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Species | Jennifer L HuntSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
BRAF mutation is unusual in chronic lymphocytic thyroiditis-associated papillary thyroid carcinomas and absent in non-neoplastic nuclear atypia of thyroiditisRachel Sargent
Department of Pathology, University of Pittsburgh Medical Center, USA
Endocr Pathol 17:235-41. 2006..These data suggest that BRAF is a less frequent mechanism of tumorigenesis in a background of CLT and that BRAF mutation is not present in the atypical follicular epithelium of CLT...
Molecular pathology in anatomic pathology practice: a review of basic principlesJennifer L Hunt
Cleveland Clinic, Department of Pathology, 9500 Euclid Ave L25, Cleveland, OH 44195, USA
Arch Pathol Lab Med 132:248-60. 2008..This review focuses on basic molecular pathology concepts, with particular emphasis on the challenge of tissue-based testing in anatomic pathology...- Histologic features of surgically removed fallopian tubesJennifer L Hunt
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 15213, USA
Arch Pathol Lab Med 126:951-5. 2002.... - Prostatic adenocarcinoma metastatic to the head and neck and the workup of an unknown epithelioid neoplasmJennifer L Hunt
PUH A616 3, Department of Pathology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, Pennsylvania 15213, USA
Head Neck 26:171-8. 2004..One unusual, but important, primary tumor that can metastasize to the head and neck is carcinoma of the prostate (CAP)... - p63 expression in sclerosing mucoepidermoid carcinomas with eosinophilia arising in the thyroidJennifer L Hunt
Department of Pathology, University of Pittsburgh Medical Center, PA 15213, USA
Mod Pathol 17:526-9. 2004..In this study, we provide additional evidence for this relationship, by demonstrating that SMECE stain strongly positive for p63, which is a new marker for UBB/solid cell nests... - Tumor suppressor gene allelic loss profiles of the variants of papillary thyroid carcinomaJennifer L Hunt
Department of Pathology, University of Pittsburgh Medical Center, Presbyterian Hospital, Pittsburgh, PA 15213, USA
Diagn Mol Pathol 13:41-6. 2004.... - Loss of heterozygosity mutations of tumor suppressor genes in cytologically atypical areas in chronic lymphocytic thyroiditisJennifer L Hunt
University of Pittsburgh, Medical Center, Pittsburgh, PA 15213, USA
Endocr Pathol 13:321-30. 2002..These genetic mutations are evidence of clonal preneoplastic or neoplastic changes in the follicular cells of CLT. The clinical malignant potential of these minute foci is likely to be very small but remains to be determined... - A microdissection and molecular genotyping assay to confirm the identity of tissue floaters in paraffin-embedded tissue blocksJennifer L Hunt
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Arch Pathol Lab Med 127:213-7. 2003..While many cases can be resolved histologically, a significant number remain unclear and may have serious clinical and medicolegal implications... - Microscopic papillary thyroid carcinoma compared with clinical carcinomas by loss of heterozygosity mutational profileJennifer L Hunt
Department of Pathology, University of Pittsburgh Medical Center, Pennsylvania, USA
Am J Surg Pathol 27:159-66. 2003..These data are further evidence that microscopic and clinically sized PTCa are pathogenetically related... - Sentinel lymph node evaluation for tumor metastasisJennifer L Hunt
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Semin Diagn Pathol 19:263-77. 2002..The history, technical details, and histopathologic work-up for sentinel lymph node biopsy are reviewed. Particular attention is paid to the intraoperative consultation and a protocol for optimal histopathologic management is presented... - A novel microdissection and genotyping of follicular-derived thyroid tumors to predict aggressivenessJennifer L Hunt
University of Pittsburgh Medical Center, Pittsburgh, PA and University of Pennsylvania Medical Center, Philadelphia, PA 15213, USA
Hum Pathol 34:375-80. 2003.... - Adenoid cystic carcinoma with high-grade transformation: a report of 11 cases and a review of the literatureRaja R Seethala
Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Am J Surg Pathol 31:1683-94. 2007..ACC-high-grade transformation is a highly aggressive salivary gland tumor with a variety of histologic patterns. The high propensity for lymph node metastases suggests a role for neck dissection in patients with this rare tumor... - Molecular evidence of anaplastic transformation in coexisting well-differentiated and anaplastic carcinomas of the thyroidJennifer L Hunt
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Am J Surg Pathol 27:1559-64. 2003..The patterns of allelic loss in our results showed that the majority of cases have a core of conserved mutations in the two morphologically distinct areas and substantial increases in mutation rates in the anaplastic components... - Molecular genotyping of medullary thyroid carcinoma can predict tumor recurrenceHina A Sheikh
Department of Pathology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Am J Surg Pathol 28:101-6. 2004..004). Frequency of allelic loss in tumor suppressor genes may provide a useful adjunctive prognostic test in medullary thyroid carcinoma... - Basal/myoepithelial cells in chronic sinusitis, respiratory epithelial adenomatoid hamartoma, inverted papilloma, and intestinal-type and nonintestinal-type sinonasal adenocarcinoma: an immunohistochemical studyJohn A Ozolek
Department of Pathology, Children s Hospital of Pittsburgh, 3705 Fifth Ave, Pittsburgh, PA 15213, USA
Arch Pathol Lab Med 131:530-7. 2007..One feature of malignant glandular lesions is loss of the basal/myoepithelial layer. The immunophenotype of the basal/myoepithelial layer has not been fully examined in benign glandular lesions of the sinonasal tract... - Thyroidectomies from patients with history of therapeutic radiation during childhood and adolescence have a unique mutational profileAdel Assaad
Department of Pathology, Virginia Mason Medical Center, Seattle, WA, USA
Mod Pathol 21:1176-82. 2008..These data from human thyroids support prior cell culture experiments and show that radiation induces genetic mutational damage even in benign proliferative processes in these thyroids... - Molecular alterations in atypical adenomatous hyperplasia occurring in benign and cancer-bearing lungsJoel F Gradowski
Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Diagn Mol Pathol 16:87-90. 2007..Therefore, AAH may represent a smoking induced low-grade neoplastic lesion that may be a precursor lesion of only a subset of invasive lung adenocarcinoma... - Fluorescence in situ hybridization for detection of MAML2 rearrangements in oncocytic mucoepidermoid carcinomas: utility as a diagnostic testJoaquin J Garcia
Pathology and Laboratory Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Hum Pathol 42:2001-9. 2011..However, we demonstrate that the presence of MAML2 rearrangement can be used as supportive evidence to distinguish oncocytic mucoepidermoid carcinoma from other oncocytic lesions... - Molecular staging of cervical lymph nodes in squamous cell carcinoma of the head and neckRobert L Ferris
Department of Otolaryngology and Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Cancer Res 65:2147-56. 2005..These assays were completed (from tissue to result) in approximately 30 minutes, thus demonstrating the feasibility of intraoperative staging of SCCHN SLNs by QRT-PCR... - Allelic loss of 3 different tumor suppressor gene loci in benign and malignant endothelial tumors of the head and neckAkosua B Domfeh
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Arch Pathol Lab Med 130:1184-7. 2006..This supports the cell culture-based theories that tumorigenesis in endothelial cells likely involves these chromosomes and provides some insight into the potential pathogenesis of angiosarcomas and benign hemangiomas... - Loss of heterozygosity of the VHL gene identifies malignancy and predicts death in follicular thyroid tumorsJennifer L Hunt
Department of Pathology, University of Pittsburgh School of Medicine, University Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Surgery 134:1043-7; discussion 1047-8. 2003..In this initial study, LOH of VHL was highly specific for malignancy and predicted death from disease. The analysis of VHL may provide for preoperative detection in cytologic samples with potential impact on clinical management of FTT... - Encapsulated papillary oncocytic neoplasms of the thyroid: morphologic, immunohistochemical, and molecular analysis of 18 casesRandall Lyndon Woodford
Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
Am J Surg Pathol 34:1582-90. 2010..Our results confirm that EPONs are histologically, immunohistochemically, and molecularly distinct from papillary thyroid carcinoma and seem to be most related to follicular neoplasms... - Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tractRaja R Seethala
Head and Neck Endocrine Division, Department of Pathology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Am J Surg Pathol 31:44-57. 2007..Immunohistochemistry can aid diagnosis by highlighting the biphasic nature of the tumor... - Molecular analysis to demonstrate that odontogenic keratocysts are neoplasticNarasimhan P Agaram
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Arch Pathol Lab Med 128:313-7. 2004..The finding of clonal deletion mutations of genomic DNA in these cysts supports the hypothesis that they are neoplastic rather than developmental in origin... - Tumor suppressor gene alterations in respiratory epithelial adenomatoid hamartoma (REAH): comparison to sinonasal adenocarcinoma and inflamed sinonasal mucosaJohn A Ozolek
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Am J Surg Pathol 30:1576-80. 2006..Appreciable allelic loss within REAH suggests the possibility that REAH may be a benign neoplasm rather than a hamartoma... - Allelic loss in parathyroid neoplasia can help characterize malignancyJennifer L Hunt
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Am J Surg Pathol 29:1049-55. 2005..This difference in the mutational profile suggests that this type of assay may be useful as an adjunctive diagnostic test in cases of parathyroid neoplasia... - NM-23 gene loss of heterozygosity and protein expression in high-stage laryngeal squamous cell carcinomasHina Sheikh
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Diagn Mol Pathol 15:1-6. 2006..These data imply that nm-23 may be tumor suppressor gene involved in HNSCC but that it may not function as a tumor metastasis suppressor in high-stage laryngeal carcinoma... - Analysis of allelic loss as an adjuvant tool in evaluation of malignancy in uterine smooth muscle tumorsNicole Nicosia Esposito
Division of Anatomic Pathology, Magee Womens Hospital, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Am J Surg Pathol 30:97-103. 2006..Molecular profiling may thus provide a valuable tool in assessment of malignancy in uterine smooth muscle tumors. Additionally, NM-23 is a promising candidate gene for determination of metastatic potential in these tumors... - Molecular assessment of allelic loss in Warthin tumorsMuammar Arida
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Mod Pathol 18:964-8. 2005.... - An update on molecular diagnostics of squamous and salivary gland tumors of the head and neckJennifer L Hunt
Department of Pathology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
Arch Pathol Lab Med 135:602-9. 2011..Within the category of salivary gland tumors, 3 tumors have recently been recognized that contain oncogenic translocations... - Analysis of loss of heterozygosity in single-system and multisystem Langerhans' cell histiocytosisKudakwashe R Chikwava
University of Pittsburgh School of Medicine and Department of Pathology, Presbyterian University Hospital, PA 15213, USA
Pediatr Dev Pathol 10:18-24. 2007..Further investigation of the potential use of LOH at 5q23 will be necessary to establish utility for this assay to predict disease progression and poor outcome... - Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targetingJohn C Sok
Department of Otolaryngology, and University of Pittsburgh Cancer Institute Biostatistics, University of Pittsburgh, Pennsylvania 15213, USA
Clin Cancer Res 12:5064-73. 2006..The present study was undertaken to determine the incidence of EGFRvIII expression in HNSCC and the biological consequences of EGFRvIII on tumor growth in response to EGFR targeting... 
Sheddase activity of tumor necrosis factor-alpha converting enzyme is increased and prognostically valuable in head and neck cancerLisheng Ge
Departments of Pathology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 1863, USA
Cancer Epidemiol Biomarkers Prev 18:2913-22. 2009..These data show that increased TACE activity in cancer is biologically and clinically relevant, and indicate that TACE activity could be a significant biomarker of cancer prognosis...- Malignant mixed tumors of the salivary gland: a study of loss of heterozygosity in tumor suppressor genesMelissa H Fowler
Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Mod Pathol 19:350-5. 2006..Furthermore, these data support prior studies that suggest a common clonal origin for the benign and malignant components of carcinomas ex pleomorphic adenoma... - Warthin tumors do not have microsatellite instability and express normal DNA mismatch repair proteinsJennifer L Hunt
Head and Neck and Endocrine Pathology, Molecular Anatomic Pathology, Presbyterian Hospital A610 2, Pittsburgh, PA 15213, USA
Arch Pathol Lab Med 130:52-6. 2006..A recent study described the absence of staining for hMLH1 and hMSH2 proteins in the epithelial component of Warthin tumors, suggesting that they arise secondary to defects in the DNA mismatch repair system... - Pathology quiz case 2. Parathyroid lipoadenomaRaja R Seethala
University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Arch Otolaryngol Head Neck Surg 132:1391-3. 2006 - Microsatellite instability is uncommon in lymphoepithelioma-like carcinoma of the lungSanja Dacic
Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, PA 15213, USA
Am J Clin Pathol 127:282-6. 2007..55). MSI is very uncommon in LELC, indicating that MSI is not an important event in carcinogenesis for this tumor subtype. The presence of LOH suggests a probable role of tumor suppressor genes in LELC carcinogenesis... - Chondrosarcoma of the sphenoid sinus resected by an endoscopic approachRicardo L Carrau
Department of Otolaryngology, UMPC Center for Cranial Base Surgery, University of Pittsburgh, PA, USA
Am J Otolaryngol 25:274-7. 2004..Surgery is the mainstay treatment for low-grade chondrosarcomas. In selected patients, complete resection can be achieved using transnasal endoscopic approaches... - Human leukocyte antigen (HLA) class I defects in head and neck cancer: molecular mechanisms and clinical significanceRobert L Ferris
Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 1523, USA
Immunol Res 33:113-33. 2005.... - Molecular mutations in thyroid carcinogenesisJennifer L Hunt
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Am J Clin Pathol 118:S116-27. 2002..Thyroid tumors and their characteristic molecular mutations are discussed in this review. The current practice in diagnostic testing for thyroid tumors also is examined... - Simultaneous diffuse sclerosis variant of papillary thyroid carcinoma and diffuse toxic hyperplasia (Graves' disease)Gladell P Paner
Department of Pathology, Loyola University Medical Center, Maywood, IL 60153, USA
Endocr Pathol 15:77-82. 2004..This report illustrates the histologic features as well as the diagnostic challenge encountered in a rare simultaneous occurrence of DSVPTC and GD.<P>.. - Clear cell carcinoma and clear cell odontogenic carcinoma: a comparative clinicopathologic and immunohistochemical studyElizabeth A Bilodeau
Department of Diagnostic Sciences, University of Pittsburgh School of Dental Medicine, 3501 Terrace St, Pittsburgh, PA 15261, USA
Head Neck Pathol 5:101-7. 2011..The differential diagnosis of clear cell malignancies in the head and neck is discussed. The relationship of CCCs and CCOCs to other clear cell tumors on the basis of their immunohistochemical staining patterns is postulated... - Non-tumor-associated psammoma bodies in the thyroidJennifer L Hunt
Department of Pathology, University of Pittsburgh Medical Center, 200 Lothrop St, Pittsburgh, PA 15213, USA
Am J Clin Pathol 119:90-4. 2003..If no carcinoma is identified in a lobectomy, discussion with the surgeon should indicate the need for close clinical follow-up... - Microdissection techniques for molecular testing in surgical pathologyJennifer L Hunt
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Arch Pathol Lab Med 128:1372-8. 2004..To describe the techniques for microdissection of paraffin-embedded and frozen tissue sections for the use in molecular applications... - Potential diagnostic use of p16INK4A, a new marker that correlates with dysplasia in oral squamoproliferative lesionsOlguta Gologan
Department of Pathology, University of Pittsburgh Medical Center, Presbyterian Hospital, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Am J Surg Pathol 29:792-6. 2005.... - Comparison of allelic losses in chondroblastoma and primary chondrosarcoma of bone and correlation with fluorescence in situ hybridization analysisDionysios J Papachristou
Department of Pathology, University of Pittsburgh Medical Center Presbyterian-Shadyside, Pittsburgh, PA 15213, USA
Hum Pathol 37:890-8. 2006..The role of p53 in CBL is uncertain; however, given the benign behavior of this tumor, it is probably unrelated to tumor progression... - Assessment of microsatellite instability in very small microdissected samples and in tumor samples that are contaminated with normal DNACynthia L Trusky
Department of Pathology, University of Pittsburgh, USA
Diagn Mol Pathol 15:63-9. 2006..Contaminating normal cell DNA can mask the presence of MSI. MSI testing on tissue fragments that are <5.5 mm can lead to a false-negative MSI test... - Repeat thyroid nodule fine-needle aspiration in patients with initial benign cytologic resultsMelina B Flanagan
Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
Am J Clin Pathol 125:698-702. 2006..1% to 11.4%. With more than 1 repeat FNA, there was no improvement in performance characteristics. These data make a strong argument for 1 repeat FNA following an initial benign FNA diagnosis... - Immunophenotypic comparison of salivary gland oncocytoma and metastatic renal cell carcinomaJohn A Ozolek
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Laryngoscope 115:1097-100. 2005..CD10 and CK20 were the most useful markers to distinguish metastatic renal cell carcinoma from oncocytomas in the salivary gland, whereas RCC, EMA, CK7, and vimentin are not as useful... - Unusual adrenal cortical tumor of unknown biologic potential: a nodule in a nodule in a noduleSarangarajan Ranganathan
Department of Pathology, Children's Hospital of Pittsburgh, PA 15213, USA
Pediatr Dev Pathol 8:483-8. 2005..Molecular analysis to assess the clonality and mutation rates of the 3 distinct areas showed only 2 genetic loci with allelic imbalances... - Unusual thyroid tumors: a review of pathologic and molecular diagnosisJennifer L Hunt
University of Pittsburgh Medical Center, Department of Pathology, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Expert Rev Mol Diagn 5:725-34. 2005..The diagnostic features of these rare tumors, including the histology, immunohistochemical expression profiles and the known molecular mutational profiles of each, are reviewed... - Controversial ectopic thyroid: a case report of thyroid tissue in the axilla and benign total thyroidectomyHaruko A Kuffner
Division of Endocrinology and Metabolism, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Thyroid 15:1095-7. 2005..This case represents the first description of thyroid tissue in the axilla with a histologically benign thyroid gland... - Pathology quiz case 2. Anaplastic thyroid carcinoma (ATC) arising in a preexisting tall cell variant of papillary thyroid cancerGenevieve Williamson
University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Arch Otolaryngol Head Neck Surg 129:486, 488. 2003 - Mixed Medullary-follicular-derived carcinomas of the thyroid glandPeter M Sadow
Department of Pathology, Massachusetts General Hospital, Boston, 02114, USA
Adv Anat Pathol 17:282-5. 2010..The clinical, histologic, and molecular features of these mixed tumors and the classification guidelines are reviewed... - Myoepithelial neoplasia of the submandibular gland: case report and therapeutic considerationsJayakar V Nayak
Department of Otolaryngology, University of Pittsburgh School of Medicine, PA, USA
Arch Otolaryngol Head Neck Surg 129:359-62. 2003..Increasing use of immunohistochemistry panels to assess parotid neoplasms also suggests that myoepithelioma may be underrecognized... - Nasal chondromesenchymal hamartoma in older children and adults: series and immunohistochemical analysisJohn A Ozolek
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Arch Pathol Lab Med 129:1444-50. 2005..Their pathogenesis is unknown, but they may be derived from embryologic rests. To our knowledge, only 1 case in an older child has been reported, and no cases have been reported in adults... - Spindle cell carcinoma of the larynx with actinomyces chondritis of the larynx and tracheaSara B Silvestri
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Otolaryngol Head Neck Surg 134:345-7. 2006 - Expression pattern of chemokine receptor 6 (CCR6) and CCR7 in squamous cell carcinoma of the head and neck identifies a novel metastatic phenotypeJun Wang
Department of Otolaryngology and Immunology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
Cancer Res 64:1861-6. 2004..Thus, CCR6, CCR7, and their ligands, normally important in controlling immune cell trafficking in response to inflammatory stimuli, may have an important role in determining the metastasis of SCCHN cells in vivo... - Pathology quiz case: cutaneous angiosarcomaLaurentia Nodit
University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Arch Otolaryngol Head Neck Surg 129:591-3. 2003 - Assessment of immunohistochemistry for p16INK4 and high-risk HPV DNA by in situ hybridization in esophageal squamous cell carcinomaSajjad M Malik
Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
Int J Surg Pathol 19:31-4. 2011..These results indicate that p16(INK4) expression in ESCC does not correlate with the presence of high-risk HPV DNA by ISH. High-risk HPV does not seem to play a major role in the carcinogenesis of ESCC in low-risk areas... - Detection and classification of diagnostic discrepancies (errors) in surgical pathologyJennifer E Roy
Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
Adv Anat Pathol 17:359-65. 2010..Most importantly, these data should be incorporated into quality assurance and quality improvement activities, such that departments strive to reduce errors, and to help improve overall quality in SP... - Recurrent sarcoidosis in lung transplant allografts: granulomas are of recipient originDiana N Ionescu
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
Diagn Mol Pathol 14:140-5. 2005..The origin of the histiocytes composing the noncaseating granulomas in the allograft lung in patients with recurrent sarcoidosis (RS) was analyzed using DNA identity testing in 4 cases... - Pathology quiz case. Granular cell tumor of the tongue, with extensive overlying pseudoepitheliomatous hyperplasiaJeffrey P Simons
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Arch Otolaryngol Head Neck Surg 129:127-8. 2003 - Correlation of protease-activated receptor-1 with differentiation markers in squamous cell carcinoma of the head and neck and its implication in lymph node metastasisXin Zhang
Department of Hematology Oncology, Emory University Winship Cancer Institute, Atlanta, Georgia 30322, USA
Clin Cancer Res 10:8451-9. 2004..Although the functions of PAR-1 in many normal cells, such as platelets and astrocytes, have been well studied, its roles in cancer progression and metastasis have not been fully elucidated, and studies to date appear contradictory... - Down-regulation of S100A2 in lymph node metastases of head and neck cancerXin Zhang
Department of Hematology and Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA
Head Neck 29:236-43. 2007..S100A2, a putative tumor suppressor, has been found to be down-regulated in several types of primary tumor as compared with the normal tissue. Only a few reports have explored its expression status and function in metastasis... - Fractional allelic loss of tumor suppressor genes identifies malignancy and predicts clinical outcome in follicular thyroid tumorsJennifer L Hunt
Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Thyroid 16:643-9. 2006..002). Based on these results, a tumor suppressor gene panel for allelic imbalance in follicular-derived tumors (FTT) may correlate with both malignancy and outcome in patients with follicular-derived carcinomas of the thyroid... - Molecular testing in solid tumors: an overviewJennifer L Hunt
Department of Anatomic Pathology, L25, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
Arch Pathol Lab Med 132:164-7. 2008.... - Microsatellite instability in nasopharyngeal and lymphoepithelial carcinomas of the head and neckJoshua Sckolnick
Department of Otolaryngology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Am J Surg Pathol 30:1250-3. 2006..These data suggest that alterations in DNA MMR system are not a common mechanism of tumorigenesis in LEC of the head and neck in a nonendemic country... - Nras loss induces metastatic conversion of Rb1-deficient neuroendocrine thyroid tumorChiaki Takahashi
Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Genet 38:118-23. 2006..These findings suggest that the loss of the proto-oncogene Nras in certain cellular contexts can promote malignant tumor progression... - Identifying cross contaminants and specimen mix-ups in surgical pathologyJennifer L Hunt
Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA
Adv Anat Pathol 15:211-7. 2008..The methods and techniques behind DNA fingerprinting for tissue and sample identity are also discussed in detail... - Encapsulated follicular variant of papillary thyroid carcinomaJennifer L Hunt
Am J Clin Pathol 118:602-3; author reply 605-6. 2002