H D Humes

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Bioartificial kidney alters cytokine response and hemodynamics in endotoxin-challenged uremic animals
    William H Fissell
    Department of Medicine, VA Medical Center and The University of Michigan, Ann Arbor, MI 48109, USA
    Blood Purif 20:55-60. 2002
  2. ncbi request reprint The future of hemodialysis membranes
    H D Humes
    Department of Internal Medicine, Division of Nephrology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    Kidney Int 69:1115-9. 2006
  3. ncbi request reprint Stem cell approaches for the treatment of renal failure
    James C Brodie
    Division of Nephrology, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Pharmacol Rev 57:299-313. 2005
  4. ncbi request reprint Differentiated growth of human renal tubule cells on thin-film and nanostructured materials
    William H Fissell
    Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA
    ASAIO J 52:221-7. 2006
  5. pmc Efficacy and safety of renal tubule cell therapy for acute renal failure
    James Tumlin
    Southeast Renal Associates Presbyterian Hospital, Charlotte, North Carolina, USA
    J Am Soc Nephrol 19:1034-40. 2008
  6. ncbi request reprint The bioartificial renal tubule assist device to enhance CRRT in acute renal failure
    H D Humes
    Department of Internal Medicine, University of Michigan and VA Medical Center, Ann Arbor 48109 0368, USA
    Am J Kidney Dis 30:S28-31. 1997
  7. ncbi request reprint Initial clinical results of the bioartificial kidney containing human cells in ICU patients with acute renal failure
    H David Humes
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Kidney Int 66:1578-88. 2004
  8. pmc Stem cells: the next therapeutic frontier
    H David Humes
    Department of Internal Medicine, University of Michigan Medical School, 4520 MSRB I, Box 0651, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0726, USA
    Trans Am Clin Climatol Assoc 116:167-83; discussion 183-4. 2005
  9. ncbi request reprint Advances in cell therapy for renal failure
    H David Humes
    Research and Development Division, Nephros Therapeutics Inc and Department of Internal Medicine, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0726, USA
    Transpl Immunol 12:219-27. 2004
  10. ncbi request reprint Renal cell therapy in the treatment of patients with acute and chronic renal failure
    H David Humes
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0726, USA
    Blood Purif 22:60-72. 2004

Detail Information

Publications36

  1. ncbi request reprint Bioartificial kidney alters cytokine response and hemodynamics in endotoxin-challenged uremic animals
    William H Fissell
    Department of Medicine, VA Medical Center and The University of Michigan, Ann Arbor, MI 48109, USA
    Blood Purif 20:55-60. 2002
    ....
  2. ncbi request reprint The future of hemodialysis membranes
    H D Humes
    Department of Internal Medicine, Division of Nephrology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    Kidney Int 69:1115-9. 2006
    ..This area of translational research is rich in creative opportunities to improve the unmet medical needs of patients with either chronic or acute renal failure...
  3. ncbi request reprint Stem cell approaches for the treatment of renal failure
    James C Brodie
    Division of Nephrology, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Pharmacol Rev 57:299-313. 2005
    ..Immunoisolation of heterologous cells by encapsulation creates opportunities for their safe use as a component of implanted or ex vivo devices...
  4. ncbi request reprint Differentiated growth of human renal tubule cells on thin-film and nanostructured materials
    William H Fissell
    Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA
    ASAIO J 52:221-7. 2006
    ....
  5. pmc Efficacy and safety of renal tubule cell therapy for acute renal failure
    James Tumlin
    Southeast Renal Associates Presbyterian Hospital, Charlotte, North Carolina, USA
    J Am Soc Nephrol 19:1034-40. 2008
    ..RAD therapy was also associated with more rapid recovery of kidney function, was well tolerated, and had the expected adverse event profile for critically ill patients with ARF...
  6. ncbi request reprint The bioartificial renal tubule assist device to enhance CRRT in acute renal failure
    H D Humes
    Department of Internal Medicine, University of Michigan and VA Medical Center, Ann Arbor 48109 0368, USA
    Am J Kidney Dis 30:S28-31. 1997
    ..Pilot human trials of the RAD are anticipated within the next year to improve current renal replacement therapy in ATN...
  7. ncbi request reprint Initial clinical results of the bioartificial kidney containing human cells in ICU patients with acute renal failure
    H David Humes
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Kidney Int 66:1578-88. 2004
    ..An FDA-approved Phase I/II clinical trial on 10 patients has been completed, and demonstrated that this experimental treatment can be delivered safely for up to 24 hours...
  8. pmc Stem cells: the next therapeutic frontier
    H David Humes
    Department of Internal Medicine, University of Michigan Medical School, 4520 MSRB I, Box 0651, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0726, USA
    Trans Am Clin Climatol Assoc 116:167-83; discussion 183-4. 2005
    ..This review will focus on our group's use of human stem/progenitor cells in the treatment of acute and chronic renal failure as extensions to the current successful renal substitution processes of hemodialysis and hemofiltration...
  9. ncbi request reprint Advances in cell therapy for renal failure
    H David Humes
    Research and Development Division, Nephros Therapeutics Inc and Department of Internal Medicine, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0726, USA
    Transpl Immunol 12:219-27. 2004
    ..This review will focus on our group's use of human stem/progenitor cells in the treatment of acute and chronic renal failure as extensions to current successful renal substitution processes of hemodialysis and hemofiltration...
  10. ncbi request reprint Renal cell therapy in the treatment of patients with acute and chronic renal failure
    H David Humes
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0726, USA
    Blood Purif 22:60-72. 2004
    ..Clinical trials in patients suffering from either ARF or ESRD are currently ongoing to evaluate the influence of the RAD on the inflammatory response in these groups of patients...
  11. ncbi request reprint Cell therapy with a tissue-engineered kidney reduces the multiple-organ consequences of septic shock
    H David Humes
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109 0726, USA
    Crit Care Med 31:2421-8. 2003
    ....
  12. ncbi request reprint Renal cell therapy is associated with dynamic and individualized responses in patients with acute renal failure
    H David Humes
    Department of Medicine, University of Michigan Medical Center, Ann Arbor 48109, USA
    Blood Purif 21:64-71. 2003
    ....
  13. ncbi request reprint Insights into ototoxicity. Analogies to nephrotoxicity
    H D Humes
    Department of Internal Medicine, VA Medical Center, Ann Arbor, Michigan, USA
    Ann N Y Acad Sci 884:15-8. 1999
    ..The ototoxicity of these agents may be indirect, due to changes in ionic composition and fluid volume within the endolymph...
  14. ncbi request reprint Metabolic replacement of kidney function in uremic animals with a bioartificial kidney containing human cells
    H David Humes
    Department of Medicine, VA Medical Center, and University of Michigan, Ann Arbor, MI 48109 0644, USA
    Am J Kidney Dis 39:1078-87. 2002
    ..With these results, clinical evaluation of this device in the treatment of severely ill patients with acute renal failure in an intensive care unit has been initiated...
  15. ncbi request reprint Replacement of renal function in uremic animals with a tissue-engineered kidney
    H D Humes
    Department of Internal Medicine, University of Michigan, VA Medical Center, Ann Arbor 48109, USA
    Nat Biotechnol 17:451-5. 1999
    ....
  16. ncbi request reprint Tissue engineering of a bioartificial renal tubule assist device: in vitro transport and metabolic characteristics
    H D Humes
    Department of Internal Medicine, University of Michigan, VA Medical Center, Ann Arbor, USA
    Kidney Int 55:2502-14. 1999
    ..This therapy is not complete renal replacement therapy because it does not provide active transport nor metabolic and endocrinologic functions of the kidney, which are located predominantly in the tubular elements of the kidney...
  17. ncbi request reprint Bioartificial kidney for full renal replacement therapy
    H D Humes
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109, USA
    Semin Nephrol 20:71-82. 2000
    ..These new approaches may result in therapeutic modalities that significantly diminish the morbidity and mortality in patients with acute renal failure or end-stage renal disease...
  18. ncbi request reprint The role of a bioengineered artificial kidney in renal failure
    W H Fissell
    Department of Internal Medicine, VA Medical Center, Ann Arbor, Michigan, USA
    Ann N Y Acad Sci 944:284-95. 2001
    ..We have observed active transport of sodium, glucose, and glutathione. We describe the design and initial preclinical testing of the bioartificial kidney, as well as future directions of our research...
  19. pmc Stem cell technology for the treatment of acute and chronic renal failure
    Christopher J Pino
    Innovative BioTherapies, Inc, Ann Arbor, MI 48108, USA
    Transl Res 156:161-8. 2010
    ..In this review, current stem cell technologies including adult stem cells, embryonic stem cells and induced pluripotent stem cells will be discussed as cell sources for the treatment of acute and chronic renal failure...
  20. ncbi request reprint The future of renal support: high-flux dialysis to bioartificial kidneys
    Khajohn Tiranathanagul
    Department of Internal Medicine, University of Michigan Medical School, 4520 MSRB I, Box 0651, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA
    Crit Care Clin 21:379-94. 2005
    ....
  21. pmc Renal cell therapy and beyond
    Joon Ho Song
    Department of Internal Medicine, School of Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Semin Dial 22:603-9. 2009
    ..Both devices may become comprehensive treatments, replacing full renal function and correcting inflammatory imbalance in patients with acute and chronic renal disorders...
  22. pmc Enhanced propagation of adult human renal epithelial progenitor cells to improve cell sourcing for tissue-engineered therapeutic devices for renal diseases
    Angela J Westover
    Innovative BioTherapies Inc, Ann Arbor, MI 48108, USA
    J Tissue Eng Regen Med 6:589-97. 2012
    ....
  23. ncbi request reprint Bioartificial kidney ameliorates gram-negative bacteria-induced septic shock in uremic animals
    William H Fissell
    Departments of Medicine, Veterans Administration Medical Center and The University of Michigan, Ann Arbor, Michigan, USA
    J Am Soc Nephrol 14:454-61. 2003
    ..These results demonstrate that the addition of cell therapy to hemofiltration in an acutely uremic animal model with septic shock ameliorates cardiovascular dysfunction, alters systemic cytokine balance, and improves survival time...
  24. ncbi request reprint Cell therapy of renal failure
    W H Fissell
    Department of Internal Medicine, VA Medical Center, Ann Arbor, Michigan, USA
    Transplant Proc 35:2837-42. 2003
    ..This bioartificial kidney has now completed a Phase I clinical trial in acute renal failure...
  25. ncbi request reprint Dialysis and nanotechnology: now, 10 years, or never?
    W H Fissell
    Department of Internal Medicine, University of Michigan, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    Blood Purif 25:12-7. 2007
    ..Recent data in membrane design and testing is presented, with a review of the challenges remaining in implementation of this technology...
  26. ncbi request reprint Rare incorporation of bone marrow-derived cells into kidney after folic acid-induced injury
    Mark S Szczypka
    Research Division, Nephros Therapeutics Inc, Ann Arbor, Michigan, USA
    Stem Cells 23:44-54. 2005
    ..These results suggest that BMDCs may incorporate into glomeruli as specialized glomerular mesangial cells; however, BMDCs rarely contribute to the repair of renal tubules in uninjured or FA-treated mouse kidneys...
  27. doi request reprint A selective cytopheretic inhibitory device to treat the immunological dysregulation of acute and chronic renal failure
    H David Humes
    Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Mich, USA
    Blood Purif 29:183-90. 2010
    ..Evolving evidence suggests that the kidney, and specifically renal epithelial cells, plays an important role in the immunological response of leukocytes under disease states...
  28. doi request reprint The bioartificial kidney and bioengineered membranes in acute kidney injury
    Feng Ding
    Department of Internal Medicine, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Nephron Exp Nephrol 109:e118-22. 2008
    ..New developments in this translational research area will improve the unmet medical needs of patients with renal failure...
  29. ncbi request reprint Is acetylcysteine effective in preventing contrast-related nephropathy? A meta-analysis
    Brahmajee K Nallamothu
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0311, USA
    Am J Med 117:938-47. 2004
    ..Although previous meta-analyses have concluded that acetylcysteine is beneficial, the recent availability of additional trials calls for reassessment of current evidence...
  30. ncbi request reprint Tissue engineering of an implantable bioartificial hemofilter
    Khajohn Tiranathanagul
    Division of Nephrology, Department of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand
    ASAIO J 53:176-86. 2007
    ..These results provide the initial proof of concept in developing a tissue-engineered hemofilter prototype on a small scale in a rodent model...
  31. doi request reprint A selective cytopheretic inhibitory device for use during cardiopulmonary bypass surgery
    C J Pino
    Innovative BioTherapies Inc, Ann Arbor, MI 48108, USA
    Perfusion 27:311-9. 2012
    ..Neutrophil-depleting filters incorporated within the extracorporeal blood circuit during CPB have been developed and evaluated, with inconsistent clinical results...
  32. ncbi request reprint Bioartificial kidney in the treatment of acute renal failure associated with sepsis
    Khajohn Tiranathanagul
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nephrology (Carlton) 11:285-91. 2006
    ..The results to date of large animal studies and recent Phase I/II and Phase II clinical trials show that such a device replaces multiple kidney functions and modifies the sepsis condition to improve survival in ARF...
  33. ncbi request reprint Kidney epithelial cells
    Peter L Smith
    Innovative BioTherapies, Inc, Ann Arbor, MI, USA
    Methods Enzymol 419:194-207. 2006
    ....
  34. ncbi request reprint BKV and SV40 infection of human kidney tubular epithelial cells in vitro
    Jonathan Low
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Virology 323:182-8. 2004
    ..It was observed that the related polyomavirus SV40 is incapable of infecting human kidney epithelium except in the presence of the GM1 ganglioside, recently reported to be an SV40 receptor...
  35. ncbi request reprint Development of continuous implantable renal replacement: past and future
    William H Fissell
    Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Transl Res 150:327-36. 2007
    ..These advances in membrane technology are fundamentally enabling for a paradigm shift from an in-center to implantable dialysis system...
  36. ncbi request reprint Cell therapy: leveraging nature's therapeutic potential
    H David Humes
    J Am Soc Nephrol 14:2211-3. 2003