H I Hurtig
Affiliation: University of Pennsylvania
- Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's diseaseH I Hurtig
Department of Neurology, University of Pennsylvania, PA, USA
Neurology 54:1916-21. 2000..Although Alzheimer's pathology has been a frequent finding, recent advances in immunostaining of alpha-synuclein have suggested the possible importance of cortical Lewy bodies (CLBs) in the brains of demented patients with PD...
- Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesionsB I Giasson
Center for Neurodegenerative Disease Research and Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Science 290:985-9. 2000..The selective and specific nitration of alpha-synuclein in these disorders provides evidence to directly link oxidative and nitrative damage to the onset and progression of neurodegenerative synucleinopathies...
- Novel CSF biomarkers for frontotemporal lobar degenerationsW T Hu
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104 4283, USA
Neurology 75:2079-86. 2010..To identify antemortem CSF diagnostic biomarkers that can potentially distinguish between the 2 main causes of frontotemporal lobar degeneration (FTLD), i.e., FTLD with TDP-43 pathology (FTLD-TDP) and FTLD with tau pathology (FTLD-tau)...
- Longitudinal decline in autopsy-defined frontotemporal lobar degenerationM Grossman
Department of Neurology, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
Neurology 70:2036-45. 2008..The natural history of patients with pathologically proven frontotemporal lobar degeneration (FTLD) is important from clinical and biologic perspectives, but is not well documented quantitatively...
- Cognitive resource limitations during sentence comprehension in Parkinson's diseaseM Grossman
Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104 4283, USA
Brain Lang 73:1-16. 2000..The sensitivity of PD patients' sentence comprehension accuracy to secondary task resource demands is most consistent with the hypothesis that limited cognitive resources contribute to sentence comprehension difficulty in PD...
- Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathologyJ E Galvin
Department of Neurology, Medical College of Pennsylvania Hahnemann University the Center for Neurodegenerative Disease Research, and the Department of Neurology, The University of Pennsylvania, Philadelphia, Pennsylvania, USA
Am J Pathol 157:361-8. 2000..These findings expand the concept of neurodegenerative synucleinopathies by implicating alphaS, betaS, and gammaS in the pathogenesis of NBIA 1...
- Dopamine supports sentence comprehension in Parkinson's DiseaseM Grossman
Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
J Neurol Sci 184:123-30. 2001..To determine the role of dopamine in the executive resource component of sentence comprehension...
- Atomoxetine for depression and other neuropsychiatric symptoms in Parkinson diseaseD Weintraub
Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
Neurology 75:448-55. 2010....
- Cognitive and motor assessment in autopsy-proven corticobasal degenerationR Murray
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Neurology 68:1274-83. 2007..To investigate the clinical features of autopsy-proven corticobasal degeneration (CBD)...
- DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkersC F Lippa
Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
Neurology 68:812-9. 2007....
- [99mTc]TRODAT-1 SPECT imaging correlates with odor identification in early Parkinson diseaseA Siderowf
Parkinson Disease and Movement Disorders Center, Department of Neurology, University of Pennsylvania, Philadelphia, USA
Neurology 64:1716-20. 2005..In vivo imaging of the dopamine transporter with [99mTc]TRODAT-1 (TRODAT) and olfactory testing have both been proposed as potential biomarkers in Parkinson disease (PD)...
- Grammatical and resource components of sentence processing in Parkinson's disease: an fMRI studyM Grossman
Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, USA
Neurology 60:775-81. 2003..The authors hypothesize that sentence comprehension difficulty in patients with mild PD is due to degradation of the large-scale neural network that supports cognitive resources during sentence processing...
- Diagnostic accuracy of [99mTc]TRODAT-1 SPECT imaging in early Parkinson's diseaseK L Chou
Parkinson s Disease and Movement Disorders Center, University of Pennsylvania School of Medicine, Pennsylvania Hospital, 330 South Ninth Street, Philadelphia, PA 19107, USA
Parkinsonism Relat Disord 10:375-9. 2004..79, specificity 0.92). These findings show that TRODAT imaging can accurately differentiate early PD patients from controls and has the potential to improve the diagnosis of patients with early signs of PD...
- Glucocerebrosidase mutations are an important risk factor for Lewy body disordersO Goker-Alpan
Section on Molecular Neurogenetics, Medical Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892 3708, USA
Neurology 67:908-10. 2006..Mutations in this lysosomal protein may interfere with the clearance or promote aggregation of alpha-synuclein...
- Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutationsA S Chen-Plotkin
Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
Neurology 70:521-7. 2008..Despite pleomorphic pathology, LRRK2 mutations are believed to manifest clinically as typical Parkinson disease (PD). However, most genetic screens have been limited to PD clinic populations...