Mary Beth Humphrey

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi The signaling adapter protein DAP12 regulates multinucleation during osteoclast development
    Mary Beth Humphrey
    Department of Medicine, VA Medical Center and University of California, San Francisco, California 94121, USA
    J Bone Miner Res 19:224-34. 2004
  2. pmc Bone microenvironment specific roles of ITAM adapter signaling during bone remodeling induced by acute estrogen-deficiency
    Yalei Wu
    Department of Medicine, VA Medical Center, University of California San Francisco, San Francisco, California, United States of America Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 2:e586. 2007
  3. ncbi TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function
    Mary Beth Humphrey
    Department of Medicine, VA Medical Center and University of California, San Francisco, California 94121, USA
    J Bone Miner Res 21:237-45. 2006
  4. pmc The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12
    Julia F Charles
    Department of Medicine, University of California San Francisco, San Francisco, California 94143, USA
    Infect Immun 76:2439-47. 2008
  5. ncbi Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12
    Jessica A Hamerman
    Department of Microbiology and Immunology, University of California San Francisco, 514 Parnassus Avenue, San Francisco, CA 94143, USA
    J Immunol 177:2051-5. 2006
  6. pmc TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1
    Qisheng Peng
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Sci Signal 3:ra38. 2010
  7. pmc The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase
    Attila Mocsai
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 101:6158-63. 2004
  8. ncbi Role of ITAM-containing adapter proteins and their receptors in the immune system and bone
    Mary Beth Humphrey
    Department of Medicine, University of California, San Francisco, CA 94121, USA
    Immunol Rev 208:50-65. 2005
  9. ncbi Mice lacking the integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state
    Nancy E Lane
    Department of Medicine, University of California at San Francisco, San Francisco, California 94143, USA
    J Bone Miner Res 20:58-66. 2005
  10. ncbi CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation
    Dong Hui Chung
    Veterans Administration Medical Center and University of California, San Francisco, CA 94121, USA
    J Immunol 171:6541-8. 2003

Collaborators

Detail Information

Publications13

  1. ncbi The signaling adapter protein DAP12 regulates multinucleation during osteoclast development
    Mary Beth Humphrey
    Department of Medicine, VA Medical Center and University of California, San Francisco, California 94121, USA
    J Bone Miner Res 19:224-34. 2004
    ..These data show a new role for DAP12 signaling in regulating formation of multinucleated osteoclasts...
  2. pmc Bone microenvironment specific roles of ITAM adapter signaling during bone remodeling induced by acute estrogen-deficiency
    Yalei Wu
    Department of Medicine, VA Medical Center, University of California San Francisco, San Francisco, California, United States of America Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 2:e586. 2007
    ....
  3. ncbi TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function
    Mary Beth Humphrey
    Department of Medicine, VA Medical Center and University of California, San Francisco, California 94121, USA
    J Bone Miner Res 21:237-45. 2006
    ..These results provide new evidence that TREM2 regulates OC function independent of its effects on multinucleated OC differentiation...
  4. pmc The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12
    Julia F Charles
    Department of Medicine, University of California San Francisco, San Francisco, California 94143, USA
    Infect Immun 76:2439-47. 2008
    ..Thus, DAP12 is an important regulator of Salmonella-induced ROS production in macrophages, and TREM2 is essential for linking DAP12 to the innate response to serovar Typhimurium...
  5. ncbi Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12
    Jessica A Hamerman
    Department of Microbiology and Immunology, University of California San Francisco, 514 Parnassus Avenue, San Francisco, CA 94143, USA
    J Immunol 177:2051-5. 2006
    ..A TREM-2 Fc fusion protein bound to macrophages, indicating that macrophages express a TREM-2 ligand. Thus, the interaction of TREM-2 and its ligand results in an inhibitory signal that can reduce the inflammatory response...
  6. pmc TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1
    Qisheng Peng
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Sci Signal 3:ra38. 2010
    ....
  7. pmc The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase
    Attila Mocsai
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 101:6158-63. 2004
    ..These results provide new insight into the biology of osteoclasts and suggest novel therapeutic targets in diseases of bony remodeling...
  8. ncbi Role of ITAM-containing adapter proteins and their receptors in the immune system and bone
    Mary Beth Humphrey
    Department of Medicine, University of California, San Francisco, CA 94121, USA
    Immunol Rev 208:50-65. 2005
    ....
  9. ncbi Mice lacking the integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state
    Nancy E Lane
    Department of Medicine, University of California at San Francisco, San Francisco, California 94143, USA
    J Bone Miner Res 20:58-66. 2005
    ..These preliminary data suggest alphavbeta5 integrin's presence on osteoclast precursors may inhibit of osteoclast formation...
  10. ncbi CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation
    Dong Hui Chung
    Veterans Administration Medical Center and University of California, San Francisco, CA 94121, USA
    J Immunol 171:6541-8. 2003
    ..Thus, we define a new family of myeloid receptors, and demonstrate that the first member of this family, CLM-1, is an inhibitory receptor, able to block osteoclastogenesis...
  11. doi Osteoclasts - the innate immune cells of the bone
    Yalei Wu
    Department of Medicine, University of California, San Francisco, CA, USA
    Autoimmunity 41:183-94. 2008
    ..Osteoclasts likely function as the innate immune cells of the bone, thus are highly regulated to appropriately respond to stress and inflammatory changes in their microenvironment...
  12. pmc Macrophage metalloelastase (MMP-12) deficiency mitigates retinal inflammation and pathological angiogenesis in ischemic retinopathy
    Jingming Li
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    PLoS ONE 7:e52699. 2012
    ..Taken together, we conclude that MMP-12 is a key regulator of macrophage infiltration and inflammation, contributing to retinal vascular dysfunction and pathological angiogenesis...
  13. pmc Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-β and Runx2 in bone is required for hearing
    Jolie L Chang
    Department of Otolaryngology, Head and Neck Surgery, University of California at San Francisco, San Francisco, California 94143, USA
    EMBO Rep 11:765-71. 2010
    ..Furthermore, our results suggest that the careful regulation of these properties is essential for healthy tissue function...