Aliya N Husain

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. doi request reprint How useful is GLUT-1 in differentiating mesothelial hyperplasia and fibrosing pleuritis from epithelioid and sarcomatoid mesotheliomas? An international collaborative study
    Aliya N Husain
    The University of Chicago Medical Center, 5841 South Maryland Avenue, Chicago, IL 60637, USA Electronic address
    Lung Cancer 83:324-8. 2014
  2. doi request reprint Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group
    Aliya N Husain
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Arch Pathol Lab Med 137:647-67. 2013
  3. pmc Cardiac tamponade mimicking tuberculous pericarditis as the initial presentation of chronic lymphocytic leukemia in a 58-year-old woman: a case report
    Elaine Lin
    Section of Cardiology, Department of Medicine, University of Chicago, Chicago, IL, USA
    J Med Case Reports 4:246. 2010
  4. pmc The EphB4 receptor tyrosine kinase promotes lung cancer growth: a potential novel therapeutic target
    Benjamin D Ferguson
    Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
    PLoS ONE 8:e67668. 2013
  5. doi request reprint Differential expression of RON in small and non-small cell lung cancers
    Rajani Kanteti
    Section of Hematology Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Genes Chromosomes Cancer 51:841-51. 2012
  6. pmc Protein kinase C beta in malignant pleural mesothelioma
    Leonardo Faoro
    Section of Hematology Oncology, Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, Illinois 60637 1470, USA
    Anticancer Drugs 19:841-8. 2008
  7. pmc EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mammalian target of rapamycin activation
    Leonardo Faoro
    Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 285:18575-85. 2010
  8. pmc Expression patterns of PAX5, c-Met, and paxillin in neuroendocrine tumors of the lung
    Jie Song
    Department of Pathology, University of Chicago Medical Center, Chicago, IL, USA
    Arch Pathol Lab Med 134:1702-5. 2010
  9. pmc Paxillin expression and amplification in early lung lesions of high-risk patients, lung adenocarcinoma and metastatic disease
    Alexander C MacKinnon
    Department of Pathology, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    J Clin Pathol 64:16-24. 2011
  10. pmc Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer
    Jalees Rehman
    Section of Cardiology, University of Chicago, 5841 South Maryland Ave, MC6080, Chicago, IL 60637, USA
    FASEB J 26:2175-86. 2012

Detail Information

Publications34

  1. doi request reprint How useful is GLUT-1 in differentiating mesothelial hyperplasia and fibrosing pleuritis from epithelioid and sarcomatoid mesotheliomas? An international collaborative study
    Aliya N Husain
    The University of Chicago Medical Center, 5841 South Maryland Avenue, Chicago, IL 60637, USA Electronic address
    Lung Cancer 83:324-8. 2014
    ..GLUT-1 has shown variable results regarding its sensitivity and specificity when used to evaluate mesothelial proliferations. We evaluated the utility of GLUT-1 immunostaining in differentiating MH and FP from MM-E and MM-S...
  2. doi request reprint Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group
    Aliya N Husain
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Arch Pathol Lab Med 137:647-67. 2013
    ..Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose...
  3. pmc Cardiac tamponade mimicking tuberculous pericarditis as the initial presentation of chronic lymphocytic leukemia in a 58-year-old woman: a case report
    Elaine Lin
    Section of Cardiology, Department of Medicine, University of Chicago, Chicago, IL, USA
    J Med Case Reports 4:246. 2010
    ..However, the signs, symptoms and laboratory findings of pericarditis related to chronic lymphocytic leukemia can mimic tuberculosis...
  4. pmc The EphB4 receptor tyrosine kinase promotes lung cancer growth: a potential novel therapeutic target
    Benjamin D Ferguson
    Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
    PLoS ONE 8:e67668. 2013
    ..Clinical trials investigating the efficacy of anti-EphB4 therapies as well as combination therapy involving EphB4 inhibition may be warranted. ..
  5. doi request reprint Differential expression of RON in small and non-small cell lung cancers
    Rajani Kanteti
    Section of Hematology Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Genes Chromosomes Cancer 51:841-51. 2012
    ..RON was expressed on the cell surface in NSCLC cell lines. Finally, knock down of RON expression resulted in a significant loss in viability as well as motility in lung cancer cells suggesting that RON is a potential therapeutic target...
  6. pmc Protein kinase C beta in malignant pleural mesothelioma
    Leonardo Faoro
    Section of Hematology Oncology, Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, Illinois 60637 1470, USA
    Anticancer Drugs 19:841-8. 2008
    ..Enzastaurin has preclinical activity against MPM, and exhibited synergism with cisplatin. PKCbeta inhibition in MPM might be able to reduce the invasiveness of MPM by affecting cytoskeletal function...
  7. pmc EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mammalian target of rapamycin activation
    Leonardo Faoro
    Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 285:18575-85. 2010
    ..Further study of EphA2 as a therapeutic target is warranted...
  8. pmc Expression patterns of PAX5, c-Met, and paxillin in neuroendocrine tumors of the lung
    Jie Song
    Department of Pathology, University of Chicago Medical Center, Chicago, IL, USA
    Arch Pathol Lab Med 134:1702-5. 2010
    ..The expression patterns of these functionally related proteins have not, to our knowledge, been systemically studied in neuroendocrine tumors of the lung...
  9. pmc Paxillin expression and amplification in early lung lesions of high-risk patients, lung adenocarcinoma and metastatic disease
    Alexander C MacKinnon
    Department of Pathology, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    J Clin Pathol 64:16-24. 2011
    ..A murine in vivo xenograft model of the most common paxillin mutation (A127T) showed increased cell proliferation and invasive tumour growth, establishing an important role for paxillin in the development of lung cancer...
  10. pmc Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer
    Jalees Rehman
    Section of Cardiology, University of Chicago, 5841 South Maryland Ave, MC6080, Chicago, IL 60637, USA
    FASEB J 26:2175-86. 2012
    ..0 ± 19 to 87.0 ± 6 mm(3) (P<0.01) with therapeutic Drp-1 inhibition. Impaired fusion and enhanced fission contribute fundamentally to the proliferation/apoptosis imbalance in cancer and constitute promising novel therapeutic targets...
  11. pmc Paxillin mutations affect focal adhesions and lead to altered mitochondrial dynamics: relevance to lung cancer
    Ichiro Kawada
    Department of Medicine, University of Chicago, Chicago, IL, USA
    Cancer Biol Ther 14:679-91. 2013
    ..The data reported herein suggest that mutant PXN variants play a prominent role in mitochondrial dynamics with direct implications on lung cancer progression and hence, deserve further exploration as therapeutic targets. ..
  12. pmc Role of PAX8 in the regulation of MET and RON receptor tyrosine kinases in non-small cell lung cancer
    Rajani Kanteti
    Department of Hematology Oncology, University of Chicago Medical Center, Chicago, IL, USA
    BMC Cancer 14:185. 2014
    ..PAX8, however, is also expressed in NSCLC cell lines. We therefore investigated the role of PAX8 in NSCLC...
  13. doi request reprint Combined MET inhibition and topoisomerase I inhibition block cell growth of small cell lung cancer
    Cleo E Rolle
    Corresponding Author Ravi Salgia, Section of Hematology Oncology, Department of Medicine, The University of Chicago, 5841 S Maryland Avenue, MC 2115, Chicago, IL 60637
    Mol Cancer Ther 13:576-84. 2014
    ..Collectively, these findings suggest that the combinatorial inhibition of MET and Top1 is a potentially efficacious treatment strategy for SCLC...
  14. ncbi request reprint Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus statement from the International Mesothelioma Interest Group
    Aliya N Husain
    Department of Pathology, University of Chicago, Chicago, IL 60631, USA
    Arch Pathol Lab Med 133:1317-31. 2009
    ..Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose...
  15. ncbi request reprint MET and phosphorylated MET as potential biomarkers in lung cancer
    Maria Tretiakova
    University of Chicago, Department of Pathology, Chicago, Illinois 60637, USA
    J Environ Pathol Toxicol Oncol 30:341-54. 2011
    ..12- 3.07; and P = .034; HR, 1.70; 95% CI, 1.04-2.78, respectively). In summary, MET, pMET, and HGF are highly expressed in both NSCLC and SCLC. Specific forms of pMET may serve as potential biomarkers in lung cancer...
  16. doi request reprint Critical role for the receptor tyrosine kinase EPHB4 in esophageal cancers
    Rifat Hasina
    Section of Hematology Oncology, Department of Medicine, Departments of Pathology and Surgery, The University of Chicago, Chicago, IL 60637, USA
    Cancer Res 73:184-94. 2013
    ..EphB4 is robustly expressed and potentially serves as a novel biomarker for targeted therapy in esophageal cancers...
  17. doi request reprint Interobserver variability in grading transbronchial lung biopsy specimens after lung transplantation
    Sangeeta M Bhorade
    Pulmonary and Critical Care Medicine, University of Chicago Medical Center, Chicago, IL 60637, USA
    Chest 143:1717-24. 2013
    ..The reliability of this grading system has not been adequately assessed by previous studies...
  18. ncbi request reprint Update in neoplastic lung diseases and mesothelioma
    Ilyssa O Gordon
    Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    Arch Pathol Lab Med 133:1106-15. 2009
    ..Identification of new molecular targets in pleural mesothelioma and in preneoplastic lesions may lead to improved therapeutic strategies...
  19. ncbi request reprint Lymphatic vessel density is not associated with lymph node metastasis in non-small cell lung carcinoma
    Leonardo Faoro
    Department of Medicine, Section of Hematology Oncology, University of Chicago, Chicago, IL, USA
    Arch Pathol Lab Med 132:1882-8. 2008
    ..Lymphatic metastasis is also an important means of tumor spread. In non-small cell lung carcinoma, the relationship of lymphangiogenesis with lymph node metastasis and, ultimately, patient prognosis is unknown...
  20. pmc Role of protein kinase C β and vascular endothelial growth factor receptor in malignant pleural mesothelioma: Therapeutic implications and the usefulness of Caenorhabditis elegans model organism
    Sivakumar Loganathan
    Section of Hematology Oncology, University of Chicago, Chicago, IL 60637, USA
    J Carcinog 10:4. 2011
    ..To examine the role of both protein kinase C (PKC)-β and vascular endothelial growth factor receptor (VEGFR)-2 in malignant pleural mesothelioma (MPM) using respective inhibitors, enzastaurin and KRN633...
  21. doi request reprint Endobronchial biopsy: a guide for asthma therapy selection in the era of bronchial thermoplasty
    Ilyssa O Gordon
    Department of Pathology, The University of Chicago, Chicago, IL, USA
    J Asthma 50:634-41. 2013
    ..In addition, we correlated invasive and non-invasive inflammatory markers in severe persistent asthma...
  22. ncbi request reprint Carbonic Anhydrase IX (CAIX) Does Not Differentiate Between Benign and Malignant Mesothelium
    Vijayalakshmi Ananthanarayanan
    From the Department of Pathology, University of Chicago, Chicago, IL, and
    Am J Clin Pathol 142:82-7. 2014
    ..To examine carbonic anhydrase IX (CAIX), a marker of renal cell carcinoma that recently has been described in malignant effusions...
  23. pmc Bronchial thermoplasty failure in severe persistent asthma: a case report
    Diana C Doeing
    Department of Medicine, The University of Chicago, Chicago, IL Chicago, IL 60637, USA
    J Asthma 50:799-801. 2013
    ..While this therapy is suggested to eliminate such smooth muscle permanently, no human studies have examined the possibility of treatment failure...
  24. doi request reprint A novel algorithm for simplification of complex gene classifiers in cancer
    Raphael A Wilson
    Authors Affiliations Division of Hematology Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center and Children s Medical Center, Dallas, Texas Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma Department of Pathology, University of Southern California and Children s Hospital of Los Angeles, Los Angeles, California Department of Pathology and Laboratory Medicine, Nationwide Children s Hospital and Department of Pathology and Pediatrics, The Ohio State University, Columbus, Ohio National Cancer Institute, Bethesda, Maryland Division of Hematology Oncology, Department of Pediatrics, University of Washington and Seattle Children s Hospital, Seattle, Washington Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska The Section of Pediatric Hematology Oncology, Department of Pediatrics, Department of Pathology, Center for Research Informatics, and The Computation Institute, University of Chicago, Chicago, Illinois
    Cancer Res 73:5625-32. 2013
    ..Our approach can easily be generalized and coupled to existing technical platforms to facilitate the discovery of simplified signatures that are ready for routine clinical use...
  25. pmc Proteomic characterization of non-small cell lung cancer in a comprehensive translational thoracic oncology database
    Mosmi Surati
    Pritzker School of Medicine, University of Chicago Pritzker School of Medicine, 924 E 57 St, Chicago, IL 60637
    J Clin Bioinforma 1:1-11. 2011
    ....
  26. ncbi request reprint Pathologic quantification of connective tissue disease-associated versus idiopathic usual interstitial pneumonia
    Nicole A Cipriani
    Departments of Pathology, University of Chicago, Chicago, IL, USA
    Arch Pathol Lab Med 136:1253-8. 2012
    ..Some studies suggest that CTD-UIP has a better prognosis than I-UIP. The histologic differences between CTD-UIP and I-UIP are not clearly defined...
  27. pmc MET/PKCbeta expression correlate with metastasis and inhibition is synergistic in lung cancer
    Leonardo Faoro
    Section of Hematology Oncology, Department of Medicine, University of Chicago Pritzker School of Medicine, and University of Chicago Cancer Research Center, Chicago, IL 60637, USA
    J Carcinog 8:15. 2009
    ..Targeted inhibition of oncogenic proteins is promising. In this study, we evaluate the expression of MET and PKCbeta and in vitro effects of their inhibition using SU11274 and enzastaurin (LY317615.HCl) respectively...
  28. pmc The clinical and immunologic features of pulmonary fibrosis in sarcoidosis
    Karen C Patterson
    Section of Pulmonary and Critical Care, University of Chicago, Chicago, Ill
    Transl Res 160:321-31. 2012
    ..Elucidating the natural history of sarcoidosis-associated PF will inform our understanding of the fundamental derangements, and will enhance prognostication and the development of therapeutic strategies...
  29. pmc Lymphatic endothelial differentiation in pulmonary lymphangioleiomyomatosis cells
    Jennifer M Davis
    Department of Pathology, Biological Sciences Division, University of Chicago, Chicago, Illinois 60637, USA
    J Histochem Cytochem 61:580-90. 2013
    ..This study has implications for the histological diagnosis of LAM, the origin of the neoplastic cells, and potential future treatment with drugs targeting lymphangiogenesis. ..
  30. doi request reprint SaLUTaRy: survey of lung transplant rejection
    Ilyssa O Gordon
    Department of Pathology, The University of Chicago, Chicago, IL, USA
    J Heart Lung Transplant 31:972-9. 2012
    ..The goal of our study was to determine how these revisions, along with nuances in the interpretation and application of the guidelines, affect patient care...
  31. pmc S100A12 in vascular smooth muscle accelerates vascular calcification in apolipoprotein E-null mice by activating an osteogenic gene regulatory program
    MARION A HOFMANN BOWMAN
    Department of Medicine, Section of Cardiology, University of Chicago, 5841 S Maryland Avenue, Chicago IL 60637, USA
    Arterioscler Thromb Vasc Biol 31:337-44. 2011
    ..In the current study, we tested the hypothesis that S100A12 expressed in vascular smooth muscle in atherosclerosis-prone apolipoprotein E (ApoE)-null mice would accelerate atherosclerosis...
  32. ncbi request reprint Multiple paragangliomata of the lungs and temporal bone
    Husain A Sattar
    Department of Pathology, University of Chicago Hospitals, MC 1035, Chicago, IL 60637, USA
    Ear Nose Throat J 87:E4-6. 2008
    ..Before any chemotherapeutic regimen is initiated, a thorough physical examination of the head and neck should be performed, and biopsy material should be tested for markers of cell division...
  33. pmc Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target
    Stephen L Archer
    Department of Medicine, Section of Cardiology, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Circulation 121:2661-71. 2010
    ..Expression and activity of mitochondrial superoxide dismutase-2 (SOD2), the major generator of H(2)O(2), is known to be reduced in PAH; however, the mechanism and therapeutic relevance of this are unknown...
  34. pmc PAX5 is expressed in small-cell lung cancer and positively regulates c-Met transcription
    Rajani Kanteti
    Department of Hematology Oncology, University of Chicago Medical Center, Chicago, IL 60637, USA
    Lab Invest 89:301-14. 2009
    ..Therefore, we propose that PAX5 could be an important regulator of c-Met transcription and a potential target for therapy in SCLC...