GEORGE S HUI

Summary

Affiliation: University of Hawaii
Country: USA

Publications

  1. ncbi Pathways for potentiation of immunogenicity during adjuvant-assisted immunizations with Plasmodium falciparum major merozoite surface protein 1
    G S Hui
    Department of Tropical Medicine, University of Hawaii, Honolulu, Hawaii 96816, USA
    Infect Immun 66:5329-36. 1998
  2. ncbi Biological activities of anti-merozoite surface protein-1 antibodies induced by adjuvant-assisted immunizations in mice with different immune gene knockouts
    George Hui
    Department of Tropical Medicine and Pharmacology, John A Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo Street, Honolulu, HI 96813, USA
    Clin Vaccine Immunol 15:1145-50. 2008
  3. ncbi Dominance of conserved B-cell epitopes of the Plasmodium falciparum merozoite surface protein, MSP1, in blood-stage infections of naive Aotus monkeys
    G S Hui
    Department of Tropical Medicine, University of Hawaii, Honolulu, Hawaii 96816, USA
    Infect Immun 64:1502-9. 1996
  4. ncbi Plasmodium falciparum anti-MSP1-19 antibodies induced by MSP1-42 and MSP1-19 based vaccines differed in specificity and parasite growth inhibition in terms of recognition of conserved versus variant epitopes
    George Hui
    Department of Tropical Medicine and Pharmacology, John A Burns School of Medicine, University of Hawaii at Manoa, United States
    Vaccine 25:948-56. 2007
  5. ncbi Interleukin-6 has differential influence on the ability of adjuvant formulations to potentiate antibody responses to a Plasmodium falciparum blood-stage vaccine
    George Hui
    Department of Tropical Medicine and Pharmacology, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, United States
    Vaccine 25:6598-603. 2007
  6. ncbi The requirement of CD80, CD86, and ICAM-1 on the ability of adjuvant formulations to potentiate antibody responses to a Plasmodium falciparum blood-stage vaccine
    George Hui
    Department of Tropical Medicine and Pharmacology, John A Burns School of Medicine, University of Hawaii at Manoa, HI 96813, United States
    Vaccine 25:8549-56. 2007
  7. ncbi Adjuvant formulations possess differing efficacy in the potentiation of antibody and cell mediated responses to a human malaria vaccine under selective immune genes knockout environment
    GEORGE S HUI
    Department of Tropical Medicine and Pharmacology, John A Burns School of Medicine, University of Hawaii at Manoa, HI 96813, USA
    Int Immunopharmacol 8:1012-22. 2008
  8. ncbi T cell epitope regions of the P. falciparum MSP1-33 critically influence immune responses and in vitro efficacy of MSP1-42 vaccines
    Kae M Pusic
    Department of Tropical Medicine, Medical Microbiology, and Pharmacology, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America
    PLoS ONE 6:e24782. 2011

Research Grants

  1. Immune Pathways as Prerequisites for Adjuvants' Efficacy
    George Hui; Fiscal Year: 2004
  2. High School Students STEP-UP To Biomedical Research
    George Hui; Fiscal Year: 2007

Collaborators

  • D C Kaslow
  • Kae M Pusic
  • AXEL LEHRER
  • Caryn N Hashimoto
  • Charmaine Aniya
  • David E Clements

Detail Information

Publications8

  1. ncbi Pathways for potentiation of immunogenicity during adjuvant-assisted immunizations with Plasmodium falciparum major merozoite surface protein 1
    G S Hui
    Department of Tropical Medicine, University of Hawaii, Honolulu, Hawaii 96816, USA
    Infect Immun 66:5329-36. 1998
    ....
  2. ncbi Biological activities of anti-merozoite surface protein-1 antibodies induced by adjuvant-assisted immunizations in mice with different immune gene knockouts
    George Hui
    Department of Tropical Medicine and Pharmacology, John A Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo Street, Honolulu, HI 96813, USA
    Clin Vaccine Immunol 15:1145-50. 2008
    ....
  3. ncbi Dominance of conserved B-cell epitopes of the Plasmodium falciparum merozoite surface protein, MSP1, in blood-stage infections of naive Aotus monkeys
    G S Hui
    Department of Tropical Medicine, University of Hawaii, Honolulu, Hawaii 96816, USA
    Infect Immun 64:1502-9. 1996
    ....
  4. ncbi Plasmodium falciparum anti-MSP1-19 antibodies induced by MSP1-42 and MSP1-19 based vaccines differed in specificity and parasite growth inhibition in terms of recognition of conserved versus variant epitopes
    George Hui
    Department of Tropical Medicine and Pharmacology, John A Burns School of Medicine, University of Hawaii at Manoa, United States
    Vaccine 25:948-56. 2007
    ..These data suggest an advantage of using MSP1-42 over MSP1-19 based vaccines...
  5. ncbi Interleukin-6 has differential influence on the ability of adjuvant formulations to potentiate antibody responses to a Plasmodium falciparum blood-stage vaccine
    George Hui
    Department of Tropical Medicine and Pharmacology, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, United States
    Vaccine 25:6598-603. 2007
    ..The results further suggest that two adjuvants utilized dissimilar pathways to potentiate the same type of immune response...
  6. ncbi The requirement of CD80, CD86, and ICAM-1 on the ability of adjuvant formulations to potentiate antibody responses to a Plasmodium falciparum blood-stage vaccine
    George Hui
    Department of Tropical Medicine and Pharmacology, John A Burns School of Medicine, University of Hawaii at Manoa, HI 96813, United States
    Vaccine 25:8549-56. 2007
    ..These studies may help to guide the formulation of vaccine adjuvants to maintain effectiveness in hosts with altered immunological environment that often result from infections...
  7. ncbi Adjuvant formulations possess differing efficacy in the potentiation of antibody and cell mediated responses to a human malaria vaccine under selective immune genes knockout environment
    GEORGE S HUI
    Department of Tropical Medicine and Pharmacology, John A Burns School of Medicine, University of Hawaii at Manoa, HI 96813, USA
    Int Immunopharmacol 8:1012-22. 2008
    ..Evaluation of adjuvants in immune knockout models may be a supplementary approach to measure and compare adjuvants' efficacy, and to further unveil their distinct biological activities...
  8. ncbi T cell epitope regions of the P. falciparum MSP1-33 critically influence immune responses and in vitro efficacy of MSP1-42 vaccines
    Kae M Pusic
    Department of Tropical Medicine, Medical Microbiology, and Pharmacology, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America
    PLoS ONE 6:e24782. 2011
    ..This study provides the rational basis to re-engineer more efficacious MSP1-42 vaccines by selective inclusion and exclusion of MSP1-33 specific T cell epitopes...

Research Grants7

  1. Immune Pathways as Prerequisites for Adjuvants' Efficacy
    George Hui; Fiscal Year: 2004
    ....
  2. High School Students STEP-UP To Biomedical Research
    George Hui; Fiscal Year: 2007
    ..To evaluate the proposed STEP-UP program in terms of process and outcome measures in order to determine its effectiveness at providing a steady pipeline of students that will pursue a career in research related to NIDDK's mission. ..