Theodore J Huppert

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Direct estimation of evoked hemoglobin changes by multimodality fusion imaging
    Theodore J Huppert
    The Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 13:054031. 2008
  2. pmc Sensitivity of neural-hemodynamic coupling to alterations in cerebral blood flow during hypercapnia
    Theodore J Huppert
    University of Pittsburgh, Department of Radiology, 200 Lothrop Street, Pittsburgh, Pennsylvania 15213, USA
    J Biomed Opt 14:044038. 2009
  3. pmc HomER: a review of time-series analysis methods for near-infrared spectroscopy of the brain
    Theodore J Huppert
    Departments of Radiology and Bioengineering, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Appl Opt 48:D280-98. 2009
  4. pmc Estimating cerebral oxygen metabolism from fMRI with a dynamic multicompartment Windkessel model
    Theodore J Huppert
    Department of Radiology, University of Pittsburgh, UPMC Presbyterian, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Hum Brain Mapp 30:1548-67. 2009
  5. pmc Near-infrared spectroscopy measurement of the pulsatile component of cerebral blood flow and volume from arterial oscillations
    George Themelis
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 12:014033. 2007
  6. pmc A vascular anatomical network model of the spatio-temporal response to brain activation
    David A Boas
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Neuroimage 40:1116-29. 2008
  7. pmc Quantitative spatial comparison of diffuse optical imaging with blood oxygen level-dependent and arterial spin labeling-based functional magnetic resonance imaging
    Theodore J Huppert
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 11:064018. 2006
  8. ncbi request reprint Physiological system identification with the Kalman filter in diffuse optical tomography
    Solomon Gilbert Diamond
    Massachusetts General Hospital, Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Med Image Comput Comput Assist Interv 8:649-56. 2005
  9. pmc Diffuse optical imaging of the whole head
    Maria Angela Franceschini
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, 13th Street, Bldg 149 RM 2301, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 11:054007. 2006
  10. pmc Calibrating the BOLD signal during a motor task using an extended fusion model incorporating DOT, BOLD and ASL data
    Meryem A Yücel
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Neuroimage 61:1268-76. 2012

Detail Information

Publications14

  1. pmc Direct estimation of evoked hemoglobin changes by multimodality fusion imaging
    Theodore J Huppert
    The Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 13:054031. 2008
    ..Using this multimodal method, we estimate the calibration of the 3 tesla BOLD signal to be -0.55%+/-0.40% signal change per micromolar change of deoxyhemoglobin...
  2. pmc Sensitivity of neural-hemodynamic coupling to alterations in cerebral blood flow during hypercapnia
    Theodore J Huppert
    University of Pittsburgh, Department of Radiology, 200 Lothrop Street, Pittsburgh, Pennsylvania 15213, USA
    J Biomed Opt 14:044038. 2009
    ..We conclude that evoked changes in blood flow and cerebral oxygen metabolism are more closely associated with underlying evoked neuronal responses...
  3. pmc HomER: a review of time-series analysis methods for near-infrared spectroscopy of the brain
    Theodore J Huppert
    Departments of Radiology and Bioengineering, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Appl Opt 48:D280-98. 2009
    ..These methods are described within the context of the MATLAB-based graphical user interface program, HomER, which we have developed and distributed to facilitate the processing of optical functional brain data...
  4. pmc Estimating cerebral oxygen metabolism from fMRI with a dynamic multicompartment Windkessel model
    Theodore J Huppert
    Department of Radiology, University of Pittsburgh, UPMC Presbyterian, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Hum Brain Mapp 30:1548-67. 2009
    ....
  5. pmc Near-infrared spectroscopy measurement of the pulsatile component of cerebral blood flow and volume from arterial oscillations
    George Themelis
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 12:014033. 2007
    ..Preliminary results show the potential of this NIRS method to measure pCBF and pCBV relative changes in neonatal pigs...
  6. pmc A vascular anatomical network model of the spatio-temporal response to brain activation
    David A Boas
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Neuroimage 40:1116-29. 2008
    ....
  7. pmc Quantitative spatial comparison of diffuse optical imaging with blood oxygen level-dependent and arterial spin labeling-based functional magnetic resonance imaging
    Theodore J Huppert
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 11:064018. 2006
    ..73, p=5x10(-6) and R=0.71, p=9x10(-6), respectively) than the flow to deoxyhemoglobin spatial correlation (R=0.26, p=0.10)...
  8. ncbi request reprint Physiological system identification with the Kalman filter in diffuse optical tomography
    Solomon Gilbert Diamond
    Massachusetts General Hospital, Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Med Image Comput Comput Assist Interv 8:649-56. 2005
    ..Cardiovascular dynamics also affect the blood oxygen dependent (BOLD) signal in functional magnetic resonance imaging (fMRI). This Kalman filter framework for DOT may be adapted for BOLD fMRI analysis and multimodal studies...
  9. pmc Diffuse optical imaging of the whole head
    Maria Angela Franceschini
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, 13th Street, Bldg 149 RM 2301, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 11:054007. 2006
    ....
  10. pmc Calibrating the BOLD signal during a motor task using an extended fusion model incorporating DOT, BOLD and ASL data
    Meryem A Yücel
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Neuroimage 61:1268-76. 2012
    ..Our method yields an independent measurement of M, which provides an alternative measurement to validate the hypercapnic calibration of the BOLD signal...
  11. ncbi request reprint Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imaging
    Danny K Joseph
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, MA 02129, USA
    Appl Opt 45:8142-51. 2006
    ..Experimental results showing the application of this instrument for imaging human brain activation are also presented. The observed improvement in spatial resolution is confirmed by functional magnetic resonance imaging...
  12. pmc Dynamic physiological modeling for functional diffuse optical tomography
    Solomon Gilbert Diamond
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Neuroimage 30:88-101. 2006
    ..This state-space approach to DOT analysis could be extended to BOLD fMRI analysis, multimodal studies and real-time analysis...
  13. pmc Quantification of the cortical contribution to the NIRS signal over the motor cortex using concurrent NIRS-fMRI measurements
    Louis Gagnon
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Neuroimage 59:3933-40. 2012
    ..While different stimuli will result in different pial vein contributions, our finger tapping results do reveal the importance of considering the pial contribution...
  14. pmc A multicompartment vascular model for inferring baseline and functional changes in cerebral oxygen metabolism and arterial dilation
    Theodore J Huppert
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    J Cereb Blood Flow Metab 27:1262-79. 2007
    ..Finally, we compare this model to earlier work and find that the multicompartment model more accurately describes the observed oxygenation changes when compared with a single compartment version...