- Huang Z, Traugh J, Bishop J. Negative control of the Myc protein by the stress-responsive kinase Pak2. Mol Cell Biol. 2004;24:1582-94 pubmed..These results indicate that Pak2 is a negative regulator of Myc, suggest that inhibition of Myc plays a role in the cellular response to stress, and raise the possibility that Pak2 may be the product of a tumor suppressor gene. ..