Research Topics
| WARNER KING HUHSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
Research Grants
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Detail Information
Publications
Consistency of in vitro chemoresponse assay results and population clinical response rates among women with endometrial carcinomaWarner K Huh
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL, USA
Int J Gynecol Cancer 21:494-9. 2011..The purpose of this investigation was to determine whether the patterns of in vitro tumor response rates as determined by ChemoFx are consistent with expected population response rates...
Bax-induced apoptosis as a novel gene therapy approach for carcinoma of the cervixW K Huh
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 35249, USA
Gynecol Oncol 83:370-7. 2001..In this regard, bax is a pro-apoptotic molecule that also functions as a tumor suppressor. The purpose of this study was to evaluate bax as a gene therapeutic in the context of cervical cancer...- Uterine papillary serous carcinoma: comparisons of outcomes in surgical Stage I patients with and without adjuvant therapyWarner K Huh
University of Alabama at Birmingham, Birmingham, AL 35249, USA
Gynecol Oncol 91:470-5. 2003..Our aim was to determine the outcomes of Stage I uterine papillary serous carcinoma (UPSC) patients with and without adjuvant therapy after comprehensive surgical staging... - Salvage of isolated vaginal recurrences in women with surgical stage I endometrial cancer: a multiinstitutional experienceW K Huh
Division of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
Int J Gynecol Cancer 17:886-9. 2007.... - The future of vaccines for cervical cancerWarner K Huh
Division of Gynecologic Oncology, University of Alabama at Birmingham, 618 20th Street South, OHB Room 538, Birmingham, AL 35233, USA
Gynecol Oncol 109:S48-56. 2008..Future applications of existing virus-like particle-based vaccines are also discussed... - Cost-effectiveness analysis of strategies for the surgical management of grade 1 endometrial adenocarcinomaDavid E Cohn
Division of Gynecologic Oncology, Ohio State University College of Medicine, Columbus, Ohio, USA
Obstet Gynecol 109:1388-95. 2007..To estimate the costs and outcomes of various strategies used for the management of grade 1 endometrial cancer... - Platinum/taxane-based chemotherapy with or without radiation therapy favorably impacts survival outcomes in stage I uterine papillary serous carcinomaAmanda Nickles Fader
Department of Obstetrics and Gynecology, Cleveland Clinic, Cleveland, Ohio, USA
Cancer 115:2119-27. 2009..A study was undertaken to determine recurrence patterns and survival outcomes of stage I uterine papillary serous carcinoma (UPSC) patients... - An updated clinicopathologic study of early-stage uterine papillary serous carcinoma (UPSC)Amanda Nickles Fader
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Cleveland Clinic, Cleveland, OH, USA
Gynecol Oncol 115:244-8. 2009..However, clinicopathologic risk factors for recurrence are not well understood. This study was undertaken to define the prognostic factors for recurrence and survival in patients with early-stage UPSC... - Novel methods to treat and prevent human papillomavirus infectionJames E Kendrick
University of Alabama at Birmingham, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, 619 19th Street South, OHB 538 Birmingham, AL 35249 7333, USA
Expert Rev Anti Infect Ther 4:593-600. 2006..A host of various vaccine techniques are currently being developed and tested and, if effective, will have a significant impact on the incidence of cervical dysplasia and carcinoma... - Therapeutic role of lymph node resection in endometrioid corpus cancer: a study of 12,333 patientsJohn K Chan
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford Cancer Center, Stanford, California 94305, USA
Cancer 107:1823-30. 2006..The purpose of the current study was to determine the potential therapeutic role of lymphadenectomy in women with endometrioid corpus cancer... - The timing of normalization of CA-125 levels during primary chemotherapy is predictive of survival in patients with epithelial ovarian cancerRodney P Rocconi
Division of Gynecologic Oncology, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA
Gynecol Oncol 114:242-5. 2009..To determine if the timing of normalization of CA-125 levels during primary chemotherapy for epithelial ovarian cancer (EOC) could predict survival... - LUMA cervical imaging systemJames E Kendrick
University of Alabama at Birmingham, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Birmingham, AL 35249 7333, USA
Expert Rev Med Devices 4:121-9. 2007..The US FDA approved this device in March 2006 to be used to enhance the sensitivity of colposcopic examinations of women with abnormal cervical cytology, in an effort to further reduce the incidence of cervical cancer... - New advances in vaccine technology and improved cervical cancer preventionWarner K Huh
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
Obstet Gynecol 109:1187-92. 2007.... - Lynch syndrome in women less than 50 years of age with endometrial cancerKellie S Matthews
Division of Gynecologic Oncology and the Division of Anatomic Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
Obstet Gynecol 111:1161-6. 2008..To estimate the frequency of mismatch repair deficiencies associated with hereditary nonpolyposis colorectal cancer, or Lynch syndrome, in women less than age 50 with endometrial cancer... - Evaluation of the interim analysis from the PATRICIA study group: efficacy of a vaccine against HPV 16 and 18Peter J Frederick
University of Alabama at Birmingham, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, 619 19th Street South, OHB 538, Birmingham, AL 35249 7333, USA
Expert Rev Anticancer Ther 8:701-5. 2008..The purpose of this review is to summarize PATRICIA, with a specific focus on the results of the interim analysis, and discuss the impact and implications of the findings... - Stage II uterine papillary serous carcinoma: Carboplatin/paclitaxel chemotherapy improves recurrence and survival outcomesAmanda Nickles Fader
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk A 81, Cleveland, Ohio 44195, USA
Gynecol Oncol 112:558-62. 2009..To determine recurrence patterns and survival outcomes of stage II uterine papillary serous carcinoma (UPSC) patients treated by various modalities with an emphasis on carboplatin/paclitaxel-based chemotherapy (CT)+/-radiotherapy (RT)... - Human papillomavirus infection: a concise review of natural historyWarner K Huh
Department of Obstetrics and Gynecology, University of Alabama Birmingham, Birmingham, Alabama, USA
Obstet Gynecol 114:139-43. 2009..This article highlights the natural history of oncogenic HPV infection of the cervix and the limitations that currently exist on the literature... - The management of cervical intraepithelial neoplasia during pregnancy: is colposcopy necessary?Luisa A Wetta
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
J Low Genit Tract Dis 13:182-5. 2009..Therefore, we sought to determine the incidence of cervical intraepithelial neoplasia (CIN) 2,3 in pregnant patients referred to a university colposcopy clinic... - Pegylated liposomal doxorubicin consolidation therapy after platinum/paclitaxel-based chemotherapy for suboptimally debulked, advanced-stage epithelial ovarian cancer patientsRodney P Rocconi
University of Alabama at Birmingham, 35233, USA
Oncologist 11:336-41. 2006.... - Conservative management of stage I endometrial carcinoma after surgical stagingJ Michael Straughn
Division of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
Gynecol Oncol 84:194-200. 2002..The aim of this study was to determine the outcomes of Stage I endometrial carcinoma patients who are managed without adjuvant radiation after comprehensive surgical staging... - Optical detection of high-grade cervical intraepithelial neoplasia in vivo: results of a 604-patient studyWarner K Huh
University of Alabama at Birmingham, Birmingham, Alabama 35233 7333, USA
Am J Obstet Gynecol 190:1249-57. 2004..The purpose of this study was to assess the in vivo optical detection of high-grade cervical intraepithelial neoplasia (2/3+) on the whole cervix with a noncontact, spectroscopic device... - Stage IC adenocarcinoma of the endometrium: survival comparisons of surgically staged patients with and without adjuvant radiation therapyJ Michael Straughn
University of Alabama at Birmingham, 35249, USA
Gynecol Oncol 89:295-300. 2003..The goal of this study was to determine the outcomes of stage IC endometrial carcinoma patients who are managed with and without adjuvant radiation therapy after comprehensive surgical staging... - A case report of rhabdomyosarcoma of the uterus associated with uterine inversionAshley S Case
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 618 South 19th Street, Old Hillman Building, Room 340, Birmingham, AL 35233, USA
Gynecol Oncol 96:850-3. 2005..This tumor is associated with a poor prognosis, especially in the adult population. Equally as rare are non-puerperal uterine inversions secondary to sarcomas... - Management strategies for stage IB2 cervical cancer: a cost-effectiveness analysisRodney P Rocconi
University of Alabama at Birmingham, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, 618 South 19th Street, Old Hillman Building Room 538, Birmingham, AL 35233, USA
Gynecol Oncol 97:387-94. 2005..To assess the potential effectiveness and medical costs of three common strategies to manage Stage IB2 squamous cell carcinoma of the cervix (CXCA)... - Outcomes of Stage I/II vulvar cancer patients after negative superficial inguinal lymphadenectomyTyler O Kirby
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, OHB 538, 619 19th Street South, Birmingham, AL 35249 7333, USA
Gynecol Oncol 98:309-12. 2005..To investigate the patterns of recurrence associated with superficial inguinal lymphadenectomy (SupIL) and vulvectomy for patients with Stage I/II vulvar cancer... - Lipoxygenase pathway receptor expression in ovarian cancerRodney P Rocconi
Department of Obstetrics and Gynecology, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36607, USA
Reprod Sci 15:321-6. 2008..To determine the expression of lipoxygenase (LOX) pathway receptors in ovarian cancer as a potential target for anti-LOX-based therapy... - Primary extrarenal rhabdoid tumor of the ovary. A case reportCharles A Leath
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 340 Old Hillman Building, 619 19th Street South, Birmingham, AL 35249 7333, USA
J Reprod Med 48:283-6. 2003..Although extrarenal rhabdoid tumors have been documented at multiple extrarenal sites, to our knowledge no primary ovarian cases have been reported... - Bowel resection at the time of primary debulking for epithelial ovarian carcinoma: outcomes in patients treated with platinum and taxane-based chemotherapyJacob M Estes
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama-Birmingham, 619 19th Street South, Birmingham, AL 35249-7333, USA
J Am Coll Surg 203:527-32. 2006..Bowel resection at the time of primary cytoreductive surgery is associated with acceptable perioperative morbidity... - Gamma mode of infiltration associated with poor prognosis in malignant teratoma of the ovary: A case reportWhitney A Spannuth
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 619 19th Street South, Old Hillman Building Room 538, Birmingham, AL 35294-7333, USA
Gynecol Oncol 98:155-7. 2005..Studies have shown stage, grade, and mode of infiltration to be predictors of recurrence and prognosis. This case supports the growing evidence linking the mode of tumor infiltration with overall prognosis of survival... - Clinical and pathologic correlates in surgical stage II endometrial carcinomaDavid E Cohn
Division of Gynecologic Oncology, Ohio State University College of Medicine, Columbus, Ohio, USA
Obstet Gynecol 109:1062-7. 2007..To identify the surgical, pathologic, and therapeutic factors that influence outcome in patients with surgical stage II endometrial adenocarcinoma... - Efficacy and safety of imatinib mesylate (Gleevec) and immunohistochemical expression of c-Kit and PDGFR-beta in a Gynecologic Oncology Group Phase Il Trial in women with recurrent or persistent carcinosarcomas of the uterusWarner K Huh
Division of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, AL, USA
Gynecol Oncol 117:248-54. 2010..This multi-institutional phase II trial assessed the activity and toxicity of imatinib mesylate and explored c-Kit and platelet-derived growth factor receptor (PDGFR)-beta in recurrent or persistent uterine carcinosarcoma... - Hormonal contraception and false-positive cervical cytology: is there an association?Anna V Hoekstra
Department of Obstetrics and Gynecology, Illinois Masonic Medical Center, Chicago, USA
J Low Genit Tract Dis 10:102-6. 2006..The aim of the study was to determine if use of hormonal contraception influences the false-positive rate of cervical cytology when compared with loop electrosurgical excision procedure or cervical biopsy specimens... - A Phase I study of combined modality (90)Yttrium-CC49 intraperitoneal radioimmunotherapy for ovarian cancerRonald D Alvarez
Department of Obstetrics, University of Alabama at Birmingham Cancer Center, Birmingham, Alabama 35233, USA
Clin Cancer Res 8:2806-11. 2002..The purpose of this study was to determine the feasibility and maximum tolerated dose of (90)Yttrium-CC49 ((90)Y-CC49) as the radioimmunotherapy (RIT) component of an i.p. combined modality treatment for recurrent ovarian cancer... - Diagnostic loop electrosurgical excisional procedure for discrepancy: do preoperative factors predict presence of significant cervical intraepithelial neoplasia?Kellie S Matthews
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35249 7333, USA
J Low Genit Tract Dis 11:69-72. 2007..Our objective was to determine the incidence of cervical intraepithelial neoplasia (CIN) 2,3 and patient factors that increase the likelihood of detecting CIN 2,3... - A prospective evaluation of "see and treat" in women with HSIL Pap smear results: is this an appropriate strategy?T Michael Numnum
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35294 7333, USA
J Low Genit Tract Dis 9:2-6. 2005..The objective of this study was to determine the incidence of CIN 2 and CIN 3 in patients with an HSIL (CIN 2) Pap smear using a see-and-treat protocol... - Comprehensive surgical staging for endometrial cancer in obese patients: comparing robotics and laparotomyLeigh G Seamon
Divisions of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio, USA
Obstet Gynecol 114:16-21. 2009..To compare adequacy and outcomes of surgical staging for endometrial cancer in obese women by robotics or laparotomy... - Postmenopausal uterine inversion associated with endometrial polypsRod Rocconi
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
Obstet Gynecol 102:521-3. 2003..CONCLUSION: Nonpuerperal uterine inversion associated with endometrial polyps was successfully treated surgically... - Gene therapyWarner K Huh
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
Cancer Treat Res 107:133-57. 2002 - Cytology versus high-risk HPV testing for follow-up of HPV-positive women without CINKristopher J Kimball
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Alabama at Birmingham, 618 South 19th Street, OHB 538, Birmingham, Alabama 35249, USA
J Natl Compr Canc Netw 6:96-100. 2008..This article presents a brief overview of related guidelines and current modalities, and reviews selected studies. Finally, future directions and a possible schema for clinical management of these patients are included... - The current and future role of screening in the era of HPV vaccinationEvan Myers
Division of Clinical and Epidemiological Research, Department of Obstetrics and Gynecology, DUMC 3279, 244 Baker House, Duke University Medical Center, Durham, NC 27710, USA
Gynecol Oncol 109:S31-9. 2008.... - Treatment considerations in advanced endometrial cancerJames E Kendrick
Division of Gynecologic Oncology, University of Alabama at Birmingham, 618 20th Street South, OHB Room 538, Birmingham, AL 35233, USA
Curr Oncol Rep 9:494-8. 2007..Over the past 10 years, the role of cytoreductive surgery, radiotherapy, and chemotherapy in endometrial cancer have been actively investigated. This review outlines and summarizes some of these important developments and findings... - Gene expression profiling of women with varying degrees of cervical intraepithelial neoplasiaJames E Kendrick
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama, Birmingham, AL 35249 7333, USA
J Low Genit Tract Dis 11:25-8. 2007..A pilot study to determine genomic microarray differences in patients with normal cervical tissue and cervical intraepithelial neoplasia (CIN) 3... - Immunohistochemical evaluation of the c-kit proto-oncogene in sarcomas of the uterus: a case seriesCharles A Leath
Division of Gynecologic Oncology, University of Alabama at Birmingham, USA
J Reprod Med 49:71-5. 2004..To evaluate the incidence of c-kit expression in uterine sarcomas... - A multi-institutional review of outcomes of endometrial stromal sarcomaCharles A Leath
Department of Obstetrics, Division of Gynecologic Oncology, The University of Alabama at Birmingham, Birmingham, AL, USA
Gynecol Oncol 105:630-4. 2007..To compare the clinical behavior and outcomes of low- and high-grade endometrial stromal sarcomas (LGESS and HGESS), respectively... - Optical detection of cervical neoplasia: results from an internally-controlled multicenter studyWarner K Huh
Division of Gynecologic Oncology, University of Alabama at Birmingham, AL 35294-7333, USA
Gynecol Oncol 99:S53. 2005 - A phase II trial of weekly topotecan for patients with secondary platinum-resistant recurrent epithelial ovarian carcinoma following the failure of second-line therapyWhitney A Spannuth
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The University of Alabama at Birmingham, AL 35294, USA
Gynecol Oncol 104:591-5. 2007..To determine the response rate, progression-free survival and toxicity associated with weekly topotecan administered to patients with platinum-sensitive recurrent epithelial ovarian (EOC) in the third-line setting... - A prospective blinded evaluation of the accuracy of frozen section for the surgical management of endometrial cancerAshley S Case
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama
Obstet Gynecol 108:1375-9. 2006..To prospectively evaluate in a blinded fashion the accuracy of frozen section in endometrial cancer... - Pelvic umbrella pack for refractory obstetric hemorrhage secondary to posterior uterine ruptureRebecca J Howard
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
Obstet Gynecol 100:1061-3. 2002..Pelvic hemorrhage continues to be a serious complication of pregnancy and can lead to significant maternal morbidity. The pelvic umbrella pack is a useful alternative to control pelvic bleeding when standard measures fail... - Uterine leiomyosarcoma metastatic to the thyroidCharles A Leath
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35249 7333, USA
Obstet Gynecol 100:1122-4. 2002..Uterine leiomyosarcoma is an aggressive tumor that has a propensity for distant metastasis. Distant sites of spread include the lung, liver, brain, and bone... - Autoclave sterilization of instruments used on women with cervical neoplasia is an effective method of eradicating residual human papillomavirus DNA: a polymerase chain reaction-based evaluationJacob M Estes
Division of Gynecologic Oncology, The University of Alabama Birmingham, Birmingham, AL 35249, USA
J Low Genit Tract Dis 11:12-7. 2007..To determine whether autoclave sterilization eradicates human papillomavirus (HPV) DNA on specula and instruments used to treat women with cervical neoplasia... - A pilot study of ovarian cancer chemoprevention using medroxyprogesterone acetate in an avian model of spontaneous ovarian carcinogenesisMack N Barnes
Department of Gynecologic Oncology, University of Alabama at Birmingham, 538 Old Hillman Building, 618 South 20th Street, Birmingham, AL 35233, USA
Gynecol Oncol 87:57-63. 2002..The current histologic findings are consistent with the theory that a reduction of ovulatory events may prevent the development of ovarian adenocarcinoma... - Protrusio acetabuli presenting as a complex pelvic mass after total hip arthroplastyCharles A Leath
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, Alabama, USA
Obstet Gynecol 104:1187-9. 2004..The differential diagnosis in an elderly woman with a complex pelvic mass includes benign and malignant diseases... - Initial lessons learned in HPV vaccinationThomas J Herzog
Columbia University, College of Physicians and Surgeons, Department of Obstetrics and Gynecology, 161 Fort Washington Avenue, 8th Floor New York, NY 10032, USA
Gynecol Oncol 109:S4-11. 2008..This article also examines the impact of the HPV vaccination awareness campaign on media and public policy dynamics... - How does public policy impact cervical screening and vaccination strategies?Thomas J Herzog
Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Gynecol Oncol 119:175-80. 2010..To examine the current approaches to cervical screening and points to consider for improving HPV vaccination acceptance and uptake in the US... - Cervical cancerBenjamin E Greer
J Natl Compr Canc Netw 6:14-36. 2008 - Carcinosarcoma of the ovary-a case seriesTeresa L Rutledge
University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Gynecol Oncol 100:128-32. 2006..To evaluate our experience with ovarian carcinosarcoma and identify prognostic factors... 
Pretreatment with cisplatin enhances E7-specific CD8+ T-Cell-mediated antitumor immunity induced by DNA vaccinationChih Wen Tseng
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
Clin Cancer Res 14:3185-92. 2008....- Age considerations when vaccinating against HPVThomas C Wright
Columbia University, New York, New York 10032, USA
Gynecol Oncol 109:S40-7. 2008..This review discusses the various considerations that should be addressed when making recommendations of who should be vaccinated against HPV...
Research Grants
- A Phase I Study to Evaluate the Safety and Immunogenicity of HPV 16 L2 11-200WARNER KING HUH; Fiscal Year: 2010..coli, may have a substantial global impact, particularly in developing nations and low resource settings where 80% of cervical cancer occurs. ..