Research Topics
Species | Christopher HunterSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Cutting edge: identification of c-Rel-dependent and -independent pathways of IL-12 production during infectious and inflammatory stimuliNicola Mason
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 168:2590-4. 2002..Together these studies reveal the presence of c-Rel-dependent pathways critical for IL-12p40 production in response to inflammatory stimuli and demonstrate a novel c-Rel-independent pathway of IL-12p40 production during toxoplasmosis...- Cutting edge: NF-kappa B2 is a negative regulator of dendritic cell functionKendra Speirs
Department of Pathobiology, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
J Immunol 172:752-6. 2004..These studies identify a novel role for NF-kappaB2 in the negative regulation of RelB-induced DC maturation, with critical consequences for the regulation of adaptive immune responses... 
Interleukin-27: balancing protective and pathological immunityChristopher A Hunter
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 380 South University Avenue, Philadelphia, PA 19104 4539, USA
Immunity 37:960-9. 2012....- Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10Jason S Stumhofer
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nat Immunol 8:1363-71. 2007..This effect was dependent on the transcription factors STAT1 and STAT3 for IL-27 and on STAT3 for IL-6. Our studies identify a previously unknown pathway that allows the immune system to temper inflammatory responses... - gp130 at the nexus of inflammation, autoimmunity, and cancerJ S Silver
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19143, USA
J Leukoc Biol 88:1145-56. 2010..The aim of this review is to discuss the role of gp130 in promoting or preventing the development of autoimmunity and cancer, two processes that are associated with aberrant inflammatory responses... - An essential role of Th1 responses and interferon gamma in infection-mediated suppression of neoplastic growthErinn B Rankin
Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6051, USA
Cancer Biol Ther 2:687-93. 2003..Interestingly, the enhancement was also apparent in uninfected animals suggesting that IFN-gamma and its anti-angiogenic effects underlie both infection-dependent and -independent tumor surveillance... - TLR ligands can activate dendritic cells to provide a MyD88-dependent negative signal for Th2 cell developmentJie Sun
Department of Pathobiology, University of Pennsylvania, Philadelphia 19104, USA
J Immunol 174:742-51. 2005..Our findings indicate that DCs can provide potent negative as well as positive instruction for Th response polarization, and that these instructional signals are distinct and independent... - Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tractAlexander M Owyang
Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
J Exp Med 203:843-9. 2006..Therefore, IL-25 is not only a critical mediator of type 2 immunity, but is also required for the regulation of inflammation in the gastrointestinal tract... - The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunityDavid Artis
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 173:5626-34. 2004..In addition, IL-27 directly suppressed CD4+ T cell proliferation and Th2 cytokine production. Together, these studies identify a novel role for IL-27/WSX-1 in limiting innate and adaptive components of type 2 immunity at mucosal sites... - NF-kappa B1 is required for optimal CD4+ Th1 cell development and resistance to Leishmania majorDavid Artis
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
J Immunol 170:1995-2003. 2003..Taken together, these results identify a novel role for NF-kappaB1 in CD4(+) T cell proliferation and the development of Th1 cell responses required for protective immunity against intracellular pathogens... - IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12Linda A Lieberman
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 173:1887-93. 2004..Together, these studies indicate that IL-12, not IL-23, plays a dominant role in resistance to toxoplasmosis but, in the absence of IL-12, IL-23 can provide a limited mechanism of resistance to this infection... - T cell-intrinsic expression of c-Rel regulates Th1 cell responses essential for resistance to Toxoplasma gondiiNicola J Mason
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 172:3704-11. 2004..Together, these studies indicate that although c-Rel is an important regulator of innate immune responses, it also plays an important role in optimization and maintenance of adaptive T cell responses during infection... 
IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBDAlejandro V Villarino
Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
Int Immunol 20:739-52. 2008..Taken together, these studies demonstrate that, in the absence of IL-10, IL-27 can promote T(h)1-type and suppress T(h)2-type intestinal inflammation but, ultimately, is not required for the development of inflammatory bowel disease...- IL-27 regulates homeostasis of the intestinal CD4+ effector T cell pool and limits intestinal inflammation in a murine model of colitisAmy E Troy
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 183:2037-44. 2009..Collectively, these data identify a role for IL-27-IL-27R interaction in controlling the homeostasis of the intestinal T cell pool and in limiting intestinal inflammation through regulation of innate and adaptive immune cell function... - Helminth antigens modulate TLR-initiated dendritic cell activationColleen M Kane
Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
J Immunol 173:7454-61. 2004..These findings indicate that SEA exerts potent anti-inflammatory effects by directly regulating the ability of DC to respond to TLR ligands... - New lessons from old pathogens: what parasitic infections have taught us about the role of nuclear factor-kappaB in the regulation of immunityNicola J Mason
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
Immunol Rev 201:48-56. 2004..Thus, studies with models of parasitic infection have revealed that individual NF-kappaB family members perform distinct, nonoverlapping, and biologically significant functions in the regulation of immunity and inflammation... - Plasmacytoid dendritic cells are activated by Toxoplasma gondii to present antigen and produce cytokinesMarion Pepper
Department of Pathobiology, University of Pennsylvania, 380 South University Avenue, Philadelphia, PA 19104, USA
J Immunol 180:6229-36. 2008..Together these studies suggest that pDCs are a prominent DC subset involved in the initial stages of T. gondii infection, presenting parasite Ags and producing cytokines that are important for controlling infection... - Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiationBrendan A Hilliard
Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 110:843-50. 2002..Thus, unlike NF-kappaB1, which selectively regulates Th2 cell differentiation, c-Rel is essential for Th1 cell differentiation and Th1 cell-mediated autoimmune inflammation... - A role for inducible costimulator protein in the CD28- independent mechanism of resistance to Toxoplasma gondiiEric N Villegas
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 169:937-43. 2002..gondii and suggest that ICOS and CD28 are parallel costimulatory pathways, either of which is sufficient to mediate resistance to this intracellular pathogen... - Positive and negative regulation of the IL-27 receptor during lymphoid cell activationAlejandro V Villarino
Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, and Wistar Institute, Philadelphia, PA 19104, USA
J Immunol 174:7684-91. 2005.... - Cutting edge: early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infectionDavid Artis
Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
J Immunol 172:4672-5. 2004..major. Thus, the requirement for WSX-1 signaling in Th type 1 cell differentiation is restricted to conditions in which IL-4 is produced... - Contribution of interleukin-12 (IL-12) and the CD28/B7 and CD40/CD40 ligand pathways to the development of a pathological T-cell response in IL-10-deficient miceUlrike Wille
School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
Infect Immun 70:6940-7. 2002..Together, these data suggest that the CD28/B7 interaction has a central role in the development of a pathological T-cell response in IL-10 KO mice, which is distinct from the role of the CD40/CD40L and IL-12 pathways... - Opposing roles of NF-kappaB family members in the regulation of NK cell proliferation and production of IFN-gammaCristina M Tato
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104 6008, USA
Int Immunol 18:505-13. 2006..Together, these studies define distinct roles for c-Rel and p50 in the function of NK cells... - The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infectionAlejandro Villarino
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St, Philadelphia, PA 19104, USA
Immunity 19:645-55. 2003.... - B7RP-1-ICOS interactions are required for optimal infection-induced expansion of CD4+ Th1 and Th2 responsesEmma H Wilson
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 177:2365-72. 2006..Taken together, these data are consistent with a model in which ICOS is not involved in dictating polarity of the Th response but rather regulates the expansion of these subsets... - Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous systemJason S Stumhofer
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6008, USA
Nat Immunol 7:937-45. 2006..Thus IL-27, a potent inhibitor of T(H)-17 cell development, may be a useful target for treating inflammatory diseases mediated by these cells... - Dendritic cell-intrinsic expression of NF-kappa B1 is required to promote optimal Th2 cell differentiationDavid Artis
Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, 19104, USA
J Immunol 174:7154-9. 2005..Taken together, these studies identify a novel requirement for DC-intrinsic expression of NF-kappaB1 in regulating the MAPK pathway and governing the competence of DC to instruct Th2 cell differentiation... - Interleukin-15-deficient mice develop protective immunity to Toxoplasma gondiiLinda A Lieberman
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
Infect Immun 72:6729-32. 2004..The studies presented here reveal that IL-15 is not required for infection-induced expansion of NK or CD8+ T cells. Furthermore, IL-15-/- mice develop long-term protective immunity to this pathogen... - The role of IL-27 in the development of T-cell responses during parasitic infectionsChristopher A Hunter
Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
Immunol Rev 202:106-14. 2004.... - Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signalsAlejandro V Villarino
Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
J Exp Med 204:65-71. 2007.... - Virulence of Toxoplasma gondii is associated with distinct dendritic cell responses and reduced numbers of activated CD8+ T cellsElia D Tait
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Room H310F Hill Pavilion, 380 South University Avenue, Philadelphia, PA 19104, USA
J Immunol 185:1502-12. 2010..Together, these data are consistent with a model of immunity to T. gondii in which strain-dependent DC responses shape the generation of Ag-specific CD8(+) T cells and determine the outcome of infection... - Differential requirement for NF-kappa B family members in control of helminth infection and intestinal inflammationDavid Artis
Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104, USA
J Immunol 169:4481-7. 2002..muris and the control of infection-induced intestinal inflammation... - Regulation of CD8+ T cell responses to infection with parasitic protozoaKimberly A Jordan
Department of Pathobiology, University of Pennsylvania, 380 South University Avenue, Philadelphia, PA 19104, USA
Exp Parasitol 126:318-25. 2010.... - IL-6 promotes NK cell production of IL-17 during toxoplasmosisSara T Passos
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 184:1776-83. 2010.... - IL-27 limits IL-2 production during Th1 differentiationAlejandro V Villarino
Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
J Immunol 176:237-47. 2006.... - A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitisEmma H Wilson
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6008, USA
J Neuroimmunol 165:63-74. 2005..Together these results point to a vital role for IL-10 in the control of CD4(+) T cell mediated inflammation in the brain during TE... - New IL-12-family members: IL-23 and IL-27, cytokines with divergent functionsChristopher A Hunter
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
Nat Rev Immunol 5:521-31. 2005..By contrast, IL-27 has a role in limiting the intensity and duration of adaptive immune responses... - Costimulation in resistance to infection and development of immune pathology: lessons from toxoplasmaChristopher A Hunter
Immunology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA
Immunol Res 27:331-40. 2003.... - NF-kappa B2 is required for optimal CD40-induced IL-12 production but dispensable for Th1 cell DifferentiationKendra Speirs
Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 168:4406-13. 2002..major is the result of an IL-12 deficiency, and we provide evidence for a specific impairment in CD40-induced IL-12 production by macrophages lacking this transcription factor... - Dendritic cells and immunity to leishmaniasis and toxoplasmosisPhillip Scott
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
Curr Opin Immunol 14:466-70. 2002..Interestingly, there appear to be differences in the DC activation pathways utilized by these two intracellular protozoa which also may differ from the pathways utilized by bacteria... - Infection and cancer: the common veinAndrei Thomas-Tikhonenko
Department of Pathobiology, University of Pennsylvania, 3800 Spruce Street, Philadelphia 19104 6051, USA
Cytokine Growth Factor Rev 14:67-77. 2003..In this review, we will discuss recent studies that implicate anti-angiogenesis in infection-mediated tumor suppression and suggest that this mechanism could also complement cytotoxic immunity arising from the use of cancer vaccines... - Susceptibility of interleukin-2-deficient mice to Toxoplasma gondii is associated with a defect in the production of gamma interferonEric N Villegas
Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia 19104 6050, USA
Infect Immun 70:4757-61. 2002..gondii and suggest that IL-2(-/-) mice have an intrinsic defect in their ability to activate and expand IFN-gamma-producing T cells required for resistance to T. gondii... - Presentation of Toxoplasma gondii antigens via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cellsFlorence Dzierszinski
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Infect Immun 75:5200-9. 2007..These findings associate nonprofessional APCs with the initial activation of CD8+ T cells during toxoplasmosis... - NF-kappaB1 contributes to T cell-mediated control of Toxoplasma gondii in the CNSTajie H Harris
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 380 S University Ave, Philadelphia, PA 19104, United States
J Neuroimmunol 222:19-28. 2010..These results demonstrate an intrinsic role for NF-kappaB1 in T cell-mediated immunity to Toxoplasmagondii... - Two distinct activation states of plasmacytoid dendritic cells induced by influenza virus and CpG 1826 oligonucleotideAmaya Iparraguirre
Immunology Program, The Wistar Institute, Department of Penn Bioinformatics Core, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Leukoc Biol 83:610-20. 2008..Thus, pDC display remarkable functional flexibility, which emphasizes their versatile functions in antimicrobial immunity and inflammatory processes... - Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesoderminAndrew M Intlekofer
Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Science 321:408-11. 2008..T-bet and Eomes, thus, ensure that CD8+ T cells adopt an appropriate course of intracellular rather than extracellular destruction... - Advances in understanding immunity to Toxoplasma gondiiElia D Tait
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Mem Inst Oswaldo Cruz 104:201-10. 2009..Ultimately, the challenge will be to use this information to develop new vaccines and therapies to manage disease in affected patients... - Kinetics and phenotype of vaccine-induced CD8+ T-cell responses to Toxoplasma gondiiKimberly A Jordan
Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Infect Immun 77:3894-901. 2009..gondii and identifies a critical role for CD4(+) T cells in the generation of protective CD8(+) T-cell responses... - Dynamic Imaging of CD8(+) T cells and dendritic cells during infection with Toxoplasma gondiiBeena John
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
PLoS Pathog 5:e1000505. 2009.... - Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemiaLei Zhao
Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 277:35350-6. 2002..The data provide support for a novel mechanism linking the 12/15-lipoxygenase pathway to a known immunomodulatory Th1 cytokine in atherogenesis... - 12/15-lipoxygenase-dependent myeloid production of interleukin-12 is essential for resistance to chronic toxoplasmosisMelissa K Middleton
The Wistar Institute, Immunology Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Infect Immun 77:5690-700. 2009.... - NF-kappaB family of transcription factors: central regulators of innate and adaptive immune functionsJorge Caamano
Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6008, USA
Clin Microbiol Rev 15:414-29. 2002.... - Inhibition of NF-kappa B activity in T and NK cells results in defective effector cell expansion and production of IFN-gamma required for resistance to Toxoplasma gondiiCristina M Tato
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 170:3139-46. 2003..Together, these studies reveal that inhibition of NF-kappa B activity in T and NK cells results in defective effector cell expansion and production of IFN-gamma required for resistance to T. gondii... - Cutting Edge: Innate production of IFN-gamma by NK cells is independent of epigenetic modification of the IFN-gamma promoterCristina M Tato
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 173:1514-7. 2004.... - TRAF6-dependent mitogen-activated protein kinase activation differentially regulates the production of interleukin-12 by macrophages in response to Toxoplasma gondiiNicola J Mason
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Infect Immun 72:5662-7. 2004..The studies presented here demonstrate for the first time that the production of IL-12(p40) in response to toxoplasma is dependent upon TRAF6 and p38 MAPK... - IL-10 fails to inhibit the production of IL-18 in response to inflammatory stimuliValerie P Zediak
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104 6050, USA
Cytokine 21:84-90. 2003..Together, these data indicate that IL-10 is not an inhibitor of the production of IL-18... - STAT1 plays a critical role in the regulation of antimicrobial effector mechanisms, but not in the development of Th1-type responses during toxoplasmosisLinda A Lieberman
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
J Immunol 172:457-63. 2004..Together these studies suggest that during toxoplasmosis the major role of STAT1 is not in the development of protective T cell responses, but, rather, STAT1 is important in the development of antimicrobial effector mechanisms... - The regulation and activation of CD44 by natural killer (NK) cells and its role in the production of IFN-gammaSarah L Sague
Department of Pathobiology, School of Veterinary Medicine, 226 Rosenthal Building, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
J Interferon Cytokine Res 24:301-9. 2004..Together, these studies indicate an important role for proinflammatory cytokines in the activation of CD44 on NK cells and identify a novel pathway to enhance the ability of activated NK cells to produce IFN-gamma... - Understanding the role of the CD40--CD40L interaction in resistance to parasitic infectionsEmma H Wilson
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6008, USA
Parasite Immunol 25:179-83. 2003 - The NF-kappaB signaling pathway: immune evasion and immunoregulation during toxoplasmosisSagi Shapira
Department of Pathobiology, University of Pennsylvania, Philadelphia 19104-6008, USA
Int J Parasitol 34:393-400. 2004..gondii and these transcription factors in infected cells, and highlights the role of different NF-kappaB family members during the development of a protective immune response to this pathogen... - With a little help from their friends: interleukin-21, T cells, and B cellsJonathan S Silver
Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Room 313, Hill Pavillion, 380 South University Avenue, Philadelphia, PA 19104 4539, USA
Immunity 29:7-9. 2008..2008, and Vogelzang et al., 2008) have identified a role for interleukin-21 in the development of these specialized cells and highlight questions about how this dedicated population is generated... - T cell expression of MyD88 is required for resistance to Toxoplasma gondiiDavid F LaRosa
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 105:3855-60. 2008..gondii. These observations show that, in addition to a role for MyD88 in innate responses, T cell expression of MyD88 is necessary for prolonged resistance to a pathogen... - The role of astrocytes in the immunopathogenesis of toxoplasmic encephalitisEmma H Wilson
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6008, USA
Int J Parasitol 34:543-8. 2004..gondii. The aim of this paper is to review what is known about the immune functions of astrocytes, and the possible role they may play during toxoplasmic encephalitis... - Biology of recently discovered cytokines: discerning the pro- and anti-inflammatory properties of interleukin-27Alejandro V Villarino
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Arthritis Res Ther 6:225-33. 2004.... - A role for IL-27p28 as an antagonist of gp130-mediated signalingJason S Stumhofer
University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA
Nat Immunol 11:1119-26. 2010..Thus, IL-27p28, as a natural antagonist of gp130-mediated signaling, may be useful as a therapeutic for managing inflammation mediated by cytokines that signal through gp130... - Effects of CD28 blockade on subsets of naïve T cells in catsLillian R Aronson
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010, USA
Am J Vet Res 66:483-92. 2005..The specificity of its mechanism of action suggests that (hu)CTLA4-Ig may prevent allograft rejection but leave memory responses to previously encountered antigens intact... - Early enhanced Th1 response after Leishmania amazonensis infection of C57BL/6 interleukin-10-deficient mice does not lead to resolution of infectionDouglas E Jones
Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA
Infect Immun 70:2151-8. 2002..These results indicate that although IL-10 plays a role in limiting the Th1 response during the acute infection phase, other immunomodulatory factors are responsible for limiting the Th1 response during the chronic phase... - Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitisYi Chen
Discovery Research, Schering Plough Biopharma, Palo Alto, California 94304, USA
J Clin Invest 116:1317-26. 2006..Thus, therapeutic targeting of IL-23 effectively inhibited multiple inflammatory pathways that are critical for driving CNS autoimmune inflammation... - Act1-ivating IL-17 inflammationChristopher A Hunter
Nat Immunol 8:232-4. 2007 - Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammationRobert A Kastelein
Discovery Research, Schering Plough Biopharma, Palo Alto, California 94304 1104, USA
Annu Rev Immunol 25:221-42. 2007..In this review, we aim to highlight the discoveries that have led to our current understanding of the biology of IL-23 and IL-27 in the context of their role in resistance to infection, immune-mediated inflammation, and cancer... - Regulatory pathways involved in the infection-induced production of IFN-gamma by NK cellsLinda A Lieberman
Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Rosenthal Bldg Room 226, 3800 Spruce Street, Philadelphia, PA 19104, USA
Microbes Infect 4:1531-8. 2002..This article reviews the role of cytokines, as well as costimulatory and signaling pathways, involved in NK cell responses associated with resistance to infection... - Control of effector CD8+ T cell function by the transcription factor EomesoderminErika L Pearce
Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Science 302:1041-3. 2003..We suggest that Eomesodermin is likely to complement the actions of T-bet and act as a key regulatory gene in the development of cell-mediated immunity... - Immunology. Neutrophil soldiers or Trojan Horses?Beena John
School of Veterinary Medicine, University of Pennsylvania, PA 19108, USA
Science 321:917-8. 2008 - T cell heterogeneity: firmly fixed, predominantly plastic or merely malleable?JOHN J O'SHEA
National Institutes of Health, Bethesda, Maryland 20852 1820, USA
Nat Immunol 9:450-3. 2008 - Understanding the pro- and anti-inflammatory properties of IL-27Alejandro V Villarino
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 173:715-20. 2004..Thus, the aim of this review is to discuss the pleotropic nature of the IL-27/IL-27R interaction and attempt to reconcile the pro- and anti-inflammatory properties of this immunomodulator... - The role of cytokines and their signaling pathways in the regulation of immunity to Toxoplasma gondiiLinda A Lieberman
Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, Pennsylvania, USA
Int Rev Immunol 21:373-403. 2002..It also addresses the role of cytokines in modulating other immune functions that are critical in determining the balance between a protective and a pathological immune response... - Cooperative binding at lipid bilayer membrane surfacesEmma L Doyle
Centre for Chemical Biology, Krebs Institute for Biomolecular Science, Department of Chemistry, The University of Sheffield, Sheffield, S3 7HF, U.K
J Am Chem Soc 125:4593-9. 2003..This implies that by increasing or decreasing the number of receptors in their membranes, cells can finely tune biological responses such as chemotaxis that depend on the size of the receptor-ligand clusters formed... - Host cell Ca2+ and protein kinase C regulate innate recognition of Toxoplasma gondiiKatherine S Masek
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Cell Sci 119:4565-73. 2006..Together these data identify host cell Ca(2+) and PKC as crucial regulators of the innate immune response to microbial stimuli, including T. gondii...
Research Grants
- REGULATION OF EARLY IMMUNE RESPONSE TO TOXOPLASMA GONDIIChristopher Hunter; Fiscal Year: 2007..gondii and determine whether agonists of ICOS and CD28 can be used therapeutically to prevent disease caused by this opportunistic pathogen. ..
- Role of dendritic cells in resistance to Toxoplasma.Christopher Hunter; Fiscal Year: 2007..gondii and their contribution to the development of innate and adaptive mechanisms of resistance to this pathogen. ..
- PARASITOLOGY: MODERN APPROACHESChristopher Hunter; Fiscal Year: 2007..abstract_text> ..
- Role of dendritic cells in resistance to Toxoplasma.Christopher A Hunter; Fiscal Year: 2010..gondii and their contribution to the development of innate and adaptive mechanisms of resistance to this pathogen. ..
- Regulation of the early immune response to toxoplasma gondiiChristopher A Hunter; Fiscal Year: 2010..The overall goal of this proposal is to understand how the molecule IL-27 prevents the immune system from over reacting to this infection. ..
- IMMUNOPATHOGENESIS OF TOXOPLASMIC ENCEPHALITISChristopher A Hunter; Fiscal Year: 2010..This work will broadly advance our understanding of how the immune system functions in the CNS and its role in the control of pathogens in this unique immunological site. ..
- Role of NFKB in resistance to Toxoplasma gondiiChristopher Hunter; Fiscal Year: 2005....
- IMMUNOPATHOGENESIS OF TOXOPLASMIC ENCEPHALITISChristopher Hunter; Fiscal Year: 2005....
- IMMUNOPATHOGENESIS OF TOXOPLASMIC ENCEPHALITISChristopher Hunter; Fiscal Year: 1999....
- REGULATION OF EARLY IMMUNE RESPONSE TO TOXOPLASMA GONDIIChristopher Hunter; Fiscal Year: 2001..We will analyze the mechanisms that underlie this pathogenic reaction and identify the T cell subsets involved in this "shock" reaction. ..
- IMMUNOPATHOGENESIS OF TOXOPLASMIC ENCEPHALITISChristopher Hunter; Fiscal Year: 2009..This work will broadly advance our understanding of how the immune system functions in the CNS and its role in the control of pathogens in this unique immunological site. ..