Aimee M Hunter

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Stressor controllability and learned helplessness research in the United States: sensitization and fatigue processes
    Thomas R Minor
    Department of Psychology, UCLA Los Angeles, 90095 1563, USA
    Integr Physiol Behav Sci 37:44-58. 2002
  2. ncbi request reprint The promise of the quantitative electroencephalogram as a predictor of antidepressant treatment outcomes in major depressive disorder
    Aimee M Hunter
    Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024 1759, USA
    Psychiatr Clin North Am 30:105-24. 2007
  3. ncbi request reprint Neurophysiologic effects of repeated exposure to antidepressant medication: are brain functional changes during antidepressant administration influenced by learning processes?
    Aimee M Hunter
    Laboratory of Brain, Behavior, and Pharmacology, and the UCLA Depression Research and Clinic Program, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA, USA Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA Electronic address
    Med Hypotheses 81:1004-11. 2013
  4. pmc A genome-wide association study of a sustained pattern of antidepressant response
    Aimee M Hunter
    Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, USA
    J Psychiatr Res 47:1157-65. 2013
  5. doi request reprint Rostral anterior cingulate activity in major depressive disorder: state or trait marker of responsiveness to medication?
    Aimee M Hunter
    Laboratory of Brain, Behavior, and Pharmacology, and UCLA Depression Research and Clinic Program, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA, USA
    J Neuropsychiatry Clin Neurosci 25:126-33. 2013
  6. pmc The antidepressant treatment response index and treatment outcomes in a placebo-controlled trial of fluoxetine
    Aimee M Hunter
    Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California 90024 1759, USA
    J Clin Neurophysiol 28:478-82. 2011
  7. doi request reprint Brain functional changes (QEEG cordance) and worsening suicidal ideation and mood symptoms during antidepressant treatment
    A M Hunter
    Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA 90024 1759, USA
    Acta Psychiatr Scand 122:461-9. 2010
  8. pmc Antidepressant response trajectories and quantitative electroencephalography (QEEG) biomarkers in major depressive disorder
    Aimee M Hunter
    Semel Institute for Neuroscience and Human Behavior at UCLA, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024 1759, United States
    J Psychiatr Res 44:90-8. 2010
  9. doi request reprint Brain functional changes during placebo lead-in and changes in specific symptoms during pharmacotherapy for major depression
    A M Hunter
    Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA, 760 Westwood Plaza, Rm 37 359, Los Angeles, CA 90024 1759, USA
    Acta Psychiatr Scand 119:266-73. 2009
  10. ncbi request reprint Changes in brain function (quantitative EEG cordance) during placebo lead-in and treatment outcomes in clinical trials for major depression
    Aimee M Hunter
    Semel Institute for Neuroscience and Human Behavior at UCLA, 760 Westwood Plaza, Rm 37 359, Los Angeles, CA 90024 1759, USA
    Am J Psychiatry 163:1426-32. 2006

Detail Information

Publications31

  1. ncbi request reprint Stressor controllability and learned helplessness research in the United States: sensitization and fatigue processes
    Thomas R Minor
    Department of Psychology, UCLA Los Angeles, 90095 1563, USA
    Integr Physiol Behav Sci 37:44-58. 2002
    ..The substrates of adaptive behavior are removed; performance deficits ensue...
  2. ncbi request reprint The promise of the quantitative electroencephalogram as a predictor of antidepressant treatment outcomes in major depressive disorder
    Aimee M Hunter
    Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024 1759, USA
    Psychiatr Clin North Am 30:105-24. 2007
    ....
  3. ncbi request reprint Neurophysiologic effects of repeated exposure to antidepressant medication: are brain functional changes during antidepressant administration influenced by learning processes?
    Aimee M Hunter
    Laboratory of Brain, Behavior, and Pharmacology, and the UCLA Depression Research and Clinic Program, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA, USA Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA Electronic address
    Med Hypotheses 81:1004-11. 2013
    ..Data suggest that brief treatment with antidepressant medication may have an enduring impact on neurophysiologic responses to a subsequent course of antidepressant treatment. Hypotheses should be tested in larger samples...
  4. pmc A genome-wide association study of a sustained pattern of antidepressant response
    Aimee M Hunter
    Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, USA
    J Psychiatr Res 47:1157-65. 2013
    ..An exploratory genetic pathway analysis revealed evidence for an involvement of the KEGG pathway of long-term potentiation (FDR=.02). Results suggest novel genetic associations to sustained response. ..
  5. doi request reprint Rostral anterior cingulate activity in major depressive disorder: state or trait marker of responsiveness to medication?
    Aimee M Hunter
    Laboratory of Brain, Behavior, and Pharmacology, and UCLA Depression Research and Clinic Program, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA, USA
    J Neuropsychiatry Clin Neurosci 25:126-33. 2013
    ..rACC activity may constitute a variable "state" indicator of responsiveness to antidepressants...
  6. pmc The antidepressant treatment response index and treatment outcomes in a placebo-controlled trial of fluoxetine
    Aimee M Hunter
    Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California 90024 1759, USA
    J Clin Neurophysiol 28:478-82. 2011
    ..Importantly, ATR index did not correlate significantly with placebo outcomes. Results extend ATR index findings to include predictive validity with fluoxetine, suggesting that this biomarker has specificity for drug effects...
  7. doi request reprint Brain functional changes (QEEG cordance) and worsening suicidal ideation and mood symptoms during antidepressant treatment
    A M Hunter
    Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA 90024 1759, USA
    Acta Psychiatr Scand 122:461-9. 2010
    ..We examined the quantitative electroencephalographic (QEEG) cordance biomarker of brain function biomarker in relation to treatment-emergent symptom worsening...
  8. pmc Antidepressant response trajectories and quantitative electroencephalography (QEEG) biomarkers in major depressive disorder
    Aimee M Hunter
    Semel Institute for Neuroscience and Human Behavior at UCLA, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024 1759, United States
    J Psychiatr Res 44:90-8. 2010
    ..Statistical methods such as GMM are needed to identify clinically relevant symptom response trajectories...
  9. doi request reprint Brain functional changes during placebo lead-in and changes in specific symptoms during pharmacotherapy for major depression
    A M Hunter
    Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA, 760 Westwood Plaza, Rm 37 359, Los Angeles, CA 90024 1759, USA
    Acta Psychiatr Scand 119:266-73. 2009
    ....
  10. ncbi request reprint Changes in brain function (quantitative EEG cordance) during placebo lead-in and treatment outcomes in clinical trials for major depression
    Aimee M Hunter
    Semel Institute for Neuroscience and Human Behavior at UCLA, 760 Westwood Plaza, Rm 37 359, Los Angeles, CA 90024 1759, USA
    Am J Psychiatry 163:1426-32. 2006
    ..The authors hypothesized that decreases in prefrontal cordance during the placebo lead-in phase would be associated with better clinical outcome in subjects treated with antidepressants...
  11. ncbi request reprint Neurophysiologic correlates of side effects in normal subjects randomized to venlafaxine or placebo
    Aimee M Hunter
    Behavioral Pharmacology Laboratory, Department of Psychiatry and Biobehavioral Sciences, UCLA Neuropsychiatric Institute, David Geffen School of Medicine, Los Angeles, CA 90024 1759, USA
    Neuropsychopharmacology 30:792-9. 2005
    ..Results of these exploratory hypothesis-generating analyses should be considered tentative until replicated...
  12. ncbi request reprint Helplessness and escape performance: glutamate-adenosine interactions in the frontal cortex
    Aimee M Hunter
    Department of Psychology, University of California, Los Angeles 90095 1563, USA
    Behav Neurosci 117:123-35. 2003
    ..These findings are consistent with the involvement of N-methyl-D-aspartate receptor activation in the frontal cortex in the helplessness effect...
  13. pmc Midline and right frontal brain function as a physiologic biomarker of remission in major depression
    Ian A Cook
    UCLA Depression Research and Clinic Program, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA, United States
    Psychiatry Res 174:152-7. 2009
    ..These results suggest that remission may be predictable from physiologic measurements after 1 week of treatment, and that this region merits further investigation in the neurobiology of treatment response...
  14. pmc Rostral anterior cingulate cortex theta current density and response to antidepressants and placebo in major depression
    Alexander S Korb
    Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024 1759, USA
    Clin Neurophysiol 120:1313-9. 2009
    ....
  15. ncbi request reprint Changes in brain function during administration of venlafaxine or placebo to normal subjects
    Andrew F Leuchter
    Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA 90024 1759, USA
    Clin EEG Neurosci 39:175-81. 2008
    ..Future studies should examine other classes of medication, as well as antidepressants with other mechanisms of action, to determine if cordance detects antidepressant medication effects in general in normal subjects...
  16. pmc Rostral anterior cingulate cortex activity and early symptom improvement during treatment for major depressive disorder
    Alexander S Korb
    Labrotory of Brain, Behavior, and Pharmacology, and the UCLA Depression Research for Clinic Program, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA, USA
    Psychiatry Res 192:188-94. 2011
    ..The model examining the mOFC showed a trend in the three-way interaction. A combination of pretreatment rACC activity and early symptom improvement may be useful for predicting treatment response...
  17. ncbi request reprint Does prior antidepressant treatment of major depression impact brain function during current treatment?
    Aimee M Hunter
    Laboratory of Brain, Behavior, and Pharmacology, and the Depression Research and Clinic Program, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, CA 90024 1759, United States
    Eur Neuropsychopharmacol 22:711-20. 2012
    ..Results suggest that prefrontal brain functional changes during treatment for MDD may differ depending upon prior treatment with antidepressant medication...
  18. ncbi request reprint Brain functional changes and duloxetine treatment response in fibromyalgia: a pilot study
    Aimee M Hunter
    Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at the University of California, Los Angeles, CA, USA
    Pain Med 10:730-8. 2009
    ..We hypothesized that cordance might also predict response to antidepressant medications for symptoms of FMS...
  19. doi request reprint Brain electrical source differences between depressed subjects and healthy controls
    Alexander S Korb
    Laboratory of Brain, Behavior, and Pharmacology, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior at UCLA, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024 1759, USA
    Brain Topogr 21:138-46. 2008
    ..Inconsistent findings among LORETA studies, and between LORETA studies and those using other functional imaging techniques, may result from differences in electrode montages...
  20. doi request reprint Monoamine oxidase a and catechol-o-methyltransferase functional polymorphisms and the placebo response in major depressive disorder
    Andrew F Leuchter
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, 760 Westwood Plaza, Rm 37 452, Los Angeles, CA 90024 1759, USA
    J Clin Psychopharmacol 29:372-7. 2009
    ..These findings support the hypothesis that genetic polymorphisms modulating monoaminergic tone are related to degree of placebo responsiveness in major depressive disorder...
  21. pmc A new paradigm for the prediction of antidepressant treatment response
    Andrew F Leuchter
    Laboratory of Brain Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA 90024, USA
    Dialogues Clin Neurosci 11:435-46. 2009
    ..We posit that this new paradigm could lead to earlier recovery from depressive illness and ultimately produce profound health and economic benefits...
  22. doi request reprint Predictive socioeconomic and clinical profiles of antidepressant response and remission
    Felipe A Jain
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90024, USA
    Depress Anxiety 30:624-30. 2013
    ..The predictive power of any single factor, however, is limited. We aimed to develop profiles of antidepressant response and remission based upon hierarchical combinations of baseline clinical and demographic factors...
  23. ncbi request reprint Quantitative electroencephalogram biomarkers for predicting likelihood and speed of achieving sustained remission in major depression: a report from the biomarkers for rapid identification of treatment effectiveness in major depression (BRITE-MD) trial
    Ian A Cook
    UCLA Semel Institute for Neuroscience and Human Behavior, Depression Research and Clinic Program and Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Clin Psychiatry 74:51-6. 2013
    ....
  24. ncbi request reprint Amygdala lateralization at rest and during viewing of neutral faces in major depressive disorder using low-resolution brain electromagnetic tomography
    Haleh Farahbod
    Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA 90024 1759, USA
    Clin EEG Neurosci 41:19-23. 2010
    ..Findings suggest a more pronounced lateralization effect in normal healthy controls than in MDD subjects when changing from a resting (eyes-closed) condition to viewing faces without emotional valence...
  25. pmc Biomarkers to predict antidepressant response
    Andrew F Leuchter
    Semel Institute for Neuroscience and Human Behavior at UCLA, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024, USA
    Curr Psychiatry Rep 12:553-62. 2010
    ..Once such biomarkers are validated, they could form the basis of new paradigms for antidepressant treatment selection...
  26. ncbi request reprint Do prefrontal midline electrodes provide unique neurophysiologic information in Major Depressive Disorder?
    Ian A Cook
    UCLA Depression Research and Clinic Program, Semel Institute for Neuroscience and Human Behavior at UCLA, Brain Research Institute, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, United States Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA, Brain Research Institute, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, United States Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, Los Angeles, CA, United States Electronic address
    J Psychiatr Res 53:69-75. 2014
    ..Salient abnormalities in MDD may be detectable by focusing on the prefrontal midline region, and EEG metrics from focused electrode arrays may offer clinical practicality for clinical monitoring. ..
  27. ncbi request reprint Neurophysiologic predictors of response to atomoxetine in young adults with attention deficit hyperactivity disorder: a pilot project
    Andrew F Leuchter
    Department of Psychiatry and Biobehavioral Sciences, and the Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA, USA UCLA Depression Research and Clinic Program, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA, USA Electronic address
    J Psychiatr Res 54:11-8. 2014
    ..Measuring theta cordance after one week of treatment could be useful in predicting atomoxetine treatment response in adult ADHD. ..
  28. ncbi request reprint Heart rate variability and treatment outcome in major depression: a pilot study
    Felipe A Jain
    Laboratory of Brain, Behavior and Pharmacology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA UCLA Depression Clinical and Research Program, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA Electronic address
    Int J Psychophysiol 93:204-10. 2014
    ..These results should be interpreted with caution due to limited sample size, but a strength of this study is its validation of the rVLF predictor in an independent sample. rVLF merits prospective confirmation as a candidate biomarker...
  29. pmc Growth modeling with nonignorable dropout: alternative analyses of the STAR*D antidepressant trial
    Bengt Muthen
    Muthén and Muthén, Los Angeles, California 90066, USA
    Psychol Methods 16:17-33. 2011
    ..The analyses provide a new way to assess drug efficiency in the presence of dropout...
  30. pmc Resting-state quantitative electroencephalography reveals increased neurophysiologic connectivity in depression
    Andrew F Leuchter
    Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e32508. 2012
    ..These results can inform the development of qEEG state and trait biomarkers for MDD...
  31. doi request reprint Assessment of the feasibility of a rehabilitation intervention program for breast cancer survivors with cognitive complaints
    Linda M Ercoli
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Brain Imaging Behav 7:543-53. 2013
    ..qEEG may serve as a potential biomarker for improvement in self-reported complaints. A randomized clinical trial is underway to test the efficacy of the intervention. ..