Jan Huisken

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Selective plane illumination microscopy techniques in developmental biology
    Jan Huisken
    Department of Biochemistry and Biophysics, and Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA
    Development 136:1963-75. 2009
  2. ncbi request reprint Even fluorescence excitation by multidirectional selective plane illumination microscopy (mSPIM)
    Jan Huisken
    Department of Biochemistry and Biophysics, University of California San Francisco, 1550 Fourth Street, San Francisco, California 94158 2324, USA
    Opt Lett 32:2608-10. 2007
  3. doi request reprint Optogenetic control of cardiac function
    Aristides B Arrenberg
    Department of Physiology, University of California, San Francisco, CA 94158, USA
    Science 330:971-4. 2010
  4. pmc Genetic and physiologic dissection of the vertebrate cardiac conduction system
    Neil C Chi
    Department of Biochemistry and Biophysics and Programs in Developmental Biology, Genetics, and Human Genetics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Biol 6:e109. 2008
  5. pmc Regulation of neurocoel morphogenesis by Pard6 gamma b
    Chantilly Munson
    Department of Biochemistry and Biophysics, Genetics and Human Genetics, University of California, San Francisco, CA 94158, USA
    Dev Biol 324:41-54. 2008
  6. pmc A dual role for ErbB2 signaling in cardiac trabeculation
    Jiandong Liu
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA
    Development 137:3867-75. 2010
  7. pmc Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation
    Shane P Herbert
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA
    Science 326:294-8. 2009
  8. pmc The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling
    Pia Aanstad
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, Cardiovascular Research Institute, Diabetes Center, University of California, San Francisco, CA 94158, USA
    Curr Biol 19:1034-9. 2009
  9. pmc Multiple roles for Med12 in vertebrate endoderm development
    Chong Hyun Shin
    Department of Biochemistry and Biophysics, Liver Center, University of California, San Francisco, CA 94158, USA
    Dev Biol 317:467-79. 2008
  10. pmc Genetic evidence for a noncanonical function of seryl-tRNA synthetase in vascular development
    Wiebke Herzog
    Department of Biochemistry and Biophysics and The Cardiovascular Research Institute, Programs in Developmental Biology, Genetics, and Human Genetics, University of California, San Francisco, San Francisco, CA 94158, USA
    Circ Res 104:1260-6. 2009

Collaborators

Detail Information

Publications16

  1. pmc Selective plane illumination microscopy techniques in developmental biology
    Jan Huisken
    Department of Biochemistry and Biophysics, and Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA
    Development 136:1963-75. 2009
    ....
  2. ncbi request reprint Even fluorescence excitation by multidirectional selective plane illumination microscopy (mSPIM)
    Jan Huisken
    Department of Biochemistry and Biophysics, University of California San Francisco, 1550 Fourth Street, San Francisco, California 94158 2324, USA
    Opt Lett 32:2608-10. 2007
    ..The multidirectional illumination proves essential in biological specimens such as millimeter-sized embryos. The performance of mSPIM is demonstrated by the imaging of live zebrafish embryos...
  3. doi request reprint Optogenetic control of cardiac function
    Aristides B Arrenberg
    Department of Physiology, University of California, San Francisco, CA 94158, USA
    Science 330:971-4. 2010
    ..Our studies combine optogenetics and light-sheet microscopy to reveal the emergence of organ function during development...
  4. pmc Genetic and physiologic dissection of the vertebrate cardiac conduction system
    Neil C Chi
    Department of Biochemistry and Biophysics and Programs in Developmental Biology, Genetics, and Human Genetics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Biol 6:e109. 2008
    ....
  5. pmc Regulation of neurocoel morphogenesis by Pard6 gamma b
    Chantilly Munson
    Department of Biochemistry and Biophysics, Genetics and Human Genetics, University of California, San Francisco, CA 94158, USA
    Dev Biol 324:41-54. 2008
    ..Altogether, these data indicate a previously unappreciated functional diversity and complexity within the vertebrate pard6 gene family...
  6. pmc A dual role for ErbB2 signaling in cardiac trabeculation
    Jiandong Liu
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA
    Development 137:3867-75. 2010
    ....
  7. pmc Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation
    Shane P Herbert
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA
    Science 326:294-8. 2009
    ..Thus, directional control of progenitor migration drives arterial-venous segregation and generation of separate parallel vessels from a single precursor vessel, a process essential for vascular development...
  8. pmc The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling
    Pia Aanstad
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, Cardiovascular Research Institute, Diabetes Center, University of California, San Francisco, CA 94158, USA
    Curr Biol 19:1034-9. 2009
    ..These data indicate that the ECD, previously thought to be dispensable for vertebrate Smo function, both regulates Smo ciliary localization and is essential for high-level Hh signaling...
  9. pmc Multiple roles for Med12 in vertebrate endoderm development
    Chong Hyun Shin
    Department of Biochemistry and Biophysics, Liver Center, University of California, San Francisco, CA 94158, USA
    Dev Biol 317:467-79. 2008
    ....
  10. pmc Genetic evidence for a noncanonical function of seryl-tRNA synthetase in vascular development
    Wiebke Herzog
    Department of Biochemistry and Biophysics and The Cardiovascular Research Institute, Programs in Developmental Biology, Genetics, and Human Genetics, University of California, San Francisco, San Francisco, CA 94158, USA
    Circ Res 104:1260-6. 2009
    ..These analyses of zebrafish and human endothelial cells reveal a new noncanonical function of Sars in endothelial development...
  11. doi request reprint Fibrillin-2b regulates endocardial morphogenesis in zebrafish
    Katharine Mellman
    Department of Biochemistry and Biophysics, Programs in Developmental and Stem Cell Biology, Genetics and Human Genetics, Cardiovascular Research Institute, University of California, San Francisco, 1550 4th St, Room 384, San Francisco, CA 94158, USA
    Dev Biol 372:111-9. 2012
    ..Integrating data obtained from microscopy and molecular biology, we posit that this mutation impacts the rigidity of Fbn2b, imparting a structural defect that weakens endocardial adhesion thereby resulting in perforated endocardium...
  12. doi request reprint High-speed imaging of developing heart valves reveals interplay of morphogenesis and function
    Paul J Scherz
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA
    Development 135:1179-87. 2008
    ..Thus, different signaling pathways regulate distinct aspects of the behavior of individual cells during valve morphogenesis, thereby influencing specific facets of valve function...
  13. pmc Zebrafish model for human long QT syndrome
    Rima Arnaout
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, Cardiovascular Research Institute, University of California, 1550 Fourth Street, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 104:11316-21. 2007
    ..Our findings provide insight into the pathogenesis of homozygous kcnh2 mutations and expand the use of zebrafish mutants as a model system to study human arrhythmias...
  14. ncbi request reprint Optical sectioning deep inside live embryos by selective plane illumination microscopy
    Jan Huisken
    European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Science 305:1007-9. 2004
    ..We also demonstrate that SPIM can be applied to visualize the embryogenesis of the relatively opaque Drosophila melanogaster in vivo...
  15. ncbi request reprint Optical scanning holography as a technique for high-resolution three-dimensional biological microscopy
    Jim Swoger
    Light Microscopy Group, European Molecular Biology Laboratory, Heidelberg, Germany
    J Opt Soc Am A Opt Image Sci Vis 19:1910-8. 2002
    ..It is also shown that, although in general OSH is restricted to thin samples, this condition can be relaxed in nonrefracting fluorescence samples, which are of importance in biological microscopy...
  16. ncbi request reprint Multiple imaging axis microscopy improves resolution for thick-sample applications
    Jim Swoger
    Cell Biology and Biophysics Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Opt Lett 28:1654-6. 2003
    ..Compared with a single-axis system, the MIAM can achieve a reduction of the axial point-spread function elongation by a factor of 5.8 and a 3.5-fold improvement in volume resolution by simple linear image combination techniques...