Research Topics
Species | S HulleySummaryAffiliation: University of California Country: USA Publications
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Publications
Estrogens should not be initiated for the secondary prevention of coronary artery disease: a debateS Hulley
University of California San Francisco, San Francisco, California 94143, USA
Can J Cardiol 16:10E-12E. 2000..In addition, HRT was associated with a threefold increase in thromboembolic events. Based on the clinical trial evidence, estrogen therapy should not be initiated for the secondary prevention of CAD...- Noncardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II)Stephen Hulley
Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, San Francisco, CA 94143 0560, USA
JAMA 288:58-66. 2002..The Heart and Estrogen/progestin Replacement Study (HERS) was a randomized trial of estrogen plus progestin therapy after menopause... 
Racial differences in incident heart failure among young adultsKirsten Bibbins-Domingo
Department of Medicine and the Division of General Internal Medicine and the UCSF Center for Vulnerable Populations, San Francisco General Hospital, University of California, San Francisco, San Francisco, USA
N Engl J Med 360:1179-90. 2009..The antecedents and epidemiology of heart failure in young adults are poorly understood...- Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research GroupS Hulley
University of California, San Francisco 94143, USA
JAMA 280:605-13. 1998..However, given the favorable pattern of CHD events after several years of therapy, it could be appropriate for women already receiving this treatment to continue... - Nonoptimal lipids commonly present in young adults and coronary calcium later in life: the CARDIA (Coronary Artery Risk Development in Young Adults) studyMark J Pletcher
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107, USA
Ann Intern Med 153:137-46. 2010..Dyslipidemia causes coronary heart disease in middle-aged and elderly adults, but the consequences of lipid exposure during young adulthood are unclear... - Effect of hormone therapy on mortality rates among women with heart failure and coronary artery diseaseKirsten Bibbins-Domingo
Division of General Internal Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA
Am J Cardiol 95:289-91. 2005..Over the 4.1-year follow-up, estrogen plus progestin use had no effect on all-cause mortality (hazard ratio 1.0, 95% confidence interval 0.7 to 1.4, p = 0.8) in women with heart failure and coronary disease... - Alcohol consumption, binge drinking, and early coronary calcification: findings from the Coronary Artery Risk Development in Young Adults (CARDIA) StudyMark J Pletcher
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA
Am J Epidemiol 161:423-33. 2005.... - Sexual functioning after total compared with supracervical hysterectomy: a randomized trialMiriam Kuppermann
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California 94143, USA
Obstet Gynecol 105:1309-18. 2005.... - Postmenopausal hormone therapy: does it cause incontinence?Jody E Steinauer
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
Obstet Gynecol 106:940-5. 2005..To estimate the effect of hormone therapy on risk of stress and urge urinary incontinence... - Cocaine and coronary calcification in young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) StudyMark J Pletcher
Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA
Am Heart J 150:921-6. 2005.... - Phenotypic predictors of response to simvastatin therapy among African-Americans and Caucasians: the Cholesterol and Pharmacogenetics (CAP) StudyJoel A Simon
General Internal Medicine Section, Medical Service, Veterans Affairs Medical Center, San Francisco, California, USA
Am J Cardiol 97:843-50. 2006..The magnitude of the lipid and lipoprotein responses, however, differed among participants according to a number of phenotypic and demographic characteristics... - Incidence and antecedents of nonmedical prescription opioid use in four US communities. The Coronary Artery Risk Development in Young Adults (CARDIA) prospective cohort studyMark J Pletcher
Department of Epidemiology and Biostatistics, University of California, San Francisco, 185 Berry Street, Suite 5700, San Francisco, CA 94107, USA
Drug Alcohol Depend 85:171-6. 2006..Nonmedical use of prescription opioids has emerged as a major public health problem during the last decade, but direct measures of incidence and predisposing factors are lacking... - Common beta-adrenergic receptor polymorphisms are not associated with risk of sudden cardiac death in patients with coronary artery diseaseZian H Tseng
Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco, USA
Heart Rhythm 5:814-21. 2008.... - Prehypertension during young adulthood and coronary calcium later in lifeMark J Pletcher
University of California, San Francisco, San Francisco General Hospital, San Francisco, California, USA
Ann Intern Med 149:91-9. 2008..High blood pressure in middle age is a well-established risk factor for cardiovascular disease, but the consequences of low-level elevations during young adulthood are unknown... - Racial differences in atrial fibrillation prevalence and left atrial sizeGregory M Marcus
Division of Cardiology, University of California, San Francisco, CA, USA
Am J Med 123:375.e1-7. 2010.... - Predictors of heart failure among women with coronary diseaseKirsten Bibbins-Domingo
Division of General Internal Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA 94143 1364, USA
Circulation 110:1424-30. 2004..We determined the risk factors for developing heart failure among postmenopausal women with established coronary disease... - Hysterectomy versus expanded medical treatment for abnormal uterine bleeding: clinical outcomes in the medicine or surgery trialLee A Learman
Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of California, San Francisco, California, USA
Obstet Gynecol 103:824-33. 2004..To compare clinical outcomes after randomization to hysterectomy versus medical treatment in patients with chronic abnormal uterine bleeding refractory to medroxyprogesterone acetate... - Fracture and the risk of coronary events in women with heart diseasePaul D Varosy
Department of Medicine, University of California, San Francisco 94143 0124, USA
Am J Med 115:196-202. 2003..Osteoporosis is associated with aortic calcification and cardiovascular mortality. However, whether skeletal fractures predict the risk of coronary events is unknown... - Effect of hysterectomy vs medical treatment on health-related quality of life and sexual functioning: the medicine or surgery (Ms) randomized trialMiriam Kuppermann
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA 94143 0856, USA
JAMA 291:1447-55. 2004..Although a quarter of US women undergo elective hysterectomy before menopause, controlled trials that evaluate the benefits and harms are lacking... - Relation of ascorbic acid to coronary artery calcium: the Coronary Artery Risk Development in Young Adults StudyJoel A Simon
General Internal Medicine Section 111A1, Medical Service, Veterans Affairs Medical Center and University of California, 4150 Clement Street, San Francisco, CA 94121, USA
Am J Epidemiol 159:581-8. 2004..Low to marginally low plasma ascorbic acid levels were associated with a higher prevalence of coronary artery calcium among men but not among women... - Aircraft cabin air recirculation and symptoms of the common coldJessica Nutik Zitter
Department of Medicine, University of California, San Francisco, Box 0843, San Francisco, CA 94143 0843, USA
JAMA 288:483-6. 2002..Whether air recirculation increases the transmission of infectious disease is unknown; some studies have demonstrated higher rates of the common cold among persons working in buildings that recirculate air... - Lipid changes on hormone therapy and coronary heart disease events in the Heart and Estrogen/progestin Replacement Study (HERS)Michael G Shlipak
General Internal Medicine Section, Veterans Affairs Medical Center, San Francisco, Calif 94121, USA
Am Heart J 146:870-5. 2003..To explore possible mechanisms, we examined the association between lipid changes and CHD outcomes among women assigned to hormone therapy... - A randomized comparison of total or supracervical hysterectomy: surgical complications and clinical outcomesLee A Learman
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California 94110, USA
Obstet Gynecol 102:453-62. 2003..To compare surgical complications and clinical outcomes after total versus supracervical abdominal hysterectomy for control of abnormal uterine bleeding, symptomatic uterine leiomyomata, or both... - Depressive symptoms, unemployment, and loss of income: The CARDIA StudyMary A Whooley
Department of Veterans Affairs Medical Center, 4150 Clement St Mail Stop 111A1, San Francisco, CA 94121
Arch Intern Med 162:2614-20. 2002..Previous studies have suggested an association between depression and low socioeconomic status, but few have empirically examined the effect of depressive symptoms on income and employment over time... - Aspirin use for the primary prevention of coronary heart disease in older adultsNicolas Rodondi
Department of Epidemiology and Biostatistics, University of California, San Francisco, Calif, USA
Am J Med 118:1288. 2005..We determined the prevalence of aspirin use in relation to coronary heart disease risk and changes over time... - Urinary tract infections in postmenopausal women: effect of hormone therapy and risk factorsJ S Brown
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California 94115, USA
Obstet Gynecol 98:1045-52. 2001..To assess the effects of hormone therapy on urinary tract infection frequency and to examine potential risk factors... - Physical and sexual function in women with chronic kidney diseaseManjula Kurella
Department of Medicine, University of California San Francisco, San Francisco, CA 94118-1211, USA
Am J Kidney Dis 43:868-76. 2004..CONCLUSION: CKD is associated with impaired physical function, and a decline in estimated GFR is associated with a decline in physical function... - Positional change in blood pressure and 8-year risk of hypertension: the CARDIA StudyRandal J Thomas
Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
Mayo Clin Proc 78:951-8. 2003..To assess the relationship between positional blood pressure change and 8-year incidence of hypertension in a biracial cohort of young adults... - Objectively measured sleep characteristics among early-middle-aged adults: the CARDIA studyDiane S Lauderdale
Department of Health Studies, University of Chicago, Chicago, IL 60637, USA
Am J Epidemiol 164:5-16. 2006..Income was independently associated with sleep latency and efficiency. Sleep duration and quality, which have consequences for health, are strongly associated with race, sex, and socioeconomic status... - Early adult risk factor levels and subsequent coronary artery calcification: the CARDIA StudyCatherine M Loria
Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 7936, USA
J Am Coll Cardiol 49:2013-20. 2007..We sought to determine whether early adult levels of cardiovascular risk factors predict subsequent coronary artery calcium (CAC) better than concurrent or average 15-year levels and independent of a 15-year change in levels... 
Kidney dysfunction and sudden cardiac death among women with coronary heart diseaseRajat Deo
Division of Cardiology, Johns Hopkins Hospital, Baltimore, MD, USA
Hypertension 51:1578-82. 2008..Advanced kidney dysfunction is an independent predictor of sudden cardiac death among women with coronary heart disease...- C-reactive protein concentration and incident hypertension in young adults: the CARDIA studySusan G Lakoski
Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, NC, USA
Arch Intern Med 166:345-9. 2006..However, it is unknown whether a similar relationship exists in younger individuals... - Medicine or Surgery (Ms): a randomized clinical trial comparing hysterectomy and medical treatment in premenopausal women with abnormal uterine bleedingR Edward Varner
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 619 South 19th Street, NHB 219, Birmingham, AL 35249 7333, USA
Control Clin Trials 25:104-18. 2004..02) and a greater prevalence of incontinence (44% vs. 16%; p=0.046). Although recruitment was difficult, we have completed enrollment in a randomized clinical trial comparing surgical and medical treatments for abnormal uterine bleeding... - Factor V Leiden, hormone replacement therapy, and risk of venous thromboembolic events in women with coronary diseaseDavid M Herrington
Department of Internal Medicine, Sections on Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Arterioscler Thromb Vasc Biol 22:1012-7. 2002..If factor V Leiden genotyping becomes less expensive, it could be cost effective to screen for the presence of the mutation before instituting HRT in women with coronary disease... - The WHI estrogen-alone trial--do things look any better?Stephen B Hulley
JAMA 291:1769-71. 2004 - Causes and demographic, medical, lifestyle and psychosocial predictors of premature mortality: the CARDIA studyCarlos Iribarren
Division of Research, Kaiser Permanente, Oakland, CA, USA
Soc Sci Med 60:471-82. 2005....
Research Grants
- CLINICAL RESEARCH TRAINING PROGRAMStephen Hulley; Fiscal Year: 2004..The combination of the extraordinary resources of UCSF and partner institutions and the expanded curriculum will produce leading scientists for the new era of clinical investigation. ..
- Multidisciplinary Clinical Research Careers Program(RMI)Stephen Hulley; Fiscal Year: 2006....
- Data Coordinating Center for VEST and PREDICTSStephen Hulley; Fiscal Year: 2007....