Research Topics
| Larry D HubbardSummaryAffiliation: University of Wisconsin Country: USA Publications
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Detail Information
Publications
Brightness, contrast, and color balance of digital versus film retinal images in the age-related eye disease study 2Larry D Hubbard
Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison, Madison, Wisconsin 53711 1068, USA
Invest Ophthalmol Vis Sci 49:3269-82. 2008....
Computer-assisted measurement of retinal vessel diameters in the Beaver Dam Eye Study: methodology, correlation between eyes, and effect of refractive errorsTien Yin Wong
Department of Ophthalmology, University of Wisconsin, Madison, Wisconsin, USA
Ophthalmology 111:1183-90. 2004....- Effect of image compression and resolution on retinal vascular caliberThomas W Pauli
Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison, Madison, WI 53717, USA
Invest Ophthalmol Vis Sci 53:5117-23. 2012.... 
Retinal vessel caliber among people with acquired immunodeficiency syndrome: relationships with disease-associated factors and mortalitySapna Gangaputra
Fundus Photograph Reading Center, Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, USA
Am J Ophthalmol 153:434-444.e1. 2012..To evaluate relationships between retinal vessel caliber, AIDS-related factors, and mortality...- Transition from film to digital fundus photography in the Longitudinal Studies of the Ocular Complications of AIDSSapna Gangaputra
Fundus Photograph Reading Center, Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison, Madison, Wisconsin 53717, USA
Retina 32:600-5. 2012..To describe the transition to digital imaging and assess any impact on ocular disease classification... - Early age-related maculopathy in the cardiovascular health studyRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53726, USA
Ophthalmology 110:25-33. 2003..Although an association was found between signs of white matter disease and early ARM, there was no evidence of an association of ARM with either hypertension or inflammatory factors... - Revised formulas for summarizing retinal vessel diametersMichael D Knudtson
Department of Ophthalmology, University of Wisconsin, Madison, WI 53726, USA
Curr Eye Res 27:143-9. 2003.... - Comparison of digital and film grading of diabetic retinopathy severity in the diabetes control and complications trial/epidemiology of diabetes interventions and complications studyLarry D Hubbard
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53717 0568, USA
Arch Ophthalmol 129:718-26. 2011.... - Monoscopic versus stereoscopic retinal photography for grading diabetic retinopathy severityHelen K Li
Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, Texas 77555 1106, USA
Invest Ophthalmol Vis Sci 51:3184-92. 2010..To assess agreement between monoscopic and stereoscopic photography for research classification of the severity of diabetic retinopathy (DR)... - Suboptimal image focus broadens retinal vessel caliber measurementCharles S Chandler
Department of Ophthalmology and Visual Sciences, Fundus Photograph Reading Center, College of Engineering, Mechanical Engineering General, University of Wisconsin Madison, Madison, WI 53717, USA
Invest Ophthalmol Vis Sci 52:8558-61. 2011..The authors explored suboptimal image focus as a possible contributing factor to artificially larger vascular caliber measurements... - The relation of atherosclerotic cardiovascular disease to retinopathy in people with diabetes in the Cardiovascular Health StudyRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53705 2397, USA
Br J Ophthalmol 86:84-90. 2002..To describe the association of retinopathy with atherosclerosis and atherosclerotic risk factors in people with diabetes... - Imaging of diabetic retinopathy and diabetic macular edemaRonald P Danis
Ophthalmology and Visual Sciences, University of Wisconsin Madison Fundus Photograph Reading Center, 8010 Excelsior Drive, Madison, WI 53717, USA
Curr Diab Rep 11:236-43. 2011..The classification of diabetic retinopathy severity continues to rely upon fundus photography, although the transition from film to digital photography presents both challenges and advantages... - A severity scale for diabetic macular edema developed from ETDRS dataRonald E Gangnon
Department of Population Health Sciences, University of Wisconsin, Madison, Wisconsin 53711 1068, USA
Invest Ophthalmol Vis Sci 49:5041-7. 2008..To develop a severity scale for diabetic macular edema (DME) and to assess relationships between severity and duration of DME and visual acuity (VA)... - The association of atherosclerosis, vascular risk factors, and retinopathy in adults with diabetes : the atherosclerosis risk in communities studyRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, 610 North Walnut Street, Madison, WI 53705-2397, USA
Ophthalmology 109:1225-34. 2002.... - Comparability of two fundus photograph reading centers in grading cytomegalovirus retinitis progressionLarry D Hubbard
Department of Ophthalmology and Visual Sciences, The University of Wisconsin Medical School, Madison Wisconsin 53711 1068, USA
Am J Ophthalmol 137:426-34. 2004..To compare grading of cytomegalovirus retinitis progression by two different fundus photograph reading centers (FPRCs)... - Morphologic assessment for glaucoma in the Multicenter Uveitis Steroid Treatment (MUST) trialSapna S Gangaputra
Fundus Photograph Reading Center, Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53717, USA
Ocul Immunol Inflamm 19:267-74. 2011..To compare Reading Center (RC) cup-to-disc ratio (CDR) assessment from stereoscopic photographs with clinician estimation in a uveitis clinical trial... - Cerebral white matter lesions, retinopathy, and incident clinical strokeTien Yin Wong
Department of Ophthalmology, University of Wisconsin, Madison, USA
JAMA 288:67-74. 2002..White matter lesions (WMLs) detected on cerebral imaging scans have been hypothesized to have a microvascular etiology and to precede the development of clinical stroke. However, few clinical data are available to support these hypotheses... - Retinal microvascular abnormalities and cognitive impairment in middle-aged persons: the Atherosclerosis Risk in Communities StudyTien Yin Wong
Department of Ophthalmology, University of Wisconsin, Madison, USA
Stroke 33:1487-92. 2002..Here, we examine the relation of retinal microvascular abnormalities with cognitive function in middle-aged persons free of stroke... - Three-year incidence and cumulative prevalence of retinopathy: the atherosclerosis risk in communities studyTien Y Wong
Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
Am J Ophthalmol 143:970-6. 2007..To describe the three-year incidence and cumulative prevalence of retinopathy and its risk factors... - Apolipoprotein e gene and age-related maculopathy in older individuals: the cardiovascular health studyGabriella Tikellis
Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
Arch Ophthalmol 125:68-73. 2007..To examine the association between the apolipoprotein E (APOE) gene and age-related maculopathy (ARM) in an older population... - Dietary glycemic index and carbohydrate in relation to early age-related macular degenerationChung-Jung Chiu
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Am J Clin Nutr 83:880-6. 2006..6) was 2.71 (95% CI: 1.24, 5.93; P for trend = 0.01). Neither dietary GI nor total carbohydrate intake was related to drusen. CONCLUSION: Our results suggest that dietary GI may be an independent risk factor for ARM... - Retinal microvascular abnormalities and MRI-defined subclinical cerebral infarction: the Atherosclerosis Risk in Communities StudyLawton S Cooper
National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Stroke 37:82-6. 2006..These data suggest that retinal photography may be useful for studying subclinical cerebrovascular disease in population-based studies... - Progression of diabetic macular edema: correlation with blood retinal barrier permeability, retinal thickness, and retinal vessel diameterBirgit Sander
Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Denmark
Invest Ophthalmol Vis Sci 48:3983-7. 2007..To study the progression of diabetic macular edema (DME) in relation to baseline retinal thickness, retinal vascular leakage, and retinal trunk vessel diameters... - Clinician versus reading center assessment of cytomegalovirus retinitis lesion sizeDavid V Weinberg
Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Ophthalmology 112:559-66. 2005..Clinician assessment of retinitis area correlates negatively with VF, a clinically meaningful visual outcome in patients with CMV retinitis... - High dose oral ganciclovir treatment for cytomegalovirus retinitisJacob P Lalezari
Quest Clinical Research, 2300 Sutter Street, Suite 202 San Francisco, CA 94115, USA
J Clin Virol 24:67-77. 2002..Median time to progression of CMV retinitis is 12-20 days shorter with oral compared to IV ganciclovir maintenance, likely due to the limited oral bioavailability of ganciclovir... - Characteristics of patients with cytomegalovirus retinitis in the era of highly active antiretroviral therapyDouglas A Jabs
Wilmer Eye Institute, 550 North Broadway, Suite 700, Baltimore, Maryland 21205, USA
Am J Ophthalmol 133:48-61. 2002..To describe the characteristics of patients with AIDS and cytomegalovirus retinitis in the era of highly active antiretroviral therapy (HAART)... - Retinal microvascular abnormalities and 10-year cardiovascular mortality: a population-based case-control studyTien Yin Wong
Singapore National Eye Center and National University of Singapore, Singapore, Republic of Singapore
Ophthalmology 110:933-40. 2003..Retinal microvascular abnormalities reflect persistent arteriolar damage from hypertension and independently predict stroke. We examined their associations with long-term cardiovascular mortality... - The Age-Related Eye Disease Study severity scale for age-related macular degeneration: AREDS Report No. 17Matthew D Davis
AREDS Coordinating Center, EMMES Corp, Rockville, MD 20850-1707, USA
Arch Ophthalmol 123:1484-98. 2005..CONCLUSIONS: The scale provides convenient risk categories and has acceptable reproducibility. Progression along it may prove to be useful as a surrogate for progression to advanced AMD... - Racial differences in the prevalence of hypertensive retinopathyTien Yin Wong
Department of Ophthalmology, Singapore National Eye Center and National University of Singapore
Hypertension 41:1086-91. 2003.... - Is early age-related maculopathy related to cognitive function? The Atherosclerosis Risk in Communities StudyTien Yin Wong
Singapore Eye Research Institute and Department of Ophthalmology, National University of Singapore, Singapore
Am J Ophthalmol 134:828-35. 2002..We describe the association between cognitive function and ARM in middle-aged persons... - Associations between the metabolic syndrome and retinal microvascular signs: the Atherosclerosis Risk In Communities studyTien Yin Wong
Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
Invest Ophthalmol Vis Sci 45:2949-54. 2004..To examine the cross-sectional relationship of the metabolic syndrome (hypertension, hyperglycemia, central obesity, and dyslipidemia) and retinal microvascular abnormalities in middle-aged men and women... - Reliability of retinal photography in the assessment of retinal microvascular characteristics: the Atherosclerosis Risk in Communities StudyDavid J Couper
Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27514, USA
Am J Ophthalmol 133:78-88. 2002..Retinal microvascular characteristics, as graded from retinal photography, have been shown to predict stroke. We evaluated the reliability of retinal photographic grading in the Atherosclerosis Risk in Communities Study... - Retinal arteriolar narrowing and risk of diabetes mellitus in middle-aged personsTien Yin Wong
Department of Ophthalmology, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
JAMA 287:2528-33. 2002..Microvascular processes have been hypothesized to play a role in the pathogenesis of type 2 diabetes mellitus, but prospective clinical data regarding this hypothesis are unavailable... - Retinal microvascular abnormalities and renal dysfunction: the atherosclerosis risk in communities studyTien Yin Wong
Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Victoria 3002, Australia
J Am Soc Nephrol 15:2469-76. 2004..Retinal microvascular abnormalities are associated with renal dysfunction, suggesting that common systemic microvascular processes may underlie the development of microvascular damage in the eye and kidneys... - The prevalence and risk factors of retinal microvascular abnormalities in older persons: The Cardiovascular Health StudyTien Yin Wong
Singapore Eye Research Institute, Singapore, Republic of Singapore
Ophthalmology 110:658-66. 2003..To describe the prevalence of retinal microvascular characteristics and their associations with atherosclerosis in elderly, nondiabetic persons... - Retinal arteriolar narrowing and risk of coronary heart disease in men and women. The Atherosclerosis Risk in Communities StudyTien Yin Wong
Department of Ophthalmology, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
JAMA 287:1153-9. 2002..Microvascular processes have been hypothesized to play a greater role in the development of coronary heart disease (CHD) in women than in men; however, prospective clinical data are limited... - Calibration of fundus images using spectral domain optical coherence tomographyBrandon J Lujan
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Ophthalmic Surg Lasers Imaging 39:S15-20. 2008..However, calibrated spectral domain OCT (SD-OCT) could offer a convenient alternative method for the calibration of any fundus image... - Relationships between age, blood pressure, and retinal vessel diameters in an older populationHarry Leung
Department of Ophthalmology, Centre for Vision Research, and the Westmead Millennium and Save Sight Institutes, The University of Sydney, NSW, Australia
Invest Ophthalmol Vis Sci 44:2900-4. 2003..The findings are consistent with those from the Atherosclerosis Risk in Communities Study suggesting that decreased retinal vessel diameters may reflect microvascular damage from elevated blood pressure... - Intake of zinc and antioxidant micronutrients and early age-related maculopathy lesionsMartha Savaria Morris
Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
Ophthalmic Epidemiol 14:288-98. 2007..Results of observational and intervention studies have been inconsistent... - Cardiovascular risk factors for retinal vein occlusion and arteriolar emboli: the Atherosclerosis Risk in Communities & Cardiovascular Health studiesTien Yin Wong
Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
Ophthalmology 112:540-7. 2005..To examine the associations of retinal vein occlusion and arteriolar emboli with cardiovascular disease... - Estrogen replacement therapy and retinal vascular caliberTien Yin Wong
Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
Ophthalmology 112:553-8. 2005..It is unclear if estrogen replacement therapy (ERT) has an effect on the retinal circulation. In the current study, we examine the association of ERT, female reproductive factors, and retinal vascular caliber... - Retinal arteriolar narrowing, hypertension, and subsequent risk of diabetes mellitusTien Yin Wong
Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria
Arch Intern Med 165:1060-5. 2005..Microvascular disease and hypertension have been linked with risk of diabetes mellitus. We examined the association of retinal arteriolar narrowing, a marker of chronic hypertension, with incident diabetes... - Retinal arteriolar diameter and risk for hypertensionTien Yin Wong
Centre for Eye Research Australia, University of Melbourne, East Melbourne Victoria, Australia
Ann Intern Med 140:248-55. 2004..Narrowing of the small arterioles has been hypothesized to contribute to the pathogenesis of hypertension, but prospective clinical data are lacking... - Prospective cohort study of retinal vessel diameters and risk of hypertensionTien Yin Wong
Centre for Eye Research Australia, University of Melbourne, Victoria 3002, Australia
BMJ 329:79. 2004..To examine the relation between diameters of the retinal arterioles and 10 year incidence of hypertension... - A prospective cohort study of retinal arteriolar narrowing and mortalityTien Yin Wong
Department of Ophthalmology, University of Melbourne, Victoria, Australia
Am J Epidemiol 159:819-25. 2004.... - Age-related macular degeneration and risk for strokeTien Yin Wong
Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia
Ann Intern Med 145:98-106. 2006..Age-related macular degeneration (AMD) affects 7 million persons 40 years of age and older in the United States. Risk factors for the disease are similar to those for stroke... - Retinal vessel diameters and their associations with age and blood pressureTien Yin Wong
Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia
Invest Ophthalmol Vis Sci 44:4644-50. 2003..To describe the cross-sectional relationship between retinal arteriolar and venular diameters with age and blood pressure... - Correlation between generalized and focal retinal arteriolar narrowing in an older populationAva G Tan
Centre for Vision Research, Department of Ophthalmology, University of Sydney, Australia
Clin Experiment Ophthalmol 31:322-5. 2003..These data suggest a moderate correlation between generalized (CRAE) and focal arteriolar narrowing. However, no significant association was found between arteriole-to-venule ratio and focal arteriolar narrowing... - Retinal vessel diameters and incident open-angle glaucoma and optic disc changes: the Rotterdam studyM Kamran Ikram
Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
Invest Ophthalmol Vis Sci 46:1182-7. 2005..CONCLUSIONS: The data show that baseline retinal vessel diameters did not influence the risk of iOAG or incident optic disc changes. These data provide no evidence for a retinal vascular role in the pathogenesis of OAG...