MICHAEL DONALD HUGHSON

Summary

Affiliation: University of Mississippi Medical Center
Country: USA

Publications

  1. ncbi request reprint Renal cell carcinoma of end-stage renal disease: an analysis of chromosome 3, 7, and 17 abnormalities by microsatellite amplification
    M D Hughson
    Research Service, Department of Veterans Affairs Medical Center, Northport, New York, USA
    Mod Pathol 12:301-9. 1999
  2. ncbi request reprint Alveolar hemorrhage and renal microangiopathy in systemic lupus erythematosus
    M D Hughson
    Department of Pathology, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216 4505, USA
    Arch Pathol Lab Med 125:475-83. 2001
  3. ncbi request reprint Glomerular size and glomerulosclerosis: relationships to disease categories, glomerular solidification, and ischemic obsolescence
    Michael D Hughson
    Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Am J Kidney Dis 39:679-88. 2002
  4. ncbi request reprint Glomerular volume and clinicopathologic features related to disease severity in renal biopsies of African Americans and whites in the southeastern United States
    Michael D Hughson
    Department of Pathology, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216, USA
    Arch Pathol Lab Med 131:1665-72. 2007
  5. ncbi request reprint Hypertension, glomerular number, and birth weight in African Americans and white subjects in the southeastern United States
    M D Hughson
    Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Kidney Int 69:671-8. 2006
  6. ncbi request reprint Expression of HIF-1 and ubiquitin in conventional renal cell carcinoma: relationship to mutations of the von Hippel-Lindau tumor suppressor gene
    Michael D Hughson
    Department of Pathology, University Medical Center, Jackson, MS, USA
    Cancer Genet Cytogenet 143:145-53. 2003
  7. pmc NADPH oxidase contributes to renal damage and dysfunction in Dahl salt-sensitive hypertension
    Niu Tian
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1858-65. 2008
  8. ncbi request reprint Expression of fibronectin and HIF-1alpha in renal cell carcinomas: relationship to von Hippel-Lindau gene inactivation
    Zhi He
    Department of Pathology, University Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Cancer Genet Cytogenet 152:89-94. 2004
  9. ncbi request reprint Regulation of 11 beta-hydroxysteroid dehydrogenase enzymes in the rat kidney by estradiol
    Elise P Gomez-Sanchez
    Endocrine Section and Research Service, G V Sonny Montgomery Veterans Affairs Medical Center, Jackson, MS 39216, USA
    Am J Physiol Endocrinol Metab 285:E272-9. 2003
  10. ncbi request reprint N-Acetylcysteine improves renal dysfunction, ameliorates kidney damage and decreases blood pressure in salt-sensitive hypertension
    Niu Tian
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    J Hypertens 24:2263-70. 2006

Research Grants

Detail Information

Publications14

  1. ncbi request reprint Renal cell carcinoma of end-stage renal disease: an analysis of chromosome 3, 7, and 17 abnormalities by microsatellite amplification
    M D Hughson
    Research Service, Department of Veterans Affairs Medical Center, Northport, New York, USA
    Mod Pathol 12:301-9. 1999
    ....
  2. ncbi request reprint Alveolar hemorrhage and renal microangiopathy in systemic lupus erythematosus
    M D Hughson
    Department of Pathology, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216 4505, USA
    Arch Pathol Lab Med 125:475-83. 2001
    ..In most cases, the lungs show "bland" alveolar hemorrhage with little or no inflammation. Whether this alveolar injury is similar to the better-defined noninflammatory renal lupus vasculopathy is unresolved...
  3. ncbi request reprint Glomerular size and glomerulosclerosis: relationships to disease categories, glomerular solidification, and ischemic obsolescence
    Michael D Hughson
    Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Am J Kidney Dis 39:679-88. 2002
    ..A biphasic change in glomerular size is characteristic of primary and secondary FSGS, but not hypertension, in which tuft collapse supports reduced rather than increased perfusion in the pathogenesis of its glomerular obsolescence...
  4. ncbi request reprint Glomerular volume and clinicopathologic features related to disease severity in renal biopsies of African Americans and whites in the southeastern United States
    Michael D Hughson
    Department of Pathology, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216, USA
    Arch Pathol Lab Med 131:1665-72. 2007
    ..Glomerulomegaly, possibly related to obesity, has been identified in high-risk populations and is suggested to be a marker for end-stage renal disease risk...
  5. ncbi request reprint Hypertension, glomerular number, and birth weight in African Americans and white subjects in the southeastern United States
    M D Hughson
    Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Kidney Int 69:671-8. 2006
    ..03). The data indicate that low nephron number and possibly low birth weight may play a role in the development of hypertension in white subjects but not African Americans...
  6. ncbi request reprint Expression of HIF-1 and ubiquitin in conventional renal cell carcinoma: relationship to mutations of the von Hippel-Lindau tumor suppressor gene
    Michael D Hughson
    Department of Pathology, University Medical Center, Jackson, MS, USA
    Cancer Genet Cytogenet 143:145-53. 2003
    ..The findings also suggest that a 3p tumor suppressor gene other than VHL may also influence HIF-1alpha degradation and that there is an additional tumorigenic pathway for cRCC that does not involve VHL or HIF-1...
  7. pmc NADPH oxidase contributes to renal damage and dysfunction in Dahl salt-sensitive hypertension
    Niu Tian
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1858-65. 2008
    ..These data suggest that NADPH oxidase plays an important role in causing renal cortical oxidative stress and inflammation, which lead to decreases in renal hemodynamics, renal cortical damage, and increases in arterial pressure...
  8. ncbi request reprint Expression of fibronectin and HIF-1alpha in renal cell carcinomas: relationship to von Hippel-Lindau gene inactivation
    Zhi He
    Department of Pathology, University Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Cancer Genet Cytogenet 152:89-94. 2004
    ..They also suggest that some C-terminal mutations may not interfere with Fn assembly and that a 3p TSG in addition to VHL influences HIF-1alpha degradation...
  9. ncbi request reprint Regulation of 11 beta-hydroxysteroid dehydrogenase enzymes in the rat kidney by estradiol
    Elise P Gomez-Sanchez
    Endocrine Section and Research Service, G V Sonny Montgomery Veterans Affairs Medical Center, Jackson, MS 39216, USA
    Am J Physiol Endocrinol Metab 285:E272-9. 2003
    ..NAD+-dependent enzymatic activity in the absence or presence of a reducing agent demonstrated that the increase in 11betaHSD2 protein was not associated with an increase in in vitro activity unless the dimers were reduced to monomers...
  10. ncbi request reprint N-Acetylcysteine improves renal dysfunction, ameliorates kidney damage and decreases blood pressure in salt-sensitive hypertension
    Niu Tian
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    J Hypertens 24:2263-70. 2006
    ..Salt-sensitive hypertension in humans and experimental animals causes progressive increases in renal damage and dysfunction. The Dahl salt-sensitive (S) rat closely mimics human salt-sensitive hypertension...
  11. ncbi request reprint Glomerular calcification in hypercalcemic nephropathy
    Jeffrey R Henegar
    Department of Pathology and Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Arch Pathol Lab Med 127:E80-5. 2003
    ..Glomerular calcinosis may also be recognized as an additional cause of segmental glomerulosclerosis and nephrotic range proteinuria in patients with extremely high levels of serum calcium...
  12. ncbi request reprint Antioxidant treatment prevents renal damage and dysfunction and reduces arterial pressure in salt-sensitive hypertension
    Niu Tian
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, USA
    Hypertension 45:934-9. 2005
    ..Antioxidant treatment with vitamins C and E improves renal dysfunction, lessens renal injury, and decreases arterial pressure in Dahl salt-sensitive hypertension...
  13. doi request reprint Associations of glomerular number and birth weight with clinicopathological features of African Americans and whites
    Michael D Hughson
    Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Am J Kidney Dis 52:18-28. 2008
    ....
  14. ncbi request reprint Accuracy of liquid-based Pap tests: comparison of concurrent liquid-based tests and cervical biopsies on 782 women with previously abnormal Pap smears
    Ming Guo
    Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Acta Cytol 49:132-8. 2005
    ..Boxborough, Massachusetts, U.S.A.), by comparing concurrent TP and cervical biopsy results on 782 patients who were referred for colposcopy because of previously abnormal conventional Pap smears (CPs)...

Research Grants3

  1. Nephron Count, Birth Weight & Hypertensive Renal Disease
    Michael Hughson; Fiscal Year: 2006
    ....