Research Topics
Species | Peter W HuntSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
HIV and inflammation: mechanisms and consequencesPeter W Hunt
UCSF Positive Health Program, San Francisco, CA 94110, USA
Curr HIV/AIDS Rep 9:139-47. 2012..Other recent studies have helped clarify the roles of persistent HIV expression and/or replication, microbial translocation, and co-infections in driving this persistent inflammatory state, identifying targets for novel interventions...
Th17, gut, and HIV: therapeutic implicationsPeter W Hunt
Positive Health Program, San Francisco General Hospital, University of California San Francisco, 995 Potrero Avenue, San Francisco, CA 94110, USA
Curr Opin HIV AIDS 5:189-93. 2010....- Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapyPeter W Hunt
Positive Health Program, San Francisco General Hospital, Bldg 80, Ward 84, 995 Potrero Ave, San Francisco, CA 94110, USA
J Infect Dis 197:126-33. 2008.... 
Role of immune activation in HIV pathogenesisPeter W Hunt
Positive Health Program, San Francisco General Hospital, Building 80, Ward 84, 995 Potrero Avenue, San Francisco, CA 94110, USA
Curr HIV/AIDS Rep 4:42-7. 2007....- A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllersPeter W Hunt
Departments of Medicine and Laboratory Medicine, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 6:e15924. 2011..These data support a model in which low frequencies of Tregs in HIV controllers may contribute to an effective adaptive immune response, but may also contribute to generalized immune activation, potentially contributing to CD4 depletion... - Impact of CD8+ T-cell activation on CD4+ T-cell recovery and mortality in HIV-infected Ugandans initiating antiretroviral therapyPeter W Hunt
Department of Medicine, University of California, San Francisco, USA
AIDS 25:2123-31. 2011..To assess whether T-cell activation independently predicts the extent of CD4(+) T-cell recovery and mortality in HIV-infected Ugandans initiating antiretroviral therapy (ART)... - Prevalence of CXCR4 tropism among antiretroviral-treated HIV-1-infected patients with detectable viremiaPeter W Hunt
Positive Health Program, San Francisco General Hospital, San Francisco, CA 94110, USA
J Infect Dis 194:926-30. 2006..CCR5 inhibitors may thus be best strategically used before salvage therapy and before significant CD4 + T cell depletion... - The independent effect of drug resistance on T cell activation in HIV infectionPeter W Hunt
Positive Health Program, San Francisco General Hospital, University of California, San Francisco, California 94110, USA
AIDS 20:691-9. 2006.... - HIV-specific CD4+ T cells may contribute to viral persistence in HIV controllersPeter W Hunt
Department of Medicine, University of California, San Francisco, California, USA
Clin Infect Dis 52:681-7. 2011..Despite robust immune responses, these individuals never eradicate HIV infection. We hypothesized that HIV-specific CD4(+) T cells might serve as target cells for HIV, contributing to viral persistence in this setting... - Valganciclovir reduces T cell activation in HIV-infected individuals with incomplete CD4+ T cell recovery on antiretroviral therapyPeter W Hunt
Department of Medicine, University of California, San Francisco, USA
J Infect Dis 203:1474-83. 2011..We hypothesized that asymptomatic cytomegalovirus (CMV) replication might contribute to immune activation in this setting... - Immunodominant HIV-specific CD8+ T-cell responses are common to blood and gastrointestinal mucosa, and Gag-specific responses dominate in rectal mucosa of HIV controllersApril L Ferre
Dept of Medical Microbiology and Immunology, University of California, Davis, CA 95616, USA
J Virol 84:10354-65. 2010.... - Immunologic and virologic evolution during periods of intermittent and persistent low-level viremiaAnnika C Karlsson
Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA
AIDS 18:981-9. 2004..It is likely that higher viremia and stronger immune activation act synergistically to accelerate the development of systemic drug resistance... - Association of abacavir and impaired endothelial function in treated and suppressed HIV-infected patientsPriscilla Y Hsue
Division of Cardiology, Positive Health Program of the Department of Medicine, San Francisco General Hospital, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
AIDS 23:2021-7. 2009..As endothelial dysfunction is central to the pathogenesis of atherosclerosis, we tested the hypothesis that current treatment with abacavir is associated with impaired endothelial function... - Increased carotid intima-media thickness in HIV patients is associated with increased cytomegalovirus-specific T-cell responsesPriscilla Y Hsue
Divisions of Cardiology, San Francisco General Hospital, University of California, San Francisco, USA
AIDS 20:2275-83. 2006.... - Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosisPriscilla Y Hsue
Division of Cardiology, San Francisco General Hospital, San Francisco, California 94110, USA
AIDS 23:1059-67. 2009.... - Evidence of persistent low-level viremia in long-term HAART-suppressed, HIV-infected individualsHiroyu Hatano
Department of Medicine, University of California, San Francisco, California, USA
AIDS 24:2535-9. 2010..HAART can effectively reduce plasma HIV RNA levels to below the level of detection in most HIV-infected patients. The degree to which residual low-level viremia persists during HAART remains unclear... - Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapyHiroyu Hatano
San Francisco General Hospital, Building 80, Ward 84, 995 Potrero Avenue, San Francisco, CA 94110, USA
J Virol 83:329-35. 2009..This confirms the failure to eradicate the virus, even in these unique individuals who are able to reduce plasma viremia to very low levels without antiretroviral therapy... - T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapyPeter W Hunt
Positive Health Program, San Francisco General Hospital, and San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Infect Dis 187:1534-43. 2003..Interventions that directly target T cell activation or the determinants of activation may prove to be useful adjuvants to antiretroviral therapy... - Continued CD4 cell count increases in HIV-infected adults experiencing 4 years of viral suppression on antiretroviral therapyPeter W Hunt
Positive Health Program, San Francisco General Hospital, University of California, San Francisco, California, USA
AIDS 17:1907-15. 2003..The immune system's capacity for CD4 T lymphocyte restoration is not limited by low pre-therapy CD4 counts... - Cytomegalovirus-specific T cells persist at very high levels during long-term antiretroviral treatment of HIV diseaseDavid M Naeger
Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 5:e8886. 2010..The impact of untreated and treated HIV infection on the frequency of these cells remains undefined... - A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4+ T cell responseHiroyu Hatano
University of California, San Francisco, USA
J Infect Dis 203:960-8. 2011..We conducted an intensification study to assess whether residual viral replication contributes to replenishment of the latent reservoir and whether mucosal HIV-specific T cell responses limit the reservoir size... - Association of vitamin D insufficiency with carotid intima-media thickness in HIV-infected personsAndy I Choi
Department of Medicine, University of California San Francisco, San Francisco, CA, USA
Clin Infect Dis 52:941-4. 2011..If confirmed, these findings support a clinical trial of vitamin D supplementation to reduce cardiovascular events in HIV-infected persons... - Cerebrospinal fluid in HIV-1 systemic viral controllers: absence of HIV-1 RNA and intrathecal inflammationJohn C Probasco
Department of Neurology, University of California, San Francisco, San Francisco, California, USA
AIDS 24:1001-5. 2010..In this group, host-mediated viral control may be accompanied by chronic systemic inflammation. It is unknown whether either infection or chronic inflammation is present within the central nervous system of these individuals... - Changes in food insecurity, nutritional status, and physical health status after antiretroviral therapy initiation in rural UgandaSheri D Weiser
Department of Medicine, Division of HIV AIDS, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA
J Acquir Immune Defic Syndr 61:179-86. 2012..To investigate whether time on antiretroviral therapy (ART) is associated with improvements in food security and nutritional status, and the extent to which associations are mediated by improved physical health status... - Expansion of CD8+ T cells lacking Sema4D/CD100 during HIV-1 infection identifies a subset of T cells with decreased functional capacityEmily M Eriksson
Division of Experimental Medicine, Department of Medicine, University of California San Francisco, USA
Blood 119:745-55. 2012..These data suggest that loss of CD100 expression probably plays an important role in dysfunctional immunity in HIV-1 infection... - Impact of HIV infection on diastolic function and left ventricular massPriscilla Y Hsue
Division of Cardiology, San Francisco General Hospital, San Francisco, CA 94110, USA
Circ Heart Fail 3:132-9. 2010..These results suggest that contemporary asymptomatic patients with HIV manifest mild functional and morphological cardiac abnormalities, which are independently associated with HIV infection... - A role for cytomegalovirus-specific CD4+CX3CR1+ T cells and cytomegalovirus-induced T-cell immunopathology in HIV-associated atherosclerosisKarim Sacre
Division of Experimental Medicine, San Francisco General Hospital, University of California San Francisco, 94110, USA
AIDS 26:805-14. 2012.... - HIV controllers with HLA-DRB1*13 and HLA-DQB1*06 alleles have strong, polyfunctional mucosal CD4+ T-cell responsesApril L Ferre
Department of Medical Microbiology and Immunology, School of Medicine, University of California, 3327 Tupper Hall, 1 Shields Ave, Davis, CA 95616, USA
J Virol 84:11020-9. 2010..43, P=0.005), suggesting that increased CD4+ T-cell "help" may be important in maintaining strong CD8+ T-cell responses in the gut of HIV controllers... - Food insecurity is associated with morbidity and patterns of healthcare utilization among HIV-infected individuals in a resource-poor settingSheri D Weiser
Division of HIV AIDS, San Francisco General Hospital, University of California, San Francisco, 94143, USA
AIDS 26:67-75. 2012..We undertook a longitudinal study in rural Uganda to understand the association of food insecurity with morbidity and patterns of healthcare utilization among HIV-infected individuals enrolled in an antiretroviral therapy program... - Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV diseaseDavid Favre
Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA 94110, USA
Sci Transl Med 2:32ra36. 2010..We postulate that induction of IDO may represent a critical initiating event that results in inversion of the T(H)17/T(reg) balance and in the consequent maintenance of a chronic inflammatory state in progressive HIV disease... - HIV-infected persons continue to lose kidney function despite successful antiretroviral therapyAndy I Choi
Department of Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
AIDS 23:2143-9. 2009..To identify risk factors associated with kidney function decline in a contemporary cohort of treated and untreated HIV-infected patients... - Short communication: HIV(+) viremic slow progressors maintain low regulatory T cell numbers in rectal mucosa but exhibit high T cell activationJulia M Shaw
Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA
AIDS Res Hum Retroviruses 29:172-7. 2013..These data reveal that the VSP phenotype is associated with elevated markers of mucosal immune activation and low numbers of mucosal Treg, suggesting that factors other than immune activation account for this phenotype... - Sexual relationship power and depression among HIV-infected women in Rural UgandaAbigail M Hatcher
Division of HIV AIDS, Department of Medicine, University of California San Francisco, San Francisco, CA, USA
PLoS ONE 7:e49821. 2012..Low sexual relationship power also contributes to HIV risk, but there is limited understanding of how it relates to mental health among HIV-infected women... - Immunologic basis of cardiovascular disease in HIV-infected adultsPriscilla Y Hsue
Division of Cardiology, Department of Medicine, San Francisco General Hospital, University of California San Francisco, 995 Potrero Ave, San Francisco, CA 94110, USA
J Infect Dis 205:S375-82. 2012.... - Trends in the clinical characteristics of HIV-infected patients initiating antiretroviral therapy in Kenya, Uganda and Tanzania between 2002 and 2009Elvin H Geng
Department of Medicine, San Francisco General Hospital, University of California at San Francisco, 995 Potrero Avenue, San Francisco, CA, USA
J Int AIDS Soc 14:46. 2011..Regionally representative socio-demographic, laboratory and clinical characteristics of patients accessing ART over time and across sites have not been well described... - Lack of evidence for mtDNA as a biomarker of innate immune activation in HIV infectionAdam S Lauring
Department of Medicine, University of California San Francisco, San Francisco, California, United States of America alauring med umich edu
PLoS ONE 7:e50486. 2012..We did, however, observe a negative correlation between age and plasma mitochondrial DNA levels in individuals with well-controlled HIV... - Regional anthropometry changes in antiretroviral-naïve persons initiating a Zidovudine-containing regimen in Mbarara, UgandaVanessa Thompson
Department of Medicine, University of California, San Francisco, 94121, USA
AIDS Res Hum Retroviruses 27:785-91. 2011..Gains in the tricep skinfold, a reliable marker of subcutaneous fat, appeared blunted, which could indicate an inhibitory effect of zidovudine on peripheral subcutaneous fat recovery... - Immune-based therapy for HIV infection: are acute and chronic HIV infection different diseases?Peter W Hunt
J Infect Dis 194:1632-4. 2006
Research Grants
- The Determinants of T Cell Activation in HIV InfectionPeter Hunt; Fiscal Year: 2007..abstract_text> ..