Mark S Humayun

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Retinal prosthesis for the blind
    Eyal Margalit
    Intraocular Prosthesis Group, Wilmer Eye Institute, Johns Hopkins, Baltimore, MD 21287 9277, USA
    Surv Ophthalmol 47:335-56. 2002
  2. ncbi request reprint Retinal prostheses for the blind
    Michael Javaheri
    Doheny Retina Institute, Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, 1450 San Pablo Street Room 3600, Los Angeles, CA 90033, USA
    Ann Acad Med Singapore 35:137-44. 2006
  3. pmc Preliminary 6 month results from the Argus II epiretinal prosthesis feasibility study
    Mark S Humayun
    Doheny Eye Insitutute, Los Angeles, CA 90017, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4566-8. 2009
  4. ncbi request reprint Retinal prosthesis
    James D Weiland
    Doheny Retina Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Annu Rev Biomed Eng 7:361-401. 2005
  5. pmc Interim results from the international trial of Second Sight's visual prosthesis
    Mark S Humayun
    Doheny Eye Institute, University of Southern California, Los Angeles, California, USA
    Ophthalmology 119:779-88. 2012
  6. ncbi request reprint Visual perception in a blind subject with a chronic microelectronic retinal prosthesis
    Mark S Humayun
    Doheny Retina Institute at the Doheny Eye Institute, University of Southern California, 1450 San Pablo Street Room 3600, Keck School of Medicine, Los Angeles, CA 14627, USA
    Vision Res 43:2573-81. 2003
  7. ncbi request reprint Effect of oxygenated intraocular irrigation solutions on the electroretinogram after vitrectomy
    Michael Javaheri
    Doheny Retina Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Retina 27:87-94. 2007
  8. doi request reprint A comparison of retinal prosthesis electrode array substrate materials
    James D Weiland
    Doheny Eye Institute, Los Angeles, California, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4140-3. 2009
  9. ncbi request reprint Preservation of retinotopic map in retinal degeneration
    John Xie
    Doheny Eye Institute, University of Southern California, 1355 San Pablo St, DVRC 100, Los Angeles, CA 90033, USA
    Exp Eye Res 98:88-96. 2012
  10. pmc Factors affecting perceptual thresholds in epiretinal prostheses
    Chloé de Balthasar
    Department of Ophthalmology and Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 49:2303-14. 2008

Detail Information

Publications100

  1. ncbi request reprint Retinal prosthesis for the blind
    Eyal Margalit
    Intraocular Prosthesis Group, Wilmer Eye Institute, Johns Hopkins, Baltimore, MD 21287 9277, USA
    Surv Ophthalmol 47:335-56. 2002
    ....
  2. ncbi request reprint Retinal prostheses for the blind
    Michael Javaheri
    Doheny Retina Institute, Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, 1450 San Pablo Street Room 3600, Los Angeles, CA 90033, USA
    Ann Acad Med Singapore 35:137-44. 2006
    ....
  3. pmc Preliminary 6 month results from the Argus II epiretinal prosthesis feasibility study
    Mark S Humayun
    Doheny Eye Insitutute, Los Angeles, CA 90017, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4566-8. 2009
    ..These preliminary results show that the Argus II system provides some functional vision to blind subjects...
  4. ncbi request reprint Retinal prosthesis
    James D Weiland
    Doheny Retina Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Annu Rev Biomed Eng 7:361-401. 2005
    ....
  5. pmc Interim results from the international trial of Second Sight's visual prosthesis
    Mark S Humayun
    Doheny Eye Institute, University of Southern California, Los Angeles, California, USA
    Ophthalmology 119:779-88. 2012
    ..This study evaluated the Argus II Retinal Prosthesis System (Second Sight Medical Products, Inc., Sylmar, CA) in blind subjects with severe outer retinal degeneration...
  6. ncbi request reprint Visual perception in a blind subject with a chronic microelectronic retinal prosthesis
    Mark S Humayun
    Doheny Retina Institute at the Doheny Eye Institute, University of Southern California, 1450 San Pablo Street Room 3600, Keck School of Medicine, Los Angeles, CA 14627, USA
    Vision Res 43:2573-81. 2003
    ..In addition, the subject was able to use a camera to detect the presence or absence of ambient light, to detect motion, and to recognize simple shapes...
  7. ncbi request reprint Effect of oxygenated intraocular irrigation solutions on the electroretinogram after vitrectomy
    Michael Javaheri
    Doheny Retina Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Retina 27:87-94. 2007
    ..To investigate the effect of oxygenated intraocular irrigating solutions on electroretinograms (ERGs) for postvitrectomy rabbits...
  8. doi request reprint A comparison of retinal prosthesis electrode array substrate materials
    James D Weiland
    Doheny Eye Institute, Los Angeles, California, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4140-3. 2009
    ..This array must meet very challenging, competing requirements for manufacturing, integration, surgical handling, and biocompatibility. Our lab has evaluated 3 polymers as retinal prosthesis substrates: polyimide, parylene, and silicone...
  9. ncbi request reprint Preservation of retinotopic map in retinal degeneration
    John Xie
    Doheny Eye Institute, University of Southern California, 1355 San Pablo St, DVRC 100, Los Angeles, CA 90033, USA
    Exp Eye Res 98:88-96. 2012
    ..Our findings suggest primary visual cortex continues to maintain its retinotopy in RD subjects despite prolonged visual loss...
  10. pmc Factors affecting perceptual thresholds in epiretinal prostheses
    Chloé de Balthasar
    Department of Ophthalmology and Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 49:2303-14. 2008
    ..S. Food and Drug Administration (FDA)-approved clinical trial...
  11. ncbi request reprint Visual performance using a retinal prosthesis in three subjects with retinitis pigmentosa
    Douglas Yanai
    Doheny Retina Institute at the Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Am J Ophthalmol 143:820-827. 2007
    ..To assess visual task performance in three blind subjects implanted with epiretinal prostheses...
  12. pmc Predicting visual sensitivity in retinal prosthesis patients
    Alan Horsager
    Neuroscience Graduate Program, University of Southern California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 50:1483-91. 2009
    ....
  13. ncbi request reprint Implantation of an inactive epiretinal poly(dimethyl siloxane) electrode array in dogs
    Dilek Guven
    Department of Ophthalmology, Keck School of Medicine, Doheny Retina Institute, Doheny Eye Institute, University of Southern California, Los Angeles, CA, USA
    Exp Eye Res 82:81-90. 2006
    ..Its implantation and handling is surgically manageable, and it forms a mechanically stable, acceptable interface with the inner retinal surface...
  14. ncbi request reprint Perceptual thresholds and electrode impedance in three retinal prosthesis subjects
    Manjunatha Mahadevappa
    Doheny Eye Institute, Los Angeles, CA 90033, USA
    IEEE Trans Neural Syst Rehabil Eng 13:201-6. 2005
    ..The data show that proximity to the retina played a role in determining the threshold and impedance, but only for electrodes that were greater than 0.5 mm from the retina...
  15. pmc Brightness as a function of current amplitude in human retinal electrical stimulation
    Scott H Greenwald
    Second Sight Medical Products, Inc, Sylmar, California, USA
    Invest Ophthalmol Vis Sci 50:5017-25. 2009
    ..The goal was to examine how apparent brightness changes as a function of stimulation intensity across electrodes...
  16. doi request reprint Natural course of experimental retinal vein occlusion in rabbit; arterial occlusion following venous photothrombosis
    Hossein Ameri
    Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Graefes Arch Clin Exp Ophthalmol 246:1429-39. 2008
    ..The aim of our study was to examine the course of experimentally created retinal vein occlusion (RVO) in rabbits...
  17. doi request reprint Intravitreal and subretinal injection of tissue plasminogen activator (tPA) in the treatment of experimentally created retinal vein occlusion in rabbits
    Hossein Ameri
    Doheny Retina Institute, Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Retina 28:350-5. 2008
    ..To evaluate the effectiveness of intravitreal or subretinal injection of tPA in the treatment of experimentally created retinal vein occlusion (RVO) in rabbits...
  18. doi request reprint Performance analysis of ultrahigh-speed vitreous cutter system
    Ramiro M Ribeiro
    Eye Concepts, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Retina 33:928-32. 2013
    ..To evaluate flow rates and duty cycle for different sizes of ultra-high-speed pneumatic vitreous cutters...
  19. pmc Acute variations in retinal vascular oxygen content in a rabbit model of retinal venous occlusion
    Gilberto Raul Lopez Jaime
    Doheny Eye Institute, University of Southern California, Los Angeles California, United States of America
    PLoS ONE 7:e50179. 2012
    ..To study the variation in intravascular oxygen saturation (oximetry) during an acute retinal vein occlusion (RVO) using hyperspectral computed tomographic spectroscopy based oximetry measurements...
  20. ncbi request reprint Outcomes of 140 consecutive cases of 25-gauge transconjunctival surgery for posterior segment disease
    Rohit R Lakhanpal
    Doheny Retina Institute, Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Ophthalmology 112:817-24. 2005
    ..To evaluate the safety and efficacy of 25-gauge instrumentation for a variety of vitreoretinal conditions on previously nonvitrectomized eyes...
  21. ncbi request reprint Characteristics of visual loss by scanning laser ophthalmoscope microperimetry in eyes with subfoveal choroidal neovascularization secondary to age-related macular degeneration
    Gildo Y Fujii
    Doheny Retina Institute, Doheny Eye Institute, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Am J Ophthalmol 136:1067-78. 2003
    ..To evaluate the effects of subfoveal choroidal neovascularization secondary to age-related macular degeneration on functional parameters obtained by scanning laser ophthalmoscope microperimetry...
  22. pmc The value of preoperative tests in the selection of blind patients for a permanent microelectronic implant
    Douglas Yanai
    Intraocular Retinal Prosthesis Group of the Doheny Retina Institute, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, USA
    Trans Am Ophthalmol Soc 101:223-8; discussion 228-30. 2003
    ....
  23. pmc Toward a wide-field retinal prosthesis
    Hossein Ameri
    Doheny Retina Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    J Neural Eng 6:035002. 2009
    ..They also showed that the arrays could conform to the inner curvature of the eye. Surgeries on an enucleated porcine eye model demonstrated feasibility of implantation of 10 mm wide arrays through a 5 mm eye wall incision...
  24. pmc Resolution of the epiretinal prosthesis is not limited by electrode size
    Matthew R Behrend
    University of Southern California, Los Angeles, CA 90033, USA
    IEEE Trans Neural Syst Rehabil Eng 19:436-42. 2011
    ..55(°) of human visual field and corresponding Snellen acuity of 20/660. Reading large print could be possible with such a prosthesis...
  25. pmc Effect of multiple injections of small divided doses vs single injection of intravitreal bevacizumab on retinal neovascular model in rabbits
    Saloomeh Saati
    Doheny Retina Institute, Doheny Eye Institute, 1450 San Pablo St, Los Angeles, CA, 90033, USA
    Graefes Arch Clin Exp Ophthalmol 248:457-66. 2010
    ..To compare effects of multiple injections of small divided doses of intravitreal bevacizumab vs a single injection using a retinal neovascular model in rabbits...
  26. pmc Mini drug pump for ophthalmic use
    Saloomeh Saati
    Doheny Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Trans Am Ophthalmol Soc 107:60-70. 2009
    ..To evaluate the feasibility of developing a novel mini drug pump for ophthalmic use...
  27. pmc Analysis of a 23-gauge ultra high-speed cutter with duty cycle control
    Bruno Diniz
    Doheny Eye Institute, Los Angeles, California, USA
    Retina 33:933-8. 2013
    ..The purpose of the study was to determine the performance of dual pneumatic ultra high-speed 23-gauge cutters operated with variable duty cycle (DC) settings...
  28. doi request reprint A passive MEMS drug delivery pump for treatment of ocular diseases
    Ronalee Lo
    Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, 1042 Downey Way, DRB 140, Los Angeles, CA 90089 1111, USA
    Biomed Microdevices 11:959-70. 2009
    ..The valve closing time constant was 10.2 s for 500 mmHg and 14.2 s for 250 mmHg. Assembled devices were successfully demonstrated in benchtop, ex vivo, and in vivo experiments...
  29. pmc Frequency and amplitude modulation have different effects on the percepts elicited by retinal stimulation
    Devyani Nanduri
    Department of Biomedical Engineering, University of Southern California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 53:205-14. 2012
    ..In this study, manipulating pulse train frequency and amplitude had different effects on the size and brightness of phosphene appearance...
  30. ncbi request reprint A system verification platform for high-density epiretinal prostheses
    Kuanfu Chen
    Bioengineering Department and the California NanoSystems Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA
    IEEE Trans Biomed Circuits Syst 7:326-37. 2013
    ..The characterization of the wireless telemetry and the demonstration of the visual display are reported in this paper using a 256-channel retinal prosthetic IC as an example. ..
  31. ncbi request reprint Long-term stimulation by active epiretinal implants in normal and RCD1 dogs
    Dilek Guven
    Doheny Retina Institute, Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    J Neural Eng 2:S65-73. 2005
    ..In summary, chronic electrical stimulation of the dog retina at up to 0.1 mC cm(-2) with an epiretinal prosthesis does not appear to adversely affect the retina...
  32. pmc Mini drug pump for ophthalmic use
    Saloomeh Saati
    Doheny Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Curr Eye Res 35:192-201. 2010
    ..To evaluate the feasibility of developing a novel mini drug pump for ophthalmic use...
  33. pmc Selective labeling of retinal ganglion cells with calcium indicators by retrograde loading in vitro
    Matthew R Behrend
    Dept of Electrical Engineering, University of Southern California, Los Angeles, CA 90033, USA
    J Neurosci Methods 179:166-72. 2009
    ..Following dye loading, the isolated retina was mounted on a microelectrode array to demonstrate that electrical activity and calcium activity were preserved, as the retina responded to electrical stimuli...
  34. ncbi request reprint Determining the acoustic properties of the lens using a high-frequency ultrasonic needle transducer
    Chih Chung Huang
    National Institutes of Health Resource on Medical Ultrasonic Transducer Technology, Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA
    Ultrasound Med Biol 33:1971-7. 2007
    ..Finally, the data obtained demonstrate that regional variations in the acoustic properties of lenses corresponding to the hardness of different types of cataract can be detected sensitively by a needle transducer...
  35. doi request reprint Both electrical stimulation thresholds and SMI-32-immunoreactive retinal ganglion cell density correlate with age in S334ter line 3 rat retina
    Leanne L H Chan
    Doheny Vision Research Center, Doheny Eye Institute, Los Angeles, CA 90033, USA
    J Neurophysiol 105:2687-97. 2011
    ..2-ms duration, respectively. Preservation of ganglion cells may enhance the efficiency and safety of electronic retinal implants...
  36. ncbi request reprint Initial experience using the transconjunctival sutureless vitrectomy system for vitreoretinal surgery
    Gildo Y Fujii
    Microsurgery Advanced Design Laboratory, Doheny Eye Institute, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Ophthalmology 109:1814-20. 2002
    ..To describe the initial experience and to evaluate the safety and feasibility of using the 25-gauge Transconjunctival Sutureless Vitrectomy System (TSV) for a variety of vitreoretinal procedures...
  37. ncbi request reprint Intraocular retinal prosthesis. Big steps to sight restoration
    James D Weiland
    Intraocular Retinal Prosthesis Laboratory, Keck School of Medicine, University of Southern California, USA
    IEEE Eng Med Biol Mag 25:60-6. 2006
  38. ncbi request reprint Electrical properties of retinal-electrode interface
    Samip Shah
    Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, CA, USA
    J Neural Eng 4:S24-9. 2007
    ..Circuit models of the electrode-retina interface are used to parameterize the different contributors to the overall impedance...
  39. pmc Vitreal oxygenation in retinal ischemia reperfusion
    Walid Abdallah
    Doheny Retina Institute, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 52:1035-42. 2011
    ..To study the feasibility of anterior vitreal oxygenation for the treatment of acute retinal ischemia...
  40. pmc Morphometric analysis of optic nerves and retina from an end-stage retinitis pigmentosa patient with an implanted active epiretinal array
    Jeffrey G Eng
    Doheny Eye Institute, Los Angeles, California 90033, USA
    Invest Ophthalmol Vis Sci 52:4610-6. 2011
    ..To characterize optic nerve and retinal changes in a patient with end-stage retinitis pigmentosa (RP) with an implanted active epiretinal array...
  41. ncbi request reprint Transvitreal limited arteriovenous-crossing manipulation without vitrectomy for complicated branch retinal vein occlusion using 25-gauge instrumentation
    Rohit R Lakhanpal
    Microsurgery Advanced Design Laboratory, Doheny Retina Institute, Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Retina 25:272-80. 2005
    ....
  42. doi request reprint In vivo detection of hESC-RPE cells via confocal near-infrared fundus reflectance
    Ramiro M Ribeiro
    Doheny Eye Institute, 1355 San Pablo Street, Los Angeles, CA 90033, USA
    Ophthalmic Surg Lasers Imaging Retina 44:380-4. 2013
    ....
  43. pmc Fluidics in a dual pneumatic ultra high-speed vitreous cutter system
    Bruno Diniz
    Doheny Eye Institute, Los Angeles, CA 90033, USA
    Ophthalmologica 229:15-20. 2013
    ..The purpose of this study is to evaluate the influence of gauge size, cut rate and aspiration on the flow rate performance of ultra high-speed cutters operated with a commercially available dual pneumatic vitrectomy system...
  44. ncbi request reprint Virtual vitreoretinal surgical simulator as a training tool
    Juliana V Rossi
    Doheny Retina Institute at the Doheny Eye Institute, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Retina 24:231-6. 2004
    ..To demonstrate the feasibility and potential applicability of a virtual reality simulator for vitreoretinal surgery as a training and/or assessment tool...
  45. ncbi request reprint Retinal thickness in normal and RCD1 dogs using optical coherence tomography
    Carla Q Panzan
    Doheny Retina Institute, Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Ophthalmic Surg Lasers Imaging 35:485-93. 2004
    ..To compare retinal thickness and retinal nerve fiber layer (RNFL) thickness values obtained by optical coherence tomography (OCT) in normal dogs and dogs with rod-cone dysplasia type 1 (RCD1)...
  46. ncbi request reprint Electrical stimulation in normal and retinal degeneration (rd1) isolated mouse retina
    Thomas M O'Hearn
    The Doheny Eye Institute, The Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA
    Vision Res 46:3198-204. 2006
    ..Thus both the electrode positioning as well as the health of the retinal tissue play a role in the stimulating current required to elicit a retinal response...
  47. ncbi request reprint A biomimetic retinal stimulating array
    James D Weiland
    Doheny Retina Institute, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    IEEE Eng Med Biol Mag 24:14-21. 2005
  48. ncbi request reprint Retinal vein cannulation with prolonged infusion of tissue plasminogen activator (t-PA) for the treatment of experimental retinal vein occlusion in dogs
    Mohamed K Tameesh
    Doheny Retina Institute, Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Am J Ophthalmol 138:829-39. 2004
    ..To evaluate the feasibility, safety, and efficacy of local thrombolytic agents directly injected into occluded retinal veins in an experimental animal model...
  49. ncbi request reprint Evaluation of lens hardness in cataract surgery using high-frequency ultrasonic parameters in vitro
    Chih Chung Huang
    NIH Resource on Medical Ultrasonic Transducer Technology, Department of Biomedical Engineering, University of Southern California, California, Los Angeles, CA 90089 1111, USA
    Ultrasound Med Biol 33:1609-16. 2007
    ..941 and 0.915, respectively). These results showed that measuring high-frequency ultrasonic parameters provides surgeons with good capability and reproducibility for selecting the optimal energy level for phacoemulsification...
  50. ncbi request reprint Quantitative analysis of retinal structures using spectral domain optical coherence tomography in normal rabbits
    Zeynep Alkin
    Doheny Retina Institute, Doheny Eye Institute, Los Angeles, CA, USA
    Curr Eye Res 38:299-304. 2013
    ....
  51. doi request reprint A novel approach for subretinal implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium monolayer
    Yuntao Hu
    Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
    Ophthalmic Res 48:186-91. 2012
    ....
  52. doi request reprint Fluorescein angiography, optical coherence tomography, and histopathologic findings in a VEGF(165) animal model of retinal angiogenesis
    Luís A Arana
    Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
    Graefes Arch Clin Exp Ophthalmol 250:1421-8. 2012
    ..To establish an animal model of retinal neovascularization using vascular endothelial growth factor (VEGF165) and analyze the model using optical coherence tomography (OCT), fluorescein angiography (FA), and histopathologic evaluation...
  53. ncbi request reprint Rapid recurrence of geographic atrophy after full macular translocation for nonexudative age-related macular degeneration
    Rahul N Khurana
    Doheny Retina Institute, Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Ophthalmology 112:1586-91. 2005
    ..To report the recurrence of geographic atrophy (GA) in a patient with nonexudative age-related macular degeneration (AMD) after full macular translocation...
  54. pmc An in vitro model of a retinal prosthesis
    Ashish K Ahuja
    Department of Electrical Engineering, University of Southern California, Los Angeles, CA 90089 2654, USA
    IEEE Trans Biomed Eng 55:1744-53. 2008
    ..66 +/- 1.30 nC/cm2, respectively, while the required charge was 12.5 +/- 6.2 and 19 +/- 3.3 nC...
  55. pmc Imaging the response of the retina to electrical stimulation with genetically encoded calcium indicators
    Andrew C Weitz
    Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA
    J Neurophysiol 109:1979-88. 2013
    ..Our method can be easily adapted to work with other fluorescent indicator proteins in both wild-type and transgenic mammals...
  56. pmc Evaluation of ultrasound-assisted thrombolysis using custom liposomes in a model of retinal vein occlusion
    Walid F Abdallah
    Doheny Eye Institute, Los Angeles, CA 90033, USA
    Invest Ophthalmol Vis Sci 53:6920-7. 2012
    ..To study the potential efficacy of ultrasound (US) assisted by custom liposome (CLP) destruction as an innovative thrombolytic tool for the treatment of retinal vein occlusion (RVO)...
  57. ncbi request reprint Limited macular translocation for the management of subfoveal choroidal neovascularization after photodynamic therapy
    Gildo Y Fujii
    Doheny Retina Institute at the Doheny Eye Center, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Am J Ophthalmol 135:109-12. 2003
    ..To report our initial experience of limited macular translocation in patients with subfoveal choroidal neovascularization secondary to age-related macular degeneration following photodynamic therapy with verteporfin...
  58. ncbi request reprint Patient selection for macular translocation surgery using the scanning laser ophthalmoscope
    Gildo Y Fujii
    Doheny Retina Institute at the Doheny Eye Center, University of Southern California, Keck School of Medicine, Los Angeles, California Wilmer Ophthalmological Institute, The Johns Hopkins Hospital Baltimore, Maryland, USA
    Ophthalmology 109:1737-44. 2002
    ....
  59. doi request reprint Impedance as a method to sense proximity at the electrode-retina interface
    Aditi Ray
    Department of Biomedical Engineering, University of Southern California, Los Angeles, 90033, USA
    IEEE Trans Neural Syst Rehabil Eng 19:696-9. 2011
    ..Optical coherence tomography imaging confirmed the distance-impedance relationship...
  60. ncbi request reprint The effects of intravitreous bevacizumab on retinal neovascular membrane and normal capillaries in rabbits
    Hossein Ameri
    Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Invest Ophthalmol Vis Sci 48:5708-15. 2007
    ..To evaluate the effects of intravitreous bevacizumab in a rabbit retinal neovascularization model...
  61. doi request reprint Artificial vision: needs, functioning, and testing of a retinal electronic prosthesis
    Gerald J Chader
    Doheny Retina Institute, USC School of Medicine, Los Angeles, CA, USA
    Prog Brain Res 175:317-32. 2009
    ..Devices with new, sophisticated designs and increasing numbers of electrodes could allow for long-term restoration of functional sight in patients with improvement in object recognition, mobility, independent living, and general QOL...
  62. doi request reprint Retinal prostheses: current clinical results and future needs
    James D Weiland
    Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Ophthalmology 118:2227-37. 2011
    ..This review focuses on 3 major areas: the histopathologic features of human retina affected by AMD and RP, current results from clinical trials, and challenges to overcome for continued improvement of retinal prostheses...
  63. ncbi request reprint Use of rotational sutures for limited retinal translocation: a new technique for superior limited macular translocation
    Dylek Güven
    Doheny Retina Institute, Doheny Eye Institute, Keck School of Medicine of the University of Southern California, 1450 San Pablo Street, Los Angeles, CA 90033, USA
    Am J Ophthalmol 137:901-7. 2004
    ..To report a modified surgical technique for retinal translocation in eyes with subfoveal choroidal neovascularization...
  64. doi request reprint Modeling and percept of transcorneal electrical stimulation in humans
    John Xie
    Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    IEEE Trans Biomed Eng 58:1932-9. 2011
    ..This study demonstrates that admittance modeling and PET imaging consistently predict the perceived location of electrically elicited phosphenes produced during TcES...
  65. doi request reprint A new dual port cutter system for vitrectomy surgery
    Luiz H Lima
    Eye Concepts, Doheny Eye Institute, University of Southern California, Los Angeles, CA 90033, USA
    Retina 30:1515-9. 2010
    ..To evaluate and compare the performance of several designs of 20-gauge dual port (DP) vitreous cutter tips with a standard 20-gauge single port tip...
  66. ncbi request reprint Nanobiolistic delivery of indicators to the living mouse retina
    Roberto Roizenblatt
    Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
    J Neurosci Methods 153:154-61. 2006
    ....
  67. ncbi request reprint Advances in the development of visual prostheses
    Rohit R Lakhanpal
    Intraocular Retinal Prosthesis IRP Group, Doheny Retina Institute, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Curr Opin Ophthalmol 14:122-7. 2003
    ..The different types of implants and recent results are discussed, but special emphasis is given to retinal implants...
  68. ncbi request reprint Limited macular translocation: current concepts
    Gildo Y Fujii
    Retina Institute, Doheny Eye Institute, Keck School of Medicine, University of Southern California, DEI 3600, 1450 San Pablo Street, Los Angeles, CA 90033, USA
    Ophthalmol Clin North Am 15:425-36. 2002
    ....
  69. ncbi request reprint Evaluation of a stereoscopic camera-based three-dimensional viewing workstation for ophthalmic surgery
    Prashant R Bhadri
    Eye Concepts Research and Development Laboratory, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    Am J Ophthalmol 143:891-2. 2007
    ..To evaluate the effectiveness of a prototype stereoscopic camera-based viewing system (Digital Microsurgical Workstation, three-dimensional (3D) Vision Systems, Irvine, California, USA) for anterior and posterior segment ophthalmic surgery...
  70. pmc Hyperspectral computed tomographic imaging spectroscopy of vascular oxygen gradients in the rabbit retina in vivo
    Amir H Kashani
    Doheny Eye Institute, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 6:e24482. 2011
    ..Application of this method to animal models of retinal vascular disease and clinical subjects will provide useful and novel information about retinal vascular disease and physiology...
  71. ncbi request reprint A new 25-gauge instrument system for transconjunctival sutureless vitrectomy surgery
    Gildo Y Fujii
    Microsurgery Advanced Design Laboratory, Doheny Eye Institute, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Ophthalmology 109:1807-12; discussion 1813. 2002
    ..To introduce and evaluate the infusion and aspiration rates and operative times of the 25-gauge transconjunctival sutureless vitrectomy system (TSV) DESIGN: In vitro experimental and comparative interventional study...
  72. ncbi request reprint Visually guided performance of simple tasks using simulated prosthetic vision
    Jasmine S Hayes
    Department of Ophthalmology, University of Southern California, Los Angeles, CA, USA
    Artif Organs 27:1016-28. 2003
    ..In all categories, subjects performed best with the 16 x 16 array and least well with the 4 x 4 array. Even with the lowest resolution array, however, some subjects could recognize simple objects and symbols...
  73. doi request reprint Biomimetic image processing for retinal prostheses: peripheral saliency cues
    Neha J Parikh
    Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4569-72. 2009
    ..Results show that a cueing system may help to reduce and organize the head movements of the subjects, whereas a time benefit exists in object location but not in mobility tasks...
  74. ncbi request reprint Performance analysis of new-generation vitreous cutters
    Sophia Y Fang
    Eye Concepts, Doheny Eye Institute, 1450 San Pablo Street, DVRC 119, Los Angeles, CA 90033 3699, USA
    Graefes Arch Clin Exp Ophthalmol 246:61-7. 2008
    ..Herein, we examine the effect of duty cycle on the flow performance of new-generation cutters relative to current instrumentation...
  75. doi request reprint A refillable microfabricated drug delivery device for treatment of ocular diseases
    Ronalee Lo
    Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA
    Lab Chip 8:1027-30. 2008
    ..An implantable manually-actuated microfabricated drug delivery device was demonstrated as a new approach for delivering therapeutic compounds to ocular tissue in acute in vitro, ex vivo, and in vivo studies...
  76. ncbi request reprint Heat effects on the retina
    Duke V Piyathaisere
    Doheny Retina Institute, Keck School of Medicine, University of Southern California, Los Angeles, 90043, USA
    Ophthalmic Surg Lasers Imaging 34:114-20. 2003
    ..The determination of thermal parameters that are nonharmful to the retina will aid in the development of an implantable intraocular electronic retinal prosthesis...
  77. pmc Immunocytochemical analysis of retinal neurons under electrical stimulation
    Aditi Ray
    Department of Biomedical Engineering and Center for Vision Science and Technology, University of Southern California, Denney Research Building 140, Los Angeles, CA 90089 1111, USA
    Brain Res 1255:89-97. 2009
    ..These results show that, although gross morphological changes are mainly concentrated around the area of electrode contact, immunocytochemistry can reveal changes in adjacent areas as well...
  78. ncbi request reprint Enucleated eye model for intraocular retinal prosthesis implantation
    Tanapat Ratanapakorn
    Doheny Retina Institute, Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Ophthalmic Surg Lasers Imaging 37:341-3. 2006
    ..A retinal prosthesis array was inserted without significant damage to the array and conformed to the curvature of the eye. Fundus photography and optical coherence tomography were performed at the end of surgery...
  79. ncbi request reprint A novel method to oxygenate intraocular irrigation fluids with an in-line oxygenator
    Rahul N Khurana
    Doheny Retina Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Retina 27:83-6. 2007
    ..We describe a novel method to oxygenate intraocular irrigation solutions involving an in-line oxygenator...
  80. ncbi request reprint PMN-PT single crystal, high-frequency ultrasonic needle transducers for pulsed-wave Doppler application
    Qifa Zhou
    NIH Resource on Medical Ultrasonic Transducer Technology, Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 54:668-75. 2007
    ..In vivo high-frequency, pulsed-wave Doppler patterns of blood flow in the posterior portion and in vitro ultrasonic backscatter microscope (UBM) images of the rabbit eye were obtained with the 44-MHz needle transducer...
  81. doi request reprint Assessment of MRI issues for the Argus II retinal prosthesis
    James D Weiland
    Doheny Eye Institute, University of Southern California, Los Angeles, CA, USA
    Magn Reson Imaging 30:382-9. 2012
    ..5 T and 3 T for the Argus II Retinal Prosthesis (Second Sight Medical Products, Sylmar, CA, USA)...
  82. ncbi request reprint In vitro electrical properties for iridium oxide versus titanium nitride stimulating electrodes
    James D Weiland
    Doheny Retina Institute, Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA
    IEEE Trans Biomed Eng 49:1574-9. 2002
    ..Iridium oxide charge storage was 4 mC/cm2, which is comparable to other published values for iridium oxide. Electrode efficiency will lead to an overall more efficient and effective device...
  83. ncbi request reprint Ganglion cell responses to retinal light stimulation in the absence of photoreceptor outer segments from retinal degenerate rodents
    Gi Jung An
    Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Curr Eye Res 24:26-32. 2002
    ..To determine whether a severely degenerated retina without photoreceptor outer segments and a non-recordable electroretinogram (ERG) can still show retinal ganglion cell (RGC) responses to retinal light stimulation...
  84. ncbi request reprint A dual band wireless power and data telemetry for retinal prosthesis
    Guoxing Wang
    Dept of Electr Eng, California Univ, Santa Cruz, CA 95064, USA
    Conf Proc IEEE Eng Med Biol Soc 1:4392-5. 2006
    ....
  85. ncbi request reprint In vitro and in vivo evaluation of ultrananocrystalline diamond for coating of implantable retinal microchips
    Xingcheng Xiao
    Materials Science Division, Argonne National Laboratory, Argonne, Illinois 60439, USA
    J Biomed Mater Res B Appl Biomater 77:273-81. 2006
    ..According to all these results, it was concluded that UNCD is a promising candidate for use as the encapsulating coatings for implantable retinal microelectronic devices...
  86. ncbi request reprint Increased spontaneous retinal ganglion cell activity in rd mice after neural retinal transplantation
    Wolfgang Radner
    Wilmer Ophthalmological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 43:3053-8. 2002
    ..To study the functional success of neural retinal transplantation by means of retinal surface ganglion cell recordings...
  87. ncbi request reprint Electrical stimulation in isolated rabbit retina
    Jeng Shyong Shyu
    Wilmer Ophthalmological Institute, Johns Hopkins University, Baltimore, MD 21287, USA
    IEEE Trans Neural Syst Rehabil Eng 14:290-8. 2006
    ..1 ms, but the 0.1-ms pulses used less charge. These experiments provide a number of valuable insights into the relative effects of several stimulation parameters critical to the development of an implanted electronic retinal prosthesis...
  88. ncbi request reprint Comparison of electrical stimulation thresholds in normal and retinal degenerated mouse retina
    Satoshi Suzuki
    Wilmer Ophthalmological Institute, Johns Hopkins University, Baltimore, MD, USA
    Jpn J Ophthalmol 48:345-9. 2004
    ..To compare the threshold for electrically elicited action potentials of retinal ganglion cells in normal mouse retina and photoreceptor degenerated (rd) mouse retina...
  89. ncbi request reprint A transcutaneous data telemetry system tolerant to power telemetry interference
    Mingcui Zhou
    Dept of Electr Eng, California Univ, Santa Cruz, CA 95064, USA
    Conf Proc IEEE Eng Med Biol Soc 1:5884-7. 2006
    ..Using subsampling and novel analog demodulation, the scheme also eliminates the requirement of carrier recovery, thus reducing circuit complexity. The receiver achieves a 1 Mbps data rate and can be upgraded to 2 Mbps...
  90. ncbi request reprint The efficacy of retrobulbar block anesthesia only in pars plana vitrectomy and transconjunctival sutureless vitrectomy
    Taehyung H Lim
    Department of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea
    Ophthalmic Surg Lasers Imaging 39:191-5. 2008
    ..To evaluate the adequacy of retrobulbar block anesthesia only in vitreoretinal surgery...
  91. ncbi request reprint Visual and electrical evoked response recorded from subdural electrodes implanted above the visual cortex in normal dogs under two methods of anesthesia
    E Margalit
    The Wilmer Ophthalmological Institute, The Johns Hopkins University, Baltimore, MD, USA
    J Neurosci Methods 123:129-37. 2003
    ..In summary, subdural electrodes show promising results for recording visual and electrical evoked responses (EERs) and thus for evaluation of the retinal prosthesis...
  92. ncbi request reprint Angiographic characteristics in patients undergoing macular translocation for subfoveal choroidal neovascularization secondary to age-related macular degeneration
    David L Kent
    Vitreoretinal Service, Wilmer Institute, Johns Hopkins University, Baltimore, Maryland, USA
    Retina 23:152-8. 2003
    ..The current study was undertaken to assess any potential effects of the translocation procedure on altering the angiographic characteristics of SFCNV before laser photocoagulation...
  93. ncbi request reprint Facial recognition using simulated prosthetic pixelized vision
    Robert W Thompson
    Lions Vision Research and Rehabilitation Center, Wilmer Ophthalmological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Invest Ophthalmol Vis Sci 44:5035-42. 2003
    ..To evaluate a model of simulated pixelized prosthetic vision using noncontiguous circular phosphenes, to test the effects of phosphene and grid parameters on facial recognition...
  94. ncbi request reprint Past, present, and future of artificial vision
    James D Weiland
    Artif Organs 27:961-2. 2003
  95. ncbi request reprint Effects of intravitreal indocyanine green injection in rabbits
    Mauricio Maia
    Wilmer Ophthalmological Institute, The Johns Hopkins University School of Medicine, 550 North Broadway, Baltimore, MD 21205, USA
    Retina 24:69-79. 2004
    ..To report the clinical, electrophysiologic, and histologic findings of different concentrations of indocyanine green (ICG) injected into the vitreous cavity of rabbit eyes...
  96. ncbi request reprint Effects of indocyanine green injection on the retinal surface and into the subretinal space in rabbits
    Mauricio Maia
    Wilmer Ophthalmological Institute, The Johns Hopkins University School of Medicine, 550 North Broadway, Baltimore, MD 21205, USA
    Retina 24:80-91. 2004
    ..To evaluate the effects of indocyanine green (ICG) injection on the retinal surface and into the subretinal space of rabbit eyes...
  97. ncbi request reprint Retinal pigment epithelial abnormalities after internal limiting membrane peeling guided by indocyanine green staining
    Mauricio Maia
    Wilmer Ophthalmological Institute, The Johns Hopkins University School of Medicine, 550 North Broadway, Baltimore, MD 21205, USA
    Retina 24:157-60. 2004
  98. ncbi request reprint Laser-induced changes in intraretinal oxygen distribution in pigmented rabbits
    Dao Yi Yu
    Centre for Ophthalmology and Visual Science, The University of Western Australia, Nedlands, Perth, Western Australia 6009
    Invest Ophthalmol Vis Sci 46:988-99. 2005
    ....
  99. ncbi request reprint Old idea, new technology
    James D Weiland
    IEEE Eng Med Biol Mag 24:12-3. 2005
  100. ncbi request reprint Paragraph text reading using a pixelized prosthetic vision simulator: parameter dependence and task learning in free-viewing conditions
    Gislin Dagnelie
    Lions Vision Research and Rehabilitation Center, Wilmer Ophthalmological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Invest Ophthalmol Vis Sci 47:1241-50. 2006
    ..To investigate the feasibility of adequate reading by recipients of future prosthetic visual implants through simulation in sighted observers...