Research Topics
| STEPHEN DAVID HURSTINGSummaryAffiliation: University of Texas Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Energy balance and carcinogenesis: underlying pathways and targets for interventionStephen D Hursting
Division of Nutritional Sciences, University of Texas, Austin, TX 78712, USA
Curr Cancer Drug Targets 7:484-91. 2007..The ultimate goal of this work is to provide the missing mechanistic information necessary to identify targets for the prevention and control of cancers related to or caused by excess body weight...- Physical activity and cancer prevention : pathways and targets for interventionConnie J Rogers
Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
Sports Med 38:271-96. 2008.... 
Dietary energy balance modulates epithelial-to-mesenchymal transition and tumor progression in murine claudin-low and basal-like mammary tumor modelsSarah M Dunlap
Department of Nutritional Sciences, University of Texas, Austin, TX, USA
Cancer Prev Res (Phila) 5:930-42. 2012..EMT pathway components may represent targets for breaking the obesity-breast cancer link, particularly for preventing and/or controlling TIC-enriched subtypes such as claudin-low breast cancer...- Reducing the weight of cancer: mechanistic targets for breaking the obesity-carcinogenesis linkStephen D Hursting
Department of Nutritional Sciences, University of Texas, Austin, TX, USA
Best Pract Res Clin Endocrinol Metab 22:659-69. 2008..The ultimate goal of this work is to provide the missing mechanistic information necessary to identify targets for the prevention and control of cancers related to or caused by excess body weight... - Calories and carcinogenesis: lessons learned from 30 years of calorie restriction researchStephen D Hursting
Department of Nutritional Sciences, The University of Texas at Austin, 103 West 24th Street, Austin, TX 78712, USA
Carcinogenesis 31:83-9. 2010..These approaches will facilitate the translation of CR research into effective strategies for cancer prevention in humans... - Carbohydrate versus energy restriction: effects on weight loss, body composition and metabolismElizabeth A Williams
Division of Nutritional Sciences, Department of Human Ecology at the University of Texas at Austin, Austin, TX 78712, USA
Ann Nutr Metab 51:232-43. 2007..To compare weight loss, body composition, and metabolic changes in response to carbohydrate versus dietary energy restriction (DER) in obese mice... - The obesity-cancer link: lessons learned from a fatless mouseStephen D Hursting
Division of Nutritional Sciences, University of Texas, Austin, Texas, USA
Cancer Res 67:2391-3. 2007..We postulate that the pathways associated with insulin resistance and inflammation, rather than adipocyte-derived factors, may represent key prevention and therapeutic targets for disrupting the obesity-cancer link... - Obesity provides a permissive milieu in inflammation-associated carcinogenesis: analysis of insulin and IGF pathwaysNomeli P Nunez
Division of Nutritional Sciences, University of Texas, Austin, TX, USA
Methods Mol Biol 512:29-37. 2009..Therefore, we postulate that the pathways associated with insulin resistance and inflammation, rather than adipocyte-derived factors, may represent key prevention or therapeutic targets for disrupting the obesity-cancer link... - Dietary calcium source influences body composition, glucose metabolism and hormone levels in a mouse model of postmenopausal obesityREBECCA E DE ANGEL
Department of Nutritional Sciences, One University Station A2703, The University of Texas at Austin, Austin, TX 78712, U S A
In Vivo 23:527-35. 2009..Epidemiologic data suggest that dietary calcium, particularly from dairy products, can decrease weight gain. The aim of this study was to evaluate effects of different calcium sources in a mouse model of postmenopausal obesity... 
Energy balance, host-related factors, and cancer progressionStephen D Hursting
The University of Texas, 1 University Station A2700, Painter Hall, Room 5 32, Austin, TX 78712, USA
J Clin Oncol 28:4058-65. 2010....- Inflammatory talk: linking obesity, NF-κB, and AromataseStephen D Hursting
Department of Nutritional Sciences, University of Texas at Austin, Dell Pediatric Research Institute, Austin, TX 78723, USA
Cancer Prev Res (Phila) 4:285-7. 2011.... - Low-carbohydrate diet versus caloric restriction: effects on weight loss, hormones, and colon tumor growth in obese miceKarrie E Wheatley
Department of Human Ecology, Division of Nutritional Sciences, The University of Texas at Austin, TX 78712, USA
Nutr Cancer 60:61-8. 2008..IGF-I levels were lower in the LC group (320.0 +/- 39.9 ng/ml) than the HF group, but tumor growth did not differ. These data suggest LC diets do not slow colon tumor growth in obese mice... - Genetic reduction of insulin-like growth factor-1 mimics the anticancer effects of calorie restriction on cyclooxygenase-2-driven pancreatic neoplasiaLaura M Lashinger
Department of Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Smithville, Texas, USA
Cancer Prev Res (Phila) 4:1030-40. 2011.... - Rapamycin partially mimics the anticancer effects of calorie restriction in a murine model of pancreatic cancerLaura M Lashinger
Department of Molecular Carcinogenesis, University of Texas M D Anderson Cancer Center, Smithville, Texas, USA
Cancer Prev Res (Phila) 4:1041-51. 2011..These findings suggest that rapamycin partially mimics the anticancer effects of CR on tumor growth in a murine model of pancreatic cancer... - Urothelial overexpression of insulin-like growth factor-1 increases susceptibility to p-cresidine-induced bladder carcinogenesis in transgenic miceStephen D Hursting
Department of Nutritional Sciences, University of Texas at Austin, Austin, Texas 78712, USA
Mol Carcinog 48:671-7. 2009..In addition, these transgenic mice provide a useful model for studying the role of the IGF-1 pathway in bladder carcinogenesis and its prevention... - The Translational Research Working Group developmental pathway for lifestyle alterationsErnest T Hawk
National Cancer Institute, Bethesda, Maryland, USA
Clin Cancer Res 14:5707-13. 2008..This article discusses key issues associated with the development of lifestyle alterations in light of the pathway... - Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating insulin-like growth factor I levelsTricia Moore
The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas, USA
Cancer Res 68:3680-8. 2008..The current data also suggest that reduced circulating IGF-I levels which occur as a result of calorie restriction may lead to the inhibition of skin tumorigenesis, at least in part, by a similar mechanism... - Environmental exposure, DNA methylation, and gene regulation: lessons from diethylstilbesterol-induced cancersShuanfang Li
Laboratory of Biosystems and Cancer, National Cancer Institute, Bethesda, Maryland 20892, USA
Ann N Y Acad Sci 983:161-9. 2003..We suggest that DNA methylation status may be influenced by environmental exposures in early life, leading to increased risk of cancer in adulthood... - Effects of energy balance on cancer in genetically altered miceArti C Patel
Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
J Nutr 134:3394S-3398S. 2004.... - Effects of alcohol on insulin-like growth factor I and insulin-like growth factor binding protein 3 in postmenopausal womenJackie A Lavigne
National Cancer Institute, Bethesda, MD 20892 4264, USA
Am J Clin Nutr 81:503-7. 2005..Studies have suggested that alcohol may affect IGF-I or IGFBP-3; however, controlled feeding studies to assess alcohol's effects on IGF-I or IGFBP-3 have not been conducted... - Adapting postdoctoral training to interdisciplinary science in the 21st century: the Cancer Prevention Fellowship Program at the National Cancer InstituteShine Chang
Office of Preventive Oncology, Division of Cancer Prevention, National Cancer Institute, NIH DHHS, 6120 Executive Boulevard, Suite T 41 MSC 7361, Bethesda, MD 20892 7361, USA
Acad Med 80:261-5. 2005.... - Phenotypic effects of calorie restriction and insulin-like growth factor-1 treatment on body composition and bone mineral density of C57BL/6 mice: implications for cancer preventionDavid Berrigan
Applied Research Program Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892, USA
In Vivo 19:667-74. 2005..Some anti-carcinogenic effects of CR are mediated by decreased circulating insulin-like growth factor-1 (IGF-1); however, IGF-1 also plays an important role in regulating growth and bone density... - Nutrition and cancer prevention: targets, strategies, and the importance of early life interventionsStephen D Hursting
Laboratory of Biosystems and Cancer, Center for Cancer Research, Bethesda, MD, USA
Nestle Nutr Workshop Ser Pediatr Program 57:153-202. 2006 - Negative energy balance induced by voluntary wheel running inhibits polyp development in APCMin miceLisa H Colbert
Department of Kinesiology, University of Wisconsin Madison, WI, USA
Carcinogenesis 27:2103-7. 2006..Although EX affected IGF-1 and corticosterone, neither marker was related to total polyp number... - Evaluating research training outcomes: experience from the cancer prevention fellowship program at the National Cancer InstituteGraca M Dores
Office of Preventive Oncology, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7361, USA
Acad Med 81:535-41. 2006.... - Combination of physical activity, nutrition, or other metabolic factors and vaccine responseKenneth W Hance
Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 1750, USA
Front Biosci 12:4997-5029. 2007..In summary, a number of energy balance- and nutrition-related interventions are viable candidates for further study in combination with cancer vaccines... - Inhibition of prostate cancer growth by muscadine grape skin extract and resveratrol through distinct mechanismsTamaro S Hudson
Laboratory of Cellular Regulation and Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Cancer Res 67:8396-405. 2007.... - Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humansStephen D Hursting
Laboratory of Biosystems and Cancer, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
Annu Rev Med 54:131-52. 2003..These approaches will facilitate the translation of CR research into strategies for effective human chronic disease prevention...
Research Grants
- Akt/mTOR Signaling in Energy Balance Modulation of Epithelial CarcinogenesisStephen Hursting; Fiscal Year: 2009..Furthermore, the proposed studies will establish molecular mechanisms underlying the anticancer effects of CR, especially in the putative target cells (i.e., stem cells) for cancer development. ..
- Akt/mTOR Signaling in Energy Balance Modulation of Epithelial CarcinogenesisSTEPHEN DAVID HURSTING; Fiscal Year: 2010..Furthermore, the proposed studies will establish molecular mechanisms underlying the anticancer effects of CR, especially in the putative target cells (i.e., stem cells) for cancer development. ..