Research Topics
| Michael G HughesSummaryAffiliation: University of Virginia Country: USA Publications
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Detail Information
Publications
E2 quasispecies specificity of hepatitis C virus association with allografts immediately after liver transplantationMichael G Hughes
University of Virginia, Department of Surgery, Surgical Infectious Disease Laboratory, Charlottesville, VA, USA
Liver Transpl 10:208-16. 2004..02 and P = 0.04, respectively). Immediately after transplantation but before actual infection, liver allografts select out from the infecting serum inoculum a less heterogeneous, more closely related population of quasispecies variants...- Does prior transfusion worsen outcomes from infection in surgical patients?Michael G Hughes
Department of Surgery, Surgical Infectious Disease Laboratory, University of Virginia, Charlottesville, Virginia 22908, USA
Surg Infect (Larchmt) 4:335-43. 2003..The objective of this study was to determine the effect of transfusion on outcomes among infected surgical patients... - Comparison of fungal and nonfungal infections in a broad-based surgical patient populationMichael G Hughes
Department of Surgery, Surgical Infectious Disease Laboratory, University of Virginia, Charlottesville, Virginia 22908, USA
Surg Infect (Larchmt) 6:55-64. 2005..Our aim was to compare fungal and nonfungal infections among a diverse surgical patient population... - HCV infection of the transplanted liver: changing CD81 and HVR1 variants immediately after liver transplantationMichael G Hughes
Department of Surgery, Surgical Infectious Disease Laboratory, University of Virginia, Charlottesville, Virginia, USA
Am J Transplant 5:2504-13. 2005..In conclusion, HVR1 quasispecies variants differentially associate with, and infect allografts, after liver transplantation. Additionally, allografts express variable amounts of CD81 after transplantation... - Effect of an intensive care unit rotating empiric antibiotic schedule on the development of hospital-acquired infections on the non-intensive care unit wardMichael G Hughes
Department of Surgery, University of Virginia, Charlottesville 22908, USA
Crit Care Med 32:53-60. 2004.... - Does body mass index affect infection-related outcomes in the intensive care unit?Robert L Smith
Department of Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Surg Infect (Larchmt) 8:581-8. 2007..We hypothesized that increasing BMI would be an independent predictor of higher mortality rates in the surgical/trauma ICU... - Cost of Gram-negative resistanceHeather L Evans
Department of Surgery, University of Virginia Health System, Charlottesville, VA, USA
Crit Care Med 35:89-95. 2007..We wished to test the hypothesis that rGNR infections are associated with higher resource utilization... - Primary human hepatocytes in spheroid formation to study hepatitis C infectionTae W Chong
Department of Surgery, Surgical Infectious Disease Laboratory, University of Virginia, Charlottesville, Virginia 22908, USA
J Surg Res 130:52-7. 2006..As hepatocytes are the primary reservoir for the virus in vivo, we report on a model using primary human hepatocytes cultured in spheroid formation... - Nature of gram-negative rod antibiotic resistance during antibiotic rotationHeather L Evans
Surgical Infectious Disease Research Laboratory, Department of Surgery, UVA Health System, Charlottesville, VA 22908 1380, USA
Surg Infect (Larchmt) 6:223-31. 2005..The aim of this study was to characterize the evolution of gram-negative antibiotic resistance during a study of empiric antibiotic rotation... - Contact isolation in surgical patients: a barrier to care?Heather L Evans
Department of Surgery, UVA Health System, Charlottesville, VA 22908, USA
Surgery 134:180-8. 2003..Contact isolation is commonly used to prevent transmission of resistant organisms. We hypothesized that contact isolation negatively impacts the amount of direct patient care... - BK viral disease in renal transplantationRobert M Cannon
Division of Transplantation, Department of Surgery, University of Louisville, Louisville, Kentucky, USA
Curr Opin Organ Transplant 16:576-9. 2011..This review is meant to highlight the literature on BK viral disease following renal transplantation published in the most recent year... - A review of the United States experience with combined heart-liver transplantationRobert M Cannon
Division of Transplantation, Department of Surgery, University of Louisville, Louisville, KY, USA
Transpl Int 25:1223-8. 2012..4%, 71.0%, 65.1%; P = 0.894) and heart transplantation alone (82.6%, 71.9%, 63.2%; P = 0.341). CHLT is a safe and effective procedure, with graft survival rates similar to isolated heart and isolated liver transplantation... - Long-term outcome in 42 pediatric liver transplant patients with alpha 1-antitrypsin deficiency: a single-center experienceMichael G Hughes
Division of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, MN, USA
Clin Transplant 25:731-6. 2011..We examined the long-term outcome of transplantation for alpha 1-antitrypsin deficiency (A1ATD)... - Transduction of human T cells with a novel T-cell receptor confers anti-HCV reactivityYi Zhang
Division of Transplantation, Department of Surgery, Medical University of South Carolina, Hollings Cancer Center, Charleston, South Carolina, USA
PLoS Pathog 6:e1001018. 2010..HCV TCR-transduced T cells may be promising for the treatment of patients with chronic HCV infections... - Human liver transplantation as a model to study hepatitis C virus pathogenesisMichael G Hughes
Department of Surgery, Medical University of South Carolina, Charleston, SC, USA
Liver Transpl 15:1395-411. 2009..Moreover, consideration is given to current and emerging antiviral therapeutic approaches based on translational research results... - Can preemptive cytomegalovirus monitoring be as effective as universal prophylaxis when implemented as the standard of care in patients at moderate risk?John W McGillicuddy
Department of Surgery, Medical University of South Carolina, Charleston, SC, USA
Transplantation 89:1218-23. 2010.... - General surgery morning report: a competency-based conference that enhances patient care and resident educationBrendon M Stiles
Department of Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Curr Surg 63:385-90. 2006..Although initially oriented toward transfer of patient information, MR is also hypothesized to serve as a competency-based resident education tool... - AMPK inactivation in mononuclear cells: a potential intracellular mechanism for exercise-induced immunosuppressionHannah Moir
Cardiff School of Health Sciences, Centre for Biomedical Sciences, University of Wales Institute Cardiff, Cardiff, Wales CF5 2YB, UK
Appl Physiol Nutr Metab 33:75-85. 2008..Thus, we suggest that prolonged, repeated, high-intensity exercise that leads to clinically relevant immunosuppression may do so via AMPK inactivation within immune cells... - The effect of warm-up on high-intensity, intermittent running using nonmotorized treadmill ergometryPeter I Brown
School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom
J Strength Cond Res 22:801-8. 2008..However, repeated sprinting ability is significantly improved after both active and passive warm-ups compared to no warm-up...