Research Topics
| Xiang Run HuangSummaryAffiliation: University of Miami Country: USA Publications
Research Grants
| Collaborators |
Detail Information
Publications
Reflectance decreases before thickness changes in the retinal nerve fiber layer in glaucomatous retinasXiang Run Huang
Bascom Palmer Eye Institute, University of Miami, Miami, Florida 33136, USA
Invest Ophthalmol Vis Sci 52:6737-42. 2011..RNFL thickness, measured with optical coherence tomography (OCT), is often used in clinical assessment of the damage. In this study the relation between the RNFL reflectance and thickness at early stages of glaucoma was investigated...- Wavelength-dependent change of retinal nerve fiber layer reflectance in glaucomatous retinasXiang Run Huang
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Invest Ophthalmol Vis Sci 53:5869-76. 2012..This study measured the changes in RNFL reflectance spectra that occurred in retinal nerve fiber bundles with different degrees of glaucomatous damage... 
Quantifying retinal nerve fiber layer thickness in whole-mounted retinaXiang Run Huang
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 1638 N W 10th Ave, Miami, FL 33136, USA
Exp Eye Res 83:1096-101. 2006..The cross-sectional images provided thickness measurements of the RNFL over the entire field-of-view, not just at the points represented by the conventional histologic section, resulting in a large increase in available data...- Distortion of axonal cytoskeleton: an early sign of glaucomatous damageXiangrun Huang
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 1638 NW Tenth Avenue, Miami, FL 33136, USA
Invest Ophthalmol Vis Sci 52:2879-88. 2011..Distribution of these components in a whole-mounted retina was examined by confocal microscopy. Fluorescent stain was quantitatively described... - Altered F-actin distribution in retinal nerve fiber layer of a rat model of glaucomaXiang Run Huang
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 1638 NW 10th Ave, Miami, FL 33136, USA
Exp Eye Res 88:1107-14. 2009..Topographic features of F-actin alteration suggest that F-actin near the ONH is more sensitive to glaucomatous damage. The alteration pattern also suggests an ONH location for the glaucomatous insult in this rat model... - Variation of peripapillary retinal nerve fiber layer birefringence in normal human subjectsXiang Run Huang
Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida 33136, USA
Invest Ophthalmol Vis Sci 45:3073-80. 2004..The birefringence (Deltan) depends on the density and composition of axonal organelles. The purpose of this study was to evaluate the distribution of birefringence around the optic nerve head (ONH) in normal subjects... - Microtubules contribute to the birefringence of the retinal nerve fiber layerXiang Run Huang
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Invest Ophthalmol Vis Sci 46:4588-93. 2005..MTs are generally assumed to be a major contributor, but this has not been demonstrated. In this study, the MT depolymerizing agent colchicine was used to evaluate the contribution of MTs to RNFL birefringence... - Microtubule contribution to the reflectance of the retinal nerve fiber layerXiang Run Huang
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Invest Ophthalmol Vis Sci 47:5363-7. 2006..To increase understanding of the anatomic basis for clinical RNFL measurements, this study was conducted to evaluate the MT contribution to RNFL reflectance in rodent retinas by using the MT depolymerizing agent colchicine... - Linear birefringence of the central human corneaRobert W Knighton
Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida 33101, USA
Invest Ophthalmol Vis Sci 43:82-6. 2002..To determine the polarization properties of the central cornea at perpendicular incidence in a normal human population on the assumption that the cornea behaves as a linear retarder... - Analytical model of scanning laser polarimetry for retinal nerve fiber layer assessmentRobert W Knighton
Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, USA
Invest Ophthalmol Vis Sci 43:383-92. 2002..To develop a quantitative understanding of scanning laser polarimetry (SLP) for retinal nerve fiber layer (RNFL) assessment in glaucoma diagnosis and management... - Corneal birefringence mapped by scanning laser polarimetryRobert W Knighton
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 1638 NW Tenth Avenue, Miami, FL 33136, USA
Opt Express 16:13738-51. 2008..Some locations in a few corneas can be uniaxial with the optical axis perpendicular to the surface. Importantly, corneal birefringence varies greatly among people and, within a single cornea, significantly with position... 
Reflectance speckle of retinal nerve fiber layer reveals axonal activityXiang Run Huang
Bascom Palmer Eye Institute, University of Miami, Miami, Florida
Invest Ophthalmol Vis Sci 54:2616-23. 2013..This study investigated the retinal nerve fiber layer (RNFL) reflectance speckle and tested the hypothesis that temporal change of RNFL speckle reveals axonal dynamic activity...- Diattenuation and polarization preservation of retinal nerve fiber layer reflectanceXiang-Run Huang
Bascom Palmer Eye Institute, University of Miami School of Medicine, PO Box 016880, Miami, Florida 33101-6880, USA
Appl Opt 42:5737-43. 2003..03. Degree of polarization (DOP) for reflection from the RNFL was also measured. DOP was close to unity at all wavelengths, which indicates that the RNFL is a polarization-preserving reflector... - Theoretical model of the polarization properties of the retinal nerve fiber layer in reflectionXiang-Run Huang
Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida 33136, USA
Appl Opt 42:5726-36. 2003.... - Linear birefringence of the retinal nerve fiber layer measured in vitro with a multispectral imaging micropolarimeterXiang-Run Huang
University of Miami School of Medicine, Bascom Palmer Eye Institute, Miami, Florida 33136, USA
J Biomed Opt 7:199-204. 2002..These results allow extrapolation of previous visible wavelength measurements to the near-infrared wavelengths used by SLP and validate the use of fixed tissue for RNFL research...
Research Grants
- Retinal nerve fiber layer in glaucoma: Optical properties and damage mechanismsXiangrun Huang; Fiscal Year: 2010..The ultimate goal of this project is to improve assessment sensitivity for RNFL damage in clinical practice. ..