H I Hurtig

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease
    H I Hurtig
    Department of Neurology, University of Pennsylvania, PA, USA
    Neurology 54:1916-21. 2000
  2. ncbi request reprint Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions
    B I Giasson
    Center for Neurodegenerative Disease Research and Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 290:985-9. 2000
  3. pmc Novel CSF biomarkers for frontotemporal lobar degenerations
    W T Hu
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104 4283, USA
    Neurology 75:2079-86. 2010
  4. ncbi request reprint Cognitive and motor assessment in autopsy-proven corticobasal degeneration
    R Murray
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Neurology 68:1274-83. 2007
  5. ncbi request reprint Cognitive resource limitations during sentence comprehension in Parkinson's disease
    M Grossman
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104 4283, USA
    Brain Lang 73:1-16. 2000
  6. pmc Longitudinal decline in autopsy-defined frontotemporal lobar degeneration
    M Grossman
    Department of Neurology, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    Neurology 70:2036-45. 2008
  7. pmc Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology
    J E Galvin
    Department of Neurology, Medical College of Pennsylvania Hahnemann University the Center for Neurodegenerative Disease Research, and the Department of Neurology, The University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Pathol 157:361-8. 2000
  8. ncbi request reprint Dopamine supports sentence comprehension in Parkinson's Disease
    M Grossman
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    J Neurol Sci 184:123-30. 2001
  9. pmc Atomoxetine for depression and other neuropsychiatric symptoms in Parkinson disease
    D Weintraub
    Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
    Neurology 75:448-55. 2010
  10. ncbi request reprint DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers
    C F Lippa
    Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Neurology 68:812-9. 2007

Detail Information

Publications15

  1. ncbi request reprint Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease
    H I Hurtig
    Department of Neurology, University of Pennsylvania, PA, USA
    Neurology 54:1916-21. 2000
    ..Although Alzheimer's pathology has been a frequent finding, recent advances in immunostaining of alpha-synuclein have suggested the possible importance of cortical Lewy bodies (CLBs) in the brains of demented patients with PD...
  2. ncbi request reprint Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions
    B I Giasson
    Center for Neurodegenerative Disease Research and Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 290:985-9. 2000
    ..The selective and specific nitration of alpha-synuclein in these disorders provides evidence to directly link oxidative and nitrative damage to the onset and progression of neurodegenerative synucleinopathies...
  3. pmc Novel CSF biomarkers for frontotemporal lobar degenerations
    W T Hu
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104 4283, USA
    Neurology 75:2079-86. 2010
    ..To identify antemortem CSF diagnostic biomarkers that can potentially distinguish between the 2 main causes of frontotemporal lobar degeneration (FTLD), i.e., FTLD with TDP-43 pathology (FTLD-TDP) and FTLD with tau pathology (FTLD-tau)...
  4. ncbi request reprint Cognitive and motor assessment in autopsy-proven corticobasal degeneration
    R Murray
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Neurology 68:1274-83. 2007
    ..To investigate the clinical features of autopsy-proven corticobasal degeneration (CBD)...
  5. ncbi request reprint Cognitive resource limitations during sentence comprehension in Parkinson's disease
    M Grossman
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104 4283, USA
    Brain Lang 73:1-16. 2000
    ..The sensitivity of PD patients' sentence comprehension accuracy to secondary task resource demands is most consistent with the hypothesis that limited cognitive resources contribute to sentence comprehension difficulty in PD...
  6. pmc Longitudinal decline in autopsy-defined frontotemporal lobar degeneration
    M Grossman
    Department of Neurology, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    Neurology 70:2036-45. 2008
    ..The natural history of patients with pathologically proven frontotemporal lobar degeneration (FTLD) is important from clinical and biologic perspectives, but is not well documented quantitatively...
  7. pmc Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology
    J E Galvin
    Department of Neurology, Medical College of Pennsylvania Hahnemann University the Center for Neurodegenerative Disease Research, and the Department of Neurology, The University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Pathol 157:361-8. 2000
    ..These findings expand the concept of neurodegenerative synucleinopathies by implicating alphaS, betaS, and gammaS in the pathogenesis of NBIA 1...
  8. ncbi request reprint Dopamine supports sentence comprehension in Parkinson's Disease
    M Grossman
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    J Neurol Sci 184:123-30. 2001
    ..To determine the role of dopamine in the executive resource component of sentence comprehension...
  9. pmc Atomoxetine for depression and other neuropsychiatric symptoms in Parkinson disease
    D Weintraub
    Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
    Neurology 75:448-55. 2010
    ....
  10. ncbi request reprint DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers
    C F Lippa
    Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Neurology 68:812-9. 2007
    ....
  11. ncbi request reprint [99mTc]TRODAT-1 SPECT imaging correlates with odor identification in early Parkinson disease
    A Siderowf
    Parkinson Disease and Movement Disorders Center, Department of Neurology, University of Pennsylvania, Philadelphia, USA
    Neurology 64:1716-20. 2005
    ..In vivo imaging of the dopamine transporter with [99mTc]TRODAT-1 (TRODAT) and olfactory testing have both been proposed as potential biomarkers in Parkinson disease (PD)...
  12. ncbi request reprint Grammatical and resource components of sentence processing in Parkinson's disease: an fMRI study
    M Grossman
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, USA
    Neurology 60:775-81. 2003
    ..The authors hypothesize that sentence comprehension difficulty in patients with mild PD is due to degradation of the large-scale neural network that supports cognitive resources during sentence processing...
  13. ncbi request reprint Diagnostic accuracy of [99mTc]TRODAT-1 SPECT imaging in early Parkinson's disease
    K L Chou
    Parkinson s Disease and Movement Disorders Center, University of Pennsylvania School of Medicine, Pennsylvania Hospital, 330 South Ninth Street, Philadelphia, PA 19107, USA
    Parkinsonism Relat Disord 10:375-9. 2004
    ..79, specificity 0.92). These findings show that TRODAT imaging can accurately differentiate early PD patients from controls and has the potential to improve the diagnosis of patients with early signs of PD...
  14. ncbi request reprint Glucocerebrosidase mutations are an important risk factor for Lewy body disorders
    O Goker-Alpan
    Section on Molecular Neurogenetics, Medical Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892 3708, USA
    Neurology 67:908-10. 2006
    ..Mutations in this lysosomal protein may interfere with the clearance or promote aggregation of alpha-synuclein...
  15. pmc Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations
    A S Chen-Plotkin
    Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    Neurology 70:521-7. 2008
    ..Despite pleomorphic pathology, LRRK2 mutations are believed to manifest clinically as typical Parkinson disease (PD). However, most genetic screens have been limited to PD clinic populations...