R L Hull

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Overall sulfation of heparan sulfate from pancreatic islet β-TC3 cells increases maximal fibril formation but does not determine binding to the amyloidogenic peptide islet amyloid polypeptide
    Rebecca L Hull
    Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Biol Chem 287:37154-64. 2012
  2. ncbi Hyaluronan and hyaluronan binding proteins are normal components of mouse pancreatic islets and are differentially expressed by islet endocrine cell types
    Rebecca L Hull
    Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA
    J Histochem Cytochem 60:749-60. 2012
  3. ncbi Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress
    R L Hull
    Division of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System 151, Seattle, WA 98108, USA
    Diabetologia 52:1102-11. 2009
  4. ncbi Inhibition of glycosaminoglycan synthesis and protein glycosylation with WAS-406 and azaserine result in reduced islet amyloid formation in vitro
    Rebecca L Hull
    Division of Metabolism, Endocrinology, and Nutrition, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    Am J Physiol Cell Physiol 293:C1586-93. 2007
  5. ncbi Long-term treatment with rosiglitazone and metformin reduces the extent of, but does not prevent, islet amyloid deposition in mice expressing the gene for human islet amyloid polypeptide
    Rebecca L Hull
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System 151, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetes 54:2235-44. 2005
  6. ncbi Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: evidence for specificity of impaired beta cell adaptation
    R L Hull
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System 151, University of Washington, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetologia 48:1350-8. 2005
  7. ncbi Genetic background determines the extent of islet amyloid formation in human islet amyloid polypeptide transgenic mice
    Rebecca L Hull
    Division of Metabolism, Endocrinology, and Nutrition, Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, WA 98108, USA
    Am J Physiol Endocrinol Metab 289:E703-9. 2005
  8. ncbi Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid
    Rebecca L Hull
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle 98108, USA
    Diabetes 52:372-9. 2003
  9. ncbi Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets
    J Udayasankar
    VA Puget Sound Health Care System 151, Seattle, WA 98108, USA
    Diabetologia 52:145-53. 2009
  10. ncbi cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets
    S L Subramanian
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, 1660 South Columbian Way, Seattle, WA 98108, USA
    Diabetologia 55:166-74. 2012

Research Grants

  1. Role of perlecan in islet amyloid formation
    REBECCA HULL MEICHLE; Fiscal Year: 2007
  2. Islet Endothelial Dysfunction in Diabetes
    REBECCA LUCY HULL MEICHLE; Fiscal Year: 2010

Detail Information

Publications19

  1. ncbi Overall sulfation of heparan sulfate from pancreatic islet β-TC3 cells increases maximal fibril formation but does not determine binding to the amyloidogenic peptide islet amyloid polypeptide
    Rebecca L Hull
    Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Biol Chem 287:37154-64. 2012
    ..This information will be important in determining approaches to reduce HS-IAPP interactions and ultimately prevent islet amyloid formation and its toxic effects in type 2 diabetes...
  2. ncbi Hyaluronan and hyaluronan binding proteins are normal components of mouse pancreatic islets and are differentially expressed by islet endocrine cell types
    Rebecca L Hull
    Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA
    J Histochem Cytochem 60:749-60. 2012
    ..Thus, dysfunction of either α or β cells likely alters islet ECM composition and could thereby further disrupt islet function...
  3. ncbi Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress
    R L Hull
    Division of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System 151, Seattle, WA 98108, USA
    Diabetologia 52:1102-11. 2009
    ..However, in human type 2 diabetes, levels of human IAPP are equivalent or decreased relative to matched controls. Thus, we sought to investigate whether ER stress is induced during amyloidogenesis at physiological levels of human IAPP...
  4. ncbi Inhibition of glycosaminoglycan synthesis and protein glycosylation with WAS-406 and azaserine result in reduced islet amyloid formation in vitro
    Rebecca L Hull
    Division of Metabolism, Endocrinology, and Nutrition, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    Am J Physiol Cell Physiol 293:C1586-93. 2007
    ....
  5. ncbi Long-term treatment with rosiglitazone and metformin reduces the extent of, but does not prevent, islet amyloid deposition in mice expressing the gene for human islet amyloid polypeptide
    Rebecca L Hull
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System 151, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetes 54:2235-44. 2005
    ....
  6. ncbi Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: evidence for specificity of impaired beta cell adaptation
    R L Hull
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System 151, University of Washington, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetologia 48:1350-8. 2005
    ..We therefore sought to determine whether the impaired beta cell adaptation is due to inadequate expansion of the beta cell population or to a lack of an adaptive increase in insulin release...
  7. ncbi Genetic background determines the extent of islet amyloid formation in human islet amyloid polypeptide transgenic mice
    Rebecca L Hull
    Division of Metabolism, Endocrinology, and Nutrition, Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, WA 98108, USA
    Am J Physiol Endocrinol Metab 289:E703-9. 2005
    ..These findings underscore the importance of genetic and environmental factors in studying metabolic disease...
  8. ncbi Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid
    Rebecca L Hull
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle 98108, USA
    Diabetes 52:372-9. 2003
    ....
  9. ncbi Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets
    J Udayasankar
    VA Puget Sound Health Care System 151, Seattle, WA 98108, USA
    Diabetologia 52:145-53. 2009
    ..The aim of the present study was to determine whether amyloid deposition is associated with reduced beta cell volume in islet grafts and the recurrence of hyperglycaemia following islet transplantation...
  10. ncbi cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets
    S L Subramanian
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, 1660 South Columbian Way, Seattle, WA 98108, USA
    Diabetologia 55:166-74. 2012
    ..We determined whether amyloid formation by endogenous hIAPP mediates beta cell apoptosis through JNK activation and downstream signalling pathways...
  11. ncbi Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis
    S Zraika
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington and VA Puget Sound Health Care System, 1660 South Columbian Way 151, Seattle, WA 98108, USA
    Diabetologia 52:626-35. 2009
    ..Since islets are susceptible to oxidative stress-induced toxicity, we sought to determine whether islet amyloid formation is associated with induction of oxidative stress...
  12. ncbi The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice
    J Vidal
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetologia 46:71-9. 2003
    ..As apolipoprotein E (apoE), another component of islet amyloid deposits, plays a critical role in amyloid formation in Alzheimer's disease, we hypothesised that apoE could play an important role in islet amyloid formation...
  13. ncbi Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets
    K Aston-Mourney
    Division of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System 151, 1660 South Columbian Way, Seattle, WA 98108, USA
    Diabetologia 54:1756-65. 2011
    ..We also hypothesised that the unique properties of the glucagon-like peptide-1 (GLP-1) receptor agonist exendin-4 to maintain or increase beta cell mass would offset the amyloid-induced toxicity...
  14. ncbi The constitutive secretory pathway is a major route for islet amyloid polypeptide secretion in neonatal but not adult rat islet cells
    C B Verchere
    Department of Medicine, Veterans Affairs Medical Center, University of Washington, Seattle, USA
    Diabetes 49:1477-84. 2000
    ..Collectively, these data suggest that a significant proportion of glucose-stimulated IAPP secretion from neonatal, but not adult, rat islet cells occurs via a constitutive secretory pathway...
  15. ncbi Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells
    F Wang
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    Diabetes 50:2514-20. 2001
    ..A reduction in islet endocrine mass starts at this early stage of islet amyloid development and progresses as amyloid mass increases...
  16. ncbi The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality
    S E Kahn
    Department of Medicine, Division of Metabolism, VA Puget Sound Health Care System 151, Seattle, WA 98108, USA
    Diabetologia 52:1003-12. 2009
    ..Based on human and animal studies, it appears that neither alone is sufficient. Rather, for glucose to rise to the level at which diabetes would be diagnosed, defects in beta cell mass and in beta cell function are required...
  17. ncbi Rosiglitazone treatment does not decrease amyloid deposition in transplanted islets from transgenic mice expressing human islet amyloid polypeptide
    J Udayasankar
    Division of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    Transplant Proc 45:574-9. 2013
    ..Rosiglitazone did not decrease amyloid deposition in hIAPP transgenic islet grafts. Therefore, rosiglitazone treatment of recipients of amyloid forming islets may not improve transplantation outcomes...
  18. ncbi Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?
    S Zraika
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, 1660 South Columbian Way 151, Seattle, WA 98108, USA
    Diabetologia 53:1046-56. 2010
    ..Keeping an open mind on the nature of the cytotoxic insult has implications for therapeutic developments and clinical care in type 2 diabetes...
  19. ncbi Resistin is not associated with insulin sensitivity or the metabolic syndrome in humans
    K M Utzschneider
    Division of Metabolism, Endocrinology and Nutrition, Veterans Affairs Puget Sound Health Care System, Harborview Medical Center, University of Washington, Seattle, WA, USA
    Diabetologia 48:2330-3. 2005
    ..The aim of this study was to further elucidate the relationship between resistin and insulin sensitivity, body fat distribution and the metabolic syndrome in humans...

Research Grants3

  1. Role of perlecan in islet amyloid formation
    REBECCA HULL MEICHLE; Fiscal Year: 2007
    ..Successful funding of this application will provide me with salary and protected research time in order to achieve my career goal of becoming an independent investigator in the field of type 2 diabetes. ..
  2. Islet Endothelial Dysfunction in Diabetes
    REBECCA LUCY HULL MEICHLE; Fiscal Year: 2010
    ..The focus of this proposal is the novel hypothesis that endothelial dysfunction occurs in the pancreatic islet in diabetes and contributes to decreased insulin release. ..