. 2000
    ....
  3. ncbi Matrix metalloproteinase-9 is differentially expressed in nonfunctioning invasive and noninvasive pituitary adenomas and increases invasion in human pituitary adenoma cell line
    Isa M Hussaini
    Department of Pathology, 415 Lane Rd, Box 800904, University of Virginia, Charlottesville, VA 22908, USA
    Am J Pathol 170:356-65. 2007
    ..These results demonstrate that MMP-9 and PKC-alpha or PKC-delta may provide putative therapeutic targets for the control of PA dural invasion...
  4. ncbi Urokinase directly activates matrix metalloproteinases-9: a potential role in glioblastoma invasion
    Yunge Zhao
    Department of Pathology, University of Virginia, 415 Lane Road, MR5 Rm3332, Charlottesville, VA 22908, USA
    Biochem Biophys Res Commun 369:1215-20. 2008
    ..These results suggest that uPA-mediated direct activation of MMP-9 may promote GBM cell invasion...
  5. ncbi An extensive invasive intracranial human glioblastoma xenograft model: role of high level matrix metalloproteinase 9
    Yunge Zhao
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Am J Pathol 176:3032-49. 2010
    ..Our data indicate that the U1242 MG xenograft model is valuable for studying GBM extensive invasion and angiogenesis as well as testing anti-invasive and anti-angiogenic therapeutic approaches...
  6. ncbi Immunohistochemistry of COUP-TFI: an adjuvant diagnostic tool for the identification of corticotroph microadenomas
    Zachary M Bush
    Division of Endocrinology and Metabolism, University of Virginia Health System, P O Box 801408, Charlottesville, VA, 22908 1408, USA
    Pituitary 13:1-7. 2010
    ..Furthermore, this study identifies two unique corticotroph tumor populations which differ in their expression of COUP-TFI, the presence of which occurs more frequently in macroadenomas...
  7. ncbi ADAM-10-mediated N-cadherin cleavage is protein kinase C-alpha dependent and promotes glioblastoma cell migration
    Zachary A Kohutek
    Departments of Pathology and Molecular Physiology and Biological Physics, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Neurosci 29:4605-15. 2009
    ..Together, these results suggest that N-cadherin cleavage is regulated by a PKC-alpha-ADAM-10 cascade in GBM cells and may be involved in mediating GBM cell migration...
  8. ncbi H-Ras increases urokinase expression and cell invasion in genetically modified human astrocytes through Ras/Raf/MEK signaling pathway
    Yunge Zhao
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    Glia 56:917-24. 2008
    ..Our results suggest that H-Ras increased uPA expression and activity via the Ras/Raf/MEK signaling pathway leading to enhanced cell invasion and this may contribute to increased invasive growth properties of astrocytomas...
  9. ncbi Protein kinase C-alpha-mediated regulation of low-density lipoprotein receptor related protein and urokinase increases astrocytoma invasion
    Samson Amos
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Cancer Res 67:10241-51. 2007
    ..Thus, a strategy of combining small molecule inhibitors of PKC-alpha and PI3K could provide a new treatment paradigm for glioblastomas...
  10. ncbi Epidermal growth factor receptor-mediated regulation of urokinase plasminogen activator expression and glioblastoma invasion via C-SRC/MAPK/AP-1 signaling pathways
    Samson Amos
    Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Neuropathol Exp Neurol 69:582-92. 2010
    ..In summary, these results suggest that c-Src, mitogen-activated protein kinase, and a composite activator protein 1 on the uPA promoter are responsible for EGF-induced uPA expression and GBM invasion...
  11. ncbi PKC eta as a therapeutic target in glioblastoma multiforme
    Patrick M Martin
    Department of Pathology, University of Virginia, Charlottesville, VA, USA
    Expert Opin Ther Targets 9:299-313. 2005
    ..The PKC isozyme, PKCeta (PKC-eta) increases cell proliferation and resistance to radiation of GBM cell lines. These properties make PKCeta an attractive target for chemotherapeutic intervention in the management of GBMs...
  12. ncbi Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells
    Samson Amos
    Department of Pathology, University of Virginia Health System, Charlottesville 22908, USA
    J Biol Chem 280:7729-38. 2005
    ..Taken together, our data demonstrate that PMA transactivates the EGFR and increases cell proliferation by activating the PKCdelta/c-Src pathway in glioblastomas...
  13. ncbi PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways
    Sean E Aeder
    Department of Pathology and Neurology, University of Virginia, Charlottesville, VA 22908, USA
    Oncogene 23:9062-9. 2004
    ..However, activation of Akt, but not mTOR was inhibited by the PI-3 kinase inhibitor LY294002. This study identifies Akt and mTOR as downstream targets of PKC-eta that are involved in GBM cell proliferation...
  14. ncbi Behavioural effect of Pavetta crassipes extract on rodents
    Samson Amos
    Department of Pharmacology and Toxicology, University of Nigeria, Nsukka, Nigeria
    Pharmacol Biochem Behav 77:751-9. 2004
    ..crassipes contains biologically active substance(s) that might be acting centrally through the inhibition of dopaminergic pathway or a system linked to this pathway to mediate the observed pharmacological effects...
  15. ncbi Protein kinase C-eta regulates resistance to UV- and gamma-irradiation-induced apoptosis in glioblastoma cells by preventing caspase-9 activation
    Isa M Hussaini
    Department of Pathology, University of Virginia, Charlottesville 22908, USA
    Neuro Oncol 4:9-21. 2002
    ..The data demonstrate that resistance to UV and gamma irradiation in glioblastoma cell lines is modified significantly by PKC-eta expression and that PKC-eta appears to block the apoptotic cascade at caspase-9 activation...
  16. ncbi Matrix metalloproteinase-9, a potential biological marker in invasive pituitary adenomas
    Jian Gong
    Department of Neurosurgery, University of Virginia Health System, Charlottesville, VA 22903, USA
    Pituitary 11:37-48. 2008
    ....
  17. ncbi Jun blockade of erythropoiesis: role for repression of GATA-1 by HERP2
    Kamaleldin E Elagib
    University of Virginia School of Medicine, P O Box 800904, Charlottesville, VA 22908, USA
    Mol Cell Biol 24:7779-94. 2004
    ..Furthermore, these results establish a connection between the Notch signaling pathway, of which the HERP factors are a critical component, and the GATA family, which participates in programming of cellular differentiation...
  18. ncbi Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways
    Jiahu Wang
    Department of Cell Biology, University of Virginia, Charlottesville, VA 22904, USA
    J Cell Biol 174:689-700. 2006
    ..Outward flow of lacritin from secretory cells through ducts may generate a proliferative/secretory field as a different unit of cellular renewal in nongermative epithelia where luminal structures predominate...
  19. ncbi Subcellular translocation of protein kinase C
    Julianne J Sando
    Department of Anesthesiology, University of Virginia, Charlottesville, USA
    Methods Mol Biol 233:77-85. 2003

Research Grants13

  1. REGULATION OF GBM INVASIVE GROWTH BY PROTEIN KINASE C-ETA
    Isa Hussaini; Fiscal Year: 2009
    ..Understanding the functional roles of these genes in GBM invasion may provide a paradigm whereby this deadly tumor may be managed. ..
  2. Role of LRP in Astrocytoma Migration
    Isa Hussaini; Fiscal Year: 2007
    ..Understanding the role of LRP in the migration and invasion astrocytic tumors will provide information on possible specific targets for therapeutic intervention. ..
  3. Role of PKCeta in Regulating Astrocytoma Invasive Growth
    Isa Hussaini; Fiscal Year: 2006
    ..Understanding the roles of specific PKC isozymes in growth and apoptosis of astrocytic tumors will provide information on possible specific targets for therapeutic intervention. ..
  4. REGULATION OF GBM INVASIVE GROWTH BY PROTEIN KINASE C-ETA
    Isa M Hussaini; Fiscal Year: 2010
    ..Understanding the functional roles of these genes in GBM invasion may provide a paradigm whereby this deadly tumor may be managed. ..