Ting Ting Huang

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc CuZnSOD gene deletion targeted to skeletal muscle leads to loss of contractile force but does not cause muscle atrophy in adult mice
    Yiqiang Zhang
    1H V R, Department of Cellular and Structural Biology, Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78249, USA
    FASEB J 27:3536-48. 2013
  2. doi request reprint Improved insulin sensitivity associated with reduced mitochondrial complex IV assembly and activity
    Sathyaseelan S Deepa
    Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX78245, USA
    FASEB J 27:1371-80. 2013
  3. doi request reprint Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus
    Yun Shi
    Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    Am J Physiol Regul Integr Comp Physiol 304:R343-55. 2013
  4. ncbi request reprint Analysis of the transcriptional activity of the 5'-flanking region of the rat catalase gene in transiently transfected cells and in transgenic mice
    H Van Remmen
    Geriatric Research, Education, and Clinical Center, South Texas Veterans Health Care System, Audie L Murphy Division, San Antonio
    J Cell Physiol 174:18-26. 1998
  5. ncbi request reprint Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress
    Holly Van Remmen
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78284 7762, USA
    Free Radic Biol Med 36:1625-34. 2004
  6. ncbi request reprint Oxidative damage to DNA and aging
    Holly Van Remmen
    Department of Physiology, University of Texas Health Science Center at San Antonio, USA
    Exerc Sport Sci Rev 31:149-53. 2003
  7. ncbi request reprint Effect of dietary restriction on hepatic and renal phosphoenolpyruvate carboxykinase induction in young and old Fischer 344 rats
    H Van Remmen
    Department of Physiology, University of Texas Health Science Center, San Antonio 78284, USA
    Mech Ageing Dev 104:263-75. 1998
  8. ncbi request reprint Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis
    H Van Remmen
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Am J Physiol Heart Circ Physiol 281:H1422-32. 2001
  9. ncbi request reprint Oxidative damage to mitochondria and aging
    H Van Remmen
    Department of Physiology, The University of Texas Health Science Center at San Antonio, and GRECC, South Texas Veterans Health Care System, San Antonio, TX 78284 7756, USA
    Exp Gerontol 36:957-68. 2001
  10. ncbi request reprint Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging
    Abdellah Mansouri
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3901, USA
    Mech Ageing Dev 127:298-306. 2006

Research Grants

Collaborators

Detail Information

Publications15

  1. pmc CuZnSOD gene deletion targeted to skeletal muscle leads to loss of contractile force but does not cause muscle atrophy in adult mice
    Yiqiang Zhang
    1H V R, Department of Cellular and Structural Biology, Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78249, USA
    FASEB J 27:3536-48. 2013
    ..Bhattacharya, A., Richardson, A., Jackson, M.J., McArdle, A., Brooks, S.V., Van Remmen, H. CuZnSOD gene deletion targeted to skeletal muscle leads to loss of contractile force but does not cause muscle atrophy in adult mice. ..
  2. doi request reprint Improved insulin sensitivity associated with reduced mitochondrial complex IV assembly and activity
    Sathyaseelan S Deepa
    Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX78245, USA
    FASEB J 27:1371-80. 2013
    ....
  3. doi request reprint Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus
    Yun Shi
    Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    Am J Physiol Regul Integr Comp Physiol 304:R343-55. 2013
    ..Nonetheless, the age-dependent increase in protein carbonyls is more pronounced in short-lived M. musculus, which supports enhanced protein homeostasis in long-lived P. leucopus...
  4. ncbi request reprint Analysis of the transcriptional activity of the 5'-flanking region of the rat catalase gene in transiently transfected cells and in transgenic mice
    H Van Remmen
    Geriatric Research, Education, and Clinical Center, South Texas Veterans Health Care System, Audie L Murphy Division, San Antonio
    J Cell Physiol 174:18-26. 1998
    ....
  5. ncbi request reprint Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress
    Holly Van Remmen
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78284 7762, USA
    Free Radic Biol Med 36:1625-34. 2004
    ....
  6. ncbi request reprint Oxidative damage to DNA and aging
    Holly Van Remmen
    Department of Physiology, University of Texas Health Science Center at San Antonio, USA
    Exerc Sport Sci Rev 31:149-53. 2003
    ..Dietary restriction extends lifespan and is associated with reduced levels of damage to mitochondrial and nuclear DNA. The effect of exercise on DNA damage appears to be related to the intensity of the exercise...
  7. ncbi request reprint Effect of dietary restriction on hepatic and renal phosphoenolpyruvate carboxykinase induction in young and old Fischer 344 rats
    H Van Remmen
    Department of Physiology, University of Texas Health Science Center, San Antonio 78284, USA
    Mech Ageing Dev 104:263-75. 1998
    ..In the kidney, there was no effect of age or dietary restriction on the induction of PEPCK as the activity of renal PEPCK did not change in response to the 12-h fast in any of the four groups of rats...
  8. ncbi request reprint Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis
    H Van Remmen
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Am J Physiol Heart Circ Physiol 281:H1422-32. 2001
    ..These experiments demonstrate that MnSOD may play an important role in the induction of the mitochondrial pathway of apoptosis in the heart, and this appears to occur primarily through the permeability transition...
  9. ncbi request reprint Oxidative damage to mitochondria and aging
    H Van Remmen
    Department of Physiology, The University of Texas Health Science Center at San Antonio, and GRECC, South Texas Veterans Health Care System, San Antonio, TX 78284 7756, USA
    Exp Gerontol 36:957-68. 2001
    ..Alterations in mitochondrial turnover with age could also contribute to an increase in the number of dysfunctional mitochondria with age...
  10. ncbi request reprint Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging
    Abdellah Mansouri
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3901, USA
    Mech Ageing Dev 127:298-306. 2006
    ..In addition, increased oxidative stress generated by reduced activity of MnSOD does not exacerbate these alterations during aging...
  11. ncbi request reprint Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy
    Florian L Muller
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Free Radic Biol Med 40:1993-2004. 2006
    ..Thus, the absence of CuZnSOD imposes elevated oxidative stress, loss of muscle mass, and physiological consequences that resemble an acceleration of normal age-related sarcopenia...
  12. ncbi request reprint Organ-specific increase in mutation accumulation and apoptosis rate in CuZn-superoxide dismutase-deficient mice
    Rita A Busuttil
    Departments of Physiology and Molecular Medicine, University of Texas Health Science Center, San Antonio, 78240, USA
    Cancer Res 65:11271-5. 2005
    ..5-fold was found not earlier than at 6 months. No increased mutation accumulation was observed in brain or spleen. These results support the hypothesis, that oxidative stress is an important causal factor of cancer in mammals...
  13. doi request reprint Redox balance- and radiation-mediated alteration in hippocampal neurogenesis
    Ting Ting Huang
    Geriatric Research, Education, and Care Center GRECC, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Free Radic Res 46:951-8. 2012
    ..15.1.1) isoforms, we have begun to determine the consequences of SOD deficiency in hippocampal neurogenesis and the related functions of learning and memory under normal condition and following cranial irradiation...
  14. pmc Oxidative stress and adult neurogenesis--effects of radiation and superoxide dismutase deficiency
    Ting Ting Huang
    Geriatric Research, Education, and Care Center GRECC, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Semin Cell Dev Biol 23:738-44. 2012
    ....
  15. pmc Lack of extracellular superoxide dismutase (EC-SOD) in the microenvironment impacts radiation-induced changes in neurogenesis
    Radoslaw Rola
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94110 0899, and GRECC, VA Palo Alto Health Care System, USA
    Free Radic Biol Med 42:1133-45; discussion 1131-2. 2007
    ..This finding may have a major impact in developing strategies to reduce cognitive impairment after cranial irradiation...

Research Grants1