C A Hunter

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Biology of recently discovered cytokines: discerning the pro- and anti-inflammatory properties of interleukin-27
    Alejandro V Villarino
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Arthritis Res Ther 6:225-33. 2004
  2. ncbi Costimulation in resistance to infection and development of immune pathology: lessons from toxoplasma
    Christopher A Hunter
    Immunology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunol Res 27:331-40. 2003
  3. ncbi IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi
    C A Hunter
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    J Immunol 158:3311-6. 1997
  4. ncbi The role of IL-27 in the development of T-cell responses during parasitic infections
    Christopher A Hunter
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    Immunol Rev 202:106-14. 2004
  5. ncbi Type I interferons enhance production of IFN-gamma by NK cells
    C A Hunter
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104 6008, USA
    Immunol Lett 59:1-5. 1997
  6. ncbi New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions
    Christopher A Hunter
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
    Nat Rev Immunol 5:521-31. 2005
  7. pmc Blockade of costimulation prevents infection-induced immunopathology in interleukin-10-deficient mice
    E N Villegas
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania 19104 6008, USA
    Infect Immun 68:2837-44. 2000
  8. ncbi Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondii
    G Cai
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 165:2619-27. 2000
  9. ncbi The CD28/B7 interaction is not required for resistance to Toxoplasma gondii in the brain but contributes to the development of immunopathology
    G Reichmann
    Department of Pathobiology, University of Pennsylvania, Philadelphia 19104, USA
    J Immunol 163:3354-62. 1999
  10. ncbi Interleukin-10 does not contribute to the pathogenesis of a virulent strain of Toxoplasma gondii
    U Wille
    Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA, USA
    Parasite Immunol 23:291-6. 2001

Detail Information

Publications94

  1. pmc Biology of recently discovered cytokines: discerning the pro- and anti-inflammatory properties of interleukin-27
    Alejandro V Villarino
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Arthritis Res Ther 6:225-33. 2004
    ....
  2. ncbi Costimulation in resistance to infection and development of immune pathology: lessons from toxoplasma
    Christopher A Hunter
    Immunology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunol Res 27:331-40. 2003
    ....
  3. ncbi IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi
    C A Hunter
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    J Immunol 158:3311-6. 1997
    ..cruzi there is a critical requirement for IL-10 to prevent the development of a pathologic immune response associated with CD4+ T cells and overproduction of IL-12...
  4. ncbi The role of IL-27 in the development of T-cell responses during parasitic infections
    Christopher A Hunter
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    Immunol Rev 202:106-14. 2004
    ....
  5. ncbi Type I interferons enhance production of IFN-gamma by NK cells
    C A Hunter
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104 6008, USA
    Immunol Lett 59:1-5. 1997
    ..These data demonstrate that the type I interferons enhance NK cell production of IFN-gamma and suggest that they may be important in the regulation of NK cell production of IFN-gamma during infection...
  6. ncbi New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions
    Christopher A Hunter
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
    Nat Rev Immunol 5:521-31. 2005
    ..By contrast, IL-27 has a role in limiting the intensity and duration of adaptive immune responses...
  7. pmc Blockade of costimulation prevents infection-induced immunopathology in interleukin-10-deficient mice
    E N Villegas
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania 19104 6008, USA
    Infect Immun 68:2837-44. 2000
    ..Together, these results demonstrate that the CD28-B7 and CD40-CD40L interactions are involved in the development of infection-induced immunopathology in the absence of IL-10...
  8. ncbi Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondii
    G Cai
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 165:2619-27. 2000
    ..gondii. However, other signaling pathways can be used to bypass STAT4-dependent production of IFN-gamma and enhance innate resistance to T. gondii...
  9. ncbi The CD28/B7 interaction is not required for resistance to Toxoplasma gondii in the brain but contributes to the development of immunopathology
    G Reichmann
    Department of Pathobiology, University of Pennsylvania, Philadelphia 19104, USA
    J Immunol 163:3354-62. 1999
    ..Taken together, our data show that resistance to T. gondii in the brain is independent of CD28 and suggest a role for CD28 in development of immune-mediated pathology during TE...
  10. ncbi Interleukin-10 does not contribute to the pathogenesis of a virulent strain of Toxoplasma gondii
    U Wille
    Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA, USA
    Parasite Immunol 23:291-6. 2001
    ..Taken together, these results indicate that IL-10 is not required for the virulence of the RH strain of T. gondii, nor is it involved in the regulation of the CD80, CD86 and MHC class II molecules during RH-infection...
  11. ncbi The NF-kappa B family member RelB is required for innate and adaptive immunity to Toxoplasma gondii
    J Caamano
    Department of Pathobiology, University of Pennsylvania, Philadelphia 19104, USA
    J Immunol 163:4453-61. 1999
    ..Together, our results demonstrate that RelB is essential for the development of innate NK and adaptive T cell responses that lead to the production of IFN-gamma and resistance to T. gondii...
  12. pmc The CD40/CD40 ligand interaction is required for resistance to toxoplasmic encephalitis
    G Reichmann
    Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6050, USA
    Infect Immun 68:1312-8. 2000
    ..gondii. However, this interaction may be more important in the control of parasite replication in the brain rather than the generation of protective T-cell responses during toxoplasmosis...
  13. pmc Advances in understanding the anti-inflammatory properties of IL-27
    J S Stumhofer
    University of Pennsylvania, School of Veterinary Medicine, Room 313, Hill Pavilion, 380 South University Avenue, Philadelphia, PA 19104 4539, United States
    Immunol Lett 117:123-30. 2008
    ....
  14. ncbi IL-10 is not required to prevent immune hyperactivity during memory responses to Toxoplasma gondii
    U Wille
    School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Parasite Immunol 26:229-36. 2004
    ..gondii, and a highly effective memory response is generated in the absence of endogenous IL-10...
  15. ncbi A role for CD44 in the production of IFN-gamma and immunopathology during infection with Toxoplasma gondii
    S L Blass
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 166:5726-32. 2001
    ..Together, these results identify a novel role for CD44 in the regulation of IFN-gamma production by CD4(+) T cells during infection and demonstrate a role for CD44 in the regulation of infection-induced immune pathology...
  16. ncbi Cutting edge: systemic inhibition of angiogenesis underlies resistance to tumors during acute toxoplasmosis
    C A Hunter
    Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 166:5878-81. 2001
    ..Our results identify the suppression of tumor neovascularization as a novel mechanism critical for infection-induced resistance to tumors...
  17. ncbi IL-10 mediates susceptibility to Leishmania donovani infection
    M L Murphy
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Eur J Immunol 31:2848-56. 2001
    ..Together these studies demonstrate for the first time that IL-10 is a critical component of the immune response that inhibits resistance to L. donovani...
  18. pmc Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract
    Alexander M Owyang
    Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Exp Med 203:843-9. 2006
    ..Therefore, IL-25 is not only a critical mediator of type 2 immunity, but is also required for the regulation of inflammation in the gastrointestinal tract...
  19. ncbi Cutting edge: identification of c-Rel-dependent and -independent pathways of IL-12 production during infectious and inflammatory stimuli
    Nicola Mason
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 168:2590-4. 2002
    ..Together these studies reveal the presence of c-Rel-dependent pathways critical for IL-12p40 production in response to inflammatory stimuli and demonstrate a novel c-Rel-independent pathway of IL-12p40 production during toxoplasmosis...
  20. ncbi TLR ligands can activate dendritic cells to provide a MyD88-dependent negative signal for Th2 cell development
    Jie Sun
    Department of Pathobiology, University of Pennsylvania, Philadelphia 19104, USA
    J Immunol 174:742-51. 2005
    ..Our findings indicate that DCs can provide potent negative as well as positive instruction for Th response polarization, and that these instructional signals are distinct and independent...
  21. ncbi An essential role of Th1 responses and interferon gamma in infection-mediated suppression of neoplastic growth
    Erinn B Rankin
    Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6051, USA
    Cancer Biol Ther 2:687-93. 2003
    ..Interestingly, the enhancement was also apparent in uninfected animals suggesting that IFN-gamma and its anti-angiogenic effects underlie both infection-dependent and -independent tumor surveillance...
  22. ncbi T cell-intrinsic expression of c-Rel regulates Th1 cell responses essential for resistance to Toxoplasma gondii
    Nicola J Mason
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 172:3704-11. 2004
    ..Together, these studies indicate that although c-Rel is an important regulator of innate immune responses, it also plays an important role in optimization and maintenance of adaptive T cell responses during infection...
  23. ncbi The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity
    David Artis
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 173:5626-34. 2004
    ..In addition, IL-27 directly suppressed CD4+ T cell proliferation and Th2 cytokine production. Together, these studies identify a novel role for IL-27/WSX-1 in limiting innate and adaptive components of type 2 immunity at mucosal sites...
  24. doi IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD
    Alejandro V Villarino
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    Int Immunol 20:739-52. 2008
    ..Taken together, these studies demonstrate that, in the absence of IL-10, IL-27 can promote T(h)1-type and suppress T(h)2-type intestinal inflammation but, ultimately, is not required for the development of inflammatory bowel disease...
  25. ncbi IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12
    Linda A Lieberman
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 173:1887-93. 2004
    ..Together, these studies indicate that IL-12, not IL-23, plays a dominant role in resistance to toxoplasmosis but, in the absence of IL-12, IL-23 can provide a limited mechanism of resistance to this infection...
  26. ncbi NF-kappa B1 is required for optimal CD4+ Th1 cell development and resistance to Leishmania major
    David Artis
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
    J Immunol 170:1995-2003. 2003
    ..Taken together, these results identify a novel role for NF-kappaB1 in CD4(+) T cell proliferation and the development of Th1 cell responses required for protective immunity against intracellular pathogens...
  27. ncbi Helminth antigens modulate TLR-initiated dendritic cell activation
    Colleen M Kane
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    J Immunol 173:7454-61. 2004
    ..These findings indicate that SEA exerts potent anti-inflammatory effects by directly regulating the ability of DC to respond to TLR ligands...
  28. ncbi Plasmacytoid dendritic cells are activated by Toxoplasma gondii to present antigen and produce cytokines
    Marion Pepper
    Department of Pathobiology, University of Pennsylvania, 380 South University Avenue, Philadelphia, PA 19104, USA
    J Immunol 180:6229-36. 2008
    ..Together these studies suggest that pDCs are a prominent DC subset involved in the initial stages of T. gondii infection, presenting parasite Ags and producing cytokines that are important for controlling infection...
  29. pmc IL-27 regulates homeostasis of the intestinal CD4+ effector T cell pool and limits intestinal inflammation in a murine model of colitis
    Amy E Troy
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 183:2037-44. 2009
    ..Collectively, these data identify a role for IL-27-IL-27R interaction in controlling the homeostasis of the intestinal T cell pool and in limiting intestinal inflammation through regulation of innate and adaptive immune cell function...
  30. ncbi New lessons from old pathogens: what parasitic infections have taught us about the role of nuclear factor-kappaB in the regulation of immunity
    Nicola J Mason
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Immunol Rev 201:48-56. 2004
    ..Thus, studies with models of parasitic infection have revealed that individual NF-kappaB family members perform distinct, nonoverlapping, and biologically significant functions in the regulation of immunity and inflammation...
  31. ncbi Role of CD28 in the generation of effector and memory responses required for resistance to Toxoplasma gondii
    E N Villegas
    Department of Pathobiology, University of Pennsylvania, Philadelphia 19104, USA
    J Immunol 163:3344-53. 1999
    ..Together, our findings demonstrate that CD28 is not required for the development of a protective T cell response to T. gondii, but CD28 is required for an optimal secondary immune response...
  32. ncbi Suppression of NF-kappaB activation by infection with Toxoplasma gondii
    S Shapira
    Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104 6008, USA
    J Infect Dis 185:S66-72. 2002
    ..gondii. Together, these data demonstrate that invasion of cells by T. gondii does not lead to the activation of NF-kappaB and suggest that the parasite may actively interfere with the pathways that lead to NF-kappaB activation...
  33. ncbi Cutting edge: NF-kappa B2 is a negative regulator of dendritic cell function
    Kendra Speirs
    Department of Pathobiology, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
    J Immunol 172:752-6. 2004
    ..These studies identify a novel role for NF-kappaB2 in the negative regulation of RelB-induced DC maturation, with critical consequences for the regulation of adaptive immune responses...
  34. pmc Opposing roles of NF-kappaB family members in the regulation of NK cell proliferation and production of IFN-gamma
    Cristina M Tato
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104 6008, USA
    Int Immunol 18:505-13. 2006
    ..Together, these studies define distinct roles for c-Rel and p50 in the function of NK cells...
  35. ncbi Cutting edge: early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection
    David Artis
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    J Immunol 172:4672-5. 2004
    ..major. Thus, the requirement for WSX-1 signaling in Th type 1 cell differentiation is restricted to conditions in which IL-4 is produced...
  36. ncbi Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
    Jason S Stumhofer
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6008, USA
    Nat Immunol 7:937-45. 2006
    ..Thus IL-27, a potent inhibitor of T(H)-17 cell development, may be a useful target for treating inflammatory diseases mediated by these cells...
  37. pmc B7RP-1-ICOS interactions are required for optimal infection-induced expansion of CD4+ Th1 and Th2 responses
    Emma H Wilson
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 177:2365-72. 2006
    ..Taken together, these data are consistent with a model in which ICOS is not involved in dictating polarity of the Th response but rather regulates the expansion of these subsets...
  38. ncbi Positive and negative regulation of the IL-27 receptor during lymphoid cell activation
    Alejandro V Villarino
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, and Wistar Institute, Philadelphia, PA 19104, USA
    J Immunol 174:7684-91. 2005
    ....
  39. ncbi The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection
    Alejandro Villarino
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St, Philadelphia, PA 19104, USA
    Immunity 19:645-55. 2003
    ....
  40. ncbi A role for inducible costimulator protein in the CD28- independent mechanism of resistance to Toxoplasma gondii
    Eric N Villegas
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 169:937-43. 2002
    ..gondii and suggest that ICOS and CD28 are parallel costimulatory pathways, either of which is sufficient to mediate resistance to this intracellular pathogen...
  41. pmc Contribution of interleukin-12 (IL-12) and the CD28/B7 and CD40/CD40 ligand pathways to the development of a pathological T-cell response in IL-10-deficient mice
    Ulrike Wille
    School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Infect Immun 70:6940-7. 2002
    ..Together, these data suggest that the CD28/B7 interaction has a central role in the development of a pathological T-cell response in IL-10 KO mice, which is distinct from the role of the CD40/CD40L and IL-12 pathways...
  42. pmc Altered endochondral ossification in collagen X mouse models leads to impaired immune responses
    E Sweeney
    Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania 19104 6046, USA
    Dev Dyn 237:2693-704. 2008
    ..These data link the disruption of collagen X function in the chondro-osseous junction to an altered hematopoietic stem cell niche in the marrow, resulting in impaired immune function...
  43. pmc Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals
    Alejandro V Villarino
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    J Exp Med 204:65-71. 2007
    ....
  44. ncbi NF-kappa B2 is required for optimal CD40-induced IL-12 production but dispensable for Th1 cell Differentiation
    Kendra Speirs
    Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 168:4406-13. 2002
    ..major is the result of an IL-12 deficiency, and we provide evidence for a specific impairment in CD40-induced IL-12 production by macrophages lacking this transcription factor...
  45. ncbi Dendritic cells and immunity to leishmaniasis and toxoplasmosis
    Phillip Scott
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
    Curr Opin Immunol 14:466-70. 2002
    ..Interestingly, there appear to be differences in the DC activation pathways utilized by these two intracellular protozoa which also may differ from the pathways utilized by bacteria...
  46. ncbi A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis
    Emma H Wilson
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6008, USA
    J Neuroimmunol 165:63-74. 2005
    ..Together these results point to a vital role for IL-10 in the control of CD4(+) T cell mediated inflammation in the brain during TE...
  47. ncbi IL-27 limits IL-2 production during Th1 differentiation
    Alejandro V Villarino
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    J Immunol 176:237-47. 2006
    ....
  48. pmc Regulation of CD8+ T cell responses to infection with parasitic protozoa
    Kimberly A Jordan
    Department of Pathobiology, University of Pennsylvania, 380 South University Avenue, Philadelphia, PA 19104, USA
    Exp Parasitol 126:318-25. 2010
    ....
  49. pmc Virulence of Toxoplasma gondii is associated with distinct dendritic cell responses and reduced numbers of activated CD8+ T cells
    Elia D Tait
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Room H310F Hill Pavilion, 380 South University Avenue, Philadelphia, PA 19104, USA
    J Immunol 185:1502-12. 2010
    ..Together, these data are consistent with a model of immunity to T. gondii in which strain-dependent DC responses shape the generation of Ag-specific CD8(+) T cells and determine the outcome of infection...
  50. pmc IL-6 promotes NK cell production of IL-17 during toxoplasmosis
    Sara T Passos
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 184:1776-83. 2010
    ....
  51. pmc Susceptibility of interleukin-2-deficient mice to Toxoplasma gondii is associated with a defect in the production of gamma interferon
    Eric N Villegas
    Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia 19104 6050, USA
    Infect Immun 70:4757-61. 2002
    ..gondii and suggest that IL-2(-/-) mice have an intrinsic defect in their ability to activate and expand IFN-gamma-producing T cells required for resistance to T. gondii...
  52. ncbi Differential requirement for NF-kappa B family members in control of helminth infection and intestinal inflammation
    David Artis
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104, USA
    J Immunol 169:4481-7. 2002
    ..muris and the control of infection-induced intestinal inflammation...
  53. pmc Interleukin-15-deficient mice develop protective immunity to Toxoplasma gondii
    Linda A Lieberman
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Infect Immun 72:6729-32. 2004
    ..The studies presented here reveal that IL-15 is not required for infection-induced expansion of NK or CD8+ T cells. Furthermore, IL-15-/- mice develop long-term protective immunity to this pathogen...
  54. ncbi Infection and cancer: the common vein
    Andrei Thomas-Tikhonenko
    Department of Pathobiology, University of Pennsylvania, 3800 Spruce Street, Philadelphia 19104 6051, USA
    Cytokine Growth Factor Rev 14:67-77. 2003
    ..In this review, we will discuss recent studies that implicate anti-angiogenesis in infection-mediated tumor suppression and suggest that this mechanism could also complement cytotoxic immunity arising from the use of cancer vaccines...
  55. ncbi Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10
    Jason S Stumhofer
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 8:1363-71. 2007
    ..This effect was dependent on the transcription factors STAT1 and STAT3 for IL-27 and on STAT3 for IL-6. Our studies identify a previously unknown pathway that allows the immune system to temper inflammatory responses...
  56. ncbi Toxoplasma gondii induces changes in intracellular calcium in macrophages
    K S Masek
    Department of Pathobiology, School of Veterinary Medicine, Room 313, Hill Pavilion, 380 South University Avenue, University of Pennsylvania, Philadelphia, PA 19104, USA
    Parasitology 134:1973-9. 2007
    ..These findings indicate that Toxoplasma gondii alters calcium homeostasis in macrophages and this activity is independent of known pathways involved in the innate recognition of this organism...
  57. pmc NF-kappaB1 contributes to T cell-mediated control of Toxoplasma gondii in the CNS
    Tajie H Harris
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 380 S University Ave, Philadelphia, PA 19104, United States
    J Neuroimmunol 222:19-28. 2010
    ..These results demonstrate an intrinsic role for NF-kappaB1 in T cell-mediated immunity to Toxoplasmagondii...
  58. pmc Presentation of Toxoplasma gondii antigens via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cells
    Florence Dzierszinski
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Infect Immun 75:5200-9. 2007
    ..These findings associate nonprofessional APCs with the initial activation of CD8+ T cells during toxoplasmosis...
  59. ncbi Two distinct activation states of plasmacytoid dendritic cells induced by influenza virus and CpG 1826 oligonucleotide
    Amaya Iparraguirre
    Immunology Program, The Wistar Institute, Department of Penn Bioinformatics Core, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Leukoc Biol 83:610-20. 2008
    ..Thus, pDC display remarkable functional flexibility, which emphasizes their versatile functions in antimicrobial immunity and inflammatory processes...
  60. pmc Dynamic Imaging of CD8(+) T cells and dendritic cells during infection with Toxoplasma gondii
    Beena John
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
    PLoS Pathog 5:e1000505. 2009
    ....
  61. pmc Kinetics and phenotype of vaccine-induced CD8+ T-cell responses to Toxoplasma gondii
    Kimberly A Jordan
    Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Infect Immun 77:3894-901. 2009
    ..gondii and identifies a critical role for CD4(+) T cells in the generation of protective CD8(+) T-cell responses...
  62. ncbi Advances in understanding immunity to Toxoplasma gondii
    Elia D Tait
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mem Inst Oswaldo Cruz 104:201-10. 2009
    ..Ultimately, the challenge will be to use this information to develop new vaccines and therapies to manage disease in affected patients...
  63. pmc Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin
    Andrew M Intlekofer
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 321:408-11. 2008
    ..T-bet and Eomes, thus, ensure that CD8+ T cells adopt an appropriate course of intracellular rather than extracellular destruction...
  64. pmc 12/15-lipoxygenase-dependent myeloid production of interleukin-12 is essential for resistance to chronic toxoplasmosis
    Melissa K Middleton
    The Wistar Institute, Immunology Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Infect Immun 77:5690-700. 2009
    ....
  65. ncbi Understanding the role of the CD40--CD40L interaction in resistance to parasitic infections
    Emma H Wilson
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6008, USA
    Parasite Immunol 25:179-83. 2003
  66. pmc TRAF6-dependent mitogen-activated protein kinase activation differentially regulates the production of interleukin-12 by macrophages in response to Toxoplasma gondii
    Nicola J Mason
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Infect Immun 72:5662-7. 2004
    ..The studies presented here demonstrate for the first time that the production of IL-12(p40) in response to toxoplasma is dependent upon TRAF6 and p38 MAPK...
  67. ncbi The regulation and activation of CD44 by natural killer (NK) cells and its role in the production of IFN-gamma
    Sarah L Sague
    Department of Pathobiology, School of Veterinary Medicine, 226 Rosenthal Building, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
    J Interferon Cytokine Res 24:301-9. 2004
    ..Together, these studies indicate an important role for proinflammatory cytokines in the activation of CD44 on NK cells and identify a novel pathway to enhance the ability of activated NK cells to produce IFN-gamma...
  68. pmc NF-kappaB family of transcription factors: central regulators of innate and adaptive immune functions
    Jorge Caamano
    Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6008, USA
    Clin Microbiol Rev 15:414-29. 2002
    ....
  69. ncbi Cutting Edge: Innate production of IFN-gamma by NK cells is independent of epigenetic modification of the IFN-gamma promoter
    Cristina M Tato
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 173:1514-7. 2004
    ....
  70. ncbi Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia
    Lei Zhao
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:35350-6. 2002
    ..The data provide support for a novel mechanism linking the 12/15-lipoxygenase pathway to a known immunomodulatory Th1 cytokine in atherogenesis...
  71. ncbi Inhibition of NF-kappa B activity in T and NK cells results in defective effector cell expansion and production of IFN-gamma required for resistance to Toxoplasma gondii
    Cristina M Tato
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 170:3139-46. 2003
    ..Together, these studies reveal that inhibition of NF-kappa B activity in T and NK cells results in defective effector cell expansion and production of IFN-gamma required for resistance to T. gondii...
  72. ncbi STAT1 plays a critical role in the regulation of antimicrobial effector mechanisms, but not in the development of Th1-type responses during toxoplasmosis
    Linda A Lieberman
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
    J Immunol 172:457-63. 2004
    ..Together these studies suggest that during toxoplasmosis the major role of STAT1 is not in the development of protective T cell responses, but, rather, STAT1 is important in the development of antimicrobial effector mechanisms...
  73. ncbi IL-10 fails to inhibit the production of IL-18 in response to inflammatory stimuli
    Valerie P Zediak
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104 6050, USA
    Cytokine 21:84-90. 2003
    ..Together, these data indicate that IL-10 is not an inhibitor of the production of IL-18...
  74. pmc Negative regulation of Th17 responses
    J S Stumhofer
    University of Pennsylvania, School of Veterinary Medicine, Room 313, Hill Pavilion, 380 South University Avenue, Philadelphia, PA 19104 4539, United States
    Semin Immunol 19:394-9. 2007
    ..The aim of this article is to review our current understanding of the regulatory networks that limit T helper subsets and how they relate to the Th17 lineage...
  75. pmc Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis
    C M Coughlin
    Biomedical Graduate Program, Institute for Human Gene Therapy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 101:1441-52. 1998
    ..This suggests that inhibition of tumor angiogenesis is an important part of the systemic antitumor effect produced by mIL-12 and mIL-18...
  76. pmc A role for IL-27p28 as an antagonist of gp130-mediated signaling
    Jason S Stumhofer
    University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA
    Nat Immunol 11:1119-26. 2010
    ..Thus, IL-27p28, as a natural antagonist of gp130-mediated signaling, may be useful as a therapeutic for managing inflammation mediated by cytokines that signal through gp130...
  77. doi With a little help from their friends: interleukin-21, T cells, and B cells
    Jonathan S Silver
    Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Room 313, Hill Pavillion, 380 South University Avenue, Philadelphia, PA 19104 4539, USA
    Immunity 29:7-9. 2008
    ..2008, and Vogelzang et al., 2008) have identified a role for interleukin-21 in the development of these specialized cells and highlight questions about how this dedicated population is generated...
  78. ncbi Effects of CD28 blockade on subsets of naïve T cells in cats
    Lillian R Aronson
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6010, USA
    Am J Vet Res 66:483-92. 2005
    ....
  79. ncbi The NF-kappaB signaling pathway: immune evasion and immunoregulation during toxoplasmosis
    Sagi Shapira
    Department of Pathobiology, University of Pennsylvania, Philadelphia 19104 6008, USA
    Int J Parasitol 34:393-400. 2004
    ..gondii and these transcription factors in infected cells, and highlights the role of different NF-kappaB family members during the development of a protective immune response to this pathogen...
  80. ncbi The role of astrocytes in the immunopathogenesis of toxoplasmic encephalitis
    Emma H Wilson
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6008, USA
    Int J Parasitol 34:543-8. 2004
    ..gondii. The aim of this paper is to review what is known about the immune functions of astrocytes, and the possible role they may play during toxoplasmic encephalitis...
  81. pmc T cell expression of MyD88 is required for resistance to Toxoplasma gondii
    David F LaRosa
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:3855-60. 2008
    ..gondii. These observations show that, in addition to a role for MyD88 in innate responses, T cell expression of MyD88 is necessary for prolonged resistance to a pathogen...
  82. pmc gp130 at the nexus of inflammation, autoimmunity, and cancer
    J S Silver
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19143, USA
    J Leukoc Biol 88:1145-56. 2010
    ..The aim of this review is to discuss the role of gp130 in promoting or preventing the development of autoimmunity and cancer, two processes that are associated with aberrant inflammatory responses...
  83. pmc Host-pathogen interactions: subversion and utilization of the NF-kappa B pathway during infection
    C M Tato
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Infect Immun 70:3311-7. 2002
  84. pmc Early enhanced Th1 response after Leishmania amazonensis infection of C57BL/6 interleukin-10-deficient mice does not lead to resolution of infection
    Douglas E Jones
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA
    Infect Immun 70:2151-8. 2002
    ..These results indicate that although IL-10 plays a role in limiting the Th1 response during the acute infection phase, other immunomodulatory factors are responsible for limiting the Th1 response during the chronic phase...
  85. pmc Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis
    Yi Chen
    Discovery Research, Schering Plough Biopharma, Palo Alto, California 94304, USA
    J Clin Invest 116:1317-26. 2006
    ..Thus, therapeutic targeting of IL-23 effectively inhibited multiple inflammatory pathways that are critical for driving CNS autoimmune inflammation...
  86. ncbi Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation
    Robert A Kastelein
    Discovery Research, Schering Plough Biopharma, Palo Alto, California 94304 1104, USA
    Annu Rev Immunol 25:221-42. 2007
    ..In this review, we aim to highlight the discoveries that have led to our current understanding of the biology of IL-23 and IL-27 in the context of their role in resistance to infection, immune-mediated inflammation, and cancer...
  87. ncbi Act1-ivating IL-17 inflammation
    Christopher A Hunter
    Nat Immunol 8:232-4. 2007
  88. ncbi Cooperative binding at lipid bilayer membrane surfaces
    Emma L Doyle
    Centre for Chemical Biology, Krebs Institute for Biomolecular Science, Department of Chemistry, The University of Sheffield, Sheffield, S3 7HF, U K
    J Am Chem Soc 125:4593-9. 2003
    ..This implies that by increasing or decreasing the number of receptors in their membranes, cells can finely tune biological responses such as chemotaxis that depend on the size of the receptor-ligand clusters formed...
  89. ncbi Host cell Ca2+ and protein kinase C regulate innate recognition of Toxoplasma gondii
    Katherine S Masek
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Sci 119:4565-73. 2006
    ..Together these data identify host cell Ca(2+) and PKC as crucial regulators of the innate immune response to microbial stimuli, including T. gondii...
  90. pmc Development of a system to study CD4+-T-cell responses to transgenic ovalbumin-expressing Toxoplasma gondii during toxoplasmosis
    Marion Pepper
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Infect Immun 72:7240-6. 2004
    ..Together, these studies establish the utility of this transgenic system to study CD4(+)-T-cell responses during toxoplasmosis...
  91. ncbi Understanding the pro- and anti-inflammatory properties of IL-27
    Alejandro V Villarino
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 173:715-20. 2004
    ..Thus, the aim of this review is to discuss the pleotropic nature of the IL-27/IL-27R interaction and attempt to reconcile the pro- and anti-inflammatory properties of this immunomodulator...
  92. ncbi The role of cytokines and their signaling pathways in the regulation of immunity to Toxoplasma gondii
    Linda A Lieberman
    Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, Pennsylvania, USA
    Int Rev Immunol 21:373-403. 2002
    ..It also addresses the role of cytokines in modulating other immune functions that are critical in determining the balance between a protective and a pathological immune response...
  93. ncbi Control of effector CD8+ T cell function by the transcription factor Eomesodermin
    Erika L Pearce
    Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 302:1041-3. 2003
    ..We suggest that Eomesodermin is likely to complement the actions of T-bet and act as a key regulatory gene in the development of cell-mediated immunity...
  94. ncbi T cell heterogeneity: firmly fixed, predominantly plastic or merely malleable?
    JOHN J O'SHEA
    National Institutes of Health, Bethesda, Maryland 20852 1820, USA
    Nat Immunol 9:450-3. 2008