Affiliation: University of California
- Regulated drug bioanalysis for human pharmacokinetic studies and therapeutic drug managementYong Huang
Drug Studies Unit, Department of Bioengineering and Therapeutic Sciences, School of Pharmacy, University of California, San Francisco, CA 94143 0446, USA
Bioanalysis 4:1919-31. 2012..Fostering interaction between bioanalysts from pharmaceutical science and clinical chemistry and reducing the regulatory gaps between different agencies for drug bioanalysis is our objective...
- Matrix effect and recovery terminology issues in regulated drug bioanalysisYong Huang
Drug Studies Unit, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94143, USA
Bioanalysis 4:271-9. 2012..We also provide our personal views on the term 'recovery'...
- Sensitive analysis of anti-HIV drugs, efavirenz, lopinavir and ritonavir, in human hair by liquid chromatography coupled with tandem mass spectrometryYong Huang
Department of Biopharmaceutical Sciences, University of California, San Francisco, CA 94143, USA
Rapid Commun Mass Spectrom 22:3401-9. 2008..This developed method allowed for the monitoring of these target medications in the hair samples of HIV-infected women on antiretroviral therapy in an observational study using small amounts of hair...
- Microanalysis of the antiretroviral nevirapine in human hair from HIV-infected patients by liquid chromatography-tandem mass spectrometryYong Huang
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94143, USA
Anal Bioanal Chem 401:1923-33. 2011..We also showed that NVP in human hair can easily be detected in a single short strand of hair. This method will allow us to identify drug non-adherence using even a single strand of hair...
- A single-nucleotide polymorphism in CYP2B6 leads to >3-fold increases in efavirenz concentrations in plasma and hair among HIV-infected womenMonica Gandhi
Department of Medicine, University of California, San Francisco, CA, USA
J Infect Dis 206:1453-61. 2012..We analyzed numerous genetic and nongenetic factors impacting short-term and long-term exposure in a large heterogeneous population of human immunodeficiency virus (HIV)-infected women...
- Atazanavir concentration in hair is the strongest predictor of outcomes on antiretroviral therapyMonica Gandhi
Departments of Medicine, University of California, San Francisco, 94122, USA
Clin Infect Dis 52:1267-75. 2011..Hair concentrations of antiretrovirals can integrate adherence and pharmacokinetics into a single assay...
- Protease inhibitor levels in hair strongly predict virologic response to treatmentMonica Gandhi
Department of Medicine, University of California, San Francisco, San Francisco, California, USA
AIDS 23:471-8. 2009..The currently available methods to assess ARV exposure are limited. Levels of ARVs in hair reflect plasma concentrations over weeks to months, and may provide a novel method for predicting therapeutic responses...
- Ligand-mediated activation of an engineered gs g protein-coupled receptor in osteoblasts increases trabecular bone formationEdward C Hsiao
Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, California 94158, USA
Mol Endocrinol 24:621-31. 2010..This model provides a powerful tool for investigating the effects of ligand-activated G(s)-GPCR signaling on dynamic bone growth and remodeling...
- 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormoneThomas S Scanlan
Department of Pharmaceutical Chemistry and Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94143 2280, USA
Nat Med 10:638-42. 2004..These results suggest the existence of a new signaling pathway, stimulation of which leads to rapid physiological and behavioral consequences that are opposite those associated with excess TH...
- Pharmacokinetics of quinacrine efflux from mouse brain via the P-glycoprotein efflux transporterMisol Ahn
Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, California, USA
PLoS ONE 7:e39112. 2012..Our findings argue that the inhibition of the P-gp efflux transporter should improve the poor pharmacokinetic properties of quinacrine in the CNS...
- Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV diseaseDavid Favre
Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA 94110, USA
Sci Transl Med 2:32ra36. 2010..We postulate that induction of IDO may represent a critical initiating event that results in inversion of the T(H)17/T(reg) balance and in the consequent maintenance of a chronic inflammatory state in progressive HIV disease...
- Y-27632 improves rotarod performance and reduces huntingtin levels in R6/2 miceMei Li
Department of Neurology, University of California, San Francisco, CA 94143, USA
Neurobiol Dis 36:413-20. 2009..However, Y-27632 treatment improved rotarod performance significantly, and also reduced soluble brain Htt levels. The ROCK signaling pathway thus remains a promising therapeutic target for HD, and more potent inhibitors may prove useful...
- Distinctive T cell-suppressive signals from nuclearized type 1 sphingosine 1-phosphate G protein-coupled receptorsJia Jun Liao
Department of Medicine, University of California, San Francisco, California 94143, USA
J Biol Chem 282:1964-72. 2007....
- Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphateRajita Pappu
Cardiovascular Research Institute, University of California, San Francisco, 600 16th Street S472D, San Francisco, CA 94143 2240, USA
Science 316:295-8. 2007..Disruption of compartmentalized S1P signaling is a plausible mechanism by which S1P-receptor-1 agonists function as immunosuppressives...
- Non-competitive androgen receptor inhibition in vitro and in vivoJeremy O Jones
Department of Neurology, University of California San Francisco, San Francisco, CA 94115, USA
Proc Natl Acad Sci U S A 106:7233-8. 2009..Pyrvinium inhibits AR-dependent gene expression in the prostate gland in vivo, and induces prostate atrophy. These results highlight new therapeutic strategies to inhibit AR activity...
- In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: characterizing the importance of transporter-enzyme interplayJustine L Lam
Professor, Department of Biopharmaceutical Sciences, University of California San Francisco, 533 Parnassus, Room U-68, San Francisco, CA 94143-0446, USA
Drug Metab Dispos 34:1336-44. 2006..Hepatic uptake and efflux transporters modulate intracellular concentrations of ERY, thereby affecting metabolism. The interplay of transporters and enzymes must be considered in evaluating potential drug-drug interactions...
- Dose-response effect of tetracyclines on cerebral matrix metalloproteinase-9 after vascular endothelial growth factor hyperstimulationChanhung Z Lee
Department of Anesthesia and Perioperative Care, University of California, San Francisco, 94110, USA
J Cereb Blood Flow Metab 26:1157-64. 2006..This study provided the evidence that the tetracyclines inhibit stimulated cerebral MMP-9 at multiple levels and are effective at very low doses, offering great potential for therapeutic use...
- Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradientsSusan R Schwab
Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0414, USA
Science 309:1735-9. 2005..We conclude that lymphocyte egress is mediated by S1P gradients that are established by S1P lyase activity and that the lyase may represent a novel immunosuppressant drug target...
- Effects of uremic toxins on hepatic uptake and metabolism of erythromycinHong Sun
Department of Biopharmaceutical Sciences, University of California, San Francisco, California 94143-0446, USA
Drug Metab Dispos 32:1239-46. 2004..Our results suggest that CMPF can directly inhibit the uptake of Ery by inhibiting Oatp2, whereas IS is more likely to inhibit the enzymatic metabolism of Ery...
- Liquid chromatographic-tandem mass spectrometric assay for the simultaneous determination of didanosine and stavudine in human plasma, bronchoalveolar lavage fluid, alveolar cells, peripheral blood mononuclear cells, seminal plasma, cerebrospinal fluid anYong Huang
Department of Biopharmaceutical Sciences, University of California San Francisco, 94117, San Francisco, CA, USA
J Chromatogr B Analyt Technol Biomed Life Sci 799:51-61. 2004..The lower limits of quantitation for both ddI and d4T were 2.0 ng/ml in plasma; 0.5 ng/ml in CSF; 0.4 ng/ml in AC, PBMC, and BALF; 1.0 ng/ml in seminal plasma; and 0.01 ng/mg in tonsil tissue...