STEPHEN DAVID HURSTING

Summary

Affiliation: University of Texas
Country: USA

Publications

  1. ncbi request reprint Energy balance and carcinogenesis: underlying pathways and targets for intervention
    Stephen D Hursting
    Division of Nutritional Sciences, University of Texas, Austin, TX 78712, USA
    Curr Cancer Drug Targets 7:484-91. 2007
  2. ncbi request reprint Physical activity and cancer prevention : pathways and targets for intervention
    Connie J Rogers
    Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Sports Med 38:271-96. 2008
  3. doi request reprint Dietary energy balance modulates epithelial-to-mesenchymal transition and tumor progression in murine claudin-low and basal-like mammary tumor models
    Sarah M Dunlap
    Department of Nutritional Sciences, University of Texas, Austin, TX, USA
    Cancer Prev Res (Phila) 5:930-42. 2012
  4. doi request reprint Reducing the weight of cancer: mechanistic targets for breaking the obesity-carcinogenesis link
    Stephen D Hursting
    Department of Nutritional Sciences, University of Texas, Austin, TX, USA
    Best Pract Res Clin Endocrinol Metab 22:659-69. 2008
  5. doi request reprint Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research
    Stephen D Hursting
    Department of Nutritional Sciences, The University of Texas at Austin, 103 West 24th Street, Austin, TX 78712, USA
    Carcinogenesis 31:83-9. 2010
  6. ncbi request reprint Carbohydrate versus energy restriction: effects on weight loss, body composition and metabolism
    Elizabeth A Williams
    Division of Nutritional Sciences, Department of Human Ecology at the University of Texas at Austin, Austin, TX 78712, USA
    Ann Nutr Metab 51:232-43. 2007
  7. ncbi request reprint The obesity-cancer link: lessons learned from a fatless mouse
    Stephen D Hursting
    Division of Nutritional Sciences, University of Texas, Austin, Texas, USA
    Cancer Res 67:2391-3. 2007
  8. doi request reprint Obesity provides a permissive milieu in inflammation-associated carcinogenesis: analysis of insulin and IGF pathways
    Nomeli P Nunez
    Division of Nutritional Sciences, University of Texas, Austin, TX, USA
    Methods Mol Biol 512:29-37. 2009
  9. ncbi request reprint Dietary calcium source influences body composition, glucose metabolism and hormone levels in a mouse model of postmenopausal obesity
    REBECCA E DE ANGEL
    Department of Nutritional Sciences, One University Station A2703, The University of Texas at Austin, Austin, TX 78712, U S A
    In Vivo 23:527-35. 2009
  10. pmc Energy balance, host-related factors, and cancer progression
    Stephen D Hursting
    The University of Texas, 1 University Station A2700, Painter Hall, Room 5 32, Austin, TX 78712, USA
    J Clin Oncol 28:4058-65. 2010

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Energy balance and carcinogenesis: underlying pathways and targets for intervention
    Stephen D Hursting
    Division of Nutritional Sciences, University of Texas, Austin, TX 78712, USA
    Curr Cancer Drug Targets 7:484-91. 2007
    ..The ultimate goal of this work is to provide the missing mechanistic information necessary to identify targets for the prevention and control of cancers related to or caused by excess body weight...
  2. ncbi request reprint Physical activity and cancer prevention : pathways and targets for intervention
    Connie J Rogers
    Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Sports Med 38:271-96. 2008
    ....
  3. doi request reprint Dietary energy balance modulates epithelial-to-mesenchymal transition and tumor progression in murine claudin-low and basal-like mammary tumor models
    Sarah M Dunlap
    Department of Nutritional Sciences, University of Texas, Austin, TX, USA
    Cancer Prev Res (Phila) 5:930-42. 2012
    ..EMT pathway components may represent targets for breaking the obesity-breast cancer link, particularly for preventing and/or controlling TIC-enriched subtypes such as claudin-low breast cancer...
  4. doi request reprint Reducing the weight of cancer: mechanistic targets for breaking the obesity-carcinogenesis link
    Stephen D Hursting
    Department of Nutritional Sciences, University of Texas, Austin, TX, USA
    Best Pract Res Clin Endocrinol Metab 22:659-69. 2008
    ..The ultimate goal of this work is to provide the missing mechanistic information necessary to identify targets for the prevention and control of cancers related to or caused by excess body weight...
  5. doi request reprint Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research
    Stephen D Hursting
    Department of Nutritional Sciences, The University of Texas at Austin, 103 West 24th Street, Austin, TX 78712, USA
    Carcinogenesis 31:83-9. 2010
    ..These approaches will facilitate the translation of CR research into effective strategies for cancer prevention in humans...
  6. ncbi request reprint Carbohydrate versus energy restriction: effects on weight loss, body composition and metabolism
    Elizabeth A Williams
    Division of Nutritional Sciences, Department of Human Ecology at the University of Texas at Austin, Austin, TX 78712, USA
    Ann Nutr Metab 51:232-43. 2007
    ..To compare weight loss, body composition, and metabolic changes in response to carbohydrate versus dietary energy restriction (DER) in obese mice...
  7. ncbi request reprint The obesity-cancer link: lessons learned from a fatless mouse
    Stephen D Hursting
    Division of Nutritional Sciences, University of Texas, Austin, Texas, USA
    Cancer Res 67:2391-3. 2007
    ..We postulate that the pathways associated with insulin resistance and inflammation, rather than adipocyte-derived factors, may represent key prevention and therapeutic targets for disrupting the obesity-cancer link...
  8. doi request reprint Obesity provides a permissive milieu in inflammation-associated carcinogenesis: analysis of insulin and IGF pathways
    Nomeli P Nunez
    Division of Nutritional Sciences, University of Texas, Austin, TX, USA
    Methods Mol Biol 512:29-37. 2009
    ..Therefore, we postulate that the pathways associated with insulin resistance and inflammation, rather than adipocyte-derived factors, may represent key prevention or therapeutic targets for disrupting the obesity-cancer link...
  9. ncbi request reprint Dietary calcium source influences body composition, glucose metabolism and hormone levels in a mouse model of postmenopausal obesity
    REBECCA E DE ANGEL
    Department of Nutritional Sciences, One University Station A2703, The University of Texas at Austin, Austin, TX 78712, U S A
    In Vivo 23:527-35. 2009
    ..Epidemiologic data suggest that dietary calcium, particularly from dairy products, can decrease weight gain. The aim of this study was to evaluate effects of different calcium sources in a mouse model of postmenopausal obesity...
  10. pmc Energy balance, host-related factors, and cancer progression
    Stephen D Hursting
    The University of Texas, 1 University Station A2700, Painter Hall, Room 5 32, Austin, TX 78712, USA
    J Clin Oncol 28:4058-65. 2010
    ....
  11. doi request reprint Inflammatory talk: linking obesity, NF-κB, and Aromatase
    Stephen D Hursting
    Department of Nutritional Sciences, University of Texas at Austin, Dell Pediatric Research Institute, Austin, TX 78723, USA
    Cancer Prev Res (Phila) 4:285-7. 2011
    ....
  12. doi request reprint Low-carbohydrate diet versus caloric restriction: effects on weight loss, hormones, and colon tumor growth in obese mice
    Karrie E Wheatley
    Department of Human Ecology, Division of Nutritional Sciences, The University of Texas at Austin, TX 78712, USA
    Nutr Cancer 60:61-8. 2008
    ..IGF-I levels were lower in the LC group (320.0 +/- 39.9 ng/ml) than the HF group, but tumor growth did not differ. These data suggest LC diets do not slow colon tumor growth in obese mice...
  13. pmc Genetic reduction of insulin-like growth factor-1 mimics the anticancer effects of calorie restriction on cyclooxygenase-2-driven pancreatic neoplasia
    Laura M Lashinger
    Department of Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Smithville, Texas, USA
    Cancer Prev Res (Phila) 4:1030-40. 2011
    ....
  14. pmc Rapamycin partially mimics the anticancer effects of calorie restriction in a murine model of pancreatic cancer
    Laura M Lashinger
    Department of Molecular Carcinogenesis, University of Texas M D Anderson Cancer Center, Smithville, Texas, USA
    Cancer Prev Res (Phila) 4:1041-51. 2011
    ..These findings suggest that rapamycin partially mimics the anticancer effects of CR on tumor growth in a murine model of pancreatic cancer...
  15. doi request reprint Urothelial overexpression of insulin-like growth factor-1 increases susceptibility to p-cresidine-induced bladder carcinogenesis in transgenic mice
    Stephen D Hursting
    Department of Nutritional Sciences, University of Texas at Austin, Austin, Texas 78712, USA
    Mol Carcinog 48:671-7. 2009
    ..In addition, these transgenic mice provide a useful model for studying the role of the IGF-1 pathway in bladder carcinogenesis and its prevention...
  16. doi request reprint The Translational Research Working Group developmental pathway for lifestyle alterations
    Ernest T Hawk
    National Cancer Institute, Bethesda, Maryland, USA
    Clin Cancer Res 14:5707-13. 2008
    ..This article discusses key issues associated with the development of lifestyle alterations in light of the pathway...
  17. doi request reprint Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating insulin-like growth factor I levels
    Tricia Moore
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas, USA
    Cancer Res 68:3680-8. 2008
    ..The current data also suggest that reduced circulating IGF-I levels which occur as a result of calorie restriction may lead to the inhibition of skin tumorigenesis, at least in part, by a similar mechanism...
  18. ncbi request reprint Environmental exposure, DNA methylation, and gene regulation: lessons from diethylstilbesterol-induced cancers
    Shuanfang Li
    Laboratory of Biosystems and Cancer, National Cancer Institute, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 983:161-9. 2003
    ..We suggest that DNA methylation status may be influenced by environmental exposures in early life, leading to increased risk of cancer in adulthood...
  19. ncbi request reprint Effects of energy balance on cancer in genetically altered mice
    Arti C Patel
    Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    J Nutr 134:3394S-3398S. 2004
    ....
  20. ncbi request reprint Effects of alcohol on insulin-like growth factor I and insulin-like growth factor binding protein 3 in postmenopausal women
    Jackie A Lavigne
    National Cancer Institute, Bethesda, MD 20892 4264, USA
    Am J Clin Nutr 81:503-7. 2005
    ..Studies have suggested that alcohol may affect IGF-I or IGFBP-3; however, controlled feeding studies to assess alcohol's effects on IGF-I or IGFBP-3 have not been conducted...
  21. ncbi request reprint Adapting postdoctoral training to interdisciplinary science in the 21st century: the Cancer Prevention Fellowship Program at the National Cancer Institute
    Shine Chang
    Office of Preventive Oncology, Division of Cancer Prevention, National Cancer Institute, NIH DHHS, 6120 Executive Boulevard, Suite T 41 MSC 7361, Bethesda, MD 20892 7361, USA
    Acad Med 80:261-5. 2005
    ....
  22. ncbi request reprint Phenotypic effects of calorie restriction and insulin-like growth factor-1 treatment on body composition and bone mineral density of C57BL/6 mice: implications for cancer prevention
    David Berrigan
    Applied Research Program Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892, USA
    In Vivo 19:667-74. 2005
    ..Some anti-carcinogenic effects of CR are mediated by decreased circulating insulin-like growth factor-1 (IGF-1); however, IGF-1 also plays an important role in regulating growth and bone density...
  23. ncbi request reprint Nutrition and cancer prevention: targets, strategies, and the importance of early life interventions
    Stephen D Hursting
    Laboratory of Biosystems and Cancer, Center for Cancer Research, Bethesda, MD, USA
    Nestle Nutr Workshop Ser Pediatr Program 57:153-202. 2006
  24. ncbi request reprint Negative energy balance induced by voluntary wheel running inhibits polyp development in APCMin mice
    Lisa H Colbert
    Department of Kinesiology, University of Wisconsin Madison, WI, USA
    Carcinogenesis 27:2103-7. 2006
    ..Although EX affected IGF-1 and corticosterone, neither marker was related to total polyp number...
  25. ncbi request reprint Evaluating research training outcomes: experience from the cancer prevention fellowship program at the National Cancer Institute
    Graca M Dores
    Office of Preventive Oncology, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7361, USA
    Acad Med 81:535-41. 2006
    ....
  26. pmc Combination of physical activity, nutrition, or other metabolic factors and vaccine response
    Kenneth W Hance
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 1750, USA
    Front Biosci 12:4997-5029. 2007
    ..In summary, a number of energy balance- and nutrition-related interventions are viable candidates for further study in combination with cancer vaccines...
  27. ncbi request reprint Inhibition of prostate cancer growth by muscadine grape skin extract and resveratrol through distinct mechanisms
    Tamaro S Hudson
    Laboratory of Cellular Regulation and Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Cancer Res 67:8396-405. 2007
    ....
  28. ncbi request reprint Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans
    Stephen D Hursting
    Laboratory of Biosystems and Cancer, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Annu Rev Med 54:131-52. 2003
    ..These approaches will facilitate the translation of CR research into strategies for effective human chronic disease prevention...

Research Grants2

  1. Akt/mTOR Signaling in Energy Balance Modulation of Epithelial Carcinogenesis
    Stephen Hursting; Fiscal Year: 2009
    ..Furthermore, the proposed studies will establish molecular mechanisms underlying the anticancer effects of CR, especially in the putative target cells (i.e., stem cells) for cancer development. ..
  2. Akt/mTOR Signaling in Energy Balance Modulation of Epithelial Carcinogenesis
    STEPHEN DAVID HURSTING; Fiscal Year: 2010
    ..Furthermore, the proposed studies will establish molecular mechanisms underlying the anticancer effects of CR, especially in the putative target cells (i.e., stem cells) for cancer development. ..