James P Hughes

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Determinants of per-coital-act HIV-1 infectivity among African HIV-1-serodiscordant couples
    James P Hughes
    Department of Biostatistics, University of Washington, Seattle 98195 7232, USA
    J Infect Dis 205:358-65. 2012
  2. pmc Handheld computers for self-administered sensitive data collection: a comparative study in Peru
    Antonio Bernabe-Ortiz
    School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, Peru
    BMC Med Inform Decis Mak 8:11. 2008
  3. ncbi The theoretical population-level impact of a prophylactic human papilloma virus vaccine
    James P Hughes
    Department of Biostatistics, University of Washington, Seattle, WA 98195, USA
    Epidemiology 13:631-9. 2002
  4. ncbi Estimating the accuracy of polymerase chain reaction-based tests using endpoint dilution
    James P Hughes
    Department of Biostatistics 357232, University of Washington, Seattle, Washington 98195, USA
    Biometrics 59:505-11. 2003
  5. ncbi Using baseline data to design a group randomized trial
    James P Hughes
    Department of Biostatistics, University of Washington, Seattle, WA 98195, U S A
    Stat Med 24:1983-94. 2005
  6. pmc Prevalence and risk factors for oncogenic human papillomavirus infections in high-risk mid-adult women
    Rachel L Winer
    Department of Epidemiology, University of Washington, Seattle, WA 98104, USA
    Sex Transm Dis 39:848-56. 2012
  7. pmc Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis
    Deborah Donnell
    Statistical Center for HIV AIDS Research and Prevention and the Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Lancet 375:2092-8. 2010
  8. doi Persistence of genital human papillomavirus infection in a long-term follow-up study of female university students
    Laura K Sycuro
    Departments of Epidemiology, University of Washington, Seattle, WA 98103, USA
    J Infect Dis 198:971-8. 2008
  9. pmc Quantitative human papillomavirus 16 and 18 levels in incident infections and cervical lesion development
    Rachel L Winer
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    J Med Virol 81:713-21. 2009
  10. ncbi Concordance of self-collected and clinician-collected swab samples for detecting human papillomavirus DNA in women 18 to 32 years of age
    Rachel L Winer
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Sex Transm Dis 34:371-7. 2007

Research Grants

  1. STATISTICAL ISSUES IN AIDS RESEARCH
    James P Hughes; Fiscal Year: 2010
  2. STATISTICAL ISSUES IN AIDS RESEARCH
    James Hughes; Fiscal Year: 2009

Collaborators

Detail Information

Publications85

  1. pmc Determinants of per-coital-act HIV-1 infectivity among African HIV-1-serodiscordant couples
    James P Hughes
    Department of Biostatistics, University of Washington, Seattle 98195 7232, USA
    J Infect Dis 205:358-65. 2012
    ..Knowledge of factors that affect per-act infectivity of human immunodeficiency virus type 1 (HIV-1) is important for designing HIV-1 prevention interventions and for the mathematical modeling of the spread of HIV-1...
  2. pmc Handheld computers for self-administered sensitive data collection: a comparative study in Peru
    Antonio Bernabe-Ortiz
    School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, Peru
    BMC Med Inform Decis Mak 8:11. 2008
    ..The goal of this study is to evaluate the quality of sexual behavior data collected with handheld computers in comparison with paper-based questionnaires...
  3. ncbi The theoretical population-level impact of a prophylactic human papilloma virus vaccine
    James P Hughes
    Department of Biostatistics, University of Washington, Seattle, WA 98195, USA
    Epidemiology 13:631-9. 2002
    ..The ongoing development of a vaccine against human papillomavirus (HPV) raises important questions about the impact of various vaccination strategies...
  4. ncbi Estimating the accuracy of polymerase chain reaction-based tests using endpoint dilution
    James P Hughes
    Department of Biostatistics 357232, University of Washington, Seattle, Washington 98195, USA
    Biometrics 59:505-11. 2003
    ..We develop parametric, nonparametric, and semiparametric (spline-based) models for the sensitivity curve. The methods are compared on a new test for M. genitalium...
  5. ncbi Using baseline data to design a group randomized trial
    James P Hughes
    Department of Biostatistics, University of Washington, Seattle, WA 98195, U S A
    Stat Med 24:1983-94. 2005
    ..The results are applied to a GRT for sexually transmitted diseases prevention in Peru...
  6. pmc Prevalence and risk factors for oncogenic human papillomavirus infections in high-risk mid-adult women
    Rachel L Winer
    Department of Epidemiology, University of Washington, Seattle, WA 98104, USA
    Sex Transm Dis 39:848-56. 2012
    ..The epidemiology of high-risk (hr) human papillomavirus (HPV) infections in mid-adult women with new sex partners is undefined...
  7. pmc Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis
    Deborah Donnell
    Statistical Center for HIV AIDS Research and Prevention and the Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Lancet 375:2092-8. 2010
    ..Initiation of antiretroviral therapy (ART) reduces plasma HIV-1 concentrations. We aimed to assess the effect of ART use by patients infected with HIV-1 on risk of transmission to their uninfected partners...
  8. doi Persistence of genital human papillomavirus infection in a long-term follow-up study of female university students
    Laura K Sycuro
    Departments of Epidemiology, University of Washington, Seattle, WA 98103, USA
    J Infect Dis 198:971-8. 2008
    ..Little is known about the epidemiology of human papillomavirus (HPV) infections that persist for more than a few years...
  9. pmc Quantitative human papillomavirus 16 and 18 levels in incident infections and cervical lesion development
    Rachel L Winer
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    J Med Virol 81:713-21. 2009
    ..05, 95% CI = 1.09-92.56) and increased HPV DNA (VLR = 16.80, 95% CI = 1.46-193.01). In newly detected HPV-16 infections, increasing levels of E7 mRNA appear to be associated with an increased risk of developing cervical pre-cancer...
  10. ncbi Concordance of self-collected and clinician-collected swab samples for detecting human papillomavirus DNA in women 18 to 32 years of age
    Rachel L Winer
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Sex Transm Dis 34:371-7. 2007
    ..The objective of this study was to determine whether self- and clinician-collected samples are comparable for human papillomavirus (HPV) detection...
  11. pmc Clinical and virologic response to episodic acyclovir for genital ulcers among HIV-1 seronegative, herpes simplex virus type 2 seropositive African women: a randomized, placebo-controlled trial
    Jared M Baeten
    Department of Global Health, University of Washington, Seattle, WA 98104, USA
    Sex Transm Dis 39:21-4. 2012
    ..1 vs. 6.0 days) and cessation of herpes simplex virus shedding (HR = 1.88, P = 0.008; mean, 3.0 vs. 5.0 days) compared with placebo, similar to results of studies in high-income countries (ClinicalTrials.gov registration NCT00808405)...
  12. ncbi Genital human papillomavirus infection in men: incidence and risk factors in a cohort of university students
    Jeffrey M Partridge
    Department of Epidemiology, University of Washington, Seattle, WA 98103, USA
    J Infect Dis 196:1128-36. 2007
    ..In contrast to the wealth of data on human papillomavirus (HPV) infections in women, much less is known about HPV in men...
  13. pmc Circumcision and acquisition of human papillomavirus infection in young men
    Kelley Vanbuskirk
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    Sex Transm Dis 38:1074-81. 2011
    ..The role of circumcision in male HPV acquisition is not clear...
  14. pmc Detection of genital HPV types in fingertip samples from newly sexually active female university students
    Rachel L Winer
    University of Washington HPV Research Group, Box 359933, 325 9th Avenue, Seattle, WA 98104, USA
    Cancer Epidemiol Biomarkers Prev 19:1682-5. 2010
    ..The study objectives were to determine the presence of genital HPV types in fingertip samples and the agreement between fingertip and genital samples for detecting HPV...
  15. pmc Risk of female human papillomavirus acquisition associated with first male sex partner
    Rachel L Winer
    Department of Epidemiology, University of Washington, Seattle, WA 98103, USA
    J Infect Dis 197:279-82. 2008
    ..6%-38.6%) and increased to almost 50% by 3 years. The risk was increased when the first male partner was sexually experienced. Our results indicate a high risk of HPV infection in young women who have had just 1 male sex partner...
  16. pmc Viral load and short-term natural history of type-specific oncogenic human papillomavirus infections in a high-risk cohort of midadult women
    Rachel L Winer
    Departments of Epidemiology, University of Washington, Seattle, WA
    Int J Cancer 134:1889-98. 2014
    ..Intermittent detection was characterized by low viral levels, suggesting that intermittent detection of persisting oncogenic HPV infection may be of limited clinical significance. ..
  17. ncbi Genital human papillomavirus infection: incidence and risk factors in a cohort of female university students
    Rachel L Winer
    Department of Epidemiology, University of Washington, Seattle, WA 98103, USA
    Am J Epidemiol 157:218-26. 2003
    ..The data show that the incidence of HPV associated with acquisition of a new sex partner is high and that nonpenetrative sexual contact is a plausible route of transmission in virgins...
  18. pmc An empiric risk scoring tool for identifying high-risk heterosexual HIV-1-serodiscordant couples for targeted HIV-1 prevention
    Erin M Kahle
    Department of Epidemiology, University of Washington, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 62:339-47. 2013
    ..A simple risk assessment tool could be useful for identifying couples at highest risk for HIV-1 transmission...
  19. ncbi Clinical findings among young women with genital human papillomavirus infection
    Constance Mao
    Department of Obstetrics and Gynecology, University of Washington, Seattle, USA
    Am J Obstet Gynecol 188:677-84. 2003
    ..The purpose of this study was to identify clinical signs and symptoms associated with detection of human papillomavirus (HPV) DNA in the female genital tract...
  20. ncbi Condom use and the risk of genital human papillomavirus infection in young women
    Rachel L Winer
    Department of Epidemiology, University of Washington, Seattle, USA
    N Engl J Med 354:2645-54. 2006
    ....
  21. pmc Using plasma viral load to guide antiretroviral therapy initiation to prevent HIV-1 transmission
    Pamela M Murnane
    Department of Epidemiology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 7:e51192. 2012
    ..Because the quantity of HIV-1 in plasma is the primary predictor of HIV-1 transmission, consideration of plasma viral load in ART initiation guidelines is warranted...
  22. pmc Human Papillomavirus (HPV) type 16 and type 18 DNA Loads at Baseline and Persistence of Type-Specific Infection during a 2-year follow-up
    Long Fu Xi
    Department of Pathology, School of Medicine, University of Washington, Seattle, USA
    J Infect Dis 200:1789-97. 2009
    ..Studies of viral load-associated persistence of human papillomavirus (HPV) infection are rare, with inconsistent results reported...
  23. pmc Viral load in the natural history of human papillomavirus type 16 infection: a nested case-control study
    Long Fu Xi
    Department of Pathology, School of Medicine, University of Washington, Seattle, Washington, USA
    J Infect Dis 203:1425-33. 2011
    ..Viral load may influence the course of human papillomavirus type 16 (HPV-16) infection...
  24. pmc Age- and gender-specific estimates of partnership formation and dissolution rates in the Seattle sex survey
    Sara J Nelson
    Department of Epidemiology, University of Washington, Center for AIDS and STD, Harborview Medical Center, 325 9thAve, Seattle, WA 98104, USA
    Ann Epidemiol 20:308-17. 2010
    ..Partnership formation and dissolution rates are primary determinants of sexually transmitted infection (STI) transmission dynamics...
  25. ncbi Development and duration of human papillomavirus lesions, after initial infection
    Rachel L Winer
    Department of Epidemiology, University of Washington, Seattle, Washington 98103, USA
    J Infect Dis 191:731-8. 2005
    ..To determine the potential value of human papillomavirus (HPV) vaccines, information concerning the incidence and duration of clinically important lesions is needed...
  26. ncbi Characterization of IgA response among women with incident HPV 16 infection
    Takashi Onda
    Program in Cancer Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Virology 312:213-21. 2003
    ..6 months for serum IgA, whereas approximately 20% of women with serum IgG antibodies reverted within 36 months. Thus, the duration of IgA in cervical secretions and sera was shorter than the duration of serum IgG (P = 0.007 and 0.001)...
  27. doi Development of genital warts after incident detection of human papillomavirus infection in young men
    Yuzo Arima
    Departments of 1Epidemiology, and 6Harborview Medical Center, University of Washington, Seattle, WA 98104, USA
    J Infect Dis 202:1181-4. 2010
    ..7% (95% CI, 0.2%-2.8%) among 331 men who tested negative for HPV. Our results suggest that genital warts are common after HPV-6 or HPV-11 infection in young men...
  28. pmc Estimating the impact of plasma HIV-1 RNA reductions on heterosexual HIV-1 transmission risk
    Jairam R Lingappa
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 5:e12598. 2010
    ....
  29. pmc Prediction of HIV acquisition among men who have sex with men
    Timothy W Menza
    Center for AIDS and STD, University of Washington, Harborview Medical Center, 325 Ninth Ave, Seattle, WA 98104, USA
    Sex Transm Dis 36:547-55. 2009
    ..To develop and validate an easy-to-use prediction model for HIV acquisition among men who have sex with men (MSM)...
  30. ncbi Evaluation of human papillomavirus testing in primary screening for cervical abnormalities: comparison of sensitivity, specificity, and frequency of referral
    Shalini L Kulasingam
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    JAMA 288:1749-57. 2002
    ..Whether HPV DNA testing alone is useful in primary screening remains to be determined...
  31. ncbi Evaluation of a population-based program of expedited partner therapy for gonorrhea and chlamydial infection
    Matthew R Golden
    Public Health Seattle and King County, Seattle, Washington, USA
    Sex Transm Dis 34:598-603. 2007
    ....
  32. doi Evaluation of primary cervical cancer screening with an oncogenic human papillomavirus DNA test and cervical cytologic findings among women who attended family planning clinics in the United States
    Janet G Baseman
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    Am J Obstet Gynecol 199:26.e1-8. 2008
    ....
  33. pmc Early natural history of incident, type-specific human papillomavirus infections in newly sexually active young women
    Rachel L Winer
    Department of Epidemiology, University of Washington, 325 9th Avenue, Seattle, WA 98104, USA
    Cancer Epidemiol Biomarkers Prev 20:699-707. 2011
    ..Characterizing short-term detection patterns of young women's incident α-genus human papillomavirus (HPV) infections may further our understanding of HPV transmission...
  34. pmc Daily acyclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomised placebo-controlled trial
    Jairam R Lingappa
    Department of Global Health, Seattle, WA, USA
    Lancet 375:824-33. 2010
    ..Daily suppression of this herpes virus reduces plasma HIV-1 concentrations, but whether it delays HIV-1 disease progression is unknown. We investigated the effect of acyclovir on HIV-1 progression...
  35. ncbi Higher concentration of HIV RNA in rectal mucosa secretions than in blood and seminal plasma, among men who have sex with men, independent of antiretroviral therapy
    Richard A Zuckerman
    Department of Medicine, University of Washington, Seattle 98104, USA
    J Infect Dis 190:156-61. 2004
    ..Thus, controlling for plasma HIV RNA, ART had an independent effect on seminal, but not rectal, HIV levels...
  36. pmc Male circumcision, religion, and infectious diseases: an ecologic analysis of 118 developing countries
    Paul K Drain
    University of Washington School of Medicine, Seattle, USA
    BMC Infect Dis 6:172. 2006
    ..Most studies have been limited in size and have not adequately controlled for religion, so these relationships remain unclear...
  37. doi A prospective study of contraceptive use among African women in HIV-1 serodiscordant partnerships
    Renee Heffron
    Department of Epidemiology, University of Washington, Seattle, WA 98104, USA
    Sex Transm Dis 37:621-8. 2010
    ..Few studies have explored contraceptive use in HIV-1 serodiscordant couples, a population at high risk for HIV-1 transmission...
  38. ncbi Comparison of incident cervical and vulvar/vaginal human papillomavirus infections in newly sexually active young women
    Rachel L Winer
    Department of Epidemiology, University of Washington, Seattle 98103, USA
    J Infect Dis 199:815-8. 2009
    ..03). Site-by-species differences were not statistically significant. Our results suggest that low- or undetermined-risk HPV types preferentially infect vaginal epithelium...
  39. pmc Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2
    C Celum
    Department of Global Health, University of Washington, Harborview Medical Center, 325 Ninth Ave, Box 359927, Seattle, WA 98104, USA
    N Engl J Med 362:427-39. 2010
    ..Therapy to suppress HSV-2 reduces the frequency of reactivation of HSV-2 as well as HIV-1 levels, suggesting that suppression of HSV-2 may reduce the risk of transmission of HIV-1...
  40. pmc Mycoplasma genitalium among young adults in the United States: an emerging sexually transmitted infection
    Lisa E Manhart
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98104 2499, USA
    Am J Public Health 97:1118-25. 2007
    ..We sought to determine the prevalence of and risk factors associated with Mycoplasma genitalium infection in a nationally representative sample of young adults in the United States...
  41. pmc Genital HIV-1 RNA predicts risk of heterosexual HIV-1 transmission
    Jared M Baeten
    Department of Global Health, University of Washington, Seattle, WA 98195, USA
    Sci Transl Med 3:77ra29. 2011
    ..These data suggest that HIV-1 RNA in genital secretions could be used as a marker of HIV-1 sexual transmission risk...
  42. ncbi Effect of expedited treatment of sex partners on recurrent or persistent gonorrhea or chlamydial infection
    Matthew R Golden
    Division of Infectious Diseases and the Center for AIDS and Sexually Transmitted Diseases, University of Washington, Seattle, USA
    N Engl J Med 352:676-85. 2005
    ..Many sex partners of persons with gonorrhea or chlamydial infections are not treated, which leads to frequent reinfections and further transmission...
  43. pmc Antibody responses in oral fluid after administration of prophylactic human papillomavirus vaccines
    Ali Rowhani-Rahbar
    Department of Epidemiology, University of Washington, Seattle, WA 98125, USA
    J Infect Dis 200:1452-5. 2009
    ..6% (95% confidence interval [CI], 42.0%-57.3%) before and 100% (95% CI, 92.0%-100%) after administration of the quadrivalent vaccine. Oral fluid may have the potential to be used for monitoring of prophylactic HPV vaccines in the future...
  44. pmc A post-trial assessment of factors influencing study drug adherence in a randomized biomedical HIV-1 prevention trial
    Shevin T Jacob
    Department of Medicine, University of Washington, Seattle, WA, USA
    AIDS Behav 15:897-904. 2011
    ....
  45. pmc Age of diagnosis of squamous cell cervical carcinoma and early sexual experience
    Zoe R Edelstein
    University of Washington, HPV Research Group, Seattle, WA 98103, USA
    Cancer Epidemiol Biomarkers Prev 18:1070-6. 2009
    ....
  46. pmc Contingency management to reduce methamphetamine use and sexual risk among men who have sex with men: a randomized controlled trial
    Timothy W Menza
    Center for AIDS and STD, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104, USA
    BMC Public Health 10:774. 2010
    ....
  47. pmc Integrated strategies for combination HIV prevention: principles and examples for men who have sex with men in the Americas and heterosexual African populations
    Connie Celum
    Department of Global Health and Medicine, University of Washington, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 63:S213-20. 2013
    ..Three examples of combination prevention concepts are summarized for men who have sex with men in the Americas, young women in sub-Saharan Africa, and HIV serodiscordant couples...
  48. pmc Standard treatment regimens for nongonococcal urethritis have similar but declining cure rates: a randomized controlled trial
    Lisa E Manhart
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    Clin Infect Dis 56:934-42. 2013
    ..We compared azithromycin and doxycycline in men with NGU, hypothesizing that azithromycin was more effective than doxycycline...
  49. doi Rates and determinants of oral human papillomavirus infection in young men
    Zoe R Edelstein
    HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute and Columbia University, New York, NY, USA
    Sex Transm Dis 39:860-7. 2012
    ..Little is known about the rates and determinants of oral human papillomavirus (HPV) infection, an infection that is etiologically linked with oropharyngeal cancers...
  50. pmc Evidence of immune memory 8.5 years following administration of a prophylactic human papillomavirus type 16 vaccine
    Ali Rowhani-Rahbar
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    J Clin Virol 53:239-43. 2012
    ..A feature of vaccines that confer long-term immunity is their ability to induce immune memory...
  51. doi An evaluation of HIV partner counseling and referral services using new disposition codes
    Matthew R Golden
    Public Health Seattle and King County, Seattle, Washington, USA
    Sex Transm Dis 36:95-101. 2009
    ..New Centers for Disease Control recommendations suggest that all persons with newly diagnosed HIV receive partner counseling and referral services (PCRS)...
  52. pmc Accuracy and cost-effectiveness of cervical cancer screening by high-risk human papillomavirus DNA testing of self-collected vaginal samples
    Akhila Balasubramanian
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    J Low Genit Tract Dis 14:185-95. 2010
    ..Estimate the accuracy and cost-effectiveness of cervical cancer screening strategies based on high-risk human papillomavirus (HPV) DNA testing of self-collected vaginal samples...
  53. ncbi Statistical methods for determining the accuracy of quantitative polymerase chain reaction-based tests
    Barbra A Richardson
    Department of Biostatistics, University of Washington, Seattle, WA 98195, USA
    Stat Med 26:895-902. 2007
    ..These methods are applied to data from an experiment to test the accuracy of a real-time PCR assay at low HIV-1 DNA copy levels...
  54. ncbi Characteristics of multiple and concurrent partnerships among women at high risk for HIV infection
    Adaora A Adimora
    Division of Infectious Diseases, University of North Carolina Schools of Medicine and UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC Department of Biostatistics, University of Washington, Seattle, WA Fred Hutchinson Cancer Research Center, Seattle, WA FHI 360, Durham, NC School of Public Health and Health Services, The George Washington University, Washington, DC Johns Hopkins University School of Medicine, Baltimore, MD ICAP Columbia University, Mailman School of Public Health, Columbia University, New York, NY Rollins School of Public Health and Center for AIDS Research, Emory University, Atlanta, GA Harlem Hospital Center, New York, NY NIAID, NIH, Bethesda, MD and Rutgers, The State University of New Jersey, Newark, NJ
    J Acquir Immune Defic Syndr 65:99-106. 2014
    ..S. communities...
  55. doi Chlamydia screening coverage estimates derived using healthcare effectiveness data and information system procedures and indirect estimation vary substantially
    Jennifer M Broad
    University of Washington, Seattle, WA, USA
    Sex Transm Dis 40:292-7. 2013
    ..Screening coverage is an important determinant of chlamydial control program success...
  56. pmc Understanding the potential impact of a combination HIV prevention intervention in a hyper-endemic community
    Ramzi A Alsallaq
    Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 8:e54575. 2013
    ....
  57. pmc Disclosure of genital human papillomavirus infection to female sex partners by young men
    Yuzo Arima
    Emerging Disease Surveillance and Response Unit, Division of Health Security and Emergencies, World Health Organization Regional Office for the Western Pacific, Manila, Philippines
    Sex Transm Dis 39:583-7. 2012
    ..Disclosure was associated with discussing the Pap test/human papillomavirus vaccine with female partners and not associated with a worsening relationship...
  58. ncbi Influence of study population on the identification of risk factors for sexually transmitted diseases using a case-control design: the example of gonorrhea
    Lisa E Manhart
    Department of Medicine, School of Medicine, University of Washington, Seattle 98104, USA
    Am J Epidemiol 160:393-402. 2004
    ..9). Risk factors identified in STD clinics will probably be confirmed in a general population sample, despite overcontrolling for shared behaviors; however, factors associated with both disease and STD clinic attendance may be missed...
  59. pmc Performance of the Focus HerpeSelect-2 enzyme immunoassay for the detection of herpes simplex virus type 2 antibodies in seven African countries
    Andrew Mujugira
    Department of Global Health, University of Washington, Seattle, Washington, USA
    Sex Transm Infect 87:238-41. 2011
    ..To compare the performance of the Focus HerpeSelect-2 enzyme immunoassay (EIA) with the gold standard herpes simplex virus (HSV) type 2 western blot, among HIV-1-uninfected men and women in east and southern Africa...
  60. pmc Longer term efficacy of a prophylactic monovalent human papillomavirus type 16 vaccine
    Ali Rowhani-Rahbar
    Department of Epidemiology, University of Washington, Seattle, WA 98125, USA
    Vaccine 27:5612-9. 2009
    ..The results suggest that this monovalent HPV-16 vaccine remains efficacious through 8.5 years after its administration...
  61. ncbi Modeling breastmilk infectivity in HIV-1 infected mothers
    Barbra A Richardson
    Department of Biostatistics, University of Washington, Harborview Medical Center, Box 359931, 325 Ninth Avenue Seattle, Washington 98104 2499, USA
    Biometrics 59:179-85. 2003
    ..Data from a randomized trial of breastfeeding versus formula feeding among HIV-1 infected mothers in Nairobi, Kenya, are used to illustrate the methods...
  62. ncbi Correlates of national HIV seroprevalence: an ecologic analysis of 122 developing countries
    Paul K Drain
    School of Medicine, University of Washington, Seattle, WA, USA
    J Acquir Immune Defic Syndr 35:407-20. 2004
    ..Ecologic analyses of social and developmental correlates of country-level HIV seroprevalence may suggest strategies for combating the HIV/AIDS epidemic...
  63. pmc Male circumcision and risk of male-to-female HIV-1 transmission: a multinational prospective study in African HIV-1-serodiscordant couples
    Jared M Baeten
    University of Washington, WA, USA
    AIDS 24:737-44. 2010
    ....
  64. ncbi Methods for assessing the accuracy of PCR-based tests: comparisons and extensions
    San San Ou
    Department of Biostatistics, University of Washington, Seattle, WA 98195, USA
    Stat Med 24:1755-64. 2005
    ..0. We also extend the general model to incorporate covariates. Simulation studies are used to compare the different estimators. The methods are applied to data from a PCR-based test for Mycoplasma genitalium...
  65. doi HIV serosorting in men who have sex with men: is it safe?
    Matthew R Golden
    Public Health Seattle and King County, Center for AIDS and STD, 400 Yesler Way, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 49:212-8. 2008
    ..Serosorting is the practice of preferentially having sex with partners of concordant HIV status or of selectively using condoms with HIV-discordant partners...
  66. ncbi Discrete proportional hazards models for mismeasured outcomes
    Amalia S Meier
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Biometrics 59:947-54. 2003
    ..However, in simulations over a wide range of conditions, the APH method with correctly specified mismeasurement rates performs very well...
  67. pmc Quality of HIV care provided by non-physician clinicians and physicians in Mozambique: a retrospective cohort study
    Kenneth H Sherr
    Department of Global Health, University of Washington, Seattle, Washington, USA
    AIDS 24:S59-66. 2010
    ..To compare HIV care quality provided by non-physician clinicians (NPC) and physicians...
  68. ncbi Development and performance of a microwell-plate-based polymerase chain reaction assay for Mycoplasma genitalium
    Susan M Dutro
    Department of Medicine, University of Washington, Seattle, USA
    Sex Transm Dis 30:756-63. 2003
    ..Further epidemiologic studies on this organism are needed, but currently used polymerase chain reaction (PCR) assays are labor-intensive and culture is insensitive...
  69. ncbi Positive predictive value of Gen-Probe APTIMA Combo 2 testing for Neisseria gonorrhoeae in a population of women with low prevalence of N. gonorrhoeae infection
    Matthew R Golden
    Division of Infectious Diseases, University of Washington, Seattle, WA, USA
    Clin Infect Dis 39:1387-90. 2004
    ..4%; 95% confidence interval, 95.1%-98.8%). Routine confirmatory testing of specimens with positive AC2 gonorrhea test results is not indicated...
  70. pmc Challenges in the design of HIV prevention trials in the United States
    Deborah Donnell
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Acquir Immune Defic Syndr 55:S136-40. 2010
    ..However, for interventions where efficacy is already established, conducting trials that test different implementation strategies in these populations could provide definitive evidence about how to achieve high levels of coverage...
  71. pmc Breast-milk infectivity in human immunodeficiency virus type 1-infected mothers
    Barbra A Richardson
    Department of Biostatistics, University of Washington, Harborview Medical Center, Box 359909, 325 Ninth Avenue, Seattle, WA 98104 2499, USA
    J Infect Dis 187:736-40. 2003
    ..The probability of HIV-1 infection per liter of breast milk ingested by an infant is similar in magnitude to the probability of heterosexual transmission of HIV-1 per unprotected sex act in adults...
  72. ncbi Continuous combination oral contraceptive pills to eliminate withdrawal bleeding: a randomized trial
    Leslie Miller
    Departments of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA
    Obstet Gynecol 101:653-61. 2003
    ..To compare bleeding profiles of a traditional 28-day oral contraceptive pill cycle with continuous administration...
  73. pmc A unified procedure for meta-analytic evaluation of surrogate end points in randomized clinical trials
    James Y Dai
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Biostatistics 13:609-24. 2012
    ..The proposed method is evaluated by simulations and applications to 2 clinical trials...
  74. ncbi Factors associated with oropharyngeal human immunodeficiency virus shedding
    Richard A Zuckerman
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    J Infect Dis 188:142-5. 2003
    ..In multivariate analysis, receipt of antiretroviral therapy, higher CD4 cell count, and history of tonsillectomy were predictors of lower pharyngeal HIV RNA levels...
  75. pmc Mutation of HIV-1 genomes in a clinical population treated with the mutagenic nucleoside KP1461
    James I Mullins
    Department of Microbiology, University of Washington, School of Medicine, Seattle, Washington, United States of America
    PLoS ONE 6:e15135. 2011
    ..09), as predicted by the mechanism of action of the drug. These results validate the proposed mechanism of action in humans and should spur development of this novel antiretroviral approach...
  76. pmc Sexual intercourse and risk of symptomatic urinary tract infection in post-menopausal women
    Elya E Moore
    Department of Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, WA, USA
    J Gen Intern Med 23:595-9. 2008
    ..Sexual intercourse increases the risk of symptomatic urinary tract infections (UTI) in young women, but its role among post-menopausal women is unclear...
  77. ncbi Acquisition and natural history of human papillomavirus type 16 variant infection among a cohort of female university students
    Long Fu Xi
    Department of Pathology, School of Medicine, University of Washington, Seattle, Washington 98103, USA
    Cancer Epidemiol Biomarkers Prev 11:343-51. 2002
    ....
  78. ncbi Randomised treatment trial of bacterial vaginosis to prevent post-abortion complication
    Leslie Miller
    Department of Obstetrics and Gynecology, University of Washington, Harborview Medical Center, 325 9th Avenue, Seattle, WA 98104 2499, USA
    BJOG 111:982-8. 2004
    ..To evaluate the efficacy of metronidazole to reduce post-abortion complications among women with bacterial vaginosis...
  79. pmc Reduced adipogenic gene expression in thigh adipose tissue precedes human immunodeficiency virus-associated lipoatrophy
    Mario Kratz
    Department of Medicine, University of Washington, Seattle, Washington 98109, USA
    J Clin Endocrinol Metab 93:959-66. 2008
    ..The expression of adipogenic genes in sc adipose tissue has been reported to be lower among patients with HIV-associated lipoatrophy than HIV-uninfected controls. It is unclear whether this is a result or cause of lipoatrophy...
  80. ncbi Determinants of cervical cancer rates in developing countries
    Paul K Drain
    International Health Program, Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
    Int J Cancer 100:199-205. 2002
    ..Finally, relatively low immunization rates and a shortage of health-care workers in countries with high CC rates suggest potential challenges for introducing prophylactic HPV vaccines...
  81. ncbi HIV-1, sexually transmitted infections, and sexual behavior trends among men who have sex with men in Lima, Peru
    Jorge Sanchez
    Asociation Civil Impacta Salud y Educacion, Av Grimaldo Del Solar 805, Lima 18, Peru
    J Acquir Immune Defic Syndr 44:578-85. 2007
    ..To assess and estimate trends in HIV, sexually transmitted infections (STIs), and sexual behavior among men who have sex with men (MSM) in Lima, Peru...
  82. ncbi Design and analysis of stepped wedge cluster randomized trials
    Michael A Hussey
    Fred Hutchinson Cancer Research Center, Seattle, WA, United States
    Contemp Clin Trials 28:182-91. 2007
    ..In this article we discuss the design and analysis of a particular type of crossover CRT - the stepped wedge - and provide an example of its use...
  83. ncbi Applications of continuous time hidden Markov models to the study of misclassified disease outcomes
    Alexandre Bureau
    Group in Biostatistics, School of Public Health, University of California, Berkeley, CA 94720, USA
    Stat Med 22:441-62. 2003
    ....
  84. ncbi Comparison of oral fluid and serum ELISAs in the determination of IgG response to natural human papillomavirus infection in university women
    Farrel J Buchinsky
    Center for Genomic Sciences, Allegheny Singer Research Institute, 320 E North Avenue, Pittsburgh, PA 15212 4772, USA
    J Clin Virol 35:450-3. 2006
    ..Venipuncture (phlebotomy) is an obstacle to subject recruitment and ongoing participation in cohort studies investigating human papillomavirus (HPV) infection. Anti-HPV antibodies are not only detected in serum but also in oral fluid...
  85. ncbi Sentinel surveillance of sexually transmitted infections/HIV and risk behaviors in vulnerable populations in 5 Central American countries
    Ramon J Soto
    World Vision International, Regional Office for Latin America and the Carribean, San Jose, Costa Rica
    J Acquir Immune Defic Syndr 46:101-11. 2007
    ..0, 95% confidence interval: 2.9 to 7.9). For these vulnerable populations, prevention must incorporate acceptable and effective sexual health services, including improved condom access and promotion...

Research Grants2

  1. STATISTICAL ISSUES IN AIDS RESEARCH
    James P Hughes; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: This research will develop statistical methods for use in studies of HIV infection. ..
  2. STATISTICAL ISSUES IN AIDS RESEARCH
    James Hughes; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: This research will develop statistical methods for use in studies of HIV infection. ..