Affiliation: University of California
- Negative control of the Myc protein by the stress-responsive kinase Pak2Zhongdong Huang
The George Williams Hooper Foundation, University of California, San Francisco, California 94143 0552, USA
Mol Cell Biol 24:1582-94. 2004..These results indicate that Pak2 is a negative regulator of Myc, suggest that inhibition of Myc plays a role in the cellular response to stress, and raise the possibility that Pak2 may be the product of a tumor suppressor gene...
- Stress signaling and Myc downregulation: implications for cancerZhongdong Huang
The George Williams Hooper Foundation, University of California, San Francisco, 94143 0522, USA
Cell Cycle 3:593-6. 2004..Additionally, phosphorylation induces degradation of the Myc protein. Activation of stress signaling pathways, including Pak2 activity, may be a potential therapeutic approach to block Myc-induced neoplasia...
- Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cellsDun Yang
G W Hooper Foundation and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0552, USA
Proc Natl Acad Sci U S A 99:9942-7. 2002..esiRNA works by eliciting the destruction of its cognate mRNA. Because of its simplicity and potency, this approach is useful for analysis of mammalian gene functions...
- Localization of p21-activated protein kinase gamma-PAK/Pak2 in the endoplasmic reticulum is required for induction of cytostasisZhongdong Huang
Department of Biochemistry, University of California, Riverside, California 92521, USA
J Biol Chem 278:13101-9. 2003..A model for the induction of cytostasis by gamma-PAK through targeting of gamma-PAK to the ER is presented in which gamma-PAK activity and Ser-490 are implicated in the regulation of cytostasis...