Research Topics
Species | John R HughesSummaryAffiliation: University of Illinois at Chicago Country: USA Publications
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Publications
Dictator Perpetuus: Julius Caesar--did he have seizures? If so, what was the etiology?John R Hughes
Department of Neurology, School of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Epilepsy Behav 5:756-64. 2004..Our best evidence comes from the ancient sources of Suetonius, Plutarch, Pliny, and Appianus...- The photoparoxysmal response: the probable cause of attacks during video gamesJohn R Hughes
Department of Neurology, University of Illinois, Medical Center at Chicago, Illinois 60612, USA
Clin EEG Neurosci 39:1-7. 2008..Drug therapy has emphasized valproic acid, but Levetiracetam has also been successful in eliminating the PPR... - Gamma, fast, and ultrafast waves of the brain: their relationships with epilepsy and behaviorJohn R Hughes
Department of Neurology and Rehabilitation, University of Illinois Medical Center in Chicago, Chicago, IL 60612, USA
Epilepsy Behav 13:25-31. 2008..They have been studied in all sensory systems and are associated with selective attention, transient binding of cognitive features, and conscious perception of the external world... - One of the hottest topics in epileptology: ABC proteins. Their inhibition may be the future for patients with intractable seizuresJohn R Hughes
Department of Neurology, University of Illinois Medical Center, 912 S Wood Street, Chicago, IL 60612, USA
Neurol Res 30:920-5. 2008..Tariquidar (XR9576) is likely to be a good candidate that appears to inhibit these proteins and therefore to allow the AEDs to control the intractable seizures that may account for nearly 40% of our patients... - Absence seizures: a review of recent reports with new conceptsJohn R Hughes
Department of Neurology, University of Illinois Medical Center M C 796, 912 South Wood Street, Chicago, IL 60612, USA
Epilepsy Behav 15:404-12. 2009..Valproic acid and lamotrigine are also first-line medications. In addition, zonisamide and levetiracetam can be very helpful in absence epilepsy... - The savant syndrome and its possible relationship to epilepsyJohn R Hughes
Department of Neurology, University of Illinois Medical Center, Chicago, IL, USA
Adv Exp Med Biol 724:332-43. 2012..Neurodegenerative Diseases, edited by Shamim I. Ahmad... - EEG in seizure prognosis: association of slow wave activity and other factors in patients with apparent misleading epileptiform findingsJohn R Hughes
Laboratory of Clinical Neurophysiology, Department of Neurology, University of Illinois Medical Center in Chicago, Chicago, Illinois 60612, USA
Clin EEG Neurosci 35:181-4. 2004..The change in the number of spikes over time also led to a more accurate prognosis... - EEG and seizures in autistic children and adolescents: further findings with therapeutic implicationsJohn R Hughes
Division of Clinical Neurophysiology and Epilepsy, Department of Neurology, School of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
Clin EEG Neurosci 36:15-20. 2005..One new finding was that a greater variability of EEG abnormalities was found in the A group. Therapeutic implications, based on these latter findings, are discussed... - Did all those famous people really have epilepsy?John R Hughes
Department of Neurology, School of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Epilepsy Behav 6:115-39. 2005..This article is an attempt to correct the record with respect to these people and also to remind us of the many reasons similar misdiagnoses are being made today... - A reappraisal of the possible seizures of Vincent van GoghJohn R Hughes
Department of Neurology, University of Illinois at Chicago, Chicago, IL 60612, USA
Epilepsy Behav 6:504-10. 2005..Although van Gogh is an excellent example of the Geschwind syndrome, at times associated with temporal lobe epilepsy, this fact does not establish such an epilepsy. Thus, the syndrome is an orphan without the parent condition... - A newly described ictal pattern: the initial ictal slow shiftJohn R Hughes
Epilepsy Clinic, University of Illinois Medical Center, M C 796, 912 S Wood Street, Room 862N, Chicago, IL 60612, USA
Clin EEG Neurosci 36:161-70. 2005..These shifts could relate to data showing that patients are not really back to a normal responsiveness for at least 5 sec after the end of the S+W complexes (see Discussion)... - The idiosyncratic aspects of the epilepsy of Fyodor DostoevskyJohn R Hughes
Department of Neurology, University of Illinois at Chicago, Chicago, IL 60612, USA
Epilepsy Behav 7:531-8. 2005..A relationship is seen between his severe obsession with gambling and his epilepsy. Finally, Fyodor Dostoevsky is an excellent example of the "temporal lobe personality.".. - A review of sleepwalking (somnambulism): the enigma of neurophysiology and polysomnography with differential diagnosis of complex partial seizuresJohn R Hughes
Department of Neurology, University of Illinois Medical Center M C 796, 912 South Wood Street, Chicago, IL 60612, USA
Epilepsy Behav 11:483-91. 2007..Associated disorders are Tourette's syndrome, sleep-disordered breathing, and migraine. Various kinds of treatment are discussed, as are legal considerations, especially murder during sleepwalking... - Autism: the first firm finding = underconnectivity?John R Hughes
Department of Neurology, University of Illinois Medical Center at Chicago, 912 South Wood Street, Chicago, IL 60612, USA
Epilepsy Behav 11:20-4. 2007.... - Alexander of Macedon, the greatest warrior of all times: did he have seizures?John R Hughes
Department of Neurology, School of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Epilepsy Behav 5:765-7. 2004..None of his other illnesses involved seizures. Clearly, Alexander the Great did not have epilepsy and his name should be removed from the list of famous individuals who have had seizures... - Review of medical reports on pedophiliaJohn R Hughes
Department of Neurology, University of Illinois Medical Center, Chicago 60612, USA
Clin Pediatr (Phila) 46:667-82. 2007..The final topic is treatment of this disorder with surgery, medication, behavioral therapy and the combination of medication and behavioral therapy... - A review of the relationships between Landau-Kleffner syndrome, electrical status epilepticus during sleep, and continuous spike-waves during sleepJohn R Hughes
Department of Neurology, University of Illinois Medical Center at Chicago, Chicago, IL 60612, USA
Epilepsy Behav 20:247-53. 2011..Memory disorders are common, because the nearly continuous generalized discharges in sleep do not allow for the memory consolidation that also occurs during sleep. Medications and possible etiologies are discussed... - Benign epilepsy of childhood with centrotemporal spikes (BECTS): to treat or not to treat, that is the questionJohn R Hughes
Department of Neurology, University of Illinois Medical Center at Chicago, IL 60612, USA
Epilepsy Behav 19:197-203. 2010..Although many neurologists oppose treatment; twice as many studies concluded in favor of treatment. The typical benign aspect of this disorder may allow for nontreatment to be without serious consequences... - Periodic lateralized epileptiform discharges: Do they represent an ictal pattern requiring treatment?John R Hughes
Department of Neurology, University of Illinois Medical Center, Chicago, IL 60612, USA
Epilepsy Behav 18:162-5. 2010.... - A review of Savant Syndrome and its possible relationship to epilepsyJohn R Hughes
Department of Neurology, University of Illinois Medical Center in Chicago, Chicago, IL 60612, USA
Epilepsy Behav 17:147-52. 2010.... - Update on autism: a review of 1300 reports published in 2008John R Hughes
Department of Neurology, University of Illinois Medical Center at Chicago, Chicago, IL, USA
Epilepsy Behav 16:569-89. 2009..As mentioned in the 2007 survey, nearly every conceivable problem that a child can have may be found in these unfortunate children and nearly every conceivable etiology has been mentioned to account for this serious disorder... - Emperor Napoleon Bonaparte: did he have seizures? Psychogenic or epileptic or both?John R Hughes
Section of Clinical Neurophysiology and Epilepsy, Department of Neurology, University of Illinois, Medical Center, M C 796, 912 South Wood Street, 60612, Chicago, IL, USA
Epilepsy Behav 4:793-6. 2003.... - Alcohol withdrawal seizuresJohn R Hughes
Department of Neurology, University of Illinois Medical Center, M C 796, 912 South Wood Street, Chicago, IL 60612, USA
Epilepsy Behav 15:92-7. 2009..Therapy has emphasized benzodiazepines, mainly diazepam and lorazepam, but more standard antiepileptic drugs, like carbamazepine and topiramate, are also effective and safe... - A review of sudden unexpected death in epilepsy: prediction of patients at riskJohn R Hughes
Department of Neurology, University of Illinois Medical Center at Chicago, Chicago, IL, USA
Epilepsy Behav 14:280-7. 2009..The most important risk factor in this study was noncompliance with antiepileptic medication, and the main message of this study to caregivers is that therapeutic drug levels are crucial to avoid SUDEP... - Is the decreased longevity among left-handers related to an increase in heart disease?John R Hughes
Department of Neurology, University of Illinois Medical Center, Chicago, Illinois 60612, USA
Clin EEG Neurosci 39:182-4. 2008..Left-handers use the right hemisphere for movement, and unilateral activation of that hemisphere in the form of EEG desynchronization and deactivation in the form of EEG slow waves are both related to cardiac abnormalities... - Factors in the interictal record predicting an ictal episode: a case studyJohn R Hughes
Epilepsy Clinic, University of Illinois Medical Center, Chicago, Illinois 60612, USA
Clin EEG Neurosci 35:158-64. 2004..Thus, the important factors in the interictal record that lead to an ictal event are the number of spikes, the amount of fast activity and the decreasing variability between the spikes... - The relationship between bilateral spike and wave complexes and focal discharges in patients with partial epilepsyJohn R Hughes
Department of Neurology, University of Illinois Medical Center, Chicago, Illinois 60612, USA
Clin EEG Neurosci 35:147-50. 2004..The discussion deals with the possibility that these bilateral spike and wave complexes may represent a reflection of a lowered threshold to a seizure... - Focal seizures and EEG: prognostic considerationsJohn R Hughes
Laboratory of Clinical Neurophysiology, Department of Neurology, University of Illinois Medical Center, M/C 796, 912 S. Wood St, Chicago, IL 60612, USA
Clin Electroencephalogr 34:174-81. 2003..When complete EEGs are done with sleep records and the results are quantified, reasonable prediction of eventual outcome can usually occur that is much more timely than waiting over 9 yrs, using only clinical data... - The EEG profile of patients with uncontrolled vs. controlled seizuresJohn R Hughes
Epilepsy Clinic, USA
Clin EEG Neurosci 35:69-77. 2004..The time between unilateral to bilateral slow waves varied between 4-9 yrs... - The seizures of Peter Alexeevich = Peter the Great, father of modern RussiaJohn R Hughes
Department of Neurology, University of Illinois Medical Center at Chicago M C 796, 912 South Wood Street, Chicago, IL 60612, USA
Epilepsy Behav 10:179-82. 2007.... - Epileptic nystagmus and its possible relationship with PGO spikesJohn R Hughes
Epilepsy Clinic, University of Illinois Medical Center, M/C 796, 912 S. Wood St, Chicago, IL 96612, USA
Clin Electroencephalogr 34:32-8. 2003.... - Electroencephalography in clinical epilepsy researchSusan T Herman
Comprehensive Epilepsy Program, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Epilepsy Behav 22:126-33. 2011..Investigators are using CEEG to study "seizure burden," to help determine what are the long-term effects of nonconvulsive seizures and NCSE, and to help guide treatment and improve outcome... - The relationship between slow and sharp waves (spikes) and also clinical seizuresJohn R Hughes
Department of Neurology and Rehabilitation, University of Illinois Medical Center, M/C 796, 912 S. Wood St, Chicago, IL 60612, USA
Clin Electroencephalogr 33:165-70. 2002..In general, there was a relationship between more slow waves, more sharp waves and more seizures. Also minimal slowing and rare discharges on the first record tended to disappear in the next EEG... - Brainstem auditory evoked potentials--a review and modified studies in healthy subjectsJames L Stone
Departments of Neurosurgery, University of Illinois Medical Center at Chicago, Chicago, Illinois 60612, USA
J Clin Neurophysiol 26:167-75. 2009.... - Progress in predicting seizure episodes with nonlinear methodsJohn R Hughes
Department of Neurology, University of Illinois Medical Center M C 796, 912 South Wood Street, Chicago, IL 60612, USA
Epilepsy Behav 12:128-35. 2008..Thus, only limited progress has been made in predicting a seizure from preictal activity, but many other related phenomena have also been studied with nonlinear methods with some success... - The frontal arousal rhythm (FAR) is an ictal pattern: a case reportJohn R Hughes
University of Illinois Medical Center, M/C 796, 912 S. Wood Street, Chicago, IL 60612, USA
Clin Electroencephalogr 34:13-4. 2003..This exact sequence was seen on three successive occasions lasting for 6,9, and 10 sec. The conclusion is the FAR is not just a sign of seizure disorder, but is actually an ictal pattern... - Long-term electro-clinical changes in the Lennox-Gastaut syndrome before, during, and after the slow spike-wave patternJohn R Hughes
Epilepsy Clinic, University of Illinois Medical Center, M/C 796, 912 S. Wood St, Chicago, IL 60612, USA
Clin Electroencephalogr 33:1-7. 2002..This study has emphasized the importance of the cortex in the LGS and also the instability of the pattern that occasionally appears... - A review of recent reports on autism: 1000 studies published in 2007John R Hughes
Department of Neurology, University of Illinois Medical Center M C 796, 912 South Wood Street, Chicago, IL 60612, USA
Epilepsy Behav 13:425-37. 2008..Nearly every conceivable problem that a child could have can be observed in these unfortunate children... - Review of the validity and significance of cannabis withdrawal syndromeAlan J Budney
Department of Psychiatry, University of Vermont, 54 W Twin Oaks Terrace, Suite 12, S Burlington, VT 05403, USA
Am J Psychiatry 161:1967-77. 2004..The magnitude and severity of these symptoms appear substantial, and these findings suggest that the syndrome has clinical importance. Diagnostic criteria for cannabis withdrawal syndrome are proposed... - Effects of abstinence from tobacco: etiology, animal models, epidemiology, and significance: a subjective reviewJohn R Hughes
Department of Psychiatry, University of Vermont, Burlington, VT 05401 1419, USA
Nicotine Tob Res 9:329-39. 2007..Tobacco withdrawal is common and can be distressing. Withdrawal-induced depression appears to undermine the smoker's ability to remain abstinent... - Measurement of the effects of abstinence from tobacco: a qualitative reviewJohn R Hughes
University of Vermont, Department of Psychiatry, Ira Allen School, Burlington, VT 05401 1419, USA
Psychol Addict Behav 21:127-37. 2007..multiple items to describe each symptom. Of the measures, 6 consistently increase with abstinence, but no single measure appears superior... - Survey of U.S. Army commanders' experiences with brigade/battalion surgeons at Fort Hood, TexasJohn R Hughes
Department of Emergency Medicine, Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA
Mil Med 171:240-5. 2006..Commanders with combat experience rated their assigned physicians significantly higher than did commanders without combat experience. Despite high ratings, several candid remarks suggest there is still room for improvement... - Errors in interpreting abstinence curves in studies of smoking cessationJohn R Hughes
Department of Psychiatry, University of Vermont, Burlington, VT 05401, USA
Nicotine Tob Res 8:7-12. 2006..They should also report both additive and multiplicative effect sizes... - Measures of abstinence in clinical trials: issues and recommendationsJohn R Hughes
Department of Psychiatry, Psychology and Family Practice University of Vermont, Burlington 05401 1419, USA
Nicotine Tob Res 5:13-25. 2003..Trials that use short-term follow-ups (< or = 3 months) to demonstrate possible efficacy should report a prolonged abstinence measure of > or = 4 weeks. We again recommend a 2-week grace period; however, that period can vary... - Should criteria for drug dependence differ across drugs?John R Hughes
University of Vermont, Burlington, VT, USA
Addiction 101:134-41. 2006..To examine the pros and cons of using the same diagnostic criteria for dependence across all drugs versus using dependence criteria specific to the drug of interest... - Past alcohol problems do not predict worse smoking cessation outcomesJohn R Hughes
Departments of Psychiatry, Psychology and Family Practice, University of Vermont, 38 Fletcher Place, Burlington, VT 05401 1419, USA
Drug Alcohol Depend 71:269-73. 2003..We conclude that a past history of alcohol problems per se does not predict inability to stop smoking... - Reduction in amount smoked predicts future cessationAndrew Hyland
Department of Health Behavior, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Psychol Addict Behav 19:221-5. 2005..7 times more likely to quit smoking by 2001 compared with those who did not reduce. Few smokers are able to reduce their consumption by 50% or more, although those who do are more likely to quit compared with those who do not... - Data to estimate the similarity of tobacco research samples to intended populationsJohn R Hughes
University of Vermont, Department of Psychiatry, Burlington, VT, USA
Nicotine Tob Res 6:177-9. 2004..S. current smokers based on the 2000 National Health Interview Survey. Researchers can use these data to estimate the similarity of their sample to those of the typical U.S. smoker... - Effects of abstinence from tobacco: valid symptoms and time courseJohn R Hughes
Department of Psychiatry, University of Vermont, Burlington, VT 05401 1419, USA
Nicotine Tob Res 9:315-27. 2007..Future studies need to investigate several possible new symptoms of withdrawal and to define more clearly the time course of symptoms...