Steven C Hunt

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi Evidence for a major gene elevating serum bilirubin concentration in Utah pedigrees
    S C Hunt
    Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City 84108, USA
    Arterioscler Thromb Vasc Biol 16:912-7. 1996
  2. pmc An investigation of the effects of lipid-lowering medications: genome-wide linkage analysis of lipids in the HyperGEN study
    Jun Wu
    Division of Statistical Genomics, Washington University School of Medicine, Campus Box 8506, 4444 Forest Park Boulevard, Saint Louis, MO 63108, USA
    BMC Genet 8:60. 2007
  3. ncbi Family history assessment: strategies for prevention of cardiovascular disease
    Steven C Hunt
    Cardiovascular Genetics Research Program, Department of Internal Medicine, University of Utah School of Medicine, 410 Chipeta Way, Room 167, Salt Lake City, UT 84108, USA
    Am J Prev Med 24:136-42. 2003
  4. ncbi Linkage of creatinine clearance to chromosome 10 in Utah pedigrees replicates a locus for end-stage renal disease in humans and renal failure in the fawn-hooded rat
    Steven C Hunt
    Cardiovascular Genetics, Department of Internal Medicine, University of Utah School of Medicine, 410 Chipeta Way, Salt Lake City, UT 84108, USA
    Kidney Int 62:1143-8. 2002
  5. ncbi Genome scans for blood pressure and hypertension: the National Heart, Lung, and Blood Institute Family Heart Study
    Steven C Hunt
    Cardiovascular Genetics Program, Cardiology Division, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Hypertension 40:1-6. 2002
  6. ncbi Lack of association of glutamate decarboxylase 2 gene polymorphisms with severe obesity in utah
    Steven C Hunt
    Cardiovascular Genetics, Department of Internal Medicine, University of Utah, Salt Lake City, 84108, USA
    Obesity (Silver Spring) 14:650-5. 2006
  7. ncbi Sodium bicarbonate cotransporter polymorphisms are associated with baseline and 10-year follow-up blood pressures
    Steven C Hunt
    Cardiovascular Genetics Division, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Hypertension 47:532-6. 2006
  8. ncbi Linkage of serum creatinine and glomerular filtration rate to chromosome 2 in Utah pedigrees
    Steven C Hunt
    Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    Am J Hypertens 17:511-5. 2004
  9. ncbi Enhanced blood pressure response to mild sodium reduction in subjects with the 235T variant of the angiotensinogen gene
    S C Hunt
    Cardiovascular Genetics Research Clinic, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City 84108, USA
    Am J Hypertens 12:460-6. 1999
  10. ncbi Angiotensinogen genotype, sodium reduction, weight loss, and prevention of hypertension: trials of hypertension prevention, phase II
    S C Hunt
    From Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City the Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Hypertension 32:393-401. 1998

Detail Information

Publications100

  1. ncbi Evidence for a major gene elevating serum bilirubin concentration in Utah pedigrees
    S C Hunt
    Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City 84108, USA
    Arterioscler Thromb Vasc Biol 16:912-7. 1996
    ..Since cross-sectional data indicate that low serum bilirubin levels increase the risk of CHD, this major gene may be protective against CHD for about 12% of the persons in this study...
  2. pmc An investigation of the effects of lipid-lowering medications: genome-wide linkage analysis of lipids in the HyperGEN study
    Jun Wu
    Division of Statistical Genomics, Washington University School of Medicine, Campus Box 8506, 4444 Forest Park Boulevard, Saint Louis, MO 63108, USA
    BMC Genet 8:60. 2007
    ..We propose an empirical method to adjust lipid levels for medication effects so that the adjusted lipid values substitute the unmedicated lipid values in the genetic analysis...
  3. ncbi Family history assessment: strategies for prevention of cardiovascular disease
    Steven C Hunt
    Cardiovascular Genetics Research Program, Department of Internal Medicine, University of Utah School of Medicine, 410 Chipeta Way, Room 167, Salt Lake City, UT 84108, USA
    Am J Prev Med 24:136-42. 2003
    ..A positive family history also identifies the relatively small subset of families in the population at highest risk for CVD who may benefit most from targeted screening and intensive intervention...
  4. ncbi Linkage of creatinine clearance to chromosome 10 in Utah pedigrees replicates a locus for end-stage renal disease in humans and renal failure in the fawn-hooded rat
    Steven C Hunt
    Cardiovascular Genetics, Department of Internal Medicine, University of Utah School of Medicine, 410 Chipeta Way, Salt Lake City, UT 84108, USA
    Kidney Int 62:1143-8. 2002
    ..4. An important question is whether this region can be detected in healthy subjects prior to onset of ESRD by examining creatinine clearance as an indicator of early renal damage...
  5. ncbi Genome scans for blood pressure and hypertension: the National Heart, Lung, and Blood Institute Family Heart Study
    Steven C Hunt
    Cardiovascular Genetics Program, Cardiology Division, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Hypertension 40:1-6. 2002
    ..These results overlap other published scans, particularly regions on chromosomes 1 and 6, which have been implicated in familial combined hyperlipidemia...
  6. ncbi Lack of association of glutamate decarboxylase 2 gene polymorphisms with severe obesity in utah
    Steven C Hunt
    Cardiovascular Genetics, Department of Internal Medicine, University of Utah, Salt Lake City, 84108, USA
    Obesity (Silver Spring) 14:650-5. 2006
    ....
  7. ncbi Sodium bicarbonate cotransporter polymorphisms are associated with baseline and 10-year follow-up blood pressures
    Steven C Hunt
    Cardiovascular Genetics Division, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Hypertension 47:532-6. 2006
    ..These results additionally confirm the involvement of SLC4A5 with blood pressure control, although the mechanism is still unclear...
  8. ncbi Linkage of serum creatinine and glomerular filtration rate to chromosome 2 in Utah pedigrees
    Steven C Hunt
    Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    Am J Hypertens 17:511-5. 2004
    ..This can lead to a loss in power to detect linkage. Therefore, in this study we also investigated serum creatinine and estimated glomerular filtration rates (GFR), both of which are more reliably measured...
  9. ncbi Enhanced blood pressure response to mild sodium reduction in subjects with the 235T variant of the angiotensinogen gene
    S C Hunt
    Cardiovascular Genetics Research Clinic, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City 84108, USA
    Am J Hypertens 12:460-6. 1999
    ..The angiotensinogen gene accounts for some of the interindividual variation of the blood pressure response to sodium reduction...
  10. ncbi Angiotensinogen genotype, sodium reduction, weight loss, and prevention of hypertension: trials of hypertension prevention, phase II
    S C Hunt
    From Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City the Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Hypertension 32:393-401. 1998
    ..We conclude that the angiotensinogen genotype may affect blood pressure response to sodium or weight reduction and the development of hypertension...
  11. ncbi Genetic localization to chromosome 1p32 of the third locus for familial hypercholesterolemia in a Utah kindred
    S C Hunt
    Cardiovascular Genetics, Department of Medicine, University of Utah, Salt Lake City 84108, USA
    Arterioscler Thromb Vasc Biol 20:1089-93. 2000
    ..The identification of the gene in this region may provide important pathophysiological insights into new mechanisms that may lead to highly elevated LDL cholesterol and other associated dyslipidemic phenotypes...
  12. ncbi Association of plasma bilirubin with coronary heart disease and segregation of bilirubin as a major gene trait: the NHLBI family heart study
    S C Hunt
    Department of Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
    Atherosclerosis 154:747-54. 2001
    ..The inferred major gene for bilirubin may protect against CHD, since elevated levels, rather than lower levels, were associated with this inferred gene...
  13. ncbi Linkage of body mass index to chromosome 20 in Utah pedigrees
    S C Hunt
    Cardiovascular Genetics, University of Utah, 410 Chipeta Way RM 167, Salt Lake City, UT 84108, USA
    Hum Genet 109:279-85. 2001
    ..This study generated significant LOD scores which confirm suggestive linkage reports from previous studies. In addition, our analyses suggest that the predisposing gene(s) is localized very near the chromosome 20 centromere...
  14. ncbi No linkage of the lipoprotein lipase locus to hypertension in Caucasians
    S C Hunt
    Department of Internal Medicine, University of Utah, Salt Lake City, USA
    J Hypertens 17:39-43. 1999
    ..The objective of the current study was to test whether markers near the lipoprotein lipase gene were linked to hypertension in Caucasians...
  15. pmc Polymorphisms in the NPY2R gene show significant associations with BMI that are additive to FTO, MC4R, and NPFFR2 gene effects
    Steven C Hunt
    Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Obesity (Silver Spring) 19:2241-7. 2011
    ....
  16. ncbi Genome-wide multipoint parametric linkage analysis of pulse pressure in large, extended utah pedigrees
    Nicola J Camp
    Genetic Epidemiology, Department of Medical Informatics, University of Utah School of Medicine, 391 Chipeta Way, Suite D, Salt Lake City, UT 84108 1206, USA
    Hypertension 42:322-8. 2003
    ..In conclusion, our results suggest that pulse pressure might be of use for identifying genes involved in blood pressure phenotypes and arterial aging...
  17. pmc Health benefits of gastric bypass surgery after 6 years
    Ted D Adams
    Department of Internal Medicine, University of Utah School of Medicine, 420 Chipeta Way, Room 1160, Salt Lake City, UT 84108, USA
    JAMA 308:1122-31. 2012
    ..Extreme obesity is associated with health and cardiovascular disease risks. Although gastric bypass surgery induces rapid weight loss and ameliorates many of these risks in the short term, long-term outcomes are uncertain...
  18. ncbi Coronary artery disease risk in familial combined hyperlipidemia and familial hypertriglyceridemia: a case-control comparison from the National Heart, Lung, and Blood Institute Family Heart Study
    Paul N Hopkins
    Cardiovascular Genetics Research, University of Utah, Salt Lake City, USA
    Circulation 108:519-23. 2003
    ..However, no population-based studies have critically addressed this issue...
  19. ncbi Upstream stimulatory factor 1 associated with familial combined hyperlipidemia, LDL cholesterol, and triglycerides
    Hilary Coon
    Neurodevelopmental Genetics Project, Department of Psychiatry, University of Utah, Salt Lake City, UT 84108, USA
    Hum Genet 117:444-51. 2005
    ..This study replicates the involvement of USF1 in FCHL and related lipid traits in a family sample not ascertained for FCHL...
  20. pmc Genotype-phenotype analysis of angiotensinogen polymorphisms and essential hypertension: the importance of haplotypes
    W Scott Watkins
    Department of Human Genetics, University of Utah, Salt Lake City, Utah, USA
    J Hypertens 28:65-75. 2010
    ..To better understand the relationship between angiotensinogen (AGT) genetic variation and essential hypertension, AGT genotypes and haplotypes were tested for association with hypertensive endophenotypes and essential hypertension...
  21. ncbi Genetic determinants of nonmodulating hypertension
    Natapong Kosachunhanun
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Hypertension 42:901-8. 2003
    ..For this subclass of essential hypertension, it is likely that genotyping can be substituted for complex phenotyping for therapeutic and preventive decision making...
  22. pmc An aromatase polymorphism modulates the relationship between weight and estradiol levels in obese men
    Ahmad Hammoud
    Division of Reproductive Endocrinology and Infertility, Department of Surgery Urology, University of Utah, Salt Lake City, Utah, USA
    Fertil Steril 94:1734-8. 2010
    ..To describe the influence of the TTTA aromatase polymorphism (TTTAn) on the relation between obesity and plasma estradiol (E(2)) in obese men...
  23. ncbi Influence of saturated fat and linolenic acid on the association between intake of dairy products and blood pressure
    Luc Djousse
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Hypertension 48:335-41. 2006
    ..This suggests that consumption of low-fat dairy products might be more beneficial for preventing HTN...
  24. doi Association of the FTO gene with BMI
    Steven C Hunt
    Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA
    Obesity (Silver Spring) 16:902-4. 2008
    ..0 for A/A; 9.7 for A/T, and 8.5 kg/m(2) for T/T, P = 0.05). We conclude that the BMI increases associated with FTO genotypes begin in youth and are maintained throughout adulthood...
  25. ncbi A genome scan for loci influencing anti-atherogenic serum bilirubin levels
    Florian Kronenberg
    Cardiovascular Genetics, University of Utah, Salt Lake City, Utah, USA
    Eur J Hum Genet 10:539-46. 2002
    ..These results provide evidence that loci influencing bilirubin variation exist on chromosomes 2q34-37, 9q21, 10q25-26, and 18q12 and confirms the association of low bilirubin levels with coronary artery disease in males...
  26. pmc A major predisposition locus for severe obesity, at 4p15-p14
    Steven Stone
    Myriad Genetics, Inc, 320 Wakara Way, Salt Lake City, UT 84108, USA
    Am J Hum Genet 70:1459-68. 2002
    ..However, further studies are necessary to clarify the effect that this gene has in males and in the general population...
  27. pmc Cancer incidence and mortality after gastric bypass surgery
    Ted D Adams
    Cardiovascular Genetics Division, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Obesity (Silver Spring) 17:796-802. 2009
    ..These findings suggest gastric bypass results in lower cancer risk, presumably related to weight loss, supporting recommendations for reducing weight to lower cancer risk...
  28. pmc Apolipoprotein ╬Á4 polymorphism does not modify the association between body mass index and high-density lipoprotein cholesterol: a cross-sectional cohort study
    Catherine R Rahilly-Tierney
    Massachusetts Veterans Epidemiology and Information Research Center MAVERIC, Boston VA Healthcare, Boston, Massachusetts, USA
    Lipids Health Dis 10:167. 2011
    ....
  29. ncbi TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition
    Steven Stone
    Myriad Genetics, Inc, Salt City, UT 84108, USA
    Hum Mol Genet 15:2709-20. 2006
    ..Finally, although the function of TBC1D1 is unknown, the protein is structurally similar to a known regulator of insulin-mediated Glut4 translocation...
  30. ncbi TXNIP gene not associated with familial combined hyperlipidemia in the NHLBI Family Heart Study
    Hilary Coon
    Neurodevelopmental Genetics Project, University of Utah, 421 Wakara Way, Suite 143, Salt Lake City, UT 84108, USA
    Atherosclerosis 174:357-62. 2004
    ..Our results suggest that in this sample, TXNIP does not play a major role in FCHL or related traits, and is unlikely to account for the positive evidence of linkage in this region...
  31. pmc Sleep apnea, reproductive hormones and quality of sexual life in severely obese men
    Ahmad O Hammoud
    Division of Reproductive Endocrinology and Infertility, University of Utah, Salt Lake City, Utah, USA
    Obesity (Silver Spring) 19:1118-23. 2011
    ..Sleep apnea was associated with reduced sexual quality of life. In summary, sleep apnea negatively affects testosterone levels independent of BMI. Severely obese men had decreased sexual quality of life...
  32. ncbi Dietary linolenic acid and fasting glucose and insulin: the National Heart, Lung, and Blood Institute Family Heart Study
    Luc Djousse
    Division of Aging, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Obesity (Silver Spring) 14:295-300. 2006
    ..To assess whether dietary linolenic acid is associated with fasting insulin and glucose...
  33. ncbi Long-term mortality after gastric bypass surgery
    Ted D Adams
    Cardiovascular Genetics Division, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
    N Engl J Med 357:753-61. 2007
    ....
  34. ncbi Urinary free cortisol: an intermediate phenotype and a potential genetic marker for a salt-resistant subset of essential hypertension
    Bindu Chamarthi
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 92:1340-6. 2007
    ..Emerging evidence suggests a role for cortisol in essential hypertension, and preliminary reports indicate that urinary free cortisol (UFC) may be an intermediate phenotype...
  35. pmc Health outcomes of gastric bypass patients compared to nonsurgical, nonintervened severely obese
    Ted D Adams
    Department of Internal Medicine, Cardiovascular Genetics Division, University of Utah, Salt Lake City, Utah, USA
    Obesity (Silver Spring) 18:121-30. 2010
    ....
  36. ncbi Genome-wide linkage analyses for age at diagnosis of hypertension and early-onset hypertension in the HyperGEN study
    Jemma B Wilk
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Hypertens 17:839-44. 2004
    ....
  37. ncbi A genome-wide screen reveals evidence for a locus on chromosome 11 influencing variation in LDL cholesterol in the NHLBI Family Heart Study
    Hilary Coon
    Department of Psychiatry, University of Utah, Salt Lake City 84108, USA
    Hum Genet 111:263-9. 2002
    ..Other scores at or above 1.9 occurred on chromosomes 5 (lod=1.89 at 1.6 cM), 10 (lod=2.47 at 127.1 cM), 17 (lod=2.33 at 116.3 cM), and 21 (lod=2.74 at 45.2 cM)...
  38. ncbi Segregation analysis of HDL cholesterol in the NHLBI Family Heart Study and in Utah pedigrees
    Florian Kronenberg
    Department of Cardiovascular Genetics, University of Utah, Salt Lake City, Utah, USA
    Eur J Hum Genet 10:367-74. 2002
    ..Instead we found some evidence for the segregation of an allele associated with high HDL-C. d..
  39. pmc Altered composition of triglyceride-rich lipoproteins and coronary artery disease in a large case-control study
    Paul N Hopkins
    Cardiovascular Genetics Research, Department of Internal Medicine, Cardiology Division, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
    Atherosclerosis 207:559-66. 2009
    ..30 with TG>150mg/dL) indicative of atherogenic remnant accumulation (type III hyperlipidemia). However, virtually no reports are available which examine potential associations between CAD and VLDL-C/TG at the lower end of the spectrum...
  40. ncbi Left ventricular hypertrophy in severe obesity: interactions among blood pressure, nocturnal hypoxemia, and body mass
    Erick Avelar
    Division of Cardiology, University of Utah School of Medicine, Salt Lake City, USA
    Hypertension 49:34-9. 2007
    ..The effects of increased blood pressure seem to amplify those of sleep apnea and more severe obesity...
  41. ncbi Association of coronary artery calcified plaque with clinical coronary heart disease in the National Heart, Lung, and Blood Institute's Family Heart Study
    Paul N Hopkins
    Cardiovascular Genetics Research, University of Utah, Salt Lake City, Utah, USA
    Am J Cardiol 97:1564-9. 2006
    ..In conclusion, CAC was strongly associated with CHD even after adjustment for standard risk factors and family history contributed independently to CHD risk...
  42. pmc Improved heart rate recovery after marked weight loss induced by gastric bypass surgery: two-year follow up in the Utah Obesity Study
    Stephen L Wasmund
    Division of Cardiology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    Heart Rhythm 8:84-90. 2011
    ..Blunted HR recovery is a very powerful predictor of increased mortality, whereas enhanced HR recovery portends a good prognosis...
  43. ncbi Alcohol consumption and plasma atrial natriuretic peptide (from the HyperGEN study)
    Luc Djousse
    Division of Aging, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 98:628-32. 2006
    ..0001 each for trend). In conclusion, our data have shown a positive and linear association between alcohol consumption and ANP in men and women, irrespective of race...
  44. ncbi Plasma triglycerides and type III hyperlipidemia are independently associated with premature familial coronary artery disease
    Paul N Hopkins
    Cardiovascular Genetics, Department of Internal Medicine, Cardiology Division, University of Utah School of Medicine, 410 Chipeta Way, Salt Lake City, UT 84108, USA
    J Am Coll Cardiol 45:1003-12. 2005
    ..This study was designed to explore contributions of plasma total triglycerides (TGs) and type III hyperlipidemia to the risk of premature familial coronary artery disease (CAD)...
  45. ncbi Model-fitting and linkage analysis of sodium-lithium countertransport
    Sandra J Hasstedt
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112 5330, USA
    Eur J Hum Genet 12:1055-61. 2004
    ..Using the inferred model, lod scores >2 were obtained for D3S3038, D11S4464, and D10S677 for the BMI-responsive locus, and for D8S1048 for the TG-responsive locus...
  46. doi Two-dimensional, sex-specific autosomal linkage scan of the number of sodium pump sites
    Sandra J Hasstedt
    Department of Human Genetics, University of Utah School of Medicine, University of Utah, Salt Lake City, Utah 84112, USA
    J Hypertens 28:740-7. 2010
    ..Obesity, hypertension, and diabetes associate with the activity of the sodium pump, motivating gene discovery for sodium pump number...
  47. pmc Evaluation of the gene-age interactions in HDL cholesterol, LDL cholesterol, and triglyceride levels: the impact of the SORT1 polymorphism on LDL cholesterol levels is age dependent
    Brian H Shirts
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA
    Atherosclerosis 217:139-41. 2011
    ..These findings may help elucidate the mode of action of the SORT1 gene and impact potential therapeutic interventions targeting this pathway...
  48. pmc Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study
    Ervin R Fox
    Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA
    Hum Mol Genet 20:2273-84. 2011
    ..More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexity...
  49. doi Relation of albuminuria to left ventricular mass (from the HyperGEN Study)
    Luc Djousse
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Cardiol 101:212-6. 2008
    ..In conclusion, these results suggest that albuminuria is positively associated with LV mass in normotensive subjects as it is in hypertensive subjects...
  50. pmc Leukocyte telomeres are longer in African Americans than in whites: the National Heart, Lung, and Blood Institute Family Heart Study and the Bogalusa Heart Study
    Steven C Hunt
    Cardiovascular Genetics Division, University of Utah School of Medicine, Salt Lake City, UT, USA NHLBI Family Heart Study
    Aging Cell 7:451-8. 2008
    ..029 kb year(-1) vs. 0.020 kb year(-1), respectively, p = 0.0001). We suggest that racial difference in LTL arises from a host of interacting biological factors, including replication rates of hematopoietic stem cells...
  51. pmc Evidence for a gene influencing heart rate on chromosome 5p13-14 in a meta-analysis of genome-wide scans from the NHLBI Family Blood Pressure Program
    Jason M Laramie
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 7:17. 2006
    ..Previous family studies have shown a significant heritable component to heart rate with several groups conducting genomic linkage scans to identify quantitative trait loci...
  52. ncbi Linkage of the cholesterol 7alpha-hydroxylase gene and low-density lipoprotein cholesterol conditional on apolipoprotein E association: the National Heart, Lung, and Blood Institute Family Heart Study
    Jing Ping Lin
    Office of Biostatistics Research, National Heart, Lung and Blood Institute, National Institutes of Health, Salt Lake City, UT 84108 3528, USA
    Chin Med J (Engl) 118:362-9. 2005
    ..We report here an investigation of the relationship between LDL-C and cholesterol 7alpha-hydroxylase (CYP7), as well as apoE and low-density lipoprotein receptor (LDLR), three pivotal genes in LDL metabolism...
  53. ncbi Influence of apolipoprotein E, smoking, and alcohol intake on carotid atherosclerosis: National Heart, Lung, and Blood Institute Family Heart Study
    Luc Djousse
    Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University School of Medicine, Boston, Mass 02118, USA
    Stroke 33:1357-61. 2002
    ..Apolipoprotein E (apoE) isoforms and lifestyle factors play an important role in the development of coronary heart disease. The association of apoE and carotid atherosclerosis remains controversial...
  54. ncbi Dietary linolenic acid is inversely associated with plasma triacylglycerol: the National Heart, Lung, and Blood Institute Family Heart Study
    Luc Djousse
    Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University School of Medicine, Room B 612, 715 Albany Street, Boston, MA 02118, USA
    Am J Clin Nutr 78:1098-102. 2003
    ..Dietary intake of linolenic acid is associated with a decreased risk of cardiovascular disease mortality. However, the mechanisms by which dietary linolenic acid affects cardiovascular disease risk are not clearly understood...
  55. ncbi Low-renin hypertension, altered sodium homeostasis, and an alpha-adducin polymorphism
    Frederick D Grant
    Endocrinology Hypertension Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Hypertension 39:191-6. 2002
    ..Homozygosity for this alpha-adducin allele may be an important determinant for approximately 10% of individuals with low-renin hypertension...
  56. ncbi Genome-wide scans meta-analysis for pulse pressure
    Elias Zintzaras
    Center for Clinical Evidence Synthesis, Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Hypertension 50:557-64. 2007
    ..04). None of the bins showed low heterogeneity (P(Q)>0.05), indicating variation in the strength of association. Further investigation of these regions may help to direct the identification of candidate genes for pulse pressure variation...
  57. ncbi Angiotensinogen genotype affects renal and adrenal responses to angiotensin II in essential hypertension
    Paul N Hopkins
    Cardiovascular Genetics, Cardiology Division, University of Utah, Salt Lake City, UT, USA
    Circulation 105:1921-7. 2002
    ..We examine herein angiotensinogen (AGT) as a candidate gene to help elucidate potential mechanisms for previously reported AGT linkage and association studies...
  58. pmc Evaluation of risk scores derived from the health family tree program
    Yuling Jiang
    Department of Biomedical Informatics, University of Utah, Salt Lake City, UT, USA
    AMIA Annu Symp Proc 2009:286-90. 2009
    ..An FHS >/=1 was determined to be a significant predictor for future development of diabetes, myocardial infarction, and early onset of myocardial infarction...
  59. ncbi PAI-1 in human hypertension: relation to hypertensive groups
    Nadarajah Srikumar
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Hypertens 15:683-90. 2002
    ..Although the renin-angiotensin system and insulin resistance (IR) have been identified as major regulators of plasminogen activator inhibitor type-1 (PAI-1), their roles in hypertensive subjects is not clearly defined...
  60. doi Gastrointestinal surgery: cardiovascular risk reduction and improved long-term survival in patients with obesity and diabetes
    Ted D Adams
    Division of Cardiovascular Genetics, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
    Curr Atheroscler Rep 14:606-15. 2012
    ..The opportunity for bariatric (and/or metabolic) surgery to provide a preventive strategy for cardiovascular disease and diabetes as well as treatment therapy is presented for clinical consideration...
  61. pmc Vitamin D dependent effects of APOA5 polymorphisms on HDL cholesterol
    Brian H Shirts
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Atherosclerosis 222:167-74. 2012
    ..Vitamin D and serum lipid levels are risk factors for cardiovascular disease. We sought to determine if vitamin D (25OHD) interacts at established lipid loci potentially explaining additional variance in lipids...
  62. pmc Genetically hypertensive Brown Norway congenic rat strains suggest intermediate traits underlying genetic hypertension
    Marijo Bilusic
    Trinitas Hospital, Department of Internal Medicine, Seton Hall University, Elizabeth, NJ, USA
    Croat Med J 49:586-99. 2008
    ....
  63. pmc Effect of Roux-en-Y gastric bypass surgery on the sex steroids and quality of life in obese men
    Ahmad Hammoud
    Division of Reproductive Endocrinology and Infertility, University of Utah, Salt Lake City, Utah 84132, USA
    J Clin Endocrinol Metab 94:1329-32. 2009
    ..The effect of bariatric surgery on the reproductive function of obese men is not entirely elucidated...
  64. ncbi Design and rationale of the Utah obesity study. A study to assess morbidity following gastric bypass surgery
    Ted D Adams
    University of Utah School of Medicine, Cardiovascular Genetics Research Program, Cardiology Division, Salt Lake City, UT 84108, USA
    Contemp Clin Trials 26:534-51. 2005
    ..This study is designed to assess the effectiveness of GBP in reducing morbidity and maintaining weight loss. A wide array of clinical tests and psycho-behavioral questionnaires are included as part of the study...
  65. ncbi Genetics of hypertension
    Paul N Hopkins
    Cardiovascular Genetics, University of Utah, Salt Lake City 84108, USA
    Genet Med 5:413-29. 2003
  66. ncbi Gender difference in diastolic function in hypertension (the HyperGEN study)
    Jonathan N Bella
    Department of Medicine, Cornell Medical Center, New York, New York 10021, USA
    Am J Cardiol 89:1052-6. 2002
    ..This gender difference in diastolic function may provide insight into gender differences in congestive heart failure and other specific cardiovascular diseases...
  67. pmc Utah's Family High Risk Program: bridging the gap between genomics and public health
    Jenny Johnson
    Utah Department of Health Chronic Disease Genomics Program, PO Box 142106, Salt Lake City, UT, 84114 2106, USA
    Prev Chronic Dis 2:A24. 2005
    ..Despite its use for predicting disease, family history has traditionally been underused in the public health setting...
  68. doi Cancer and obesity: effect of bariatric surgery
    Ted D Adams
    Cardiovascular Genetics Division, University of Utah School of Medicine, Salt Lake City, UT, USA
    World J Surg 33:2028-33. 2009
    ..Study limitations and future research questions related to cancer and bariatric surgery are briefly discussed...
  69. pmc Genetic architecture of complex traits predisposing to nephropathy: hypertension
    Steven C Hunt
    Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Semin Nephrol 30:150-63. 2010
    ..A brief review is provided of some key genes found to be associated with hypertension, including the genes identified from the nine genome-wide association studies published to date...
  70. pmc Strategies to improve detection of hypertension genes
    Steven C Hunt
    Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84108, USA
    J Nutrigenet Nutrigenomics 3:182-91. 2010
    ..Genes found to be significant in such studies should be densely typed in clinical trials and large population studies to assess public health and clinical applications of the findings...
  71. pmc Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol
    Latisha Love-Gregory
    Department of Medicine, Center for Human Nutrition, Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 17:1695-704. 2008
    ..0059). Fifteen additional SNPs associated with HDL-C (P = 0.0028-0.044). We conclude that CD36 variants may impact MetS pathophysiology and HDL metabolism, both predictors of the risk of heart disease and type 2 diabetes...
  72. ncbi Common variant of human NEDD4L activates a cryptic splice site to form a frameshifted transcript
    Diane M Dunn
    Department of Human Genetics, Rm 308 BPRB, 20 South 2030 East, University of Utah, Salt Lake City, UT 84112, USA
    J Hum Genet 47:665-76. 2002
    ..Differential function of NEDD4L isoforms could prove significant in blood pressure regulation through an effect on ENaC-dependent sodium reabsorption...
  73. pmc Refined mapping of suggestive linkage to renal function in African Americans: the HyperGEN study
    Andrew T Dewan
    Am J Hum Genet 71:204-5. 2002
  74. ncbi A meta-analysis of genome-wide linkage scans for hypertension: the National Heart, Lung and Blood Institute Family Blood Pressure Program
    Michael A Province
    Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Hypertens 16:144-7. 2003
    ..The networks used different family designs and targeted multiple ethnic groups, using standardized protocols and definitions. Linkage genome scans were done on samples within each network (N = 6245 relatives)...
  75. ncbi Quantitative trait loci for metabolic syndrome in the Hypertension Genetic Epidemiology Network study
    Aldi T Kraja
    Division of Biostatistics, Washington University School of Medicine, Campus Box 8067, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
    Obes Res 13:1885-90. 2005
    ..The most promising candidate loci on 11q24 for lipids-INS and 13p12 for obesity-INS in blacks, 8p23 for lipids-INS, 14q24 for obesity-INS, and 15q15 for BP in whites warrant further investigation...
  76. ncbi Sex-specific effects of ACE I/D and AGT-M235T on pulse pressure: the HyperGEN Study
    Amy I Lynch
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
    Hum Genet 122:33-40. 2007
    ..This evidence for a genotype-by-sex interaction helps our understanding of the complex genetic underpinnings of blood pressure phenotypes...
  77. pmc Regarding "Testing for population subdivision and association in four case-control studies"
    James S Pankow
    Am J Hum Genet 71:1478-80. 2002
  78. ncbi Association study of CRP gene polymorphisms with serum CRP level and cardiovascular risk in the NHLBI Family Heart Study
    Qingwei Wang
    Cardiovascular Research Institute, Atlanta, GA 30310, USA
    Am J Physiol Heart Circ Physiol 291:H2752-7. 2006
    ....
  79. ncbi Interarm differences in seated systolic and diastolic blood pressure: the Hypertension Genetic Epidemiology Network study
    Donna K Arnett
    University of Alabama at Birmingham, School of Public Health, Department of Epidemiology, Birmingham, Alabama 55294 0022, USA
    J Hypertens 23:1141-7. 2005
    ..To examine whether blood pressure (BP) differs between arms in hypertensive siblings and randomly selected volunteers, and whether this difference is explained by cardiovascular risk factors...
  80. ncbi Haplotype association analysis of AGT variants with hypertension-related traits: the HyperGEN study
    C Charles Gu
    Division of Biostatistics, Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Hered 60:164-76. 2005
    ..We set out to examine a hypothesis that multiple genetic variants in the system act together in blood pressure regulation, via intermediate phenotypes such as blood pressure reactivity...
  81. ncbi The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes
    Veit Schoenborn
    Division of Genetic Epidemiology, Department of Medical Genetics, Molecular Clinical Pharmacology, Innsbruck Medical University, Schopfstrasse 41, A 6020 Innsbruck, Austria
    Diabetes 55:1270-5. 2006
    ..These results complement previous findings of functional studies in mammals and elucidate a potential role of ATGL in pathways involved in components of the metabolic syndrome...
  82. ncbi Quantitative trait loci on chromosome 8q24 for pancreatic beta-cell function and 7q11 for insulin sensitivity in obese nondiabetic white and black families: evidence from genome-wide linkage scans in the NHLBI Hypertension Genetic Epidemiology Network (Hy
    Ping An
    Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Diabetes 55:551-8. 2006
    ..These regions replicate previous reports for type 2 diabetes-associated traits...
  83. ncbi Growth hormone receptor variant (L526I) modifies plasma HDL cholesterol phenotype in familial hypercholesterolemia: intra-familial association study in an eight-generation hyperlipidemic kindred
    Daisuke Takada
    Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, Japan
    Am J Med Genet A 121:136-40. 2003
    ..0021). The results indicate a significant modification of the phenotype of FH with the defective LDLR allele, by GHR Leu variation in the kindred studied...
  84. pmc Genomewide linkage and linkage disequilibrium analyses identify COL6A1, on chromosome 21, as the locus for ossification of the posterior longitudinal ligament of the spine
    Toshihiro Tanaka
    Division of Genetic Diagnosis, The Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Am J Hum Genet 73:812-22. 2003
    ..Identification of the locus of susceptibility to OPLL by genomewide linkage and linkage disequilibrium studies permits us to investigate the pathogenesis of the disease, which may lead to the development of novel therapeutic tools...
  85. ncbi Assessment of the interaction of heritability of volume load and left ventricular mass: the HyperGEN offspring study
    Giovanni de Simone
    Weill Medical College of Cornell University, New York, NY, USA
    J Hypertens 25:1397-402. 2007
    ..Left ventricular mass (LVM) is more closely associated with volume load than pressure load. We assessed whether part of the genetic heritability of LVM can be explained by stroke volume (SV) inheritance...
  86. pmc Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies
    Hua Tang
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Am J Hum Genet 76:268-75. 2005
    ..S. population. Implications of this genetic structure for case-control association studies are discussed...
  87. ncbi Genome-wide linkage mapping for valve calcification susceptibility loci in hypertensive sibships: the Hypertension Genetic Epidemiology Network Study
    Jonathan N Bella
    Weill Medical College, Cornell University, New York, NY, USA
    Hypertension 49:453-60. 2007
    ..1-q22.3 and suggestive linkage to chromosome 19p13.11-p11 and identifies several other promising genomic regions that may contain specific susceptibility loci for valve calcification...
  88. ncbi Linkage analysis of diabetes status among hypertensive families: the Hypertension Genetic Epidemiology Network study
    Christy L Avery
    Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC 27514, USA
    Diabetes 53:3307-12. 2004
    ..The identification and replication of type 2 diabetes QTLs will bring us closer to the detection of functional genes that influence diabetes susceptibility...
  89. ncbi Evidence for a gene on chromosome 13 influencing postural systolic blood pressure change and body mass index
    Kari E North
    Department of Epidemiology, University of North Carolina Chapel Hill, Bank of America Center, 137 E Franklin St, Suite 306, Chapel Hill, NC 27514, USA
    Hypertension 43:780-4. 2004
    ..4 and 0.9, respectively). These findings suggest that a gene(s) on chromosome 13q jointly regulates the SBP response to postural change and BMI...
  90. ncbi Genome scan of glomerular filtration rate and albuminuria: the HyperGEN study
    Joanlise M Leon
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, USA
    Nephrol Dial Transplant 22:763-71. 2007
    ..We performed genome-wide scans to detect loci impacting these parameters in 1251 African American (AAs) and 1129 European American (EAs) hypertensive siblings from the Hypertension Genetic Epidemiology Network study...
  91. doi INSIG2 polymorphism is neither associated with BMI nor with phenotypes of lipoprotein metabolism
    Eva Boes
    Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria
    Obesity (Silver Spring) 16:827-33. 2008
    ....
  92. ncbi Positional identification of hypertension susceptibility genes on chromosome 2
    Ruth Ann Barkley
    Human Genetics Center and Institute of Molecular Medicine, of Texas Health Science Center at Houston, USA
    Hypertension 43:477-82. 2004
    ..Moreover, the present study validates previous evidence for one or more genes on chromosome 2 that influence hypertension-related phenotypes in the population-at-large...
  93. ncbi Soluble epoxide hydrolase variant (Glu287Arg) modifies plasma total cholesterol and triglyceride phenotype in familial hypercholesterolemia: intrafamilial association study in an eight-generation hyperlipidemic kindred
    Keiko Sato
    Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1 396 Kosugi cho, Kawasaki 211 8533, Japan
    J Hum Genet 49:29-34. 2004
    ..These results indicate a significant modification of the phenotype of FH with defective LDLR allele by EPHX2-287Arg variation in our studied kindred...
  94. pmc Sex-specific association of the putative fructose transporter SLC2A9 variants with uric acid levels is modified by BMI
    Anita Brandst├Ątter
    Department of Medical Genetics, Molecular and ClinicalPharmacology, Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria
    Diabetes Care 31:1662-7. 2008
    ..The aim of the present study was to examine the association of four single nucleotide polymorphisms within this gene with uric acid levels and to determine whether this association is modified by obesity...
  95. ncbi Further evidence of a quantitative trait locus on chromosome 18 influencing postural change in systolic blood pressure: the Hypertension Genetic Epidemiology Network (HyperGEN) Study
    James S Pankow
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Am J Hypertens 18:672-8. 2005
    ..The objective of this study was to characterize further a possible quantitative trait locus on chromosome 18q21 influencing SBP response to a postural challenge...
  96. doi Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM
    Makoto Daimon
    Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Biochem Biophys Res Commun 374:576-80. 2008
    ..44 g/day) (p=0.002). A case-control association study also showed a significant association with diabetes only in subjects with low salt consumption (p=0.006)...
  97. pmc Association of the melanocortin-4 receptor V103I polymorphism with dietary intake in severely obese persons
    Michaela Pichler
    Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria
    Am J Clin Nutr 88:797-800. 2008
    ..A recent study found an association of the MC4R 103I variant with carbohydrate intake, which may mediate some of the association of this variant with leanness...
  98. pmc Estimating the single nucleotide polymorphism genotype misclassification from routine double measurements in a large epidemiologic sample
    Iris M Heid
    Helmholtz Zentrum Munchen German Research Center for Environmental Health, Institute of Epidemiology, 85764 Neuherberg, Germany
    Am J Epidemiol 168:878-89. 2008
    ..In situations with more substantial error, the presented approach using duplicate genotyping and the MC-SIMEX method is practical and helpful for quantifying the genotyping error and its impact...
  99. doi Genome-wide admixture mapping for coronary artery calcification in African Americans: the NHLBI Family Heart Study
    Qunyuan Zhang
    Division of Statistical Genomics, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Genet Epidemiol 32:264-72. 2008
    ..On the basis of the results from this and other independent studies, the location of D6S1053 at 80cM on chromosome 6 (6q12) seems to harbor a highly promising quantitative trait loci for atherosclerosis...
  100. pmc Factor relationships of metabolic syndrome and echocardiographic phenotypes in the HyperGEN study
    Pinchia Huang
    Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Hypertens 26:1360-6. 2008
    ..Metabolic syndrome and its risk factors are predictors of cardiovascular events. Metabolic syndrome is also directly associated with echocardiographic phenotypes...