Romney M Humphries

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Successful treatment of pan-resistant Klebsiella pneumoniae pneumonia and bacteraemia with a combination of high-dose tigecycline and colistin
    Romney M Humphries
    UCLA David Geffen School of Medicine, Department of Pathology and Laboratory Medicine, Los Angeles, CA, USA
    J Med Microbiol 59:1383-6. 2010
  2. pmc New Delhi metallo-β-lactamase (NDM-1)-producing Klebsiella pneumoniae: case report and laboratory detection strategies
    A Brian Mochon
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Brentwood Annex, Los Angeles, CA 90095 1732, USA
    J Clin Microbiol 49:1667-70. 2011
  3. doi request reprint Point-Counterpoint: Reflex Cultures Reduce Laboratory Workload and Improve Antimicrobial Stewardship in Patients Suspected of Having Urinary Tract Infections
    Romney M Humphries
    Department of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, California, USA
    J Clin Microbiol 54:254-8. 2016
  4. doi request reprint Continuing Challenges for the Clinical Laboratory for Detection of Carbapenem-Resistant Enterobacteriaceae
    Romney M Humphries
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA
    J Clin Microbiol 53:3712-4. 2015
  5. doi request reprint Superbugs on Duodenoscopes: the Challenge of Cleaning and Disinfection of Reusable Devices
    Romney M Humphries
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA
    J Clin Microbiol 53:3118-25. 2015
  6. doi request reprint First Report of Ceftazidime-Avibactam Resistance in a KPC-3-Expressing Klebsiella pneumoniae Isolate
    Romney M Humphries
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Antimicrob Agents Chemother 59:6605-7. 2015
  7. pmc Laboratory evaluation of three rapid diagnostic tests for dual detection of HIV and Treponema pallidum antibodies
    Romney M Humphries
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Clin Microbiol 52:4394-7. 2014
  8. pmc In vitro antimicrobial susceptibility of Aerococcus urinae
    Romney M Humphries
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Clin Microbiol 52:2177-80. 2014
  9. pmc Genotypic and phenotypic evaluation of the evolution of high-level daptomycin nonsusceptibility in vancomycin-resistant Enterococcus faecium
    Romney M Humphries
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    Antimicrob Agents Chemother 56:6051-3. 2012
  10. pmc Performance of Clostridium difficile toxin enzyme immunoassay and nucleic acid amplification tests stratified by patient disease severity
    Romney M Humphries
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Clin Microbiol 51:869-73. 2013

Collaborators

Detail Information

Publications28

  1. doi request reprint Successful treatment of pan-resistant Klebsiella pneumoniae pneumonia and bacteraemia with a combination of high-dose tigecycline and colistin
    Romney M Humphries
    UCLA David Geffen School of Medicine, Department of Pathology and Laboratory Medicine, Los Angeles, CA, USA
    J Med Microbiol 59:1383-6. 2010
    ..Despite a poor prognosis, the patient recovered, but remains colonized with the pan-resistant isolate...
  2. pmc New Delhi metallo-β-lactamase (NDM-1)-producing Klebsiella pneumoniae: case report and laboratory detection strategies
    A Brian Mochon
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Brentwood Annex, Los Angeles, CA 90095 1732, USA
    J Clin Microbiol 49:1667-70. 2011
    ..We describe strategies for the detection of this novel resistance mechanism encountered in an isolate of Klebsiella pneumoniae...
  3. doi request reprint Point-Counterpoint: Reflex Cultures Reduce Laboratory Workload and Improve Antimicrobial Stewardship in Patients Suspected of Having Urinary Tract Infections
    Romney M Humphries
    Department of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, California, USA
    J Clin Microbiol 54:254-8. 2016
    ..Romney Humphries from UCLA supports the idea that reflex urine cultures are of value and describes what reflex parameters are most useful, while Jennifer Dien Bard of Children's Hospital Los Angeles discusses their limitations. ..
  4. doi request reprint Continuing Challenges for the Clinical Laboratory for Detection of Carbapenem-Resistant Enterobacteriaceae
    Romney M Humphries
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA
    J Clin Microbiol 53:3712-4. 2015
    ..N. Jassem, J. P. Dekker, and K. M. Frank, J Clin Microbiol 53:3729-3737, 2015, http://dx.doi.org/10.1128/JCM.01921-15) evaluate the performance of a research-use-only PCR for the detection of CRE in rectal surveillance specimens...
  5. doi request reprint Superbugs on Duodenoscopes: the Challenge of Cleaning and Disinfection of Reusable Devices
    Romney M Humphries
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA
    J Clin Microbiol 53:3118-25. 2015
    ....
  6. doi request reprint First Report of Ceftazidime-Avibactam Resistance in a KPC-3-Expressing Klebsiella pneumoniae Isolate
    Romney M Humphries
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Antimicrob Agents Chemother 59:6605-7. 2015
    ..We report a KPC-producing K. pneumoniae isolate resistant to ceftazidime-avibactam (MIC, 32/4 μg/ml) from a patient with no prior treatment with ceftazidime-avibactam. ..
  7. pmc Laboratory evaluation of three rapid diagnostic tests for dual detection of HIV and Treponema pallidum antibodies
    Romney M Humphries
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Clin Microbiol 52:4394-7. 2014
    ..The RDTs performed comparably, with sensitivities of 93 to 99% and specificities of 97 to 100%. The kappa statistic between the RDTs was 0.95. ..
  8. pmc In vitro antimicrobial susceptibility of Aerococcus urinae
    Romney M Humphries
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Clin Microbiol 52:2177-80. 2014
    ..However, 55% of the isolates had MICs to clindamycin of >0.25 μg/ml, 44% had MICs to erythromycin of >0.25 μg/ml, and 16% had MICs to levofloxacin of >2 μg/ml. ..
  9. pmc Genotypic and phenotypic evaluation of the evolution of high-level daptomycin nonsusceptibility in vancomycin-resistant Enterococcus faecium
    Romney M Humphries
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    Antimicrob Agents Chemother 56:6051-3. 2012
    ..Membrane studies revealed a higher net surface charge among the daptomycin-nonsusceptible isolates and increased septum formation in the isolate with a daptomycin MIC of 192 μg/ml...
  10. pmc Performance of Clostridium difficile toxin enzyme immunoassay and nucleic acid amplification tests stratified by patient disease severity
    Romney M Humphries
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Clin Microbiol 51:869-73. 2013
    ..The presence of stool toxin measured by EIA does not correlate with disease severity...
  11. ncbi request reprint In vitro susceptibility testing of fluoroquinolone activity against Salmonella: recent changes to CLSI standards
    Romney M Humphries
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles California, USA
    Clin Infect Dis 55:1107-13. 2012
    ....
  12. pmc Enteric fever in a 6-year-old traveler caused by Salmonella enterica serotypes Typhi and Paratyphi A: laboratory detection strategies and treatment options
    Romney M Humphries
    Department of Medicine, Division of Infectious Diseases, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Brentwood Annex, Los Angeles, CA 90095, USA
    J Clin Microbiol 49:452-4. 2011
    ..Mixed infections are infrequently reported, potentially because detection of two different Salmonella serotypes in blood cultures is technically challenging. We suggest laboratory strategies to aid in the recognition of mixed infections...
  13. pmc Aerococcus urinae and trimethoprim-sulfamethoxazole
    Romney M Humphries
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    J Clin Microbiol 49:3934-5. 2011
    ..Twenty-seven clinical isolates of A. urinae tested susceptible to SXT in cation-adjusted Mueller-Hinton broth (CAMHB) plus lysed horse blood and resistant in CAMHB plus lysed sheep blood...
  14. pmc Frequency of susceptibility testing for patients with persistent methicillin-resistant Staphylococcus aureus bacteremia
    Carmen L Giltner
    David Geffen School of Medicine, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA
    J Clin Microbiol 52:357-61. 2014
    ....
  15. pmc Performance of Vitek 2 for antimicrobial susceptibility testing of Enterobacteriaceae with Vitek 2 (2009 FDA) and 2014 CLSI breakpoints
    April M Bobenchik
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Clin Microbiol 53:816-23. 2015
    ..Ongoing studies are warranted to assess performance in isolates with emerging resistance. ..
  16. pmc A current perspective on daptomycin for the clinical microbiologist
    Romney M Humphries
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California, Los Angeles, California, USA
    Clin Microbiol Rev 26:759-80. 2013
    ..aureus, E. faecium, and E. faecalis. The challenges faced by the clinical laboratory in obtaining accurate susceptibility results and reporting daptomycin MICs are also discussed...
  17. pmc Performance of Vitek 2 for antimicrobial susceptibility testing of Staphylococcus spp. and Enterococcus spp
    April M Bobenchik
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Clin Microbiol 52:392-7. 2014
    ..With the exception of detecting ICR in S. aureus, Vitek 2 performed reliably for antimicrobial susceptibility testing of staphylococci and enterococci. ..
  18. doi request reprint Performance of Vitek 2 for Antimicrobial Susceptibility Testing of Staphylococcus spp. and Enterococcus spp
    April M Bobenchik
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Clin Microbiol 52:392-7. 2014
    ..With the exception of detecting ICR in S. aureus, Vitek 2 performed reliably for antimicrobial susceptibility testing of staphylococci and enterococci. ..
  19. pmc Ciprofloxacin-resistant Aeromonas hydrophila cellulitis following leech therapy
    Carmen L Giltner
    David Geffen School of Medicine, Department of Pathology, University of California, Los Angeles, California, USA
    J Clin Microbiol 51:1324-6. 2013
    ..These data suggest that ciprofloxacin monotherapy as a prophylaxis regimen prior to leech therapy may not be effective in preventing infection...
  20. doi request reprint Evaluation of Surrogate Disk Tests for Detection of Ciprofloxacin and Levofloxacin Resistance in Clinical Isolates of Salmonella enterica
    Eszter Deak
    Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA Santa Clara Valley Medical Center, Santa Clara, California, USA
    J Clin Microbiol 53:3405-10. 2015
    ..Ciprofloxacin and pefloxacin provided clearer differentiation of susceptible and resistant isolates. ..
  21. doi request reprint Development of a novel real-time PCR assay with high-resolution melt analysis to detect and differentiate OXA-48-Like β-lactamases in carbapenem-resistant Enterobacteriaceae
    Peera Hemarajata
    Pathology and Laboratory Medicine, UCLA, Los Angeles, California, USA
    Antimicrob Agents Chemother 59:5574-80. 2015
    ..This approach has potential for use in epidemiological investigations and continuous surveillance to help control the spread of CRE strains producing OXA-48-like enzymes. ..
  22. pmc Colistin MIC variability by method for contemporary clinical isolates of multidrug-resistant Gram-negative bacilli
    Janet A Hindler
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Clin Microbiol 51:1678-84. 2013
    ..Based on these data, we urge clinical laboratories to be aware of the variable results that can occur when using different methods for colistin MIC testing and, in particular, to use caution with the Etest...
  23. doi request reprint Investigation of a suspected nosocomial transmission of blaKPC3-mediated carbapenem-resistant Klebsiella pneumoniae by whole genome sequencing
    Shangxin Yang
    Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, USA
    Diagn Microbiol Infect Dis 84:337-42. 2016
    ..While WGS provided additional information that was not available by PFGE, in this study, neither method could definitively conclude the relatedness between the isolates. ..
  24. pmc Performance of Etest and disk diffusion for detection of ciprofloxacin and levofloxacin resistance in Salmonella enterica
    Eszter Deak
    Department of Pathology and Laboratory Medicine, Santa Clara Valley Medical Center, San Jose, California, USA
    J Clin Microbiol 53:298-301. 2015
    ..Categorical agreements for the ciprofloxacin and levofloxacin Etests were 89.6 and 83.7%, respectively. Disk diffusion categorical agreements were 88.2 and 93.3%, respectively. Only minor errors were observed. ..
  25. doi request reprint Antimicrobial Susceptibilities of Abiotrophia defectiva, Granulicatella adiacens, and Granulicatella elegans
    Michael O Alberti
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Antimicrob Agents Chemother 60:1411-20. 2015
    ..Species-level identification of NVS organisms when susceptibility testing is not readily available may aid in treatment decisions. ..
  26. pmc Precision of vancomycin and daptomycin MICs for methicillin-resistant Staphylococcus aureus and effect of subculture and storage
    Carmen L Charlton
    UCLA David Geffen School of Medicine, Department of Pathology and Laboratory Medicine, Los Angeles, California, USA Alberta Health Services, Edmonton, Alberta, Canada
    J Clin Microbiol 52:3898-905. 2014
    ..g., MICs between serial 2-fold dilutions) is a possibility. A more accurate method for measuring vancomycin MIC results is thus possible, but further standardization of BMD testing would be required to achieve this goal...
  27. pmc Serological misdiagnosis of acute liver failure associated with echovirus 25 due to immunological similarities to hepatitis A virus and prozone effect
    Susan K Wollersheim
    Department of Pediatrics, Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Clin Microbiol 53:309-10. 2015
    ..Initial serological studies were consistent with hepatitis A virus (HAV), with prozone phenomenon. The similarity of E25 to HAV may obscure accurate diagnosis in some cases of hepatitis. ..
  28. pmc Rapid detection of Campylobacter antigen by enzyme immunoassay leads to increased positivity rates
    Carmen L Giltner
    David Geffen School of Medicine, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA
    J Clin Microbiol 51:618-20. 2013
    ..Verification studies of an EIA compared to culture revealed a positive predictive value (PPV) of 91%, whereas PPV fell to 42% during routine diagnostic testing. We suggest all positive EIA results be confirmed via culture...