Yanfang Huang

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Estrogen receptors similarly mediate the effects of 17β-estradiol on cellular responses but differ in their potencies
    Yanfang Huang
    Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, NY 14642, USA
    Endocrine 39:48-61. 2011
  2. pmc Genomic responses from the estrogen-responsive element-dependent signaling pathway mediated by estrogen receptor alpha are required to elicit cellular alterations
    Stephanie L Nott
    Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, New York 14642, USA
    J Biol Chem 284:15277-88. 2009
  3. pmc Designer monotransregulators provide a basis for a transcriptional therapy for de novo endocrine-resistant breast cancer
    Stephanie L Nott
    Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, New York, United States of America
    Mol Med 16:10-8. 2010
  4. pmc Gene expression profiling reveals that the regulation of estrogen-responsive element-independent genes by 17 beta-estradiol-estrogen receptor beta is uncoupled from the induction of phenotypic changes in cell models
    Xiaodong Li
    Departments of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, New York 14642, USA
    J Mol Endocrinol 40:211-29. 2008
  5. pmc The ligand-mediated nuclear mobility and interaction with estrogen-responsive elements of estrogen receptors are subtype specific
    Mesut Muyan
    Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, New York 14642, USA
    J Mol Endocrinol 49:249-66. 2012
  6. pmc What are comparative studies telling us about the mechanism of ERbeta action in the ERE-dependent E2 signaling pathway?
    Xiaodong Li
    Department of Biochemistry and Biophysics, University of Rochester, Rochester, NY 14642, USA
    J Steroid Biochem Mol Biol 109:266-72. 2008

Collaborators

  • Xing Qiu
  • Jing Huang
  • Ming Chen
  • Bruce M Fenton
  • Mesut Muyan
  • Stephanie L Nott
  • Xiaodong Li
  • Brian R Fluharty
  • Linda M Callahan
  • Andrew J Lee
  • Scott F Paoni
  • Kathryn Harper
  • Aja Kalkanoglu
  • Shuyuan Yeh
  • Wade V Welshons
  • Russell Hilf
  • Robert A Bambara
  • Stephen Welle
  • Andrei Yakovlev

Detail Information

Publications6

  1. pmc Estrogen receptors similarly mediate the effects of 17β-estradiol on cellular responses but differ in their potencies
    Yanfang Huang
    Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, NY 14642, USA
    Endocrine 39:48-61. 2011
    ..Our results suggest that differences in potencies to regulate the expression of genes are a critical feature of the ER subtypes in mediating E2 signaling in cancer cell lines...
  2. pmc Genomic responses from the estrogen-responsive element-dependent signaling pathway mediated by estrogen receptor alpha are required to elicit cellular alterations
    Stephanie L Nott
    Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, New York 14642, USA
    J Biol Chem 284:15277-88. 2009
    ..E2-ERalpha, on the other hand, effectively repressed growth in this cell line. Our findings suggest that genomic responses from the ERE-dependent signaling pathway are required for E2-ERalpha to induce alterations in cellular responses...
  3. pmc Designer monotransregulators provide a basis for a transcriptional therapy for de novo endocrine-resistant breast cancer
    Stephanie L Nott
    Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, New York, United States of America
    Mol Med 16:10-8. 2010
    ..Moreover, the ERE-binding monotransregulator repressed xenograft tumor growth in a nude mice model. Thus, specific regulation of genes bearing EREs could offer a therapeutic approach for de novo endocrine-resistant breast cancers...
  4. pmc Gene expression profiling reveals that the regulation of estrogen-responsive element-independent genes by 17 beta-estradiol-estrogen receptor beta is uncoupled from the induction of phenotypic changes in cell models
    Xiaodong Li
    Departments of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, New York 14642, USA
    J Mol Endocrinol 40:211-29. 2008
    ..These findings suggest that the ERE-dependent pathway is a required signaling route for E(2)-ERbeta to induce cellular responses...
  5. pmc The ligand-mediated nuclear mobility and interaction with estrogen-responsive elements of estrogen receptors are subtype specific
    Mesut Muyan
    Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, New York 14642, USA
    J Mol Endocrinol 49:249-66. 2012
    ..Therefore, while ERs are highly mobile molecules interacting with target sites with fast kinetics, an indication of the hit-and-run model of transcription, they differ mechanistically to modulate transcriptions...
  6. pmc What are comparative studies telling us about the mechanism of ERbeta action in the ERE-dependent E2 signaling pathway?
    Xiaodong Li
    Department of Biochemistry and Biophysics, University of Rochester, Rochester, NY 14642, USA
    J Steroid Biochem Mol Biol 109:266-72. 2008
    ..Thus, the structurally distinct amino-termini of ERs are important determinants in defining the function of ER-subtypes in the ERE-dependent pathway. This could differentially affect the physiology and pathophysiology of E2 signaling...