Molly A Hughes

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi Amebic liver abscess
    M A Hughes
    Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, USA
    Infect Dis Clin North Am 14:565-82, viii. 2000
  2. ncbi MyD88-dependent signaling contributes to protection following Bacillus anthracis spore challenge of mice: implications for Toll-like receptor signaling
    Molly A Hughes
    Department of Internal Medicine, Division of Infectious Diseases, University of Virginia Health Sciences System, P O Box 800513, Charlottesville, VA 22908, USA
    Infect Immun 73:7535-40. 2005
  3. ncbi Identification of Entamoeba histolytica thiol-specific antioxidant as a GalNAc lectin-associated protein
    Molly A Hughes
    Department of Internal Medicine, Division of Infectious Diseases, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Mol Biochem Parasitol 127:113-20. 2003
  4. ncbi The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis
    Robert M Strieter
    Department of Medicine, Division of Pulmonary Critical Care, Box 800466, Charlottesville, VA 22908 0466, USA
    J Leukoc Biol 86:1111-8. 2009
  5. ncbi Identification of the bacterial protein FtsX as a unique target of chemokine-mediated antimicrobial activity against Bacillus anthracis
    Matthew A Crawford
    Department of Medicine, Division of Infectious Diseases, University of Virginia, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 108:17159-64. 2011
  6. ncbi Antimicrobial effects of interferon-inducible CXC chemokines against Bacillus anthracis spores and bacilli
    Matthew A Crawford
    Department of Medicine, Division of Infectious Diseases, University of Virginia Health Sciences System, Charlottesville, VA 22908, USA
    Infect Immun 77:1664-78. 2009
  7. ncbi Early NK cell-derived IFN-{gamma} is essential to host defense in neutropenic invasive aspergillosis
    Stacy J Park
    Department of Microbiology, University of Virginia, Charlottesville, 22908, USA
    J Immunol 182:4306-12. 2009
  8. ncbi Identification and characterization of an Entamoeba histolytica upstream regulatory element 3 sequence-specific DNA-binding protein containing EF-hand motifs
    C A Gilchrist
    Departments of Internal Medicine, Microbiology, and Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 276:11838-43. 2001

Research Grants

  1. Identification of E. histolytica virulence factors
    Molly Hughes; Fiscal Year: 2004
  2. Studies on Macrophage Resistance to Anthrax Lethal Toxin
    Molly Hughes; Fiscal Year: 2004

Collaborators

  • B J Mann
  • Borna Mehrad
  • William Petri
  • Robert M Strieter
  • Matthew A Crawford
  • Marie D Burdick
  • Stacy J Park
  • C A Gilchrist
  • Debra J Fisher
  • John W Beaber
  • David E Lowe
  • Ian J Glomski
  • Jason Zemansky
  • Scott Stibitz
  • Roger D Plaut
  • Farhang Alem
  • Marie Burdick
  • ALISON D O'BRIEN
  • Yinghua Zhu
  • Patrick Sanz
  • Ellen C Keeley
  • Candace S Green
  • C F Holm
  • J M Schaenman

Detail Information

Publications8

  1. ncbi Amebic liver abscess
    M A Hughes
    Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, USA
    Infect Dis Clin North Am 14:565-82, viii. 2000
    ..This article reviews epidemiologic features, pathophysiology, clinical features, diagnostic tests, imaging studies, treatment of amebic liver abscess, and prevention measures...
  2. ncbi MyD88-dependent signaling contributes to protection following Bacillus anthracis spore challenge of mice: implications for Toll-like receptor signaling
    Molly A Hughes
    Department of Internal Medicine, Division of Infectious Diseases, University of Virginia Health Sciences System, P O Box 800513, Charlottesville, VA 22908, USA
    Infect Immun 73:7535-40. 2005
    ..We conclude that, although recognition of B. anthracis occurs via TLR2, additional MyD88-dependent pathways contribute to the host innate immune response to anthrax infection...
  3. ncbi Identification of Entamoeba histolytica thiol-specific antioxidant as a GalNAc lectin-associated protein
    Molly A Hughes
    Department of Internal Medicine, Division of Infectious Diseases, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Mol Biochem Parasitol 127:113-20. 2003
    ..Recruitment of TSA by the GalNAc lectin suggests a novel mechanism of parasite defense against reactive oxygen intermediates generated by host peripheral mononuclear cells...
  4. ncbi The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis
    Robert M Strieter
    Department of Medicine, Division of Pulmonary Critical Care, Box 800466, Charlottesville, VA 22908 0466, USA
    J Leukoc Biol 86:1111-8. 2009
    ..In this review, we present data supporting the critical role these cells play in the pathogenesis of pulmonary fibrosis...
  5. ncbi Identification of the bacterial protein FtsX as a unique target of chemokine-mediated antimicrobial activity against Bacillus anthracis
    Matthew A Crawford
    Department of Medicine, Division of Infectious Diseases, University of Virginia, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 108:17159-64. 2011
    ....
  6. ncbi Antimicrobial effects of interferon-inducible CXC chemokines against Bacillus anthracis spores and bacilli
    Matthew A Crawford
    Department of Medicine, Division of Infectious Diseases, University of Virginia Health Sciences System, Charlottesville, VA 22908, USA
    Infect Immun 77:1664-78. 2009
    ..anthracis infection as well as infections caused by other spore-forming organisms...
  7. ncbi Early NK cell-derived IFN-{gamma} is essential to host defense in neutropenic invasive aspergillosis
    Stacy J Park
    Department of Microbiology, University of Virginia, Charlottesville, 22908, USA
    J Immunol 182:4306-12. 2009
    ..Taken together, these data indicate that NK cells are the main source of early IFN-gamma in the lungs in neutropenic invasive aspergillosis, and this is an important mechanism in the defense against this infection...
  8. ncbi Identification and characterization of an Entamoeba histolytica upstream regulatory element 3 sequence-specific DNA-binding protein containing EF-hand motifs
    C A Gilchrist
    Departments of Internal Medicine, Microbiology, and Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 276:11838-43. 2001
    ..Characterization of URE3-BP should provide insight into transcription regulation and virulence control in this parasite...

Research Grants3

  1. Identification of E. histolytica virulence factors
    Molly Hughes; Fiscal Year: 2004
    ..Successful completion of these studies will yield a fundamental understanding of amebic proteins that interact with the E. histolytica GalNAc lectin and their role in pathogenicity. ..
  2. Studies on Macrophage Resistance to Anthrax Lethal Toxin
    Molly Hughes; Fiscal Year: 2004
    ..Successful completion of these studies will yield a fundamental understanding of mechanisms of macrophage resistance to LT. ..