Zhongdong Huang

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Negative control of the Myc protein by the stress-responsive kinase Pak2
    Zhongdong Huang
    The George Williams Hooper Foundation, University of California, San Francisco, California 94143 0552, USA
    Mol Cell Biol 24:1582-94. 2004
  2. ncbi request reprint Stress signaling and Myc downregulation: implications for cancer
    Zhongdong Huang
    The George Williams Hooper Foundation, University of California, San Francisco, 94143 0522, USA
    Cell Cycle 3:593-6. 2004
  3. pmc Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells
    Dun Yang
    G W Hooper Foundation and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0552, USA
    Proc Natl Acad Sci U S A 99:9942-7. 2002
  4. ncbi request reprint Localization of p21-activated protein kinase gamma-PAK/Pak2 in the endoplasmic reticulum is required for induction of cytostasis
    Zhongdong Huang
    Department of Biochemistry, University of California, Riverside, California 92521, USA
    J Biol Chem 278:13101-9. 2003

Detail Information

Publications4

  1. pmc Negative control of the Myc protein by the stress-responsive kinase Pak2
    Zhongdong Huang
    The George Williams Hooper Foundation, University of California, San Francisco, California 94143 0552, USA
    Mol Cell Biol 24:1582-94. 2004
    ..These results indicate that Pak2 is a negative regulator of Myc, suggest that inhibition of Myc plays a role in the cellular response to stress, and raise the possibility that Pak2 may be the product of a tumor suppressor gene...
  2. ncbi request reprint Stress signaling and Myc downregulation: implications for cancer
    Zhongdong Huang
    The George Williams Hooper Foundation, University of California, San Francisco, 94143 0522, USA
    Cell Cycle 3:593-6. 2004
    ..Additionally, phosphorylation induces degradation of the Myc protein. Activation of stress signaling pathways, including Pak2 activity, may be a potential therapeutic approach to block Myc-induced neoplasia...
  3. pmc Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells
    Dun Yang
    G W Hooper Foundation and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0552, USA
    Proc Natl Acad Sci U S A 99:9942-7. 2002
    ..esiRNA works by eliciting the destruction of its cognate mRNA. Because of its simplicity and potency, this approach is useful for analysis of mammalian gene functions...
  4. ncbi request reprint Localization of p21-activated protein kinase gamma-PAK/Pak2 in the endoplasmic reticulum is required for induction of cytostasis
    Zhongdong Huang
    Department of Biochemistry, University of California, Riverside, California 92521, USA
    J Biol Chem 278:13101-9. 2003
    ..A model for the induction of cytostasis by gamma-PAK through targeting of gamma-PAK to the ER is presented in which gamma-PAK activity and Ser-490 are implicated in the regulation of cytostasis...